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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:trichlorfon
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Accession:CHEBI:6908 term browser browse the term
Definition:A phosphonic ester that is dimethyl phosphonate in which the hydrogen atom attched to the phosphorous is substituted by a 2,2,2-trichloro-1-hydroxyethyl group.
Synonyms:exact_synonym: dimethyl (2,2,2-trichloro-1-hydroxyethyl)phosphonate
 related_synonym: 1-Hydroxy-2,2,2-trichloroethylphosphonic acid dimethyl ester;   Chlorophos;   Formula=C4H8Cl3O4P;   InChI=1S/C4H8Cl3O4P/c1-10-12(9,11-2)3(8)4(5,6)7/h3,8H,1-2H3;   InChIKey=NFACJZMKEDPNKN-UHFFFAOYSA-N;   Methyl chlorophos;   Metrifonate;   SMILES=COP(=O)(OC)C(O)C(Cl)(Cl)Cl;   metrifonato;   metrifonatum
 xref: Beilstein:1709434;   CAS:52-68-6;   Drug_Central:1787;   KEGG:C07971;   KEGG:D00805;   LINCS:LSM-4995
 xref_mesh: MESH:D014236
 xref: PMID:19775726;   PMID:24122545;   PPDB:657;   Reaxys:1709434;   VSDB:657;   Wikipedia:Metrifonate


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trichlorfon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
decreases activity
affects activity		 ISO
EXP		 [Trichlorfon co-treated with Dichlorvos] results in decreased activity of ACHE protein; asoxime chloride inhibits the reaction [Trichlorfon results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [Trichlorfon results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Trichlorfon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Trichlorfon results in decreased activity of ACHE protein]
Trichlorfon metabolite results in decreased activity of ACHE protein; Trichlorfon results in decreased activity of ACHE protein
[Trichlorfon results in decreased activity of ACHE protein] which affects the localization of CHRM2 protein
Trichlorfon affects the activity of ACHE protein		 CTD PMID:235931 PMID:1852719 PMID:4859365 PMID:8783813 PMID:9268605 More... NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G App amyloid beta precursor protein increases secretion
affects cleavage
affects metabolic processing		 ISO
EXP		 Trichlorfon results in increased secretion of APP protein alternative form
Trichlorfon affects the cleavage of APP protein
Trichlorfon affects the metabolism of APP protein		 CTD PMID:10773217 PMID:11099780 PMID:11526466 PMID:11822883 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Bche butyrylcholinesterase multiple interactions
decreases activity		 ISO
EXP		 1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]; asoxime chloride inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]; Obidoxime Chloride inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein] CTD PMID:235931 PMID:11311445 PMID:18825528 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO Tetradecanoylphorbol Acetate inhibits the reaction [Trichlorfon results in decreased expression of BCL2 protein] CTD PMID:19631781 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp12 caspase 12 multiple interactions ISO [Verapamil co-treated with Ruthenium Red co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP12 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP12 protein]; Trichlorfon results in increased cleavage of and results in increased activity of CASP12 protein CTD PMID:19631781 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Verapamil co-treated with Ruthenium Red co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP3 protein]; Trichlorfon results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:19631781 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase decreases activity
increases activity		 ISO Trichlorfon results in decreased activity of CAT protein
Trichlorfon results in increased activity of CAT protein		 CTD PMID:15386949 PMID:17697763 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO [Trichlorfon results in decreased activity of ACHE protein] which affects the localization of CHRM2 protein CTD PMID:12794734 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103 		JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 affects expression EXP Trichlorfon affects the expression of CHRM4 mRNA; Trichlorfon affects the expression of CHRM4 protein CTD PMID:12093157 NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases activity
decreases expression		 ISO
EXP		 Trichlorfon results in decreased activity of CYP11A1 protein
Trichlorfon results in decreased expression of CYP11A1 mRNA; Trichlorfon results in decreased expression of CYP11A1 protein		 CTD PMID:17350742 PMID:37419161 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression
decreases activity		 EXP Trichlorfon results in decreased expression of CYP17A1 mRNA
Trichlorfon results in decreased activity of CYP17A1 protein		 CTD PMID:37419161 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO Trichlorfon inhibits the reaction [FSHB protein results in increased abundance of Progesterone] CTD PMID:17329077 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Gap43 growth associated protein 43 decreases expression ISO Trichlorfon results in decreased expression of GAP43 protein CTD PMID:27939611 NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases expression EXP Trichlorfon results in decreased expression of GPX1 mRNA; Trichlorfon results in decreased expression of GPX1 protein CTD PMID:37419161 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha increases activity ISO Trichlorfon results in increased activity of HNF4A protein CTD PMID:20143881 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression
decreases activity		 EXP Trichlorfon results in decreased expression of HSD3B1 mRNA
Trichlorfon results in decreased activity of HSD3B1 protein		 CTD PMID:37419161 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999 		JBrowse link
G Nefh neurofilament heavy chain decreases expression ISO Trichlorfon results in decreased expression of NEFH protein CTD PMID:27939611 NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 increases activity ISO Trichlorfon results in increased activity of NFE2L2 protein CTD PMID:20143881 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 decreases activity ISO Trichlorfon results in decreased activity of PNPLA6 protein CTD PMID:9268605 NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734 		JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N decreases expression ISO Trichlorfon results in decreased expression of SERPINA3 protein CTD PMID:10599054 NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433 		JBrowse link
G Sod2 superoxide dismutase 2 decreases expression EXP Trichlorfon results in decreased expression of SOD2 mRNA; Trichlorfon results in decreased expression of SOD2 protein CTD PMID:37419161 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Srd5a1 steroid 5 alpha-reductase 1 decreases expression
decreases activity		 EXP Trichlorfon results in decreased expression of SRD5A1 mRNA
Trichlorfon results in decreased activity of SRD5A1 protein		 CTD PMID:37419161 NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461 		JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO
EXP		 Trichlorfon results in decreased expression of STAR mRNA
Trichlorfon results in decreased expression of STAR mRNA; Trichlorfon results in decreased expression of STAR protein		 CTD PMID:17329077 PMID:17350742 PMID:37419161 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672 		JBrowse link
G Syn1 synapsin I decreases expression ISO Trichlorfon results in decreased expression of SYN1 protein CTD PMID:27939611 NCBI chr  X:1,172,208...1,227,400
Ensembl chr  X:1,172,208...1,227,396 		JBrowse link
G Syp synaptophysin decreases expression ISO Trichlorfon results in decreased expression of SYP protein CTD PMID:27939611 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO Trichlorfon results in increased expression of TP53 protein CTD PMID:19631781 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
Term paths to the root
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  CHEBI ontology 19808
    role 19784
      application 19627
        agrochemical 16259
          trichlorfon 26
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  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      chalcogen 19513
                        oxygen atom 19488
                          oxygen molecular entity 19488
                            hydroxides 19299
                              oxoacid 18736
                                pnictogen oxoacid 13211
                                  phosphorus oxoacid 12414
                                    phosphorus oxoacid derivative 11762
                                      phosphonic acid derivative 2352
                                        phosphonate 184
                                          organic phosphonate 184
                                            trichlorfon 26
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