RGD Reference Report - Distribution of small Rho GTPases in the developing rat submandibular gland. - Rat Genome Database

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Distribution of small Rho GTPases in the developing rat submandibular gland.

Authors: Crema, VO  Fossati, AC  Hamassaki, DE  Santos, MF 
Citation: Crema VO, etal., J Mol Histol. 2008 Oct;39(5):519-25. Epub 2008 Sep 11.
RGD ID: 5688282
Pubmed: PMID:18784978   (View Abstract at PubMed)
DOI: DOI:10.1007/s10735-008-9192-z   (Journal Full-text)

During the rat submandibular gland (SMG) development, organogenesis and cytodifferentiation depend on the actin cytoskeleton, which is regulated by small Rho GTPases. These proteins link cell surface receptors to pathways that regulate cell motility, polarity, gene expression, vesicular trafficking, proliferation and apoptosis. The aim of this study was to evaluate, by immunohistochemistry, the distribution pattern of RhoA, RhoB, RhoC, Rac1 and Cdc42 during cytodifferentiation of the rat SMG and in male adults. All GTPases were found in epithelial and mesenchymal tissues throughout gland development. Rac1 appeared to be important for parenchyma expansion at the beginning of cytodifferentiation, while RhoC, Cdc42 and the inactive phosphorylated form of Rac1 seemed associated with lumen formation and cell polarization in terminal tubules. RhoA and RhoB labeling was evident throughout development. All GTPases were differentially expressed in the adult gland, suggesting that they play specific roles during differentiation and function of the rat SMG.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Cdc42Ratsubmandibular salivary gland formation  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cdc42  (cell division cycle 42)


Additional Information