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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:PRIM-O-GLUCOSYLCIMIFUGIN
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Accession:CHEBI:187279 term browser browse the term
Synonyms:exact_synonym: (2S)-2-(2-hydroxypropan-2-yl)-4-methoxy-7-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]-2,3-dihydrouro[3,2-g]chromen-5-one
 related_synonym: Formula=C22H28O11;   InChI=1S/C22H28O11/c1-22(2,28)15-5-10-12(32-15)6-13-16(20(10)29-3)11(24)4-9(31-13)8-30-21-19(27)18(26)17(25)14(7-23)33-21/h4,6,14-15,17-19,21,23,25-28H,5,7-8H2,1-3H3/t14-,15+,17-,18+,19-,21-/m1/s1;   InChIKey=XIUVHOSBSDYXRG-UVTAEQIVSA-N;   SMILES=O1[C@@H]([C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OCC=2OC=3C(=C(OC)C=4C[C@](OC4C3)(C(O)(C)C)[H])C(=O)C2)CO
 xref: Chemspider:24534049
 xref_mesh: MESH:C498945


show annotations for term's descendants           Sort by:
PRIM-O-GLUCOSYLCIMIFUGIN term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arg1 arginase 1 decreases expression
multiple interactions		 ISO prim-O-glucosylcimifugin results in decreased expression of ARG1 mRNA
prim-O-glucosylcimifugin results in decreased expression of and results in decreased activity of ARG1 protein		 CTD PMID:31462297 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422 		JBrowse link
G Casp1 caspase 1 decreases cleavage
multiple interactions		 ISO prim-O-glucosylcimifugin results in decreased cleavage of CASP1 protein
prim-O-glucosylcimifugin inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein]		 CTD PMID:36088791 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 decreases expression ISO prim-O-glucosylcimifugin results in decreased expression of F2RL1 mRNA CTD PMID:29910215 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226 		JBrowse link
G Fmod fibromodulin increases expression EXP prim-O-glucosylcimifugin results in increased expression of FMOD protein CTD PMID:37872152 NCBI chr13:45,493,517...45,504,134
Ensembl chr13:45,493,517...45,504,133 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 decreases expression ISO prim-O-glucosylcimifugin results in decreased expression of GSTM1 mRNA CTD PMID:34135758 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 decreases expression ISO prim-O-glucosylcimifugin results in decreased expression of GSTP1 mRNA CTD PMID:34135758 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO prim-O-glucosylcimifugin inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL18 protein]; prim-O-glucosylcimifugin results in decreased expression of and results in decreased secretion of IL18 protein CTD PMID:36088791 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression		 ISO
EXP		 prim-O-glucosylcimifugin inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of and results in increased secretion of IL1B protein]; prim-O-glucosylcimifugin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; prim-O-glucosylcimifugin results in decreased expression of and results in decreased secretion of IL1B protein; STAT3 protein inhibits the reaction [prim-O-glucosylcimifugin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]
prim-O-glucosylcimifugin results in decreased expression of IL1B mRNA		 CTD PMID:28839360 PMID:36088791 PMID:37872152 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression		 ISO
EXP		 prim-O-glucosylcimifugin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; STAT3 protein inhibits the reaction [prim-O-glucosylcimifugin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]
prim-O-glucosylcimifugin results in decreased expression of IL6 mRNA		 CTD PMID:28839360 PMID:37872152 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO prim-O-glucosylcimifugin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JAK2 protein] CTD PMID:28839360 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Mylk myosin light chain kinase decreases expression ISO prim-O-glucosylcimifugin results in decreased expression of MYLK mRNA CTD PMID:29910215 NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions
decreases expression		 ISO prim-O-glucosylcimifugin inhibits the reaction [[Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased expression of NLRP3 protein]
prim-O-glucosylcimifugin results in decreased expression of NLRP3 protein		 CTD PMID:36088791 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases expression		 ISO prim-O-glucosylcimifugin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; prim-O-glucosylcimifugin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; STAT3 protein inhibits the reaction [prim-O-glucosylcimifugin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]
prim-O-glucosylcimifugin results in decreased expression of NOS2 mRNA; prim-O-glucosylcimifugin results in decreased expression of NOS2 protein		 CTD PMID:28839360 PMID:31462297 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Ocln occludin affects localization ISO prim-O-glucosylcimifugin affects the localization of OCLN protein CTD PMID:29910215 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 increases expression EXP prim-O-glucosylcimifugin results in increased expression of POU5F1 mRNA CTD PMID:37872152 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO prim-O-glucosylcimifugin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; prim-O-glucosylcimifugin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; STAT3 protein inhibits the reaction [prim-O-glucosylcimifugin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]] CTD PMID:28839360 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression		 EXP prim-O-glucosylcimifugin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of RELA protein]
prim-O-glucosylcimifugin results in decreased expression of RELA protein		 CTD PMID:37872152 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Scx scleraxis bHLH transcription factor increases expression EXP prim-O-glucosylcimifugin results in increased expression of SCX protein CTD PMID:37872152 NCBI chr 7:108,176,608...108,178,626
Ensembl chr 7:108,176,608...108,178,626 		JBrowse link
G Sox2 SRY-box transcription factor 2 increases expression EXP prim-O-glucosylcimifugin results in increased expression of SOX2 mRNA CTD PMID:37872152 NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338 		JBrowse link
G Sqstm1 sequestosome 1 decreases expression EXP prim-O-glucosylcimifugin results in decreased expression of SQSTM1 protein CTD PMID:37872152 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Stat2 signal transducer and activator of transcription 2 multiple interactions ISO prim-O-glucosylcimifugin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT2 protein] CTD PMID:28839360 NCBI chr 7:702,565...718,349
Ensembl chr 7:702,495...718,967 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO STAT3 protein inhibits the reaction [prim-O-glucosylcimifugin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; STAT3 protein inhibits the reaction [prim-O-glucosylcimifugin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; STAT3 protein inhibits the reaction [prim-O-glucosylcimifugin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; STAT3 protein inhibits the reaction [prim-O-glucosylcimifugin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]; STAT3 protein inhibits the reaction [prim-O-glucosylcimifugin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]] CTD PMID:28839360 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tjp1 tight junction protein 1 increases expression ISO prim-O-glucosylcimifugin results in increased expression of TJP1 protein CTD PMID:29910215 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tnc tenascin C increases expression
multiple interactions		 EXP prim-O-glucosylcimifugin results in increased expression of TNC protein
prim-O-glucosylcimifugin inhibits the reaction [TNF protein results in increased secretion of TNC protein]		 CTD PMID:37872152 NCBI chr 5:77,375,851...77,460,712
Ensembl chr 5:77,375,851...77,460,624 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression		 ISO
EXP		 prim-O-glucosylcimifugin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; STAT3 protein inhibits the reaction [prim-O-glucosylcimifugin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
prim-O-glucosylcimifugin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of RELA protein]; prim-O-glucosylcimifugin inhibits the reaction [TNF protein results in increased secretion of TNC protein]
prim-O-glucosylcimifugin results in decreased expression of TNF mRNA		 CTD PMID:28839360 PMID:37872152 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnmd tenomodulin increases expression EXP prim-O-glucosylcimifugin results in increased expression of TNMD protein CTD PMID:37872152 NCBI chr  X:97,057,137...97,072,634
Ensembl chr  X:97,057,137...97,072,634 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    chemical entity 19806
      atom 19806
        nonmetal atom 19744
          oxygen atom 19488
            oxygen molecular entity 19488
              organooxygen compound 19141
                oxacycle 17866
                  PRIM-O-GLUCOSYLCIMIFUGIN 26
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic heterocyclic compound 18848
                                  organic heteropolycyclic compound 18278
                                    organic heterotricyclic compound 15623
                                      PRIM-O-GLUCOSYLCIMIFUGIN 26
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