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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:trabectedin
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Accession:CHEBI:84050 term browser browse the term
Definition:A tetrahydroisoquinoline alkaloid obtained from a Caribbean tunicate Ecteinascidia turbinata. Used for the treatment of soft tissue sarcoma and relapsed ovarian cancer.
Synonyms:exact_synonym: (6R,6aR,7R,13S,14S,16R,20R)-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethyl-19-oxo-3',4',6,7,12,13,14,16-octahydro-2'H,6aH-spiro[7,13-epimino-6,16-(epithiopropanooxymethano)[1,3]dioxolo[7,8]isoquinolino[3,2-b][3]benzazocine-20,1'-isoquinolin]-5-yl acetate
 related_synonym: ET-743;   ET743;   Ect 743;   Ecteinascidin;   Ecteinascidin 743;   Formula=C39H43N3O11S;   InChI=1S/C39H43N3O11S/c1-16-9-20-10-22-37(46)42-23-13-50-38(47)39(21-12-25(48-5)24(44)11-19(21)7-8-40-39)14-54-36(30(42)29(41(22)4)26(20)31(45)32(16)49-6)28-27(23)35-34(51-15-52-35)17(2)33(28)53-18(3)43/h9,11-12,22-23,29-30,36-37,40,44-46H,7-8,10,13-15H2,1-6H3/t22-,23-,29+,30+,36+,37-,39+/m0/s1;   InChIKey=PKVRCIRHQMSYJX-AIFWHQITSA-N;   SMILES=COc1cc2c(CCN[C@]22CS[C@H]3[C@H]4[C@@H]5N(C)[C@@H](Cc6cc(C)c(OC)c(O)c56)[C@H](O)N4[C@@H](COC2=O)c2c4OCOc4c(C)c(OC(C)=O)c32)cc1O;   Yondelis
 xref: CAS:114899-77-3;   DrugBank:DB05109;   Drug_Central:4633;   HMDB:HMDB0015609;   KEGG:C16875;   KEGG:D06199
 xref_mesh: MESH:C099150
 xref: PMID:18728699;   PMID:21403840;   PMID:21499557;   PMID:23149213;   PMID:24001124;   PMID:24277455;   PMID:24662672;   PMID:24692579;   PMID:24696229;   PMID:24707261;   PMID:24755886;   PMID:24756367;   PMID:24803896;   PMID:24844217;   PMID:24917554;   PMID:24941346;   PMID:24982387;   PMID:25048043;   PMID:25048044;   PMID:25050069;   PMID:25076252;   PMID:25100135;   PMID:25209722;   PMID:25263179;   PMID:25273374;   PMID:25479910;   Reaxys:7617615;   Wikipedia:Trabectedin


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trabectedin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
increases expression
ISO
EXP
[ABCB1A protein mutant form co-treated with ABCB1B protein mutant form] results in increased susceptibility to trabectedin
trabectedin results in increased expression of ABCB1A mRNA
CTD PMID:12154027 PMID:19238326 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B multiple interactions
increases expression
ISO
EXP
[ABCB1A protein mutant form co-treated with ABCB1B protein mutant form] results in increased susceptibility to trabectedin
trabectedin results in increased expression of ABCB1B mRNA
CTD PMID:12154027 PMID:19238326 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Ca3 carbonic anhydrase 3 decreases expression EXP trabectedin results in decreased expression of CAR3 mRNA CTD PMID:12154027 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO trabectedin results in decreased expression of CCNA2 mRNA CTD PMID:15961672 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO trabectedin results in decreased expression of CCNB1 mRNA CTD PMID:15961672 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnb2 cyclin B2 decreases expression ISO trabectedin results in decreased expression of CCNB2 mRNA CTD PMID:15961672 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
JBrowse link
G Ccnd1 cyclin D1 increases expression EXP trabectedin results in increased expression of CCND1 mRNA CTD PMID:12154027 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccne1 cyclin E1 increases expression ISO trabectedin results in increased expression of CCNE1 mRNA CTD PMID:15961672 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression EXP trabectedin results in increased expression of CDK1 mRNA CTD PMID:12154027 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases expression EXP trabectedin results in decreased expression of CYP1A2 mRNA CTD PMID:12154027 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity EXP trabectedin results in decreased activity of CYP2E1 protein CTD PMID:12154027 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity EXP trabectedin results in decreased activity of CYP3A2 protein CTD PMID:12154027 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 multiple interactions EXP Trabectedin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP3A23-3A1 mRNA] CTD PMID:12504080 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 decreases expression EXP trabectedin results in decreased expression of CYP3A13 mRNA CTD PMID:12154027 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Dhfr dihydrofolate reductase decreases expression ISO trabectedin results in decreased expression of DHFR mRNA CTD PMID:15961672 NCBI chr 2:23,585,876...23,611,199
Ensembl chr 2:23,586,031...23,613,713
JBrowse link
G E2f1 E2F transcription factor 1 increases expression ISO trabectedin results in increased expression of E2F1 mRNA CTD PMID:15961672 NCBI chr 3:143,064,535...143,075,362 JBrowse link
G Mki67 marker of proliferation Ki-67 increases expression EXP trabectedin results in increased expression of MKI67 protein CTD PMID:12154027 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases response to substance
ISO everolimus inhibits the reaction [MTOR results in decreased susceptibility to trabectedin] CTD PMID:21622721 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nfya nuclear transcription factor Y subunit alpha multiple interactions ISO trabectedin affects the activity of [NFYA protein binds to NFYB protein binds to NFYC protein] CTD PMID:15961672 NCBI chr 9:12,587,437...12,613,911
Ensembl chr 9:12,586,259...12,613,898
JBrowse link
G Nfyb nuclear transcription factor Y subunit beta multiple interactions ISO trabectedin affects the activity of [NFYA protein binds to NFYB protein binds to NFYC protein] CTD PMID:15961672 NCBI chr 7:20,964,988...20,980,569
Ensembl chr 7:20,964,993...20,980,565
JBrowse link
G Nfyc nuclear transcription factor Y subunit gamma multiple interactions ISO trabectedin affects the activity of [NFYA protein binds to NFYB protein binds to NFYC protein] CTD PMID:15961672 NCBI chr 5:134,336,802...134,405,372
Ensembl chr 5:134,336,808...134,405,377
JBrowse link
G Tk1 thymidine kinase 1 decreases expression ISO trabectedin results in decreased expression of TK1 mRNA CTD PMID:15961672 NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920
JBrowse link

Term paths to the root
Path 1
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  CHEBI ontology 19812
    role 19761
      application 19471
        anti-inflammatory agent 15836
          trabectedin 22
Path 2
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  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        monocarboxylic acid 17632
                                          acetic acid 10854
                                            acetate ester 3875
                                              trabectedin 22
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