CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: phosphonate
Accession: CHEBI:26066
browse the term
Synonyms: related_synonym: phosphonates
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Ahr
aryl hydrocarbon receptor
affects activity
ISO
adefovir dipivoxil affects the activity of AHR protein
CTD
PMID:25596134
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Ak4
adenylate kinase 4
increases expression
ISO
adefovir dipivoxil results in increased expression of AK4 mRNA
CTD
PMID:25596134
NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618
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Akr1c2
aldo-keto reductase family 1, member C2
decreases expression
ISO
adefovir dipivoxil results in decreased expression of AKR1C2 mRNA
CTD
PMID:25596134
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
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Aldh18a1
aldehyde dehydrogenase 18 family, member A1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of ALDH18A1 mRNA
CTD
PMID:25596134
NCBI chr 1:239,375,657...239,407,967
Ensembl chr 1:239,375,669...239,407,890
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Aldh1a3
aldehyde dehydrogenase 1 family, member A3
increases expression
ISO
adefovir dipivoxil results in increased expression of ALDH1A3 mRNA
CTD
PMID:25596134
NCBI chr 1:119,982,272...120,017,416
Ensembl chr 1:119,982,277...120,017,436
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Als2cl
ALS2 C-terminal like
increases expression
ISO
adefovir dipivoxil results in increased expression of ALS2CL mRNA
CTD
PMID:25596134
NCBI chr 8:110,863,753...110,884,434
Ensembl chr 8:110,864,975...110,884,419
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Angptl4
angiopoietin-like 4
increases expression
ISO
adefovir dipivoxil results in increased expression of ANGPTL4 mRNA
CTD
PMID:25596134
NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
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Asns
asparagine synthetase (glutamine-hydrolyzing)
decreases expression
ISO
adefovir dipivoxil results in decreased expression of ASNS mRNA
CTD
PMID:25596134
NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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Atad2
ATPase family, AAA domain containing 2
increases expression
ISO
adefovir dipivoxil results in increased expression of ATAD2 mRNA
CTD
PMID:25596134
NCBI chr 7:89,634,123...89,676,738
Ensembl chr 7:89,634,123...89,676,738
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Atf3
activating transcription factor 3
increases expression
ISO
adefovir dipivoxil results in increased expression of ATF3 mRNA
CTD
PMID:25596134
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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Aurkb
aurora kinase B
increases expression
ISO
adefovir dipivoxil results in increased expression of AURKB mRNA
CTD
PMID:25596134
NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
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Axl
Axl receptor tyrosine kinase
increases expression
ISO
adefovir dipivoxil results in increased expression of AXL mRNA
CTD
PMID:25596134
NCBI chr 1:81,265,656...81,296,278
Ensembl chr 1:81,265,088...81,296,265
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
adefovir dipivoxil results in increased expression of BAX mRNA
CTD
PMID:25596134
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcar3
BCAR3 adaptor protein, NSP family member
increases expression
ISO
adefovir dipivoxil results in increased expression of BCAR3 mRNA
CTD
PMID:25596134
NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798
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Bend5
BEN domain containing 5
decreases expression
ISO
adefovir dipivoxil results in decreased expression of BEND5 mRNA
CTD
PMID:25596134
NCBI chr 5:126,290,648...126,336,662
Ensembl chr 5:125,254,956...126,534,367
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Bmf
Bcl2 modifying factor
decreases expression
ISO
adefovir dipivoxil results in decreased expression of BMF mRNA
CTD
PMID:25596134
NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145
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Btg2
BTG anti-proliferation factor 2
increases expression
ISO
adefovir dipivoxil results in increased expression of BTG2 mRNA
CTD
PMID:25596134
NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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Ccne2
cyclin E2
increases expression
ISO
adefovir dipivoxil results in increased expression of CCNE2 mRNA
CTD
PMID:25596134
NCBI chr 5:24,285,078...24,298,258
Ensembl chr 5:24,284,922...24,297,632
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Cdk6
cyclin-dependent kinase 6
increases expression
ISO
adefovir dipivoxil results in increased expression of CDK6 mRNA
CTD
PMID:25596134
NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
adefovir dipivoxil results in increased expression of CDKN1A mRNA
CTD
PMID:25596134
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cmbl
carboxymethylenebutenolidase homolog
increases expression
ISO
adefovir dipivoxil results in increased expression of CMBL mRNA
CTD
PMID:25596134
NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009
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Coch
cochlin
increases expression
ISO
adefovir dipivoxil results in increased expression of COCH mRNA
CTD
PMID:25596134
NCBI chr 6:69,031,139...69,045,124
Ensembl chr 6:69,031,167...69,045,109
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Col4a1
collagen type IV alpha 1 chain
decreases expression
ISO
adefovir dipivoxil results in decreased expression of COL4A1 mRNA
CTD
PMID:25596134
NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
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Cth
cystathionine gamma-lyase
decreases expression
ISO
adefovir dipivoxil results in decreased expression of CTH mRNA
CTD
PMID:25596134
NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
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Ctsc
cathepsin C
decreases expression
ISO
adefovir dipivoxil results in decreased expression of CTSC mRNA
CTD
PMID:25596134
NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
increases expression
ISO
adefovir dipivoxil results in increased expression of CYP1B1 mRNA
CTD
PMID:25596134
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
decreases activity
ISO
adefovir dipivoxil results in decreased activity of CYP3A4 protein
CTD
PMID:17162464
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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Ddb2
damage specific DNA binding protein 2
increases expression
ISO
adefovir dipivoxil results in increased expression of DDB2 mRNA
CTD
PMID:25596134
NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631
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Dgka
diacylglycerol kinase, alpha
increases expression
ISO
adefovir dipivoxil results in increased expression of DGKA mRNA
CTD
PMID:25596134
NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110
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Dlgap5
DLG associated protein 5
increases expression
ISO
adefovir dipivoxil results in increased expression of DLGAP5 mRNA
CTD
PMID:25596134
NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518
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Dlx1
distal-less homeobox 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of DLX1 mRNA
CTD
PMID:25596134
NCBI chr 3:56,356,190...56,360,780
Ensembl chr 3:56,356,190...56,360,780
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Dnai3
dynein axonemal intermediate chain 3
increases expression
ISO
adefovir dipivoxil results in increased expression of DNAI3 mRNA
CTD
PMID:25596134
NCBI chr 2:234,947,910...235,006,173
Ensembl chr 2:234,929,677...235,006,173
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Dpysl3
dihydropyrimidinase-like 3
increases expression
ISO
adefovir dipivoxil results in increased expression of DPYSL3 mRNA
CTD
PMID:25596134
NCBI chr18:35,374,429...35,480,462
Ensembl chr18:35,377,181...35,480,157
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Efna1
ephrin A1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of EFNA1 mRNA
CTD
PMID:25596134
NCBI chr 2:174,681,676...174,690,306
Ensembl chr 2:174,681,682...174,690,866
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Ero1a
endoplasmic reticulum oxidoreductase 1 alpha
increases expression
ISO
adefovir dipivoxil results in increased expression of ERO1A mRNA
CTD
PMID:25596134
NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478
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Fas
Fas cell surface death receptor
increases expression
ISO
adefovir dipivoxil results in increased expression of FAS mRNA
CTD
PMID:25596134
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Fbxo22
F-box protein 22
increases expression
ISO
adefovir dipivoxil results in increased expression of FBXO22 mRNA
CTD
PMID:25596134
NCBI chr 8:55,579,906...55,595,981
Ensembl chr 8:55,579,891...55,596,148
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Gabarapl1
GABA type A receptor associated protein like 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of GABARAPL1 mRNA
CTD
PMID:25596134
NCBI chr 4:162,980,309...162,989,452
Ensembl chr 4:162,980,249...162,989,450
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Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
ISO
adefovir dipivoxil results in increased expression of GADD45A mRNA
CTD
PMID:25596134
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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Galnt16
polypeptide N-acetylgalactosaminyltransferase 16
decreases expression
ISO
adefovir dipivoxil results in decreased expression of GALNT16 mRNA
CTD
PMID:25596134
NCBI chr 6:100,168,943...100,250,718
Ensembl chr 6:100,170,306...100,250,705
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Gcnt3
glucosaminyl (N-acetyl) transferase 3, mucin type
increases expression
ISO
adefovir dipivoxil results in increased expression of GCNT3 mRNA
CTD
PMID:25596134
NCBI chr 8:70,689,173...70,696,476
Ensembl chr 8:70,686,844...70,699,562
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Gdf15
growth differentiation factor 15
increases expression
ISO
adefovir dipivoxil results in increased expression of GDF15 mRNA
CTD
PMID:25596134
NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
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Got1
glutamic-oxaloacetic transaminase 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of GOT1 mRNA
CTD
PMID:25596134
NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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Gpr87
G protein-coupled receptor 87
increases expression
ISO
adefovir dipivoxil results in increased expression of GPR87 mRNA
CTD
PMID:25596134
NCBI chr 2:143,439,741...143,440,901
Ensembl chr 2:143,439,735...143,458,190
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H1f2
H1.2 linker histone, cluster member
increases expression
ISO
adefovir dipivoxil results in increased expression of H1-2 mRNA
CTD
PMID:25596134
NCBI chr17:41,391,106...41,392,611
Ensembl chr17:41,388,477...41,392,635
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Hmox1
heme oxygenase 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of HMOX1 mRNA
CTD
PMID:25596134
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hspa1b
heat shock protein family A (Hsp70) member 1B
decreases expression
ISO
adefovir dipivoxil results in decreased expression of HSPA1B mRNA
CTD
PMID:25596134
NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
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Ifng
interferon gamma
multiple interactions
ISO
adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]
CTD
PMID:9354585
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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Il19
interleukin 19
increases secretion
ISO
adefovir dipivoxil results in increased secretion of IL19 protein
CTD
PMID:24714768
NCBI chr13:42,397,715...42,411,637
Ensembl chr13:42,399,138...42,405,473
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Kat6b
lysine acetyltransferase 6B
decreases expression
ISO
adefovir dipivoxil results in decreased expression of KAT6B mRNA
CTD
PMID:25596134
NCBI chr15:2,638,885...2,811,977
Ensembl chr15:2,639,200...2,812,316
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Kdm3a
lysine demethylase 3A
decreases expression
ISO
adefovir dipivoxil results in decreased expression of KDM3A mRNA
CTD
PMID:25596134
NCBI chr 4:103,630,907...103,675,073
Ensembl chr 4:103,630,908...103,675,073
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Krt15
keratin 15
increases expression
ISO
adefovir dipivoxil results in increased expression of KRT15 mRNA
CTD
PMID:25596134
NCBI chr10:85,066,797...85,070,614
Ensembl chr10:85,066,802...85,171,799
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Lama3
laminin subunit alpha 3
increases expression
ISO
adefovir dipivoxil results in increased expression of LAMA3 mRNA
CTD
PMID:25596134
NCBI chr18:3,523,168...3,751,722
Ensembl chr18:3,523,133...3,751,353
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Lcn2
lipocalin 2
increases secretion
ISO
adefovir dipivoxil results in increased secretion of LCN2 protein
CTD
PMID:24714768
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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Map3k8
mitogen-activated protein kinase kinase kinase 8
increases expression
ISO
adefovir dipivoxil results in increased expression of MAP3K8 mRNA
CTD
PMID:25596134
NCBI chr17:53,382,908...53,403,216
Ensembl chr17:53,383,131...53,403,216
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Mdm2
MDM2 proto-oncogene
increases expression
ISO
adefovir dipivoxil results in increased expression of MDM2 mRNA
CTD
PMID:25596134
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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Mxi1
MAX interactor 1, dimerization protein
decreases expression
ISO
adefovir dipivoxil results in decreased expression of MXI1 mRNA
CTD
PMID:25596134
NCBI chr 1:252,323,915...252,383,682
Ensembl chr 1:252,323,303...252,383,681
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Ncapd2
non-SMC condensin I complex, subunit D2
increases expression
ISO
adefovir dipivoxil results in increased expression of NCAPD2 mRNA
CTD
PMID:25596134
NCBI chr 4:157,968,814...157,992,314
Ensembl chr 4:157,968,815...157,992,020
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Ninj1
ninjurin 1
increases expression
ISO
adefovir dipivoxil results in increased expression of NINJ1 mRNA
CTD
PMID:25596134
NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]
CTD
PMID:9354585
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nqo1
NAD(P)H quinone dehydrogenase 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of NQO1 mRNA
CTD
PMID:25596134
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nrep
neuronal regeneration related protein
decreases expression
ISO
adefovir dipivoxil results in decreased expression of NREP mRNA
CTD
PMID:25596134
NCBI chr18:25,017,069...25,046,564
Ensembl chr18:25,017,083...25,046,591
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Ntpcr
nucleoside-triphosphatase, cancer-related
increases expression
ISO
adefovir dipivoxil results in increased expression of NTPCR mRNA
CTD
PMID:25596134
NCBI chr19:53,701,496...53,715,260
Ensembl chr19:53,695,976...53,715,202
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P4ha1
prolyl 4-hydroxylase subunit alpha 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of P4HA1 mRNA
CTD
PMID:25596134
NCBI chr20:27,302,046...27,352,098
Ensembl chr20:27,302,141...27,352,786
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Pank1
pantothenate kinase 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of PANK1 mRNA
CTD
PMID:25596134
NCBI chr 1:232,324,718...232,395,445
Ensembl chr 1:232,328,430...232,396,829
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Pdia5
protein disulfide isomerase family A, member 5
increases expression
ISO
adefovir dipivoxil results in increased expression of PDIA5 mRNA
CTD
PMID:25596134
NCBI chr11:65,272,152...65,359,087
Ensembl chr11:65,272,155...65,359,084
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Pdlim1
PDZ and LIM domain 1
increases expression
ISO
adefovir dipivoxil results in increased expression of PDLIM1 mRNA
CTD
PMID:25596134
NCBI chr 1:239,042,372...239,091,074
Ensembl chr 1:239,042,385...239,091,076
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Pgr
progesterone receptor
multiple interactions
ISO
adefovir dipivoxil binds to and results in decreased activity of PGR protein
CTD
PMID:25752796
NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Phlda3
pleckstrin homology-like domain, family A, member 3
increases expression
ISO
adefovir dipivoxil results in increased expression of PHLDA3 mRNA
CTD
PMID:25596134
NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335
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Pidd1
p53-induced death domain protein 1
increases expression
ISO
adefovir dipivoxil results in increased expression of PIDD1 mRNA
CTD
PMID:25596134
NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699
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Pir
pirin
increases expression
ISO
adefovir dipivoxil results in increased expression of PIR mRNA
CTD
PMID:25596134
NCBI chr X:30,108,536...30,219,269
Ensembl chr X:30,108,538...30,219,218
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Plec
plectin
increases expression
ISO
adefovir dipivoxil results in increased expression of PLEC mRNA
CTD
PMID:25596134
NCBI chr 7:107,887,764...107,949,100
Ensembl chr 7:107,887,764...107,945,467
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Pmaip1
phorbol-12-myristate-13-acetate-induced protein 1
increases expression
ISO
adefovir dipivoxil results in increased expression of PMAIP1 mRNA
CTD
PMID:25596134
NCBI chr18:59,986,187...59,990,174
Ensembl chr18:59,986,017...59,992,429
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Pparg
peroxisome proliferator-activated receptor gamma
affects activity
ISO
adefovir dipivoxil affects the activity of PPARG protein
CTD
PMID:25596134
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Ppm1d
protein phosphatase, Mg2+/Mn2+ dependent, 1D
increases expression
ISO
adefovir dipivoxil results in increased expression of PPM1D mRNA
CTD
PMID:25596134
NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607
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Prc1
protein regulator of cytokinesis 1
increases expression
ISO
adefovir dipivoxil results in increased expression of PRC1 mRNA
CTD
PMID:25596134
NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
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Prdm1
PR/SET domain 1
increases expression
ISO
adefovir dipivoxil results in increased expression of PRDM1 mRNA
CTD
PMID:25596134
NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488
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Prkab2
protein kinase AMP-activated non-catalytic subunit beta 2
decreases expression
ISO
adefovir dipivoxil results in decreased expression of PRKAB2 mRNA
CTD
PMID:25596134
NCBI chr 2:185,257,218...185,272,846
Ensembl chr 2:185,257,213...185,269,872
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Psat1
phosphoserine aminotransferase 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of PSAT1 mRNA
CTD
PMID:25596134
NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682
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Rara
retinoic acid receptor, alpha
decreases expression
ISO
adefovir dipivoxil results in decreased expression of RARA mRNA
CTD
PMID:25596134
NCBI chr10:83,883,490...83,928,932
Ensembl chr10:83,893,384...83,928,142
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Rps27l
ribosomal protein S27-like
increases expression
ISO
adefovir dipivoxil results in increased expression of RPS27L mRNA
CTD
PMID:25596134
NCBI chr 8:67,562,483...67,567,418
Ensembl chr 8:67,562,483...67,567,418
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Rrm2b
ribonucleotide reductase regulatory TP53 inducible subunit M2B
increases expression
ISO
adefovir dipivoxil results in increased expression of RRM2B mRNA
CTD
PMID:25596134
NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633
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Serpinb5
serpin family B member 5
increases expression
ISO
adefovir dipivoxil results in increased expression of SERPINB5 mRNA
CTD
PMID:25596134
NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756
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Sesn1
sestrin 1
increases expression
ISO
adefovir dipivoxil results in increased expression of SESN1 mRNA
CTD
PMID:25596134
NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697
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Sfn
stratifin
increases expression
ISO
adefovir dipivoxil results in increased expression of SFN mRNA
CTD
PMID:25596134
Ensembl chr 5:145,826,201...145,831,314
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Sh3tc1
SH3 domain and tetratricopeptide repeats 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of SH3TC1 mRNA
CTD
PMID:25596134
NCBI chr14:75,005,691...75,050,001
Ensembl chr14:75,016,875...75,049,995
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Slc27a2
solute carrier family 27 member 2
decreases expression
ISO
adefovir dipivoxil results in decreased expression of SLC27A2 mRNA
CTD
PMID:25596134
NCBI chr 3:113,804,728...113,842,208
Ensembl chr 3:113,804,728...113,842,208
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Slc6a9
solute carrier family 6 member 9
decreases expression
ISO
adefovir dipivoxil results in decreased expression of SLC6A9 mRNA
CTD
PMID:25596134
NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728
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Slco2b1
solute carrier organic anion transporter family, member 2b1
increases expression
ISO
adefovir dipivoxil results in increased expression of SLCO2B1 mRNA
CTD
PMID:25596134
NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
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Smap1
small ArfGAP 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of SMAP1 mRNA
CTD
PMID:25596134
NCBI chr 9:26,250,178...26,342,151
Ensembl chr 9:26,249,978...26,342,170
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Sulf2
sulfatase 2
increases expression
ISO
adefovir dipivoxil results in increased expression of SULF2 mRNA
CTD
PMID:25596134
NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415
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Thra
thyroid hormone receptor alpha
multiple interactions
ISO
adefovir dipivoxil binds to and results in decreased activity of THRA protein
CTD
PMID:25752796
NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
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Tigar
TP53 induced glycolysis regulatory phosphatase
increases expression
ISO
adefovir dipivoxil results in increased expression of TIGAR mRNA
CTD
PMID:25596134
NCBI chr 4:159,927,138...159,946,094
Ensembl chr 4:159,927,139...159,946,029
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Tiparp
TCDD-inducible poly(ADP-ribose) polymerase
increases expression
ISO
adefovir dipivoxil results in increased expression of TIPARP mRNA
CTD
PMID:25596134
NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327
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Tnfsf9
TNF superfamily member 9
increases expression
ISO
adefovir dipivoxil results in increased expression of TNFSF9 mRNA
CTD
PMID:25596134
NCBI chr 9:1,944,017...1,946,351
Ensembl chr 9:1,944,017...1,946,345
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Tp53
tumor protein p53
affects activity
ISO
adefovir dipivoxil affects the activity of TP53 protein
CTD
PMID:25596134
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tp53inp1
tumor protein p53 inducible nuclear protein 1
increases expression
ISO
adefovir dipivoxil results in increased expression of TP53INP1 mRNA
CTD
PMID:25596134
NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968
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Trafd1
TRAF type zinc finger domain containing 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of TRAFD1 mRNA
CTD
PMID:25596134
NCBI chr12:35,165,606...35,179,525
Ensembl chr12:35,165,606...35,179,525
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Triap1
TP53 regulated inhibitor of apoptosis 1
increases expression
ISO
adefovir dipivoxil results in increased expression of TRIAP1 mRNA
CTD
PMID:25596134
NCBI chr12:41,267,534...41,270,053
Ensembl chr12:41,267,549...41,270,042
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Ube2o
ubiquitin-conjugating enzyme E2O
decreases expression
ISO
adefovir dipivoxil results in decreased expression of UBE2O mRNA
CTD
PMID:25596134
NCBI chr10:101,765,572...101,812,736
Ensembl chr10:101,766,005...101,812,899
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Yars1
tyrosyl-tRNA synthetase 1
decreases expression
ISO
adefovir dipivoxil results in decreased expression of YARS1 mRNA
CTD
PMID:25596134
NCBI chr 5:141,535,815...141,564,029
Ensembl chr 5:141,535,759...141,563,833
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Zmat3
zinc finger, matrin type 3
increases expression
ISO
adefovir dipivoxil results in increased expression of ZMAT3 mRNA
CTD
PMID:25596134
NCBI chr 2:115,106,050...115,136,863
Ensembl chr 2:115,106,966...115,136,863
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Ar
androgen receptor
multiple interactions
ISO
Dihydrotestosterone inhibits the reaction [Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester results in increased activity of AR protein]
CTD
PMID:15064155
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Esr1
estrogen receptor 1
increases activity
ISO
Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester results in increased activity of ESR1 protein
CTD
PMID:15064155
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Esr2
estrogen receptor 2
increases activity
ISO
Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester results in increased activity of ESR2 protein
CTD
PMID:15064155
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester binds to and results in increased activity of NR1I2 protein
CTD
PMID:21115097
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases activity
ISO
Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester results in increased activity of NR1I3 protein
CTD
PMID:28927721
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
fotemustine results in increased expression of CDKN1A mRNA
CTD
PMID:25125662
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Fas
Fas cell surface death receptor
increases expression
ISO
fotemustine results in increased expression of FAS mRNA
CTD
PMID:25125662
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions increases expression
ISO
FOS mutant form inhibits the reaction [fotemustine results in increased expression of TREX1 mRNA] fotemustine results in increased expression of FOS mRNA; fotemustine results in increased expression of FOS protein
CTD
PMID:23578789
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
ISO
fotemustine results in increased expression of GADD45A mRNA
CTD
PMID:25125662
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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H2ax
H2A.X variant histone
increases expression
ISO
fotemustine results in increased expression of H2AX protein modified form
CTD
PMID:25125662
NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
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Hsf1
heat shock transcription factor 1
increases activity
ISO
fotemustine results in increased activity of HSF1 protein
CTD
PMID:34170685
NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions increases expression
ISO
fotemustine promotes the reaction [JUN protein binds to TREX1 promoter]; JUN mutant form inhibits the reaction [fotemustine results in increased expression of TREX1 mRNA] fotemustine results in increased expression of JUN mRNA; fotemustine results in increased expression of JUN protein
CTD
PMID:23578789
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Mgmt
O-6-methylguanine-DNA methyltransferase
decreases response to substance
ISO
MGMT protein results in decreased susceptibility to fotemustine
CTD
PMID:12970393 PMID:16039682 PMID:20556481
NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756
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Polh
DNA polymerase eta
multiple interactions decreases response to substance increases expression
ISO
Dactinomycin inhibits the reaction [fotemustine results in increased expression of POLH mRNA]; fotemustine promotes the reaction [TP53 protein binds to POLH promoter]; pifithrin inhibits the reaction [fotemustine results in increased expression of POLH mRNA]; pifithrin inhibits the reaction [fotemustine results in increased expression of POLH protein] POLH protein results in decreased susceptibility to fotemustine fotemustine results in increased expression of POLH mRNA; fotemustine results in increased expression of POLH protein
CTD
PMID:25125662
NCBI chr 9:14,778,355...14,813,210
Ensembl chr 9:14,777,888...14,812,723
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Tp53
tumor protein p53
multiple interactions increases expression
ISO
fotemustine promotes the reaction [TP53 protein binds to POLH promoter] fotemustine results in increased expression of TP53 protein; fotemustine results in increased expression of TP53 protein modified form
CTD
PMID:25125662
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Trex1
three prime repair exonuclease 1
multiple interactions affects response to substance increases expression
ISO
FOS mutant form inhibits the reaction [fotemustine results in increased expression of TREX1 mRNA]; fotemustine promotes the reaction [JUN protein binds to TREX1 promoter]; JUN mutant form inhibits the reaction [fotemustine results in increased expression of TREX1 mRNA] TREX1 affects the susceptibility to fotemustine fotemustine results in increased expression of TREX1 mRNA; fotemustine results in increased expression of TREX1 protein
CTD
PMID:23578789
NCBI chr 8:109,706,613...109,707,913
Ensembl chr 8:109,706,613...109,708,796
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Ache
acetylcholinesterase
decreases activity
ISO EXP
isocarbophos metabolite results in decreased activity of ACHE protein isocarbophos results in decreased activity of ACHE protein
CTD
PMID:24752505 PMID:26818681 PMID:33844597
NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
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Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
isocarbophos analog results in increased expression of BAX protein
CTD
PMID:20688129
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
isocarbophos analog results in decreased expression of BCL2 protein
CTD
PMID:20688129
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Casp3
caspase 3
increases cleavage
EXP
isocarbophos results in increased cleavage of CASP3 protein
CTD
PMID:26818681
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions
ISO
CYP1A2 protein results in increased metabolism of and results in decreased sulfation of and affects the activity of isocarbophos
CTD
PMID:24752505
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp2c6v1
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1
multiple interactions
ISO
CYP2C19 protein results in increased metabolism of and results in decreased sulfation of and affects the activity of isocarbophos
CTD
PMID:24752505
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
multiple interactions
ISO
CYP2D6 protein results in increased metabolism of and results in decreased sulfation of and affects the activity of isocarbophos
CTD
PMID:24752505
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions
ISO
CYP3A4 protein results in increased metabolism of and results in decreased sulfation of and affects the activity of isocarbophos
CTD
PMID:24752505
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
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Gja1
gap junction protein, alpha 1
increases expression
EXP
isocarbophos results in increased expression of GJA1 protein
CTD
PMID:26818681
NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
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Icam1
intercellular adhesion molecule 1
increases expression
EXP
isocarbophos results in increased expression of ICAM1 protein
CTD
PMID:26818681
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Mapk1
mitogen activated protein kinase 1
increases phosphorylation multiple interactions
ISO
isocarbophos analog results in increased phosphorylation of MAPK1 protein manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [isocarbophos analog results in increased phosphorylation of MAPK1 protein]
CTD
PMID:20688129
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
increases phosphorylation multiple interactions
ISO
isocarbophos analog results in increased phosphorylation of MAPK3 protein manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [isocarbophos analog results in increased phosphorylation of MAPK3 protein]
CTD
PMID:20688129
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Vcam1
vascular cell adhesion molecule 1
increases expression
EXP
isocarbophos results in increased expression of VCAM1 protein
CTD
PMID:26818681
NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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Ar
androgen receptor
multiple interactions
ISO
Dihydrotestosterone inhibits the reaction [isofenphos results in increased activity of AR protein]
CTD
PMID:15064155
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases expression
ISO
isofenphos results in increased expression of CYP3A4 mRNA
CTD
PMID:17293382
NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
G
Esr1
estrogen receptor 1
increases activity
ISO
isofenphos results in increased activity of ESR1 protein
CTD
PMID:15064155
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
isofenphos binds to and results in increased activity of NR1I2 protein; isofenphos metabolite binds to and results in increased activity of NR1I2 protein
CTD
PMID:21115097
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases activity
ISO
isofenphos results in increased activity of NR1I3 protein
CTD
PMID:28927721
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
G
Ache
acetylcholinesterase
decreases activity
ISO
Leptophos metabolite results in decreased activity of ACHE protein; Leptophos results in decreased activity of ACHE protein
CTD
PMID:33844597
NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
G
Ar
androgen receptor
multiple interactions
ISO
Dihydrotestosterone inhibits the reaction [Leptophos results in increased activity of AR protein]
CTD
PMID:15064155
NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925
G
Esr1
estrogen receptor 1
increases activity
ISO
Leptophos results in increased activity of ESR1 protein
CTD
PMID:15064155
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Esr2
estrogen receptor 2
increases activity
ISO
Leptophos results in increased activity of ESR2 protein
CTD
PMID:15064155
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
Leptophos binds to and results in increased activity of NR1I2 protein
CTD
PMID:21115097
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
G
Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases activity
ISO
Leptophos results in increased activity of NR1I3 protein
CTD
PMID:28927721
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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Abcb4
ATP binding cassette subfamily B member 4
decreases activity
ISO
Tenofovir results in decreased activity of ABCB4 protein
CTD
PMID:28437613
NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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Acacb
acetyl-CoA carboxylase beta
affects expression
ISO
Tenofovir affects the expression of ACACB mRNA
CTD
PMID:20032539
NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655
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Bnip3l
BCL2 interacting protein 3 like
increases expression
ISO
Tenofovir results in increased expression of BNIP3L protein
CTD
PMID:23640862
NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
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Cat
catalase
multiple interactions
EXP
[efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in decreased activity of CAT protein
CTD
PMID:34118364
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Ccl20
C-C motif chemokine ligand 20
increases expression multiple interactions
ISO
Tenofovir results in increased expression of CCL20 mRNA Tenofovir results in increased expression of and results in increased secretion of CCL20 protein
CTD
PMID:24205323
NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
multiple interactions increases expression
ISO
[Emtricitabine co-treated with Tenofovir] results in increased expression of CDKN1A protein Tenofovir results in increased expression of CDKN1A protein
CTD
PMID:31545371
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
decreases activity
ISO
Tenofovir results in decreased activity of CYP2E1 protein
CTD
PMID:17162464
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Edn1
endothelin 1
increases secretion multiple interactions
ISO
Tenofovir results in increased secretion of EDN1 protein coenzyme Q10 inhibits the reaction [Tenofovir results in increased secretion of EDN1 protein]
CTD
PMID:23640862
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Eif2s1
eukaryotic translation initiation factor 2 subunit alpha
affects phosphorylation
ISO
Tenofovir affects the phosphorylation of EIF2S1 protein
CTD
PMID:27041070
NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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Havcr1
hepatitis A virus cellular receptor 1
increases secretion multiple interactions
ISO
Tenofovir results in increased secretion of HAVCR1 protein Tenofovir inhibits the reaction [cidofovir results in increased secretion of HAVCR1 protein]
CTD
PMID:29738843
NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
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Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
affects expression
ISO
Tenofovir affects the expression of HSD11B1 mRNA
CTD
PMID:20032539
NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
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Hspd1
heat shock protein family D (Hsp60) member 1
affects expression
ISO
Tenofovir affects the expression of HSPD1 protein
CTD
PMID:27041070
NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
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Lipe
lipase E, hormone sensitive type
affects expression
ISO
Tenofovir affects the expression of LIPE mRNA
CTD
PMID:20032539
NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310
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Lonp1
lon peptidase 1, mitochondrial
affects expression
ISO
Tenofovir affects the expression of LONP1 protein
CTD
PMID:27041070
NCBI chr 9:1,447,444...1,459,771
Ensembl chr 9:1,447,447...1,459,771
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Mapk8
mitogen-activated protein kinase 8
affects phosphorylation
ISO
Tenofovir affects the phosphorylation of MAPK8 protein
CTD
PMID:27041070
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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Mpo
myeloperoxidase
multiple interactions
EXP
[efavirenz co-treated with Lamivudine co-treated with Tenofovir] promotes the reaction [[isoniazid, pyrazinamide, rifampin drug combination co-treated with Ethambutol] results in increased activity of MPO protein]; [efavirenz co-treated with Lamivudine co-treated with Tenofovir] results in increased activity of MPO protein
CTD
PMID:34118364
NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
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Mt-co2
mitochondrially encoded cytochrome c oxidase II
multiple interactions
ISO
Tenofovir promotes the reaction [Didanosine results in decreased expression of COX2 mRNA]
CTD
PMID:16940060
NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
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Nfkbia
NFKB inhibitor alpha
decreases expression
EXP
Tenofovir results in decreased expression of NFKBIA protein
CTD
PMID:27899301
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nos2
nitric oxide synthase 2
increases expression
EXP
Tenofovir results in increased expression of NOS2 mRNA; Tenofovir results in increased expression of NOS2 protein
CTD
PMID:27899301
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nos3
nitric oxide synthase 3
multiple interactions decreases phosphorylation
ISO
coenzyme Q10 inhibits the reaction [Tenofovir results in decreased phosphorylation of NOS3 protein]
CTD
PMID:23640862
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
G
Nr3c1
nuclear receptor subfamily 3, group C, member 1
affects expression
ISO
Tenofovir affects the expression of NR3C1 mRNA
CTD
PMID:20032539
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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Nt5e
5' nucleotidase, ecto
increases expression
ISO
Tenofovir results in increased expression of NT5E mRNA
CTD
PMID:24205323
NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881
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Nt5m
5',3'-nucleotidase, mitochondrial
decreases expression
ISO
Tenofovir results in decreased expression of NT5M mRNA
CTD
PMID:24205323
NCBI chr10:44,652,845...44,680,549
Ensembl chr10:44,652,975...44,679,150
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Pparg
peroxisome proliferator-activated receptor gamma
affects expression
ISO
Tenofovir affects the expression of PPARG mRNA
CTD
PMID:20032539
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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Prkn
parkin RBR E3 ubiquitin protein ligase
multiple interactions
ISO
[Emtricitabine co-treated with Tenofovir] results in decreased expression of PRKN protein
CTD
PMID:31545371
NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
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Ptgs2
prostaglandin-endoperoxide synthase 2
increases expression
EXP
Tenofovir results in increased expression of PTGS2 mRNA; Tenofovir results in increased expression of PTGS2 protein
CTD
PMID:27899301
NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions affects localization increases expression
EXP
Melatonin inhibits the reaction [Tenofovir affects the localization of RELA protein]; Melatonin inhibits the reaction [Tenofovir results in increased expression of and results in increased activity of RELA protein]; Melatonin inhibits the reaction [Tenofovir results in increased expression of RELA mRNA]; Tenofovir results in increased expression of and results in increased activity of RELA protein
CTD
PMID:27899301
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Sirt3
sirtuin 3
increases expression
ISO
Tenofovir results in increased expression of SIRT3 protein
CTD
PMID:27041070
NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808
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Slc22a6
solute carrier family 22 member 6
increases response to substance increases import multiple interactions
ISO
SLC22A6 protein results in increased susceptibility to Tenofovir SLC22A6 protein results in increased import of Tenofovir Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to Tenofovir]; SLC22A6 protein results in increased uptake of and results in increased susceptibility to Tenofovir; Tenofovir inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]
CTD
PMID:23856525 PMID:25448811 PMID:29738843
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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Slc22a8
solute carrier family 22 member 8
increases response to substance increases import
ISO
SLC22A8 protein results in increased susceptibility to Tenofovir SLC22A8 protein results in increased import of Tenofovir
CTD
PMID:25448811 PMID:29738843
NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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Tnf
tumor necrosis factor
decreases expression increases expression
ISO EXP
Tenofovir results in decreased expression of TNF mRNA Tenofovir results in increased expression of TNF mRNA; Tenofovir results in increased expression of TNF protein
CTD
PMID:24205323 PMID:27899301
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tp53
tumor protein p53
multiple interactions increases expression
ISO
[Emtricitabine co-treated with Tenofovir] results in increased expression of TP53 protein Tenofovir results in increased expression of TP53 protein
CTD
PMID:31545371
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Ache
acetylcholinesterase
multiple interactions affects activity decreases activity
ISO EXP
[Trichlorfon co-treated with Dichlorvos] results in decreased activity of ACHE protein; asoxime chloride inhibits the reaction [Trichlorfon results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [Trichlorfon results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Trichlorfon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Trichlorfon results in decreased activity of ACHE protein] Trichlorfon affects the activity of ACHE protein [Trichlorfon results in decreased activity of ACHE protein] which affects the localization of CHRM2 protein Trichlorfon metabolite results in decreased activity of ACHE protein; Trichlorfon results in decreased activity of ACHE protein
CTD
PMID:235931 PMID:1852719 PMID:4859365 PMID:8783813 PMID:9268605 PMID:9515941 PMID:10718203 PMID:10791297 PMID:11311445 PMID:11526466 PMID:11822883 PMID:12111444 PMID:12794734 PMID:15386949 PMID:15569517 PMID:16822217 PMID:18070496 PMID:18804659 PMID:19631781 PMID:30625376 More...
NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
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App
amyloid beta precursor protein
increases secretion affects cleavage affects metabolic processing
ISO EXP
Trichlorfon results in increased secretion of APP protein alternative form Trichlorfon affects the cleavage of APP protein Trichlorfon affects the metabolism of APP protein
CTD
PMID:10773217 PMID:11099780 PMID:11526466 PMID:11822883
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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Bche
butyrylcholinesterase
multiple interactions decreases activity
ISO EXP
1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]; asoxime chloride inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]; Obidoxime Chloride inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]
CTD
PMID:235931 PMID:11311445 PMID:18825528
NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
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Bcl2
BCL2, apoptosis regulator
multiple interactions decreases expression
ISO
Tetradecanoylphorbol Acetate inhibits the reaction [Trichlorfon results in decreased expression of BCL2 protein]
CTD
PMID:19631781
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Casp12
caspase 12
multiple interactions
ISO
[Verapamil co-treated with Ruthenium Red co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP12 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP12 protein]; Trichlorfon results in increased cleavage of and results in increased activity of CASP12 protein
CTD
PMID:19631781
NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
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Casp3
caspase 3
multiple interactions
ISO
[Verapamil co-treated with Ruthenium Red co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP3 protein]; Trichlorfon results in increased cleavage of and results in increased activity of CASP3 protein
CTD
PMID:19631781
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
decreases activity increases activity
ISO
Trichlorfon results in decreased activity of CAT protein Trichlorfon results in increased activity of CAT protein
CTD
PMID:15386949 PMID:17697763
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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Chrm2
cholinergic receptor, muscarinic 2
multiple interactions
ISO
[Trichlorfon results in decreased activity of ACHE protein] which affects the localization of CHRM2 protein
CTD
PMID:12794734
NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
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Chrm4
cholinergic receptor, muscarinic 4
affects expression
EXP
Trichlorfon affects the expression of CHRM4 mRNA; Trichlorfon affects the expression of CHRM4 protein
CTD
PMID:12093157
NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159
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Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
decreases activity decreases expression
ISO
Trichlorfon results in decreased activity of CYP11A1 protein Trichlorfon results in decreased expression of CYP11A1 mRNA; Trichlorfon results in decreased expression of CYP11A1 protein
CTD
PMID:17350742
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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Fshb
follicle stimulating hormone subunit beta
multiple interactions
ISO
Trichlorfon inhibits the reaction [FSHB protein results in increased abundance of Progesterone]
CTD
PMID:17329077
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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Gap43
growth associated protein 43
decreases expression
ISO
Trichlorfon results in decreased expression of GAP43 protein
CTD
PMID:27939611
NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
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Hnf4a
hepatocyte nuclear factor 4, alpha
increases activity
ISO
Trichlorfon results in increased activity of HNF4A protein
CTD
PMID:20143881
NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
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Nefh
neurofilament heavy chain
decreases expression
ISO
Trichlorfon results in decreased expression of NEFH protein
CTD
PMID:27939611
NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
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Nfe2l2
NFE2 like bZIP transcription factor 2
increases activity
ISO
Trichlorfon results in increased activity of NFE2L2 protein
CTD
PMID:20143881
NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
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Pnpla6
patatin-like phospholipase domain containing 6
decreases activity
ISO
Trichlorfon results in decreased activity of PNPLA6 protein
CTD
PMID:9268605
NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734
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Serpina3n
serine (or cysteine) peptidase inhibitor, clade A, member 3N
decreases expression
ISO
Trichlorfon results in decreased expression of SERPINA3 protein
CTD
PMID:10599054
NCBI chr 6:123,323,632...123,331,166
Ensembl chr 6:123,323,629...123,332,433
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Star
steroidogenic acute regulatory protein
decreases expression
ISO
Trichlorfon results in decreased expression of STAR mRNA Trichlorfon results in decreased expression of STAR mRNA; Trichlorfon results in decreased expression of STAR protein
CTD
PMID:17329077 PMID:17350742
NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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Syn1
synapsin I
decreases expression
ISO
Trichlorfon results in decreased expression of SYN1 protein
CTD
PMID:27939611
NCBI chr X:1,172,208...1,227,400
Ensembl chr X:1,172,208...1,227,396
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Syp
synaptophysin
decreases expression
ISO
Trichlorfon results in decreased expression of SYP protein
CTD
PMID:27939611
NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745
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Tp53
tumor protein p53
increases expression
ISO
Trichlorfon results in increased expression of TP53 protein
CTD
PMID:19631781
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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