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Gene: PVT1 (Pvt1 oncogene) Homo sapiens
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Symbol: PVT1
Name: Pvt1 oncogene
Description: This gene represents a long non-coding RNA locus that has been identified as a candidate oncogene. Increased copy number and overexpression of this gene are associated with many types of cancers including breast and ovarian cancers, acute myeloid leukemia and Hodgkin lymphoma. Allelic variants of this gene are also associated with end-stage renal disease attributed to type 1 diabetes. Consistent with its association with various types of cancer, transcription of this gene is regulated by the tumor suppressor p53 through a canonical p53-binding site, and it has been implicated in regulating levels of the proto-oncogene MYC to promote tumorigenesis. [provided by RefSeq, Sep 2015]
Type: ncrna
RefSeq Status: REVIEWED
Also known as: LINC00079; MGC21751; MIR1204HG; MYC; NCRNA00079; onco-lncRNA-100; Pvt1 oncogene (non-protein coding)
Orthologs:
Mus musculus (house mouse) : Pvt1 (Pvt1 oncogene)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pvt1 (Pvt1 oncogene)  Alliance
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl8127,794,526 - 128,187,101 (+)Ensembl
GRCh388127,794,533 - 128,101,253 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh378128,902,874 - 129,113,499 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368128,875,961 - 129,182,681 (+)NCBINCBI36hg18NCBI36
Celera8124,987,142 - 125,293,818 (+)NCBI
Cytogenetic Map8q24.21NCBI
HuRef8124,224,893 - 124,436,191 (+)NCBIHuRef
CHM1_18128,847,026 - 129,153,800 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PVT1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1348372
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.