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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:phosphonate
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Accession:CHEBI:26066 term browser browse the term
Synonyms:related_synonym: phosphonates

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adefovir pivoxil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor affects activity ISO adefovir dipivoxil affects the activity of AHR protein CTD PMID:25596134 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Ak4 adenylate kinase 4 increases expression ISO adefovir dipivoxil results in increased expression of AK4 mRNA CTD PMID:25596134 NCBI chr 5:120,250,318...120,309,153
Ensembl chr 5:120,250,616...120,305,897 		JBrowse link
G Akr1c2 aldo-keto reductase family 1, member C2 decreases expression ISO adefovir dipivoxil results in decreased expression of AKR1C2 mRNA CTD PMID:25596134 NCBI chr17:69,388,337...69,435,160
Ensembl chr17:69,388,335...69,404,341 		JBrowse link
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 decreases expression ISO adefovir dipivoxil results in decreased expression of ALDH18A1 mRNA CTD PMID:25596134 NCBI chr 1:259,641,673...259,674,521
Ensembl chr 1:259,641,676...259,674,425
Ensembl chr 1:259,641,676...259,674,425 		JBrowse link
G Aldh1a3 aldehyde dehydrogenase 1 family, member A3 increases expression ISO adefovir dipivoxil results in increased expression of ALDH1A3 mRNA CTD PMID:25596134 NCBI chr 1:127,302,920...127,337,828
Ensembl chr 1:127,301,128...127,337,882 		JBrowse link
G Als2cl ALS2 C-terminal like increases expression ISO adefovir dipivoxil results in increased expression of ALS2CL mRNA CTD PMID:25596134 NCBI chr 8:119,156,081...119,176,680
Ensembl chr 8:119,160,731...119,174,830 		JBrowse link
G Angptl4 angiopoietin-like 4 increases expression ISO adefovir dipivoxil results in increased expression of ANGPTL4 mRNA CTD PMID:25596134 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO adefovir dipivoxil results in decreased expression of ASNS mRNA CTD PMID:25596134 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163 		JBrowse link
G Atad2 ATPase family, AAA domain containing 2 increases expression ISO adefovir dipivoxil results in increased expression of ATAD2 mRNA CTD PMID:25596134 NCBI chr 7:97,984,754...98,027,379
Ensembl chr 7:97,984,862...98,026,052 		JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO adefovir dipivoxil results in increased expression of ATF3 mRNA CTD PMID:25596134 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632 		JBrowse link
G Aurkb aurora kinase B increases expression ISO adefovir dipivoxil results in increased expression of AURKB mRNA CTD PMID:25596134 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991 		JBrowse link
G Axl Axl receptor tyrosine kinase increases expression ISO adefovir dipivoxil results in increased expression of AXL mRNA CTD PMID:25596134 NCBI chr 1:82,550,892...82,580,761
Ensembl chr 1:82,549,420...82,580,761 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO adefovir dipivoxil results in increased expression of BAX mRNA CTD PMID:25596134 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcar3 BCAR3 adaptor protein, NSP family member increases expression ISO adefovir dipivoxil results in increased expression of BCAR3 mRNA CTD PMID:25596134 NCBI chr 2:226,563,050...226,679,449
Ensembl chr 2:226,563,050...226,679,438 		JBrowse link
G Bend5 BEN domain containing 5 decreases expression ISO adefovir dipivoxil results in decreased expression of BEND5 mRNA CTD PMID:25596134 NCBI chr 5:131,257,127...131,312,335
Ensembl chr 5:131,257,127...131,312,335 		JBrowse link
G Bmf Bcl2 modifying factor decreases expression ISO adefovir dipivoxil results in decreased expression of BMF mRNA CTD PMID:25596134 NCBI chr 3:110,303,515...110,324,125
Ensembl chr 3:110,306,067...110,324,084 		JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression ISO adefovir dipivoxil results in increased expression of BTG2 mRNA CTD PMID:25596134 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982 		JBrowse link
G Ccne2 cyclin E2 increases expression ISO adefovir dipivoxil results in increased expression of CCNE2 mRNA CTD PMID:25596134 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406 		JBrowse link
G Cdk6 cyclin-dependent kinase 6 increases expression ISO adefovir dipivoxil results in increased expression of CDK6 mRNA CTD PMID:25596134 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO adefovir dipivoxil results in increased expression of CDKN1A mRNA CTD PMID:25596134 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cmbl carboxymethylenebutenolidase homolog increases expression ISO adefovir dipivoxil results in increased expression of CMBL mRNA CTD PMID:25596134 NCBI chr 2:84,645,084...84,666,836
Ensembl chr 2:84,645,084...84,666,835 		JBrowse link
G Coch cochlin increases expression ISO adefovir dipivoxil results in increased expression of COCH mRNA CTD PMID:25596134 NCBI chr 6:72,359,702...72,373,710
Ensembl chr 6:72,359,791...72,373,695 		JBrowse link
G Col4a1 collagen type IV alpha 1 chain decreases expression ISO adefovir dipivoxil results in decreased expression of COL4A1 mRNA CTD PMID:25596134 NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153 		JBrowse link
G Cth cystathionine gamma-lyase decreases expression ISO adefovir dipivoxil results in decreased expression of CTH mRNA CTD PMID:25596134 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046 		JBrowse link
G Ctsc cathepsin C decreases expression ISO adefovir dipivoxil results in decreased expression of CTSC mRNA CTD PMID:25596134 NCBI chr 1:151,918,514...151,949,979
Ensembl chr 1:151,918,571...151,949,983 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO adefovir dipivoxil results in increased expression of CYP1B1 mRNA CTD PMID:25596134 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity ISO adefovir dipivoxil results in decreased activity of CYP3A4 protein CTD PMID:17162464 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Ddb2 damage specific DNA binding protein 2 increases expression ISO adefovir dipivoxil results in increased expression of DDB2 mRNA CTD PMID:25596134 NCBI chr 3:80,030,437...80,052,984
Ensembl chr 3:80,030,437...80,052,953 		JBrowse link
G Dgka diacylglycerol kinase, alpha increases expression ISO adefovir dipivoxil results in increased expression of DGKA mRNA CTD PMID:25596134 NCBI chr 7:3,143,826...3,170,764
Ensembl chr 7:3,143,827...3,170,146 		JBrowse link
G Dlgap5 DLG associated protein 5 increases expression ISO adefovir dipivoxil results in increased expression of DLGAP5 mRNA CTD PMID:25596134 NCBI chr15:24,167,484...24,199,417
Ensembl chr15:24,167,486...24,199,341 		JBrowse link
G Dlx1 distal-less homeobox 1 decreases expression ISO adefovir dipivoxil results in decreased expression of DLX1 mRNA CTD PMID:25596134 NCBI chr 3:58,164,931...58,169,521
Ensembl chr 3:58,164,931...58,169,521 		JBrowse link
G Dnai3 dynein axonemal intermediate chain 3 increases expression ISO adefovir dipivoxil results in increased expression of DNAI3 mRNA CTD PMID:25596134 NCBI chr 2:251,912,432...251,970,699
Ensembl chr 2:251,912,368...251,970,768 		JBrowse link
G Dpysl3 dihydropyrimidinase-like 3 increases expression ISO adefovir dipivoxil results in increased expression of DPYSL3 mRNA CTD PMID:25596134 NCBI chr18:37,716,371...37,819,347
Ensembl chr18:37,716,143...37,819,097 		JBrowse link
G Efna1 ephrin A1 decreases expression ISO adefovir dipivoxil results in decreased expression of EFNA1 mRNA CTD PMID:25596134 NCBI chr 2:188,588,808...188,596,156
Ensembl chr 2:188,588,796...188,596,222 		JBrowse link
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha increases expression ISO adefovir dipivoxil results in increased expression of ERO1A mRNA CTD PMID:25596134 NCBI chr15:19,619,947...19,655,381
Ensembl chr15:19,619,973...19,655,381 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO adefovir dipivoxil results in increased expression of FAS mRNA CTD PMID:25596134 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Fbxo22 F-box protein 22 increases expression ISO adefovir dipivoxil results in increased expression of FBXO22 mRNA CTD PMID:25596134 NCBI chr 8:59,770,032...59,786,061
Ensembl chr 8:59,769,994...59,786,065 		JBrowse link
G Gabarapl1 GABA type A receptor associated protein like 1 decreases expression ISO adefovir dipivoxil results in decreased expression of GABARAPL1 mRNA CTD PMID:25596134 NCBI chr 4:163,293,724...163,302,866
Ensembl chr 4:163,293,724...163,302,858 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO adefovir dipivoxil results in increased expression of GADD45A mRNA CTD PMID:25596134 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842 		JBrowse link
G Galnt16 polypeptide N-acetylgalactosaminyltransferase 16 decreases expression ISO adefovir dipivoxil results in decreased expression of GALNT16 mRNA CTD PMID:25596134 NCBI chr 6:104,069,853...104,250,177
Ensembl chr 6:104,068,547...104,250,174 		JBrowse link
G Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type increases expression ISO adefovir dipivoxil results in increased expression of GCNT3 mRNA CTD PMID:25596134 NCBI chr 8:76,449,078...76,459,431
Ensembl chr 8:76,449,081...76,452,554 		JBrowse link
G Gdf15 growth differentiation factor 15 increases expression ISO adefovir dipivoxil results in increased expression of GDF15 mRNA CTD PMID:25596134 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 decreases expression ISO adefovir dipivoxil results in decreased expression of GOT1 mRNA CTD PMID:25596134 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762 		JBrowse link
G Gpr87 G protein-coupled receptor 87 increases expression ISO adefovir dipivoxil results in increased expression of GPR87 mRNA CTD PMID:25596134 NCBI chr 2:149,398,949...149,418,041
Ensembl chr 2:149,398,949...149,417,212 		JBrowse link
G H1f2 H1.2 linker histone, cluster member increases expression ISO adefovir dipivoxil results in increased expression of H1-2 mRNA CTD PMID:25596134 NCBI chr17:43,638,938...43,640,445
Ensembl chr17:43,639,749...43,640,387 		JBrowse link
G Hmox1 heme oxygenase 1 decreases expression ISO adefovir dipivoxil results in decreased expression of HMOX1 mRNA CTD PMID:25596134 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B decreases expression ISO adefovir dipivoxil results in decreased expression of HSPA1B mRNA CTD PMID:25596134 NCBI chr20:4,877,638...4,880,112
Ensembl chr20:2,699,712...2,701,815 		JBrowse link
G Ifng interferon gamma multiple interactions ISO adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein] CTD PMID:9354585 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il19 interleukin 19 increases secretion ISO adefovir dipivoxil results in increased secretion of IL19 protein CTD PMID:24714768 NCBI chr13:47,663,592...47,677,869
Ensembl chr13:47,664,080...47,670,407 		JBrowse link
G Kat6b lysine acetyltransferase 6B decreases expression ISO adefovir dipivoxil results in decreased expression of KAT6B mRNA CTD PMID:25596134 NCBI chr15:2,811,933...2,966,833
Ensembl chr15:2,813,537...2,966,576 		JBrowse link
G Kdm3a lysine demethylase 3A decreases expression ISO adefovir dipivoxil results in decreased expression of KDM3A mRNA CTD PMID:25596134 NCBI chr 4:99,503,160...99,547,315
Ensembl chr 4:99,503,176...99,546,905 		JBrowse link
G Krt15 keratin 15 increases expression ISO adefovir dipivoxil results in increased expression of KRT15 mRNA CTD PMID:25596134 NCBI chr10:88,046,803...88,050,622
Ensembl chr10:88,046,803...88,050,622 		JBrowse link
G Lama3 laminin subunit alpha 3 increases expression ISO adefovir dipivoxil results in increased expression of LAMA3 mRNA CTD PMID:25596134 NCBI chr18:3,704,866...3,941,215
Ensembl chr18:3,705,916...3,940,838 		JBrowse link
G Lcn2 lipocalin 2 increases secretion ISO adefovir dipivoxil results in increased secretion of LCN2 protein CTD PMID:24714768 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546 		JBrowse link
G Map3k8 mitogen-activated protein kinase kinase kinase 8 increases expression ISO adefovir dipivoxil results in increased expression of MAP3K8 mRNA CTD PMID:25596134 NCBI chr17:56,109,403...56,129,925
Ensembl chr17:56,109,549...56,129,919 		JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression ISO adefovir dipivoxil results in increased expression of MDM2 mRNA CTD PMID:25596134 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328 		JBrowse link
G Mxi1 MAX interactor 1, dimerization protein decreases expression ISO adefovir dipivoxil results in decreased expression of MXI1 mRNA CTD PMID:25596134 NCBI chr 1:274,030,748...274,090,071
Ensembl chr 1:274,030,978...274,090,071 		JBrowse link
G Ncapd2 non-SMC condensin I complex, subunit D2 increases expression ISO adefovir dipivoxil results in increased expression of NCAPD2 mRNA CTD PMID:25596134 NCBI chr 4:157,682,855...157,705,903
Ensembl chr 4:157,683,077...157,704,596 		JBrowse link
G Ninj1 ninjurin 1 increases expression ISO adefovir dipivoxil results in increased expression of NINJ1 mRNA CTD PMID:25596134 NCBI chr17:15,866,235...15,881,284
Ensembl chr17:15,866,237...15,881,327 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased activity of NOS2 protein]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; adefovir dipivoxil inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein] CTD PMID:9354585 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 decreases expression ISO adefovir dipivoxil results in decreased expression of NQO1 mRNA CTD PMID:25596134 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Nrep neuronal regeneration related protein decreases expression ISO adefovir dipivoxil results in decreased expression of NREP mRNA CTD PMID:25596134 NCBI chr18:26,183,753...26,212,796
Ensembl chr18:26,185,259...26,211,445 		JBrowse link
G Ntpcr nucleoside-triphosphatase, cancer-related increases expression ISO adefovir dipivoxil results in increased expression of NTPCR mRNA CTD PMID:25596134 NCBI chr19:58,565,576...58,579,276
Ensembl chr19:58,565,576...58,579,265 		JBrowse link
G P4ha1 prolyl 4-hydroxylase subunit alpha 1 decreases expression ISO adefovir dipivoxil results in decreased expression of P4HA1 mRNA CTD PMID:25596134 NCBI chr20:28,920,616...28,972,576
Ensembl chr20:28,920,616...28,971,966 		JBrowse link
G Pank1 pantothenate kinase 1 decreases expression ISO adefovir dipivoxil results in decreased expression of PANK1 mRNA CTD PMID:25596134 NCBI chr 1:253,115,400...253,189,643
Ensembl chr 1:253,119,112...253,185,533 		JBrowse link
G Pdia5 protein disulfide isomerase family A, member 5 increases expression ISO adefovir dipivoxil results in increased expression of PDIA5 mRNA CTD PMID:25596134 NCBI chr11:68,493,035...68,578,999
Ensembl chr11:68,493,035...68,578,995 		JBrowse link
G Pdlim1 PDZ and LIM domain 1 increases expression ISO adefovir dipivoxil results in increased expression of PDLIM1 mRNA CTD PMID:25596134 NCBI chr 1:259,308,326...259,357,006
Ensembl chr 1:259,308,296...259,357,056 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO adefovir dipivoxil binds to and results in decreased activity of PGR protein CTD PMID:25752796 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796 		JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 increases expression ISO adefovir dipivoxil results in increased expression of PHLDA3 mRNA CTD PMID:25596134 NCBI chr13:52,588,917...52,592,002
Ensembl chr13:52,588,917...52,592,001 		JBrowse link
G Pidd1 p53-induced death domain protein 1 increases expression ISO adefovir dipivoxil results in increased expression of PIDD1 mRNA CTD PMID:25596134 NCBI chr 1:214,418,751...214,423,959
Ensembl chr 1:214,419,240...214,423,881 		JBrowse link
G Pir pirin increases expression ISO adefovir dipivoxil results in increased expression of PIR mRNA CTD PMID:25596134 NCBI chr  X:31,852,322...31,968,152
Ensembl chr  X:31,852,323...31,968,152 		JBrowse link
G Plec plectin increases expression ISO adefovir dipivoxil results in increased expression of PLEC mRNA CTD PMID:25596134 NCBI chr 7:117,230,319...117,291,859
Ensembl chr 7:117,230,319...117,289,961 		JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO adefovir dipivoxil results in increased expression of PMAIP1 mRNA CTD PMID:25596134 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects activity ISO adefovir dipivoxil affects the activity of PPARG protein CTD PMID:25596134 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D increases expression ISO adefovir dipivoxil results in increased expression of PPM1D mRNA CTD PMID:25596134 NCBI chr10:72,909,550...72,945,884
Ensembl chr10:72,909,550...72,945,884 		JBrowse link
G Prc1 protein regulator of cytokinesis 1 increases expression ISO adefovir dipivoxil results in increased expression of PRC1 mRNA CTD PMID:25596134 NCBI chr 1:142,087,181...142,108,746
Ensembl chr 1:142,087,208...142,108,746 		JBrowse link
G Prdm1 PR/SET domain 1 increases expression ISO adefovir dipivoxil results in increased expression of PRDM1 mRNA CTD PMID:25596134 NCBI chr20:49,464,921...49,556,623
Ensembl chr20:49,464,919...49,556,518 		JBrowse link
G Prkab2 protein kinase AMP-activated non-catalytic subunit beta 2 decreases expression ISO adefovir dipivoxil results in decreased expression of PRKAB2 mRNA CTD PMID:25596134 NCBI chr 2:199,831,990...199,847,623
Ensembl chr 2:199,831,990...199,847,629 		JBrowse link
G Psat1 phosphoserine aminotransferase 1 decreases expression ISO adefovir dipivoxil results in decreased expression of PSAT1 mRNA CTD PMID:25596134 NCBI chr 1:233,124,089...233,145,941
Ensembl chr 1:233,124,092...233,145,941 		JBrowse link
G Rara retinoic acid receptor, alpha decreases expression ISO adefovir dipivoxil results in decreased expression of RARA mRNA CTD PMID:25596134 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210 		JBrowse link
G Rps27l ribosomal protein S27-like increases expression ISO adefovir dipivoxil results in increased expression of RPS27L mRNA CTD PMID:25596134 NCBI chr 8:72,741,155...72,746,090
Ensembl chr 8:72,741,155...72,746,090 		JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression ISO adefovir dipivoxil results in increased expression of RRM2B mRNA CTD PMID:25596134 NCBI chr 7:76,750,045...76,780,817
Ensembl chr 7:76,750,050...76,780,817 		JBrowse link
G Serpinb5 serpin family B member 5 increases expression ISO adefovir dipivoxil results in increased expression of SERPINB5 mRNA CTD PMID:25596134 NCBI chr13:26,903,052...26,923,250
Ensembl chr13:26,903,052...26,923,250 		JBrowse link
G Sesn1 sestrin 1 increases expression ISO adefovir dipivoxil results in increased expression of SESN1 mRNA CTD PMID:25596134 NCBI chr20:46,667,116...46,758,306
Ensembl chr20:46,667,121...46,758,305 		JBrowse link
G Sfn stratifin increases expression ISO adefovir dipivoxil results in increased expression of SFN mRNA CTD PMID:25596134 NCBI chr 5:151,823,422...151,824,937
Ensembl chr 5:151,823,887...151,824,633 		JBrowse link
G Sh3tc1 SH3 domain and tetratricopeptide repeats 1 decreases expression ISO adefovir dipivoxil results in decreased expression of SH3TC1 mRNA CTD PMID:25596134 NCBI chr14:80,184,814...80,229,207
Ensembl chr14:80,195,715...80,229,214 		JBrowse link
G Slc27a2 solute carrier family 27 member 2 decreases expression ISO adefovir dipivoxil results in decreased expression of SLC27A2 mRNA CTD PMID:25596134 NCBI chr 3:119,014,620...119,052,531
Ensembl chr 3:119,014,620...119,052,531 		JBrowse link
G Slc6a9 solute carrier family 6 member 9 decreases expression ISO adefovir dipivoxil results in decreased expression of SLC6A9 mRNA CTD PMID:25596134 NCBI chr 5:136,669,674...136,703,702
Ensembl chr 5:136,669,674...136,703,697 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 increases expression ISO adefovir dipivoxil results in increased expression of SLCO2B1 mRNA CTD PMID:25596134 NCBI chr 1:164,623,313...164,671,612
Ensembl chr 1:164,623,599...164,671,577 		JBrowse link
G Smap1 small ArfGAP 1 decreases expression ISO adefovir dipivoxil results in decreased expression of SMAP1 mRNA CTD PMID:25596134 NCBI chr 9:30,068,888...30,161,753
Ensembl chr 9:30,068,659...30,161,578 		JBrowse link
G Sulf2 sulfatase 2 increases expression ISO adefovir dipivoxil results in increased expression of SULF2 mRNA CTD PMID:25596134 NCBI chr 3:162,791,349...162,872,984
Ensembl chr 3:162,791,355...162,872,831 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO adefovir dipivoxil binds to and results in decreased activity of THRA protein CTD PMID:25752796 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933 		JBrowse link
G Tigar TP53 induced glycolysis regulatory phosphatase increases expression ISO adefovir dipivoxil results in increased expression of TIGAR mRNA CTD PMID:25596134 NCBI chr 4:159,635,145...159,654,108
Ensembl chr 4:159,635,153...159,654,063 		JBrowse link
G Tiparp TCDD-inducible poly(ADP-ribose) polymerase increases expression ISO adefovir dipivoxil results in increased expression of TIPARP mRNA CTD PMID:25596134 NCBI chr 2:157,316,293...157,342,979
Ensembl chr 2:157,316,266...157,341,469 		JBrowse link
G Tnfsf9 TNF superfamily member 9 increases expression ISO adefovir dipivoxil results in increased expression of TNFSF9 mRNA CTD PMID:25596134 NCBI chr 9:9,909,942...9,912,276
Ensembl chr 9:9,909,948...9,912,276 		JBrowse link
G Tp53 tumor protein p53 affects activity ISO adefovir dipivoxil affects the activity of TP53 protein CTD PMID:25596134 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Tp53inp1 tumor protein p53 inducible nuclear protein 1 increases expression ISO adefovir dipivoxil results in increased expression of TP53INP1 mRNA CTD PMID:25596134 NCBI chr 5:24,402,895...24,419,651
Ensembl chr 5:24,410,863...24,416,888 		JBrowse link
G Trafd1 TRAF type zinc finger domain containing 1 decreases expression ISO adefovir dipivoxil results in decreased expression of TRAFD1 mRNA CTD PMID:25596134 NCBI chr12:40,695,520...40,709,438
Ensembl chr12:40,695,520...40,709,462 		JBrowse link
G Triap1 TP53 regulated inhibitor of apoptosis 1 increases expression ISO adefovir dipivoxil results in increased expression of TRIAP1 mRNA CTD PMID:25596134 NCBI chr12:46,987,404...46,989,906
Ensembl chr12:46,987,404...46,989,897
Ensembl chr12:46,987,404...46,989,897 		JBrowse link
G Ube2o ubiquitin-conjugating enzyme E2O decreases expression ISO adefovir dipivoxil results in decreased expression of UBE2O mRNA CTD PMID:25596134 NCBI chr10:105,505,721...105,553,167
Ensembl chr10:105,506,955...105,552,986 		JBrowse link
G Yars1 tyrosyl-tRNA synthetase 1 decreases expression ISO adefovir dipivoxil results in decreased expression of YARS1 mRNA CTD PMID:25596134 NCBI chr 5:147,375,350...147,403,578
Ensembl chr 5:147,375,350...147,403,571 		JBrowse link
G Zmat3 zinc finger, matrin type 3 increases expression ISO adefovir dipivoxil results in increased expression of ZMAT3 mRNA CTD PMID:25596134 NCBI chr 2:118,715,229...118,746,109
Ensembl chr 2:118,721,334...118,745,766 		JBrowse link
EPN term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester results in increased activity of AR protein] CTD PMID:15064155 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester results in increased activity of ESR1 protein CTD PMID:15064155 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester results in increased activity of ESR2 protein CTD PMID:15064155 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
fotemustine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO fotemustine results in increased expression of CDKN1A mRNA CTD PMID:25125662 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO fotemustine results in increased expression of FAS mRNA CTD PMID:25125662 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 ISO FOS mutant form inhibits the reaction [fotemustine results in increased expression of TREX1 mRNA]
fotemustine results in increased expression of FOS mRNA; fotemustine results in increased expression of FOS protein		 CTD PMID:23578789 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO fotemustine results in increased expression of GADD45A mRNA CTD PMID:25125662 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842 		JBrowse link
G H2ax H2A.X variant histone increases expression ISO fotemustine results in increased expression of H2AX protein modified form CTD PMID:25125662 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression		 ISO fotemustine promotes the reaction [JUN protein binds to TREX1 promoter]; JUN mutant form inhibits the reaction [fotemustine results in increased expression of TREX1 mRNA]
fotemustine results in increased expression of JUN mRNA; fotemustine results in increased expression of JUN protein		 CTD PMID:23578789 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases response to substance ISO MGMT protein results in decreased susceptibility to fotemustine CTD PMID:12970393 PMID:16039682 PMID:20556481 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190 		JBrowse link
G Polh DNA polymerase eta multiple interactions
decreases response to substance
increases expression		 ISO Dactinomycin inhibits the reaction [fotemustine results in increased expression of POLH mRNA]; fotemustine promotes the reaction [TP53 protein binds to POLH promoter]; pifithrin inhibits the reaction [fotemustine results in increased expression of POLH mRNA]; pifithrin inhibits the reaction [fotemustine results in increased expression of POLH protein]
POLH protein results in decreased susceptibility to fotemustine
fotemustine results in increased expression of POLH mRNA; fotemustine results in increased expression of POLH protein		 CTD PMID:25125662 NCBI chr 9:17,163,354...17,198,006
Ensembl chr 9:17,163,354...17,197,132 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO fotemustine promotes the reaction [TP53 protein binds to POLH promoter]
fotemustine results in increased expression of TP53 protein; fotemustine results in increased expression of TP53 protein modified form		 CTD PMID:25125662 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Trex1 three prime repair exonuclease 1 multiple interactions
affects response to substance
increases expression		 ISO FOS mutant form inhibits the reaction [fotemustine results in increased expression of TREX1 mRNA]; fotemustine promotes the reaction [JUN protein binds to TREX1 promoter]; JUN mutant form inhibits the reaction [fotemustine results in increased expression of TREX1 mRNA]
TREX1 affects the susceptibility to fotemustine
fotemustine results in increased expression of TREX1 mRNA; fotemustine results in increased expression of TREX1 protein		 CTD PMID:23578789 NCBI chr 8:117,796,127...117,797,427
Ensembl chr 8:117,796,128...117,797,427 		JBrowse link
isocarbophos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO
EXP		 isocarbophos metabolite results in decreased activity of ACHE protein
isocarbophos results in decreased activity of ACHE protein		 CTD PMID:24752505 PMID:26818681 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO isocarbophos analog results in increased expression of BAX protein CTD PMID:20688129 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO isocarbophos analog results in decreased expression of BCL2 protein CTD PMID:20688129 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp3 caspase 3 increases cleavage EXP isocarbophos results in increased cleavage of CASP3 protein CTD PMID:26818681 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO CYP1A2 protein results in increased metabolism of and results in decreased sulfation of and affects the activity of isocarbophos CTD PMID:24752505 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions ISO CYP2C19 protein results in increased metabolism of and results in decreased sulfation of and affects the activity of isocarbophos CTD PMID:24752505 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO CYP2D6 protein results in increased metabolism of and results in decreased sulfation of and affects the activity of isocarbophos CTD PMID:24752505 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions ISO CYP3A4 protein results in increased metabolism of and results in decreased sulfation of and affects the activity of isocarbophos CTD PMID:24752505 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Gja1 gap junction protein, alpha 1 increases expression EXP isocarbophos results in increased expression of GJA1 protein CTD PMID:26818681 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression EXP isocarbophos results in increased expression of ICAM1 protein CTD PMID:26818681 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 ISO isocarbophos analog results in increased phosphorylation of MAPK1 protein
manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [isocarbophos analog results in increased phosphorylation of MAPK1 protein]		 CTD PMID:20688129 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO isocarbophos analog results in increased phosphorylation of MAPK3 protein
manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [isocarbophos analog results in increased phosphorylation of MAPK3 protein]		 CTD PMID:20688129 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression EXP isocarbophos results in increased expression of VCAM1 protein CTD PMID:26818681 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
isofenphos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO Dihydrotestosterone inhibits the reaction [isofenphos results in increased activity of AR protein] CTD PMID:15064155 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases expression ISO isofenphos results in increased expression of CYP3A4 mRNA CTD PMID:17293382 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO isofenphos results in increased activity of ESR1 protein CTD PMID:15064155 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO isofenphos binds to and results in increased activity of NR1I2 protein; isofenphos metabolite binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 increases activity ISO isofenphos results in increased activity of NR1I3 protein CTD PMID:28927721 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277 		JBrowse link
tenofovir disoproxil fumarate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 decreases activity ISO Tenofovir results in decreased activity of ABCB4 protein CTD PMID:28437613 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Acacb acetyl-CoA carboxylase beta affects expression ISO Tenofovir affects the expression of ACACB mRNA CTD PMID:20032539 NCBI chr12:48,127,149...48,238,969
Ensembl chr12:48,127,149...48,238,887 		JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression ISO Tenofovir results in increased expression of BNIP3L protein CTD PMID:23640862 NCBI chr15:43,643,897...43,667,123
Ensembl chr15:43,643,897...43,667,029 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 increases expression
multiple interactions		 ISO Tenofovir results in increased expression of CCL20 mRNA
Tenofovir results in increased expression of and results in increased secretion of CCL20 protein		 CTD PMID:24205323 NCBI chr 9:88,918,359...88,921,017
Ensembl chr 9:88,918,433...88,921,001 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO [Emtricitabine co-treated with Tenofovir] results in increased expression of CDKN1A protein
Tenofovir results in increased expression of CDKN1A protein		 CTD PMID:31545371 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Tenofovir results in decreased activity of CYP2E1 protein CTD PMID:17162464 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Edn1 endothelin 1 increases secretion
multiple interactions		 ISO Tenofovir results in increased secretion of EDN1 protein
coenzyme Q10 inhibits the reaction [Tenofovir results in increased secretion of EDN1 protein]		 CTD PMID:23640862 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha affects phosphorylation ISO Tenofovir affects the phosphorylation of EIF2S1 protein CTD PMID:27041070 NCBI chr 6:102,048,372...102,073,041
Ensembl chr 6:102,048,372...102,073,041 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 increases secretion
multiple interactions		 ISO Tenofovir results in increased secretion of HAVCR1 protein
Tenofovir inhibits the reaction [cidofovir results in increased secretion of HAVCR1 protein]		 CTD PMID:29738843 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379 		JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 affects expression ISO Tenofovir affects the expression of HSD11B1 mRNA CTD PMID:20032539 NCBI chr13:111,946,626...111,996,536
Ensembl chr13:111,926,442...111,972,603 		JBrowse link
G Hspd1 heat shock protein family D (Hsp60) member 1 affects expression ISO Tenofovir affects the expression of HSPD1 protein CTD PMID:27041070 NCBI chr 9:61,680,529...61,691,202
Ensembl chr 9:61,680,530...61,690,956 		JBrowse link
G Lipe lipase E, hormone sensitive type affects expression ISO Tenofovir affects the expression of LIPE mRNA CTD PMID:20032539 NCBI chr 1:82,248,031...82,266,727
Ensembl chr 1:82,248,046...82,266,727 		JBrowse link
G Lonp1 lon peptidase 1, mitochondrial affects expression ISO Tenofovir affects the expression of LONP1 protein CTD PMID:27041070 NCBI chr 9:10,428,853...10,441,180
Ensembl chr 9:10,428,853...10,441,177 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 affects phosphorylation ISO Tenofovir affects the phosphorylation of MAPK8 protein CTD PMID:27041070 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mt-co2 mitochondrially encoded cytochrome c oxidase II multiple interactions ISO Tenofovir promotes the reaction [Didanosine results in decreased expression of COX2 mRNA] CTD PMID:16940060 NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases expression EXP Tenofovir results in decreased expression of NFKBIA protein CTD PMID:27899301 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression EXP Tenofovir results in increased expression of NOS2 mRNA; Tenofovir results in increased expression of NOS2 protein CTD PMID:27899301 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases phosphorylation		 ISO coenzyme Q10 inhibits the reaction [Tenofovir results in decreased phosphorylation of NOS3 protein] CTD PMID:23640862 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects expression ISO Tenofovir affects the expression of NR3C1 mRNA CTD PMID:20032539 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647 		JBrowse link
G Nt5e 5' nucleotidase, ecto increases expression ISO Tenofovir results in increased expression of NT5E mRNA CTD PMID:24205323 NCBI chr 8:95,969,002...96,012,733
Ensembl chr 8:95,968,652...96,012,696 		JBrowse link
G Nt5m 5',3'-nucleotidase, mitochondrial decreases expression ISO Tenofovir results in decreased expression of NT5M mRNA CTD PMID:24205323 NCBI chr10:46,216,494...46,244,478
Ensembl chr10:46,216,884...46,243,077 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression ISO Tenofovir affects the expression of PPARG mRNA CTD PMID:20032539 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO [Emtricitabine co-treated with Tenofovir] results in decreased expression of PRKN protein CTD PMID:31545371 NCBI chr 1:48,880,015...50,069,998 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression EXP Tenofovir results in increased expression of PTGS2 mRNA; Tenofovir results in increased expression of PTGS2 protein CTD PMID:27899301 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
increases expression		 EXP Melatonin inhibits the reaction [Tenofovir affects the localization of RELA protein]; Melatonin inhibits the reaction [Tenofovir results in increased expression of and results in increased activity of RELA protein]; Melatonin inhibits the reaction [Tenofovir results in increased expression of RELA mRNA]; Tenofovir results in increased expression of and results in increased activity of RELA protein CTD PMID:27899301 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Sirt3 sirtuin 3 increases expression ISO Tenofovir results in increased expression of SIRT3 protein CTD PMID:27041070 NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 increases response to substance
increases import
multiple interactions		 ISO SLC22A6 protein results in increased susceptibility to Tenofovir
SLC22A6 protein results in increased import of Tenofovir
Probenecid inhibits the reaction [SLC22A6 protein results in increased susceptibility to Tenofovir]; SLC22A6 protein results in increased uptake of and results in increased susceptibility to Tenofovir; Tenofovir inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]		 CTD PMID:23856525 PMID:25448811 PMID:29738843 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 increases response to substance
increases import		 ISO SLC22A8 protein results in increased susceptibility to Tenofovir
SLC22A8 protein results in increased import of Tenofovir		 CTD PMID:25448811 PMID:29738843 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482 		JBrowse link
G Tnf tumor necrosis factor decreases expression
increases expression		 ISO
EXP		 Tenofovir results in decreased expression of TNF mRNA
Tenofovir results in increased expression of TNF mRNA; Tenofovir results in increased expression of TNF protein		 CTD PMID:24205323 PMID:27899301 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO [Emtricitabine co-treated with Tenofovir] results in increased expression of TP53 protein
Tenofovir results in increased expression of TP53 protein		 CTD PMID:31545371 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
trichlorfon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
affects activity
decreases activity		 ISO
EXP		 [Trichlorfon co-treated with Dichlorvos] results in decreased activity of ACHE protein; asoxime chloride inhibits the reaction [Trichlorfon results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [Trichlorfon results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Trichlorfon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Trichlorfon results in decreased activity of ACHE protein]
Trichlorfon affects the activity of ACHE protein
[Trichlorfon results in decreased activity of ACHE protein] which affects the localization of CHRM2 protein
Trichlorfon metabolite results in decreased activity of ACHE protein; Trichlorfon results in decreased activity of ACHE protein		 CTD PMID:235931 PMID:1852719 PMID:4859365 PMID:8783813 PMID:9268605 PMID:9515941 PMID:10718203 PMID:10791297 PMID:11311445 PMID:11526466 PMID:11822883 PMID:12111444 PMID:12794734 PMID:15386949 PMID:15569517 PMID:16822217 PMID:18070496 PMID:18804659 PMID:19631781 PMID:30625376 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
G App amyloid beta precursor protein increases secretion
affects metabolic processing
affects cleavage		 ISO
EXP		 Trichlorfon results in increased secretion of APP protein alternative form
Trichlorfon affects the metabolism of APP protein
Trichlorfon affects the cleavage of APP protein		 CTD PMID:10773217 PMID:11099780 PMID:11526466 PMID:11822883 NCBI chr11:24,425,013...24,641,872
Ensembl chr11:24,425,005...24,641,858 		JBrowse link
G Bche butyrylcholinesterase multiple interactions
decreases activity		 ISO
EXP		 1-(4-hydroxyiminomethylpyridinium)-4-(4-carbamoylpyridinium)butane inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]; asoxime chloride inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]; Obidoxime Chloride inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein]; pralidoxime inhibits the reaction [Trichlorfon results in decreased activity of BCHE protein] CTD PMID:235931 PMID:11311445 PMID:18825528 NCBI chr 2:171,104,476...171,196,186
Ensembl chr 2:171,100,140...171,196,395 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO Tetradecanoylphorbol Acetate inhibits the reaction [Trichlorfon results in decreased expression of BCL2 protein] CTD PMID:19631781 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp12 caspase 12 multiple interactions ISO [Verapamil co-treated with Ruthenium Red co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP12 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP12 protein]; Trichlorfon results in increased cleavage of and results in increased activity of CASP12 protein CTD PMID:19631781 NCBI chr 8:2,658,892...2,686,160
Ensembl chr 8:2,659,865...2,686,160 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [Verapamil co-treated with Ruthenium Red co-treated with 2-aminoethoxydiphenyl borate] inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Trichlorfon results in increased cleavage of and results in increased activity of CASP3 protein]; Trichlorfon results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:19631781 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cat catalase decreases activity
increases activity		 ISO Trichlorfon results in decreased activity of CAT protein
Trichlorfon results in increased activity of CAT protein		 CTD PMID:15386949 PMID:17697763 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 multiple interactions ISO [Trichlorfon results in decreased activity of ACHE protein] which affects the localization of CHRM2 protein CTD PMID:12794734 NCBI chr 4:64,089,028...64,091,090
Ensembl chr 4:64,088,900...64,091,090 		JBrowse link
G Chrm4 cholinergic receptor, muscarinic 4 affects expression EXP Trichlorfon affects the expression of CHRM4 mRNA; Trichlorfon affects the expression of CHRM4 protein CTD PMID:12093157 NCBI chr 3:80,833,272...80,841,165
Ensembl chr 3:80,833,272...80,841,006 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases activity
decreases expression		 ISO Trichlorfon results in decreased activity of CYP11A1 protein
Trichlorfon results in decreased expression of CYP11A1 mRNA; Trichlorfon results in decreased expression of CYP11A1 protein		 CTD PMID:17350742 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO Trichlorfon inhibits the reaction [FSHB protein results in increased abundance of Progesterone] CTD PMID:17329077 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131 		JBrowse link
G Gap43 growth associated protein 43 decreases expression ISO Trichlorfon results in decreased expression of GAP43 protein CTD PMID:27939611 NCBI chr11:58,624,198...58,717,916
Ensembl chr11:58,624,198...58,717,914 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha increases activity ISO Trichlorfon results in increased activity of HNF4A protein CTD PMID:20143881 NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003 		JBrowse link
G LOC299277 similar to serine (or cysteine) peptidase inhibitor, clade A, member 3B decreases expression ISO Trichlorfon results in decreased expression of SERPINA3 protein CTD PMID:10599054 NCBI chr 6:127,871,895...127,888,287
Ensembl chr 6:127,872,666...127,886,540 		JBrowse link
G Nefh neurofilament heavy decreases expression ISO Trichlorfon results in decreased expression of NEFH protein CTD PMID:27939611 NCBI chr14:85,181,572...85,191,557
Ensembl chr14:85,181,572...85,191,557 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases activity ISO Trichlorfon results in increased activity of NFE2L2 protein CTD PMID:20143881 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 decreases activity ISO Trichlorfon results in decreased activity of PNPLA6 protein CTD PMID:9268605 NCBI chr12:2,068,749...2,098,139
Ensembl chr12:2,069,959...2,097,904 		JBrowse link
G Star steroidogenic acute regulatory protein decreases expression ISO Trichlorfon results in decreased expression of STAR mRNA
Trichlorfon results in decreased expression of STAR mRNA; Trichlorfon results in decreased expression of STAR protein		 CTD PMID:17329077 PMID:17350742 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847 		JBrowse link
G Syn1 synapsin I decreases expression ISO Trichlorfon results in decreased expression of SYN1 protein CTD PMID:27939611 NCBI chr  X:1,321,315...1,379,202
Ensembl chr  X:1,321,315...1,379,198 		JBrowse link
G Syp synaptophysin decreases expression ISO Trichlorfon results in decreased expression of SYP protein CTD PMID:27939611 NCBI chr  X:15,694,699...15,709,244
Ensembl chr  X:15,695,566...15,707,436 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO Trichlorfon results in increased expression of TP53 protein CTD PMID:19631781 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19875
    role 19825
      application 19494
        pesticide 16613
          fungicide 10738
            phosphonic acid 3111
              phosphonic acid derivative 2333
                phosphonate 167
                  inorganic phosphonate + 0
                  organic phosphonate + 167
Path 2
Term Annotations click to browse term
  CHEBI ontology 19875
    subatomic particle 19873
      composite particle 19873
        hadron 19873
          baryon 19873
            nucleon 19873
              atomic nucleus 19873
                atom 19873
                  main group element atom 19763
                    p-block element atom 19763
                      chalcogen 19454
                        oxygen atom 19415
                          oxygen molecular entity 19415
                            hydroxides 19139
                              oxoacid 18273
                                pnictogen oxoacid 10308
                                  phosphorus oxoacid 9228
                                    phosphorus oxoacid derivative 8653
                                      phosphonic acid derivative 2333
                                        phosphonate 167
                                          inorganic phosphonate + 0
                                          organic phosphonate + 167
paths to the root