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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Auriculasin
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Accession:CHEBI:178564 term browser browse the term
Synonyms:exact_synonym: 7-(3,4-dihydroxyphenyl)-5-hydroxy-2,2-dimethyl-10-(3-methylbut-2-enyl)pyrano[3,2-g]chromen-6-one
 related_synonym: Formula=C25H24O6;   InChI=1S/C25H24O6/c1-13(2)5-7-16-23-15(9-10-25(3,4)31-23)21(28)20-22(29)17(12-30-24(16)20)14-6-8-18(26)19(27)11-14/h5-6,8-12,26-28H,7H2,1-4H3;   InChIKey=PSEBCAMYGWGJMH-UHFFFAOYSA-N;   SMILES=O1C(C=CC=2C1=C(C=3OC=C(C(=O)C3C2O)C4=CC(O)=C(O)C=C4)CC=C(C)C)(C)C
 xref: Chemspider:4513925;   LIPID_MAPS_instance:LMPK12050247
 xref_mesh: MESH:C516713



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Auriculasin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization
multiple interactions
ISO auriculasin affects the localization of AIFM1 protein
[TNFSF10 protein co-treated with auriculasin] affects the localization of AIFM1 protein; TNFRSF10B protein affects the reaction [[TNFSF10 protein co-treated with auriculasin] affects the localization of AIFM1 protein]
CTD PMID:30817944 NCBI chr  X:132,528,107...132,567,237
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [TNFSF10 protein co-treated with auriculasin] results in decreased phosphorylation of AKT1 protein; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein] CTD PMID:30236598 PMID:30817944 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [auriculasin co-treated with TNFSF10 protein] results in increased expression of BAX protein; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of BAX protein] CTD PMID:30817944 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO auriculasin results in decreased expression of BCL2 protein
[auriculasin co-treated with TNFSF10 protein] results in decreased expression of BCL2 protein; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in decreased expression of BCL2 protein]
CTD PMID:30236598 PMID:30817944 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743
JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO auriculasin results in decreased expression of BCL2L1 protein CTD PMID:30236598 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP3 protein; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP3 protein] CTD PMID:30817944 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP8 protein; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP8 protein] CTD PMID:30817944 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions ISO [auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP9 protein; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP9 protein] CTD PMID:30817944 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases metabolic processing
multiple interactions
ISO CYP2C19 protein results in increased metabolism of auriculasin
Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of auriculasin]
CTD PMID:31515991 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing
multiple interactions
ISO CYP2C8 protein results in increased metabolism of auriculasin
Quercetin inhibits the reaction [CYP2C8 protein results in increased metabolism of auriculasin]
CTD PMID:31515991
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
increases metabolic processing
ISO Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of auriculasin] CTD PMID:31515991 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO auriculasin results in decreased activity of CYP3A4 protein CTD PMID:31515991 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
ISO [TNFSF10 protein co-treated with auriculasin] results in increased expression of DDIT3 protein; TNFRSF10B protein affects the reaction [[TNFSF10 protein co-treated with auriculasin] results in increased expression of DDIT3 protein]
auriculasin results in increased expression of DDIT3 protein
CTD PMID:30817944 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Endog endonuclease G multiple interactions
affects localization
ISO [TNFSF10 protein co-treated with auriculasin] affects the localization of ENDOG protein
auriculasin affects the localization of ENDOG protein
CTD PMID:30817944 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO auriculasin inhibits the reaction [VEGFA protein results in increased activity of and results in increased phosphorylation of KDR protein] CTD PMID:30236598 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein] CTD PMID:30236598 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein] CTD PMID:30236598 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO [TNFSF10 protein co-treated with auriculasin] results in decreased phosphorylation of MTOR protein; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of MTOR protein] CTD PMID:30236598 PMID:30817944 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [auriculasin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein] CTD PMID:30817944 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of SRC protein] CTD PMID:30236598 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [auriculasin co-treated with TNFSF10 protein] affects the expression of CASP10 protein; [auriculasin co-treated with TNFSF10 protein] results in decreased expression of BCL2 protein; [auriculasin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein; [auriculasin co-treated with TNFSF10 protein] results in increased expression of BAX protein; [auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP3 protein; [auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP8 protein; [auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP9 protein; [TNFSF10 protein co-treated with auriculasin] affects the localization of AIFM1 protein; [TNFSF10 protein co-treated with auriculasin] affects the localization of ENDOG protein; [TNFSF10 protein co-treated with auriculasin] results in decreased phosphorylation of AKT1 protein; [TNFSF10 protein co-treated with auriculasin] results in decreased phosphorylation of MTOR protein; [TNFSF10 protein co-treated with auriculasin] results in increased expression of DDIT3 protein; [TNFSF10 protein co-treated with auriculasin] results in increased expression of TNFRSF10B protein; [TNFSF10 protein co-treated with auriculasin] results in increased expression of TP53 protein; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in decreased expression of BCL2 protein]; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein]; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of BAX protein]; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP3 protein]; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP8 protein]; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP9 protein]; TNFRSF10B protein affects the reaction [[TNFSF10 protein co-treated with auriculasin] affects the localization of AIFM1 protein]; TNFRSF10B protein affects the reaction [[TNFSF10 protein co-treated with auriculasin] results in increased expression of DDIT3 protein]; TNFRSF10B protein affects the reaction [[TNFSF10 protein co-treated with auriculasin] results in increased expression of TNFRSF10B protein]; TNFRSF10B protein affects the reaction [[TNFSF10 protein co-treated with auriculasin] results in increased expression of TP53 protein] CTD PMID:30817944 NCBI chr 2:112,136,550...112,155,903
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [TNFSF10 protein co-treated with auriculasin] results in increased expression of TP53 protein; TNFRSF10B protein affects the reaction [[TNFSF10 protein co-treated with auriculasin] results in increased expression of TP53 protein] CTD PMID:30817944 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 decreases activity ISO auriculasin results in decreased activity of UGT1A6 protein CTD PMID:31515991 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
ISO auriculasin inhibits the reaction [VEGFA protein results in increased activity of and results in increased phosphorylation of KDR protein]; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein]; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of MTOR protein]; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of SRC protein]
auriculasin results in decreased expression of VEGFA protein
CTD PMID:30236598 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641
JBrowse link

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  CHEBI ontology 19904
    chemical entity 19902
      group 19854
        inorganic group 19438
          oxo group 18948
            organic oxo compound 18948
              carbonyl compound 18948
                ketone 17284
                  cyclic ketone 15926
                    isoflavanones 86
                      Auriculasin 24
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  CHEBI ontology 19904
    subatomic particle 19902
      composite particle 19902
        hadron 19902
          baryon 19902
            nucleon 19902
              atomic nucleus 19902
                atom 19902
                  main group element atom 19841
                    p-block element atom 19841
                      carbon group element atom 19779
                        carbon atom 19776
                          organic molecular entity 19776
                            organic molecule 19730
                              organic cyclic compound 19522
                                organic heterocyclic compound 18896
                                  oxacycle 17926
                                    benzopyran 11985
                                      1-benzopyran 11739
                                        isoflavonoid 3837
                                          isoflavans 136
                                            isoflavanones 86
                                              Auriculasin 24
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