Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Nutlin-3
go back to main search page
Accession:CHEBI:46742 term browser browse the term
Definition:A Nutlin that has formula C30H30Cl2N4O4.
Synonyms:exact_synonym: rel-4-{[(4R,5S)-4,5-bis(4-chlorophenyl)-2-{2-[(propan-2-yl)oxy]-4-methoxyphenyl}-4,5-dihydro-1H-imidazol-1-yl]carbonyl}piperazin-2-one
 related_synonym: Formula=C30H30Cl2N4O4;   InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m1/s1;   InChIKey=BDUHCSBCVGXTJM-IZLXSDGUSA-N;   SMILES=COc1ccc(c(OC(C)C)c1)C1=N[C@@H]([C@@H](N1C(=O)N1CCNC(=O)C1)c1ccc(Cl)cc1)c1ccc(Cl)cc1;   cis-4-{[4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazol-1-yl]carbonyl}piperazin-2-one
 xref: Beilstein:10243211;   CAS:548472-68-0
 xref_mesh: MESH:C482205


show annotations for term's descendants           Sort by:
Nutlin-3 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 increases expression EXP Nutlin-3 increases expression of ABCA1 mRNA and protein in human cell lines SK-HEP-1 and HCT116 RGD PMID:30580964 RGD:24922199 NCBI chr 9:104,781,006...104,928,155
Ensembl chr 9:104,781,006...104,928,155 		JBrowse link
G ABCB1 ATP binding cassette subfamily B member 1 affects response to substance
multiple interactions
decreases expression		 EXP ABCB1 protein affects the susceptibility to nutlin 3
PVT1 protein inhibits the reaction [nutlin 3 results in decreased expression of ABCB1 protein]		 CTD PMID:33974899 PMID:35213076 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) multiple interactions
decreases expression		 EXP PVT1 protein inhibits the reaction [nutlin 3 results in decreased expression of ABCC1 protein] CTD PMID:35213076 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 decreases expression
multiple interactions		 EXP nutlin 3 results in decreased expression of ABCC2 protein
PVT1 protein inhibits the reaction [nutlin 3 results in decreased expression of ABCC2 protein]		 CTD PMID:35213076 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G BAK1 BCL2 antagonist/killer 1 multiple interactions EXP [nutlin 3 co-treated with Bortezomib] results in increased activity of BAK1 protein CTD PMID:20850924 NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 EXP
ISO		 [nutlin 3 co-treated with Bortezomib] results in increased activity of BAX protein; Cisplatin promotes the reaction [nutlin 3 results in increased expression of BAX mRNA]; PVT1 protein inhibits the reaction [nutlin 3 results in increased expression of BAX protein modified form]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of BAX mRNA]
nutlin 3 results in increased expression of BAX; nutlin 3 results in increased expression of BAX mRNA; nutlin 3 results in increased expression of BAX protein		 CTD PMID:16014563 PMID:16439685 PMID:16949053 PMID:20422343 PMID:20850924 More... NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BBC3 BCL2 binding component 3 increases expression
multiple interactions		 EXP nutlin 3 results in increased expression of BBC3; nutlin 3 results in increased expression of BBC3 mRNA; nutlin 3 results in increased expression of BBC3 protein
nutlin 3 promotes the reaction [Cisplatin results in increased expression of BBC3 mRNA]; TP53 protein affects the reaction [nutlin 3 results in increased expression of BBC3 protein]		 CTD PMID:16014563 PMID:16439685 PMID:20422343 PMID:21109480 NCBI chr19:47,220,824...47,232,860
Ensembl chr19:47,220,822...47,232,766 		JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
multiple interactions		 EXP nutlin 3 results in decreased expression of BCL2; nutlin 3 results in decreased expression of BCL2 protein
PVT1 protein inhibits the reaction [nutlin 3 results in decreased expression of BCL2 protein]		 CTD PMID:20422343 PMID:35213076 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions
decreases expression		 EXP nutlin 3 promotes the reaction [TP53 protein binds to BCL2L1 protein]
nutlin 3 results in decreased expression of BCL2L1 protein		 CTD PMID:16014563 PMID:21109480 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989 		JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity		 EXP [nutlin 3 co-treated with Bortezomib] results in increased activity of CASP3 protein; nutlin 3 results in increased cleavage of and results in increased activity of CASP3 protein; TP53 mutant form inhibits the reaction [nutlin 3 results in increased activity of CASP3 protein] CTD PMID:16014563 PMID:20850924 PMID:21109480 PMID:22260869 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP7 caspase 7 increases activity
multiple interactions		 EXP nutlin 3 results in increased activity of CASP7 protein
TP53 mutant form inhibits the reaction [nutlin 3 results in increased activity of CASP7 protein]		 CTD PMID:22260869 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907 		JBrowse link
G CASP8 caspase 8 multiple interactions EXP nutlin 3 results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:16014563 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CASP9 caspase 9 multiple interactions EXP [nutlin 3 co-treated with Bortezomib] results in increased activity of CASP9 protein; nutlin 3 results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:16014563 PMID:20850924 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression
multiple interactions		 EXP
ISO		 nutlin 3 results in increased expression of CDKN1A mRNA; nutlin 3 results in increased expression of CDKN1A protein
Cisplatin promotes the reaction [nutlin 3 results in increased expression of CDKN1A mRNA]; Cisplatin promotes the reaction [nutlin 3 results in increased expression of CDKN1A protein]; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDKN1A mRNA]; nutlin 3 promotes the reaction [Cisplatin results in increased activity of and results in increased expression of CDKN1A protein]; nutlin 3 promotes the reaction [Doxorubicin results in increased activity of and results in increased expression of CDKN1A protein]; nutlin 3 promotes the reaction [Methotrexate results in increased activity of and results in increased expression of CDKN1A protein]; nutlin 3 results in increased activity of and results in increased expression of CDKN1A protein; PVT1 protein inhibits the reaction [nutlin 3 results in increased expression of CDKN1A protein modified form]; TP53 affects the reaction [nutlin 3 promotes the reaction [Cisplatin results in increased activity of and results in increased expression of CDKN1A protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Doxorubicin results in increased activity of and results in increased expression of CDKN1A protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Methotrexate results in increased activity of and results in increased expression of CDKN1A protein]]; TP53 affects the reaction [nutlin 3 results in increased activity of and results in increased expression of CDKN1A protein]; TP53 protein affects the reaction [nutlin 3 results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of CDKN1A mRNA]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of CDKN1A protein]		 CTD PMID:16014563 PMID:16439677 PMID:16439685 PMID:16949053 PMID:19098008 More... NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337 		JBrowse link
G DDB1 damage specific DNA binding protein 1 increases expression EXP nutlin 3 results in increased expression of DDB1 mRNA CTD PMID:16439677 NCBI chr11:61,299,451...61,333,105
Ensembl chr11:61,299,451...61,342,596 		JBrowse link
G EDN1 endothelin 1 increases expression EXP nutlin 3 results in increased expression of EDN1 mRNA; nutlin 3 results in increased expression of EDN1 protein CTD PMID:19098008 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194 		JBrowse link
G FAS Fas cell surface death receptor multiple interactions EXP [nutlin 3 promotes the reaction [FAS protein binds to FASLG protein]] which results in increased susceptibility to Cisplatin; nutlin 3 promotes the reaction [FAS protein binds to FASLG protein]; nutlin 3 promotes the reaction [TP53 protein results in increased expression of FAS protein] CTD PMID:21509038 NCBI chr10:88,964,050...89,017,059
Ensembl chr10:88,953,813...89,029,605 		JBrowse link
G FASLG Fas ligand multiple interactions EXP [nutlin 3 promotes the reaction [FAS protein binds to FASLG protein]] which results in increased susceptibility to Cisplatin; nutlin 3 promotes the reaction [FAS protein binds to FASLG protein] CTD PMID:21509038 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876 		JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha increases expression EXP nutlin 3 results in increased expression of GADD45A protein CTD PMID:19098008 NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334 		JBrowse link
G GDF15 growth differentiation factor 15 increases expression EXP nutlin 3 results in increased expression of GDF15 mRNA CTD PMID:16439677 NCBI chr19:18,386,158...18,389,176
Ensembl chr19:18,374,731...18,389,176 		JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions EXP nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GPX1 mRNA] CTD PMID:20530418 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605 		JBrowse link
G H19 H19 imprinted maternally expressed transcript decreases expression EXP nutlin 3 results in decreased expression of H19 mRNA CTD PMID:25860607 NCBI chr11:1,995,176...2,001,466
Ensembl chr11:1,995,166...2,004,552 		JBrowse link
G KITLG KIT ligand increases expression EXP nutlin 3 results in increased expression of KITLG mRNA; nutlin 3 results in increased expression of KITLG protein CTD PMID:19098008 NCBI chr12:88,492,793...88,580,471
Ensembl chr12:88,492,793...88,580,851 		JBrowse link
G MDM2 MDM2 proto-oncogene multiple interactions
decreases expression
increases expression		 EXP
ISO		 [nutlin 3 inhibits the reaction [TP53 protein binds to MDM2 protein]] which results in increased activity of TP53 protein; nutlin 3 inhibits the reaction [TP53 protein binds to MDM2 protein]; nutlin 3 inhibits the reaction [TP73 binds to MDM2]; nutlin 3 promotes the reaction [Cisplatin results in increased activity of and results in increased expression of MDM2 protein]; nutlin 3 promotes the reaction [Doxorubicin results in increased activity of and results in increased expression of MDM2 protein]; nutlin 3 promotes the reaction [Methotrexate results in increased activity of and results in increased expression of MDM2 protein]; nutlin 3 results in increased activity of and results in increased expression of MDM2 protein; nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein modified form]; nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of MDM2 protein]; PVT1 protein inhibits the reaction [nutlin 3 results in decreased expression of MDM2 protein]; TP53 affects the reaction [nutlin 3 promotes the reaction [Cisplatin results in increased activity of and results in increased expression of MDM2 protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Doxorubicin results in increased activity of and results in increased expression of MDM2 protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Methotrexate results in increased activity of and results in increased expression of MDM2 protein]]; TP53 affects the reaction [nutlin 3 results in increased activity of and results in increased expression of MDM2 protein]; TP53 protein affects the reaction [nutlin 3 results in increased expression of MDM2 protein]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of MDM2 mRNA]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of MDM2 protein]
nutlin 3 results in increased expression of MDM2 mRNA; nutlin 3 results in increased expression of MDM2 protein; nutlin 3 results in increased expression of MDM2 protein modified form		 CTD PMID:16014563 PMID:16439685 PMID:16949053 PMID:19098008 PMID:20422343 More... NCBI chr12:68,808,172...68,850,686
Ensembl chr12:68,808,177...68,845,544 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 EXP TP53 mutant form inhibits the reaction [nutlin 3 results in increased cleavage of PARP1 protein] CTD PMID:22260869 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PCNA proliferating cell nuclear antigen increases expression EXP nutlin 3 results in increased expression of PCNA mRNA CTD PMID:16439677 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626 		JBrowse link
G PERP p53 apoptosis effector related to PMP22 increases expression ISO nutlin 3 results in increased expression of PERP mRNA CTD PMID:16949053 NCBI chr 6:138,088,505...138,107,419
Ensembl chr 6:138,088,505...138,107,419 		JBrowse link
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression
multiple interactions		 EXP nutlin 3 results in increased expression of PMAIP1 protein
[nutlin 3 co-treated with Bortezomib] results in increased expression of PMAIP1 protein; [nutlin 3 co-treated with Cisplatin] results in increased expression of PMAIP1 mRNA		 CTD PMID:16014563 PMID:20850924 PMID:21109480 PMID:21205074 NCBI chr18:59,899,996...59,904,305
Ensembl chr18:59,899,996...59,904,305 		JBrowse link
G PVT1 Pvt1 oncogene multiple interactions EXP PVT1 protein inhibits the reaction [nutlin 3 results in decreased expression of ABCB1 protein]; PVT1 protein inhibits the reaction [nutlin 3 results in decreased expression of ABCC1 protein]; PVT1 protein inhibits the reaction [nutlin 3 results in decreased expression of ABCC2 protein]; PVT1 protein inhibits the reaction [nutlin 3 results in decreased expression of BCL2 protein]; PVT1 protein inhibits the reaction [nutlin 3 results in decreased expression of MDM2 protein]; PVT1 protein inhibits the reaction [nutlin 3 results in increased expression of BAX protein modified form]; PVT1 protein inhibits the reaction [nutlin 3 results in increased expression of CDKN1A protein modified form]; PVT1 protein inhibits the reaction [nutlin 3 results in increased expression of TP53 protein modified form]; PVT1 protein inhibits the reaction [nutlin 3 results in increased expression of TP53 protein] CTD PMID:35213076 NCBI chr 8:127,794,524...128,101,256
Ensembl chr 8:127,794,526...128,187,101 		JBrowse link
G SESN2 sestrin 2 multiple interactions EXP nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SESN2 mRNA] CTD PMID:20530418 NCBI chr 1:28,259,518...28,282,491
Ensembl chr 1:28,259,518...28,282,491 		JBrowse link
G TNFRSF10B TNF receptor superfamily member 10b increases expression EXP nutlin 3 results in increased expression of TNFRSF10B mRNA; nutlin 3 results in increased expression of TNFRSF10B protein CTD PMID:16439677 PMID:18092340 NCBI chr 8:23,020,133...23,069,031
Ensembl chr 8:23,020,133...23,069,031 		JBrowse link
G TP53 tumor protein p53 multiple interactions
increases expression
increases activity
increases response to substance
increases stability		 EXP
ISO		 [nutlin 3 inhibits the reaction [TP53 protein binds to MDM2 protein]] which results in increased activity of TP53 protein; [nutlin 3 results in increased stability of TP53 protein] which results in increased susceptibility to Cisplatin; [nutlin 3 results in increased stability of TP53 protein] which results in increased susceptibility to Fluorouracil; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein]; nutlin 3 inhibits the reaction [Camptothecin results in increased expression of TP53 protein]; nutlin 3 inhibits the reaction [TP53 protein binds to MDM2 protein]; nutlin 3 promotes the reaction [Cisplatin results in increased expression of TP53 mRNA]; nutlin 3 promotes the reaction [Cisplatin results in increased expression of TP53 protein]; nutlin 3 promotes the reaction [Cisplatin results in increased localization of TP53 protein]; nutlin 3 promotes the reaction [Doxorubicin results in increased expression of TP53 protein]; nutlin 3 promotes the reaction [Methotrexate results in increased expression of TP53 protein]; nutlin 3 promotes the reaction [TP53 protein binds to BCL2L1 protein]; nutlin 3 promotes the reaction [TP53 protein results in increased expression of FAS protein]; nutlin 3 results in increased expression of and affects the localization of TP53 protein; nutlin 3 results in increased expression of and results in increased localization of and results in increased activity of TP53 protein; nutlin 3 results in increased expression of and results in increased phosphorylation of TP53 protein; nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein modified form]; nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]; PVT1 protein inhibits the reaction [nutlin 3 results in increased expression of TP53 protein modified form]; PVT1 protein inhibits the reaction [nutlin 3 results in increased expression of TP53 protein]; Tetrachlorodibenzodioxin results in decreased susceptibility to [nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein modified form]]; Tetrachlorodibenzodioxin results in decreased susceptibility to [nutlin 3 results in increased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Cisplatin results in increased activity of and results in increased expression of CDKN1A protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Cisplatin results in increased activity of and results in increased expression of MDM2 protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Doxorubicin results in increased activity of and results in increased expression of CDKN1A protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Doxorubicin results in increased activity of and results in increased expression of MDM2 protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Methotrexate results in increased activity of and results in increased expression of CDKN1A protein]]; TP53 affects the reaction [nutlin 3 promotes the reaction [Methotrexate results in increased activity of and results in increased expression of MDM2 protein]]; TP53 affects the reaction [nutlin 3 results in increased activity of and results in increased expression of CDKN1A protein]; TP53 affects the reaction [nutlin 3 results in increased activity of and results in increased expression of MDM2 protein]; TP53 mutant form inhibits the reaction [nutlin 3 results in increased activity of CASP3 protein]; TP53 mutant form inhibits the reaction [nutlin 3 results in increased activity of CASP7 protein]; TP53 mutant form inhibits the reaction [nutlin 3 results in increased cleavage of PARP1 protein]; TP53 protein affects the reaction [nutlin 3 results in increased expression of BBC3 protein]; TP53 protein affects the reaction [nutlin 3 results in increased expression of CDKN1A protein]; TP53 protein affects the reaction [nutlin 3 results in increased expression of MDM2 protein]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of BAX mRNA]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of CDKN1A mRNA]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of CDKN1A protein]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of MDM2 mRNA]; TP53 protein promotes the reaction [nutlin 3 results in increased expression of MDM2 protein]
nutlin 3 results in increased expression of TRP53 protein
nutlin 3 results in increased activity of TRP53 protein
TP53 results in increased susceptibility to nutlin 3
nutlin 3 results in increased expression of TP53 mRNA; nutlin 3 results in increased expression of TP53 protein; nutlin 3 results in increased expression of TP53 protein modified form
nutlin 3 results in increased activity of TP53 protein		 CTD PMID:16014563 PMID:16439677 PMID:16439685 PMID:16949053 PMID:18092340 More... NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546 		JBrowse link
G TP53I3 tumor protein p53 inducible protein 3 increases expression EXP nutlin 3 results in increased expression of TP53I3 mRNA; nutlin 3 results in increased expression of TP53I3 protein CTD PMID:16439677 PMID:16439685 NCBI chr 2:24,077,433...24,084,834
Ensembl chr 2:24,077,433...24,085,861 		JBrowse link
G TP73 tumor protein p73 multiple interactions EXP nutlin 3 inhibits the reaction [TP73 binds to MDM2] CTD PMID:20422343 NCBI chr 1:3,652,516...3,736,201
Ensembl chr 1:3,652,516...3,736,201 		JBrowse link
G ZMAT3 zinc finger matrin-type 3 increases expression EXP nutlin 3 results in increased expression of ZMAT3 mRNA; nutlin 3 results in increased expression of ZMAT3 protein CTD PMID:16439685 NCBI chr 3:179,017,223...179,072,513
Ensembl chr 3:178,960,121...179,072,215 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    role 25956
      biological role 25935
        antimicrobial agent 21917
          antiviral agent 11731
            anticoronaviral agent 10270
              Nutlin-3 35
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      carbon group element atom 25437
                        carbon atom 25395
                          organic molecular entity 25395
                            heteroorganic entity 24770
                              organochalcogen compound 24383
                                organooxygen compound 24060
                                  carbon oxoacid 22761
                                    carboxylic acid 22741
                                      carboacyl group 20058
                                        univalent carboacyl group 20058
                                          carbamoyl group 19571
                                            carboxamide 19571
                                              monocarboxylic acid amide 16962
                                                urea 5716
                                                  ureas 5714
                                                    N-carbamoylpiperazine 36
                                                      Nutlin 35
                                                        Nutlin-3 35
paths to the root