3-hydroxypregnan-20-one - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	3-hydroxypregnan-20-one	go back to main search page
Accession:	CHEBI:50168	browse the term
Definition:	A C21-steroid that is pregnane substituted by an oxo group at position 20 and a hydroxy group at position 3.
Synonyms:	related_synonym:	Formula=C21H34O2; InChI=1S/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14?,15?,16-,17+,18-,19-,20-,21+/m0/s1; InChIKey=AURFZBICLPNKBZ-SRJHXTLLSA-N; SMILES=[H][C@@]12CCC3CC(O)CC[C@]3(C)[C@@]1([H])CC[C@]1(C)[C@]([H])(CC[C@@]21[H])C(C)=O
	xref:	Beilstein:10478053

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Genes (30)

3alpha-hydroxy-5beta-pregnan-20-one

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldo-keto reductase family 1, member C1

increases reduction
affects metabolic processing

AKR1C1 protein results in increased reduction of Pregnanolone
AKR1C1 protein affects the metabolism of Pregnanolone

PMID:11995921 PMID:12604236

NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326

G

aldo-keto reductase family 1, member C2

increases reduction
affects metabolic processing

AKR1C2 protein results in increased reduction of Pregnanolone
AKR1C2 protein affects the metabolism of Pregnanolone

PMID:11995921 PMID:12604236

NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764

G

aldo-keto reductase family 1, member C3

increases chemical synthesis

AKR1C3 protein results in increased chemical synthesis of Pregnanolone

NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873

G

corticotropin releasing hormone

affects expression
multiple interactions

Pregnanolone affects the expression of CRH mRNA
Pregnanolone inhibits the reaction [Methoxamine results in increased secretion of CRH protein]

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

G

cytochrome P450, family 17, subfamily a, polypeptide 1

increases hydroxylation

CYP17A1 protein results in increased hydroxylation of Pregnanolone analog

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

early growth response 2

increases expression

Pregnanolone results in increased expression of EGR2 mRNA; Pregnanolone results in increased expression of EGR2 protein

NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562

G

gamma-aminobutyric acid type A receptor subunit alpha 1

multiple interactions

Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]; Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]

NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864

G

gamma-aminobutyric acid type A receptor subunit alpha 2

multiple interactions

Pregnanolone results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]

NCBI chr14:37,097,251...37,230,030
Ensembl chr14:37,097,279...37,228,944

G

gamma-aminobutyric acid type A receptor subunit alpha 4

increases expression
multiple interactions

Pregnanolone deficiency results in increased expression of GABRA4 mRNA; Pregnanolone deficiency results in increased expression of GABRA4 protein
Pregnanolone results in increased activity of [GABRA4 protein binds to GABRB3 binds to GABRD protein]

PMID:9651210 PMID:29038840

NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844

G

gamma-aminobutyric acid type A receptor subunit alpha6

increases response to substance
multiple interactions

GABRA6 protein results in increased susceptibility to Pregnanolone
Pregnanolone results in increased activity of [GABRA6 protein binds to GABRB3 binds to GABRG2 protein alternative form]

PMID:9281599 PMID:29038840

NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769

G

gamma-aminobutyric acid type A receptor subunit beta1

multiple interactions

Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]

NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948

G

gamma-aminobutyric acid type A receptor subunit beta 2

multiple interactions

Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]

NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251

G

gamma-aminobutyric acid type A receptor subunit beta 3

multiple interactions

Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Pregnanolone results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Pregnanolone results in increased activity of [GABRA4 protein binds to GABRB3 binds to GABRD protein]; Pregnanolone results in increased activity of [GABRA6 protein binds to GABRB3 binds to GABRG2 protein alternative form]

NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961

G

gamma-aminobutyric acid type A receptor subunit delta

decreases expression
multiple interactions

Pregnanolone results in decreased expression of GABRD protein
Pregnanolone results in increased activity of [GABRA4 protein binds to GABRB3 binds to GABRD protein]

PMID:16914187 PMID:29038840

NCBI chr 5:165,958,508...165,970,407
Ensembl chr 5:165,958,484...165,970,411

G

gamma-aminobutyric acid type A receptor subunit epsilon

decreases response to substance

GABRE protein results in decreased susceptibility to Pregnanolone

NCBI chr X:150,060,035...150,078,773
Ensembl chr X:150,060,040...150,078,693

G

gamma-aminobutyric acid type A receptor subunit gamma 2

multiple interactions

Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB1 binds to GABRG2 protein alternative form]; Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB2 binds to GABRG2 protein alternative form]; Pregnanolone results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Pregnanolone results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Pregnanolone results in increased activity of [GABRA6 protein binds to GABRB3 binds to GABRG2 protein alternative form]

NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346

G

glycogen synthase kinase 3 beta

decreases expression

Pregnanolone results in decreased expression of GSK3B protein

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

G

hydroxysteroid (17-beta) dehydrogenase 10

multiple interactions

[Pregnanolone co-treated with NAD] binds to HSD17B10 protein

NCBI chr X:21,089,142...21,091,603
Ensembl chr X:21,089,122...21,109,488

G

interleukin 1 beta

decreases response to substance

Pregnanolone results in decreased susceptibility to IL1B protein

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

myelin-associated glycoprotein

increases expression

Pregnanolone results in increased expression of MAG mRNA

NCBI chr 1:86,148,227...86,163,726
Ensembl chr 1:86,148,228...86,163,656

G

mitogen activated protein kinase 1

multiple interactions

Pregnanolone results in decreased phosphorylation of and results in decreased activity of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

microtubule-associated protein tau

increases phosphorylation
decreases expression

Pregnanolone results in increased phosphorylation of MAPT protein
Pregnanolone results in decreased expression of MAPT protein

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

G

myelin protein zero

increases expression

Pregnanolone results in increased expression of MPZ mRNA

NCBI chr13:83,570,811...83,576,680
Ensembl chr13:83,570,811...83,576,679

G

nuclear receptor subfamily 1, group H, member 4

multiple interactions
increases activity

Pregnanolone metabolite inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]
Pregnanolone metabolite results in increased activity of NR1H4 protein

NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047

G

nuclear receptor subfamily 3, group C, member 1

multiple interactions

Pregnanolone analog inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]; Pregnanolone inhibits the reaction [Corticosterone results in increased activity of NR3C1 protein]

NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375

G

proenkephalin

increases expression

Pregnanolone results in increased expression of PENK mRNA

NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129

G

peripheral myelin protein 22

increases expression

Pregnanolone results in increased expression of PMP22 mRNA

NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714

G

protein kinase C, alpha

decreases expression

Pregnanolone results in decreased expression of PRKCA protein

NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012

G

solute carrier family 1 member 1

multiple interactions

Pregnanolone results in increased localization of and results in increased activity of SLC1A1 protein

NCBI chr 1:226,549,932...226,631,925
Ensembl chr 1:226,549,842...226,630,402

G

steroid 5 alpha-reductase 1

increases chemical synthesis

SRD5A1 protein results in increased chemical synthesis of Pregnanolone

NCBI chr 1:33,686,069...33,720,468
Ensembl chr 1:33,686,391...33,720,461

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19808
chemical entity	19806
molecular entity	19806
polyatomic entity	19764
heteroatomic molecular entity	19720
hydroxides	19299
organic hydroxy compound	18923
hydroxy steroid	14425
3-hydroxy steroid	12764
3-hydroxypregnan-20-one	30
3-hydroxy-5alpha-pregnan-20-one +	0
3-hydroxy-5beta-pregnan-20-one +	30
Path 2
Term	Annotations
CHEBI ontology	19808
subatomic particle	19806
composite particle	19806
hadron	19806
baryon	19806
nucleon	19806
atomic nucleus	19806
atom	19806
main group element atom	19756
p-block element atom	19756
carbon group element atom	19705
carbon atom	19702
organic molecular entity	19702
heteroorganic entity	19460
organochalcogen compound	19224
organooxygen compound	19141
carbonyl compound	18869
ketone	17165
oxo steroid	10530
20-oxo steroid	7669
3-hydroxypregnan-20-one	30
3-hydroxy-5alpha-pregnan-20-one +	0
3-hydroxy-5beta-pregnan-20-one +	30

paths to the root