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ONTOLOGY REPORT - ANNOTATIONS


Term:trabectedin
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Accession:CHEBI:84050 term browser browse the term
Definition:A tetrahydroisoquinoline alkaloid obtained from a Caribbean tunicate Ecteinascidia turbinata. Used for the treatment of soft tissue sarcoma and relapsed ovarian cancer.
Synonyms:exact_synonym: (6R,6aR,7R,13S,14S,16R,20R)-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-19-oxo-3',4',6,7,12,13,14,16-octahydro-2'H,6aH-spiro[7,13-epimino-6,16-(epithiopropanooxymethano)[1,3]dioxolo[7,8]isoquinolino[3,2-b][3]benzazocine-20,1'-isoquinolin]-5-yl acetate
 related_synonym: ET-743;   ET743;   Ect 743;   Ecteinascidin;   Ecteinascidin 743;   Formula=C39H43N3O11S;   InChI=1S/C39H43N3O11S/c1-16-9-20-10-22-37(46)42-23-13-50-38(47)39(21-12-25(48-5)24(44)11-19(21)7-8-40-39)14-54-36(30(42)29(41(22)4)26(20)31(45)32(16)49-6)28-27(23)35-34(51-15-52-35)17(2)33(28)53-18(3)43/h9,11-12,22-23,29-30,36-37,40,44-46H,7-8,10,13-15H2,1-6H3/t22-,23-,29+,30+,36+,37-,39+/m0/s1;   InChIKey=PKVRCIRHQMSYJX-AIFWHQITSA-N;   SMILES=COc1cc2c(CCN[C@]22CS[C@H]3[C@H]4[C@@H]5N(C)[C@@H](Cc6cc(C)c(OC)c(O)c56)[C@H](O)N4[C@@H](COC2=O)c2c4OCOc4c(C)c(OC(C)=O)c32)cc1O;   Yondelis
 xref: CAS:114899-77-3 "ChemIDplus";   CAS:114899-77-3 "KEGG COMPOUND";   DrugBank:DB05109;   Drug_Central:4633 "DrugCentral";   HMDB:HMDB0015609;   KEGG:C16875;   KEGG:D06199
 xref_mesh: MESH:C099150
 xref: PMID:21403840 "Europe PMC";   PMID:21499557 "Europe PMC";   PMID:23149213 "Europe PMC";   PMID:24001124 "Europe PMC";   PMID:24277455 "Europe PMC";   PMID:24662672 "Europe PMC";   PMID:24692579 "Europe PMC";   PMID:24696229 "Europe PMC";   PMID:24707261 "Europe PMC";   PMID:24755886 "Europe PMC";   PMID:24756367 "Europe PMC";   PMID:24803896 "Europe PMC";   PMID:24844217 "Europe PMC";   PMID:24917554 "Europe PMC";   PMID:24941346 "Europe PMC";   PMID:24982387 "Europe PMC";   PMID:25048043 "Europe PMC";   PMID:25048044 "Europe PMC";   PMID:25050069 "Europe PMC";   PMID:25076252 "Europe PMC";   PMID:25100135 "Europe PMC";   PMID:25209722 "Europe PMC";   PMID:25263179 "Europe PMC";   PMID:25273374 "Europe PMC";   PMID:25479910 "Europe PMC";   Reaxys:7617615 "Reaxys";   Wikipedia:Trabectedin


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trabectedin term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:6480464
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B JBrowse link 4 22,225,123 22,307,577 RGD:6480464
G Ca3 carbonic anhydrase 3 JBrowse link 2 88,126,519 88,136,063 RGD:6480464
G Ccna2 cyclin A2 JBrowse link 2 123,274,727 123,282,266 RGD:6480464
G Ccnb1 cyclin B1 JBrowse link 2 30,782,133 30,791,106 RGD:6480464
G Ccnb2 cyclin B2 JBrowse link 8 76,847,972 76,861,165 RGD:6480464
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:6480464
G Ccne1 cyclin E1 JBrowse link 1 94,485,830 94,495,112 RGD:6480464
G Cdk1 cyclin-dependent kinase 1 JBrowse link 20 20,576,341 20,591,510 RGD:6480464
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:6480464
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:6480464
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 JBrowse link 12 11,641,500 11,677,818 RGD:6480464
G Cyp3a23/3a1 cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 1 JBrowse link 12 11,053,888 11,082,742 RGD:6480464
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 JBrowse link 12 19,074,288 19,114,491 RGD:6480464
G Dhfr dihydrofolate reductase JBrowse link 2 21,931,887 21,958,927 RGD:6480464
G E2f1 E2F transcription factor 1 JBrowse link 3 150,062,895 150,073,721 RGD:6480464
G Mki67 marker of proliferation Ki-67 JBrowse link 1 207,993,895 208,020,454 RGD:6480464
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:6480464
G Nfya nuclear transcription factor Y subunit alpha JBrowse link 9 14,551,752 14,577,002 RGD:6480464
G Nfyb nuclear transcription factor Y subunit beta JBrowse link 7 27,081,667 27,097,481 RGD:6480464
G Nfyc nuclear transcription factor Y subunit gamma JBrowse link 5 139,687,442 139,760,154 RGD:6480464
G Tk1 thymidine kinase 1 JBrowse link 10 106,817,556 106,828,888 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19662
    role 19606
      application 19232
        anti-inflammatory agent 14910
          trabectedin 22
Path 2
Term Annotations click to browse term
  CHEBI ontology 19662
    subatomic particle 19658
      composite particle 19658
        hadron 19658
          baryon 19658
            nucleon 19658
              atomic nucleus 19658
                atom 19658
                  main group element atom 19539
                    p-block element atom 19539
                      carbon group element atom 19422
                        carbon atom 19414
                          organic molecular entity 19414
                            organic group 18340
                              organic divalent group 18330
                                organodiyl group 18330
                                  carbonyl group 18217
                                    carbonyl compound 18217
                                      carboxylic acid 17921
                                        monocarboxylic acid 17256
                                          acetic acid 10587
                                            acetate ester 3176
                                              trabectedin 22
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.