Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:Auriculasin
go back to main search page
Accession:CHEBI:178564 term browser browse the term
Synonyms:exact_synonym: 7-(3,4-dihydroxyphenyl)-5-hydroxy-2,2-dimethyl-10-(3-methylbut-2-enyl)pyrano[3,2-g]chromen-6-one
 related_synonym: Formula=C25H24O6;   InChI=1S/C25H24O6/c1-13(2)5-7-16-23-15(9-10-25(3,4)31-23)21(28)20-22(29)17(12-30-24(16)20)14-6-8-18(26)19(27)11-14/h5-6,8-12,26-28H,7H2,1-4H3;   InChIKey=PSEBCAMYGWGJMH-UHFFFAOYSA-N;   SMILES=O1C(C=CC=2C1=C(C=3OC=C(C(=O)C3C2O)C4=CC(O)=C(O)C=C4)CC=C(C)C)(C)C
 xref: Chemspider:4513925;   LIPID_MAPS_instance:LMPK12050247
 xref_mesh: MESH:C516713


show annotations for term's descendants           Sort by:
Auriculasin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 affects localization
multiple interactions		 ISO auriculasin affects the localization of AIFM1 protein
[TNFSF10 protein co-treated with auriculasin] affects the localization of AIFM1 protein; TNFRSF10B protein affects the reaction [[TNFSF10 protein co-treated with auriculasin] affects the localization of AIFM1 protein]		 CTD PMID:30817944 NCBI chr  X:132,528,107...132,567,237
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [TNFSF10 protein co-treated with auriculasin] results in decreased phosphorylation of AKT1 protein; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein] CTD PMID:30236598 PMID:30817944 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [auriculasin co-treated with TNFSF10 protein] results in increased expression of BAX protein; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of BAX protein] CTD PMID:30817944 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions		 ISO auriculasin results in decreased expression of BCL2 protein
[auriculasin co-treated with TNFSF10 protein] results in decreased expression of BCL2 protein; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in decreased expression of BCL2 protein]		 CTD PMID:30236598 PMID:30817944 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO auriculasin results in decreased expression of BCL2L1 protein CTD PMID:30236598 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP3 protein; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP3 protein] CTD PMID:30817944 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP8 protein; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP8 protein] CTD PMID:30817944 NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO [auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP9 protein; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP9 protein] CTD PMID:30817944 Ensembl chr 5:154,109,046...154,126,626 JBrowse link
G Cyp2c6 cytochrome P450, family 2, subfamily C, polypeptide 6 increases metabolic processing
multiple interactions		 ISO CYP2C19 protein results in increased metabolism of auriculasin
Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of auriculasin]		 CTD PMID:31515991 NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases metabolic processing
multiple interactions		 ISO CYP2C8 protein results in increased metabolism of auriculasin
Quercetin inhibits the reaction [CYP2C8 protein results in increased metabolism of auriculasin]		 CTD PMID:31515991
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
increases metabolic processing		 ISO Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of auriculasin] CTD PMID:31515991 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO auriculasin results in decreased activity of CYP3A4 protein CTD PMID:31515991 NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression		 ISO [TNFSF10 protein co-treated with auriculasin] results in increased expression of DDIT3 protein; TNFRSF10B protein affects the reaction [[TNFSF10 protein co-treated with auriculasin] results in increased expression of DDIT3 protein]
auriculasin results in increased expression of DDIT3 protein		 CTD PMID:30817944 NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Endog endonuclease G multiple interactions
affects localization		 ISO [TNFSF10 protein co-treated with auriculasin] affects the localization of ENDOG protein
auriculasin affects the localization of ENDOG protein		 CTD PMID:30817944 NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO auriculasin inhibits the reaction [VEGFA protein results in increased activity of and results in increased phosphorylation of KDR protein] CTD PMID:30236598 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein] CTD PMID:30236598 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein] CTD PMID:30236598 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO [TNFSF10 protein co-treated with auriculasin] results in decreased phosphorylation of MTOR protein; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of MTOR protein] CTD PMID:30236598 PMID:30817944 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [auriculasin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein] CTD PMID:30817944 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of SRC protein] CTD PMID:30236598 NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [auriculasin co-treated with TNFSF10 protein] affects the expression of CASP10 protein; [auriculasin co-treated with TNFSF10 protein] results in decreased expression of BCL2 protein; [auriculasin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein; [auriculasin co-treated with TNFSF10 protein] results in increased expression of BAX protein; [auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP3 protein; [auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP8 protein; [auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP9 protein; [TNFSF10 protein co-treated with auriculasin] affects the localization of AIFM1 protein; [TNFSF10 protein co-treated with auriculasin] affects the localization of ENDOG protein; [TNFSF10 protein co-treated with auriculasin] results in decreased phosphorylation of AKT1 protein; [TNFSF10 protein co-treated with auriculasin] results in decreased phosphorylation of MTOR protein; [TNFSF10 protein co-treated with auriculasin] results in increased expression of DDIT3 protein; [TNFSF10 protein co-treated with auriculasin] results in increased expression of TNFRSF10B protein; [TNFSF10 protein co-treated with auriculasin] results in increased expression of TP53 protein; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in decreased expression of BCL2 protein]; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein]; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of BAX protein]; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP3 protein]; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP8 protein]; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP9 protein]; TNFRSF10B protein affects the reaction [[TNFSF10 protein co-treated with auriculasin] affects the localization of AIFM1 protein]; TNFRSF10B protein affects the reaction [[TNFSF10 protein co-treated with auriculasin] results in increased expression of DDIT3 protein]; TNFRSF10B protein affects the reaction [[TNFSF10 protein co-treated with auriculasin] results in increased expression of TNFRSF10B protein]; TNFRSF10B protein affects the reaction [[TNFSF10 protein co-treated with auriculasin] results in increased expression of TP53 protein] CTD PMID:30817944 NCBI chr 2:112,136,550...112,155,903
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [TNFSF10 protein co-treated with auriculasin] results in increased expression of TP53 protein; TNFRSF10B protein affects the reaction [[TNFSF10 protein co-treated with auriculasin] results in increased expression of TP53 protein] CTD PMID:30817944 NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 decreases activity ISO auriculasin results in decreased activity of UGT1A6 protein CTD PMID:31515991 NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression		 ISO auriculasin inhibits the reaction [VEGFA protein results in increased activity of and results in increased phosphorylation of KDR protein]; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein]; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of MTOR protein]; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of SRC protein]
auriculasin results in decreased expression of VEGFA protein		 CTD PMID:30236598 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19904
    chemical entity 19902
      group 19854
        inorganic group 19438
          oxo group 18948
            organic oxo compound 18948
              carbonyl compound 18948
                ketone 17284
                  cyclic ketone 15926
                    isoflavanones 86
                      Auriculasin 24
Path 2
Term Annotations click to browse term
  CHEBI ontology 19904
    subatomic particle 19902
      composite particle 19902
        hadron 19902
          baryon 19902
            nucleon 19902
              atomic nucleus 19902
                atom 19902
                  main group element atom 19841
                    p-block element atom 19841
                      carbon group element atom 19779
                        carbon atom 19776
                          organic molecular entity 19776
                            organic molecule 19730
                              organic cyclic compound 19522
                                organic heterocyclic compound 18896
                                  oxacycle 17926
                                    benzopyran 11985
                                      1-benzopyran 11739
                                        isoflavonoid 3837
                                          isoflavans 136
                                            isoflavanones 86
                                              Auriculasin 24
paths to the root