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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:trabectedin
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Accession:CHEBI:84050 term browser browse the term
Definition:A tetrahydroisoquinoline alkaloid obtained from a Caribbean tunicate Ecteinascidia turbinata. Used for the treatment of soft tissue sarcoma and relapsed ovarian cancer.
Synonyms:exact_synonym: (6R,6aR,7R,13S,14S,16R,20R)-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-19-oxo-3',4',6,7,12,13,14,16-octahydro-2'H,6aH-spiro[7,13-epimino-6,16-(epithiopropanooxymethano)[1,3]dioxolo[7,8]isoquinolino[3,2-b][3]benzazocine-20,1'-isoquinolin]-5-yl acetate
 related_synonym: ET-743;   ET743;   Ect 743;   Ecteinascidin;   Ecteinascidin 743;   Formula=C39H43N3O11S;   InChI=1S/C39H43N3O11S/c1-16-9-20-10-22-37(46)42-23-13-50-38(47)39(21-12-25(48-5)24(44)11-19(21)7-8-40-39)14-54-36(30(42)29(41(22)4)26(20)31(45)32(16)49-6)28-27(23)35-34(51-15-52-35)17(2)33(28)53-18(3)43/h9,11-12,22-23,29-30,36-37,40,44-46H,7-8,10,13-15H2,1-6H3/t22-,23-,29+,30+,36+,37-,39+/m0/s1;   InChIKey=PKVRCIRHQMSYJX-AIFWHQITSA-N;   SMILES=COc1cc2c(CCN[C@]22CS[C@H]3[C@H]4[C@@H]5N(C)[C@@H](Cc6cc(C)c(OC)c(O)c56)[C@H](O)N4[C@@H](COC2=O)c2c4OCOc4c(C)c(OC(C)=O)c32)cc1O;   Yondelis
 xref: CAS:114899-77-3;   DrugBank:DB05109;   Drug_Central:4633;   HMDB:HMDB0015609;   KEGG:C16875;   KEGG:D06199
 xref_mesh: MESH:C099150
 xref: PMID:18728699;   PMID:21403840;   PMID:21499557;   PMID:23149213;   PMID:24001124;   PMID:24277455;   PMID:24662672;   PMID:24692579;   PMID:24696229;   PMID:24707261;   PMID:24755886;   PMID:24756367;   PMID:24803896;   PMID:24844217;   PMID:24917554;   PMID:24941346;   PMID:24982387;   PMID:25048043;   PMID:25048044;   PMID:25050069;   PMID:25076252;   PMID:25100135;   PMID:25209722;   PMID:25263179;   PMID:25273374;   PMID:25479910;   Reaxys:7617615;   Wikipedia:Trabectedin


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trabectedin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression		 ISO
EXP		 [ABCB1A protein mutant form co-treated with ABCB1B protein mutant form] results in increased susceptibility to trabectedin
trabectedin results in increased expression of ABCB1A mRNA		 CTD PMID:12154027 PMID:19238326 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb1b ATP-binding cassette, sub-family B member 1B multiple interactions
increases expression		 ISO
EXP		 [ABCB1A protein mutant form co-treated with ABCB1B protein mutant form] results in increased susceptibility to trabectedin
trabectedin results in increased expression of ABCB1B mRNA		 CTD PMID:12154027 PMID:19238326 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199 		JBrowse link
G Aco1 aconitase 1 increases expression ISO Trabectedin results in increased expression of ACO1 mRNA; Trabectedin results in increased expression of ACO1 protein CTD PMID:36396105 NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391 		JBrowse link
G Car3 carbonic anhydrase 3 decreases expression EXP trabectedin results in decreased expression of CAR3 mRNA CTD PMID:12154027 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO trabectedin results in decreased expression of CCNA2 mRNA CTD PMID:15961672 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO trabectedin results in decreased expression of CCNB1 mRNA CTD PMID:15961672 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccnb2 cyclin B2 decreases expression ISO trabectedin results in decreased expression of CCNB2 mRNA CTD PMID:15961672 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874 		JBrowse link
G Ccnd1 cyclin D1 increases expression EXP trabectedin results in increased expression of CCND1 mRNA CTD PMID:12154027 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 increases expression ISO trabectedin results in increased expression of CCNE1 mRNA CTD PMID:15961672 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression EXP trabectedin results in increased expression of CDK1 mRNA CTD PMID:12154027 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression EXP trabectedin results in decreased expression of CYP1A2 mRNA CTD PMID:12154027 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity EXP trabectedin results in decreased activity of CYP2E1 protein CTD PMID:12154027 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity EXP trabectedin results in decreased activity of CYP3A2 protein CTD PMID:12154027 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions EXP Trabectedin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 mRNA] CTD PMID:12504080 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases expression EXP trabectedin results in decreased expression of CYP3A13 mRNA CTD PMID:12154027 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Dhfr dihydrofolate reductase decreases expression ISO trabectedin results in decreased expression of DHFR mRNA CTD PMID:15961672 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713 		JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO trabectedin results in increased expression of E2F1 mRNA CTD PMID:15961672 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361 		JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression ISO Trabectedin results in decreased expression of GPX4 mRNA; Trabectedin results in decreased expression of GPX4 protein CTD PMID:36396105 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases expression ISO Trabectedin results in increased expression of HIF1A mRNA; Trabectedin results in increased expression of HIF1A protein CTD PMID:36396105 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression ISO Trabectedin results in increased expression of KEAP1 protein CTD PMID:36396105 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862 		JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression EXP trabectedin results in increased expression of MKI67 protein CTD PMID:12154027 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases response to substance		 ISO everolimus inhibits the reaction [MTOR results in decreased susceptibility to trabectedin] CTD PMID:21622721 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression ISO Trabectedin results in decreased expression of NFE2L2 protein CTD PMID:36396105 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfya nuclear transcription factor Y subunit alpha multiple interactions ISO trabectedin affects the activity of [NFYA protein binds to NFYB protein binds to NFYC protein] CTD PMID:15961672 NCBI chr 9:12,587,437...12,613,911
Ensembl chr 9:12,586,259...12,613,898 		JBrowse link
G Nfyb nuclear transcription factor Y subunit beta multiple interactions ISO trabectedin affects the activity of [NFYA protein binds to NFYB protein binds to NFYC protein] CTD PMID:15961672 NCBI chr 7:20,964,988...20,980,569
Ensembl chr 7:20,964,993...20,980,565 		JBrowse link
G Nfyc nuclear transcription factor Y subunit gamma multiple interactions ISO trabectedin affects the activity of [NFYA protein binds to NFYB protein binds to NFYC protein] CTD PMID:15961672 NCBI chr 5:134,336,802...134,405,372
Ensembl chr 5:134,336,808...134,405,377 		JBrowse link
G Tfrc transferrin receptor increases expression ISO Trabectedin results in increased expression of TFRC mRNA; Trabectedin results in increased expression of TFRC protein CTD PMID:36396105 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Tk1 thymidine kinase 1 decreases expression ISO trabectedin results in decreased expression of TK1 mRNA CTD PMID:15961672 NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920 		JBrowse link
Term paths to the root
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  CHEBI ontology 19811
    role 19818
      application 19630
        anti-inflammatory agent 16579
          trabectedin 28
Path 2
Term Annotations click to browse term
  CHEBI ontology 19811
    subatomic particle 19809
      composite particle 19809
        hadron 19840
          baryon 19809
            nucleon 19809
              atomic nucleus 19809
                atom 19809
                  main group element atom 19759
                    p-block element atom 19759
                      carbon group element atom 19708
                        carbon atom 19734
                          organic molecular entity 19705
                            heteroorganic entity 19459
                              organochalcogen compound 19222
                                organooxygen compound 19137
                                  carbon oxoacid 18597
                                    carboxylic acid 18594
                                      monocarboxylic acid 17952
                                        acetic acid 11055
                                          acetate ester 4059
                                            trabectedin 28
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