Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Olmesartan medoxomil
go back to main search page
Accession:CHEBI:31932 term browser browse the term
Synonyms:related_synonym: CS-866;   CS866;   Formula=C29H30N6O6;   InChI=1S/C29H30N6O6/c1-5-8-23-30-25(29(3,4)38)24(27(36)39-16-22-17(2)40-28(37)41-22)35(23)15-18-11-13-19(14-12-18)20-9-6-7-10-21(20)26-31-33-34-32-26/h6-7,9-14,38H,5,8,15-16H2,1-4H3,(H,31,32,33,34);   InChIKey=UQGKUQLKSCSZGY-UHFFFAOYSA-N;   SMILES=CCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)C(=O)OCC5=C(OC(=O)O5)C)C(C)(C)O;   olmetec
 alt_id: CHEBI:93384
 xref: CAS:144689-63-4;   Drug_Central:1985;   KEGG:D01204;   LINCS:LSM-3767
 xref_mesh: MESH:D000068557


show annotations for term's descendants           Sort by:
Olmesartan medoxomil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 decreases activity ISO Olmesartan Medoxomil results in decreased activity of ABCB11 protein CTD PMID:23956101 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Olmesartan Medoxomil inhibits the reaction [Acetic Acid results in increased expression of BAX protein] CTD PMID:30594690 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP Olmesartan Medoxomil inhibits the reaction [Acetic Acid results in decreased expression of BCL2 protein] CTD PMID:30594690 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP Olmesartan Medoxomil inhibits the reaction [Acetic Acid results in increased expression of CASP3 protein] CTD PMID:30594690 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions EXP Olmesartan Medoxomil inhibits the reaction [Acetic Acid results in decreased activity of CAT protein] CTD PMID:30594690 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression EXP Olmesartan Medoxomil results in decreased expression of COL1A1 mRNA CTD PMID:18501344 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Crp C-reactive protein multiple interactions EXP Olmesartan Medoxomil inhibits the reaction [Acetic Acid results in increased expression of CRP protein] CTD PMID:30594690 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Edn1 endothelin 1 decreases expression EXP Olmesartan Medoxomil results in decreased expression of EDN1 mRNA CTD PMID:16336959 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Fasn fatty acid synthase decreases expression EXP Olmesartan Medoxomil results in decreased expression of FASN mRNA CTD PMID:18501344 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP Olmesartan Medoxomil inhibits the reaction [Acetic Acid results in decreased expression of HMOX1 mRNA] CTD PMID:30594690 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP Olmesartan Medoxomil inhibits the reaction [Acetic Acid results in decreased expression of IL10 protein] CTD PMID:30594690 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il15 interleukin 15 multiple interactions ISO Olmesartan Medoxomil results in increased expression of and results in increased secretion of IL15 protein CTD PMID:26423313 NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP Olmesartan Medoxomil inhibits the reaction [Acetic Acid results in increased expression of IL1B protein] CTD PMID:30594690 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP Olmesartan Medoxomil inhibits the reaction [Acetic Acid results in increased expression of IL6 protein] CTD PMID:30594690 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Olmesartan Medoxomil inhibits the reaction [Acetic Acid results in increased activity of MPO protein]; Olmesartan Medoxomil inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein] CTD PMID:23665423 PMID:30594690 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Olmesartan Medoxomil inhibits the reaction [Acetic Acid results in decreased expression of NFE2L2 mRNA] CTD PMID:30594690 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP Olmesartan Medoxomil inhibits the reaction [Acetic Acid results in decreased expression of NFKBIA protein]; Olmesartan Medoxomil inhibits the reaction [Acetic Acid results in increased expression of NFKBIA mRNA] CTD PMID:30594690 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nppb natriuretic peptide B decreases expression EXP Olmesartan Medoxomil results in decreased expression of NPPB mRNA CTD PMID:16336959 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Olmesartan Medoxomil inhibits the reaction [Acetic Acid results in increased expression of RELA mRNA]; Olmesartan Medoxomil inhibits the reaction [Acetic Acid results in increased expression of RELA protein]; Olmesartan Medoxomil inhibits the reaction [Acetic Acid results in increased phosphorylation of RELA protein] CTD PMID:30594690 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Serpine1 serpin family E member 1 decreases expression EXP Olmesartan Medoxomil results in decreased expression of SERPINE1 mRNA CTD PMID:18501344 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression EXP Olmesartan Medoxomil results in decreased expression of SREBF1 mRNA CTD PMID:18501344 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression
multiple interactions		 EXP Olmesartan Medoxomil results in decreased expression of TGFB1 mRNA
Olmesartan Medoxomil inhibits the reaction [Acetic Acid results in increased expression of TGFB1 protein]		 CTD PMID:16336959 PMID:18501344 PMID:30594690 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tjp1 tight junction protein 1 affects localization ISO Olmesartan Medoxomil affects the localization of TJP1 protein CTD PMID:26423313 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 EXP Olmesartan Medoxomil inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Olmesartan Medoxomil inhibits the reaction [Amiodarone results in increased expression of TNF mRNA]; Olmesartan Medoxomil inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]
Olmesartan Medoxomil results in decreased expression of TNF protein		 CTD PMID:18501344 PMID:23665423 PMID:26781185 PMID:30594690 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19838
    chemical entity 19836
      molecular entity 19836
        polyatomic entity 19794
          molecule 19699
            cyclic compound 19514
              ring assembly 9184
                biphenyls 6252
                  Olmesartan medoxomil 24
Path 2
Term Annotations click to browse term
  CHEBI ontology 19838
    subatomic particle 19836
      composite particle 19836
        hadron 19836
          baryon 19836
            nucleon 19836
              atomic nucleus 19836
                atom 19836
                  main group element atom 19786
                    p-block element atom 19786
                      carbon group element atom 19734
                        carbon atom 19731
                          organic molecular entity 19731
                            organic molecule 19684
                              organic cyclic compound 19496
                                carbocyclic compound 18584
                                  benzenoid aromatic compound 17996
                                    biphenyls 6252
                                      Olmesartan medoxomil 24
paths to the root