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G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
affects localization multiple interactions |
ISO |
auriculasin affects the localization of AIFM1 protein [TNFSF10 protein co-treated with auriculasin] affects the localization of AIFM1 protein; TNFRSF10B protein affects the reaction [[TNFSF10 protein co-treated with auriculasin] affects the localization of AIFM1 protein] |
CTD |
PMID:30817944 |
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NCBI chr X:132,528,107...132,567,237
Ensembl chr X:127,650,226...127,689,256
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
[TNFSF10 protein co-treated with auriculasin] results in decreased phosphorylation of AKT1 protein; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:30236598 PMID:30817944 |
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NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
[auriculasin co-treated with TNFSF10 protein] results in increased expression of BAX protein; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of BAX protein] |
CTD |
PMID:30817944 |
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NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
ISO |
auriculasin results in decreased expression of BCL2 protein [auriculasin co-treated with TNFSF10 protein] results in decreased expression of BCL2 protein; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in decreased expression of BCL2 protein] |
CTD |
PMID:30236598 PMID:30817944 |
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NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression |
ISO |
auriculasin results in decreased expression of BCL2L1 protein |
CTD |
PMID:30236598 |
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NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
[auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP3 protein; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP3 protein] |
CTD |
PMID:30817944 |
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NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
[auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP8 protein; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP8 protein] |
CTD |
PMID:30817944 |
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NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
[auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP9 protein; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP9 protein] |
CTD |
PMID:30817944 |
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Ensembl chr 5:154,109,046...154,126,626
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
increases metabolic processing multiple interactions |
ISO |
CYP2C19 protein results in increased metabolism of auriculasin Omeprazole inhibits the reaction [CYP2C19 protein results in increased metabolism of auriculasin] |
CTD |
PMID:31515991 |
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NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
increases metabolic processing multiple interactions |
ISO |
CYP2C8 protein results in increased metabolism of auriculasin Quercetin inhibits the reaction [CYP2C8 protein results in increased metabolism of auriculasin] |
CTD |
PMID:31515991 |
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
multiple interactions increases metabolic processing |
ISO |
Quinidine inhibits the reaction [CYP2D6 protein results in increased metabolism of auriculasin] |
CTD |
PMID:31515991 |
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NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases activity |
ISO |
auriculasin results in decreased activity of CYP3A4 protein |
CTD |
PMID:31515991 |
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NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
multiple interactions increases expression |
ISO |
[TNFSF10 protein co-treated with auriculasin] results in increased expression of DDIT3 protein; TNFRSF10B protein affects the reaction [[TNFSF10 protein co-treated with auriculasin] results in increased expression of DDIT3 protein] auriculasin results in increased expression of DDIT3 protein |
CTD |
PMID:30817944 |
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NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
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G |
Endog |
endonuclease G |
multiple interactions affects localization |
ISO |
[TNFSF10 protein co-treated with auriculasin] affects the localization of ENDOG protein auriculasin affects the localization of ENDOG protein |
CTD |
PMID:30817944 |
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NCBI chr 3:13,449,113...13,451,715
Ensembl chr 3:13,449,086...13,451,932
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G |
Kdr |
kinase insert domain receptor |
multiple interactions |
ISO |
auriculasin inhibits the reaction [VEGFA protein results in increased activity of and results in increased phosphorylation of KDR protein] |
CTD |
PMID:30236598 |
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NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:30236598 |
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NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:30236598 |
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NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions |
ISO |
[TNFSF10 protein co-treated with auriculasin] results in decreased phosphorylation of MTOR protein; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of MTOR protein] |
CTD |
PMID:30236598 PMID:30817944 |
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NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
[auriculasin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein] |
CTD |
PMID:30817944 |
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NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
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G |
Src |
SRC proto-oncogene, non-receptor tyrosine kinase |
multiple interactions |
ISO |
auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of SRC protein] |
CTD |
PMID:30236598 |
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NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476
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G |
Tnfsf10 |
TNF superfamily member 10 |
multiple interactions |
ISO |
[auriculasin co-treated with TNFSF10 protein] affects the expression of CASP10 protein; [auriculasin co-treated with TNFSF10 protein] results in decreased expression of BCL2 protein; [auriculasin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein; [auriculasin co-treated with TNFSF10 protein] results in increased expression of BAX protein; [auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP3 protein; [auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP8 protein; [auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP9 protein; [TNFSF10 protein co-treated with auriculasin] affects the localization of AIFM1 protein; [TNFSF10 protein co-treated with auriculasin] affects the localization of ENDOG protein; [TNFSF10 protein co-treated with auriculasin] results in decreased phosphorylation of AKT1 protein; [TNFSF10 protein co-treated with auriculasin] results in decreased phosphorylation of MTOR protein; [TNFSF10 protein co-treated with auriculasin] results in increased expression of DDIT3 protein; [TNFSF10 protein co-treated with auriculasin] results in increased expression of TNFRSF10B protein; [TNFSF10 protein co-treated with auriculasin] results in increased expression of TP53 protein; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in decreased expression of BCL2 protein]; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased cleavage of PARP1 protein]; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of BAX protein]; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP3 protein]; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP8 protein]; TNFRSF10B protein affects the reaction [[auriculasin co-treated with TNFSF10 protein] results in increased expression of CASP9 protein]; TNFRSF10B protein affects the reaction [[TNFSF10 protein co-treated with auriculasin] affects the localization of AIFM1 protein]; TNFRSF10B protein affects the reaction [[TNFSF10 protein co-treated with auriculasin] results in increased expression of DDIT3 protein]; TNFRSF10B protein affects the reaction [[TNFSF10 protein co-treated with auriculasin] results in increased expression of TNFRSF10B protein]; TNFRSF10B protein affects the reaction [[TNFSF10 protein co-treated with auriculasin] results in increased expression of TP53 protein] |
CTD |
PMID:30817944 |
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NCBI chr 2:112,136,550...112,155,903
Ensembl chr 2:110,207,916...110,225,135
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
ISO |
[TNFSF10 protein co-treated with auriculasin] results in increased expression of TP53 protein; TNFRSF10B protein affects the reaction [[TNFSF10 protein co-treated with auriculasin] results in increased expression of TP53 protein] |
CTD |
PMID:30817944 |
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NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
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G |
Ugt1a6 |
UDP glucuronosyltransferase family 1 member A6 |
decreases activity |
ISO |
auriculasin results in decreased activity of UGT1A6 protein |
CTD |
PMID:31515991 |
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NCBI chr 9:88,747,213...88,808,465
Ensembl chr 9:88,713,184...88,808,465
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G |
Vegfa |
vascular endothelial growth factor A |
multiple interactions decreases expression |
ISO |
auriculasin inhibits the reaction [VEGFA protein results in increased activity of and results in increased phosphorylation of KDR protein]; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of AKT1 protein]; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK1 protein]; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of MAPK3 protein]; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of MTOR protein]; auriculasin inhibits the reaction [VEGFA protein results in increased phosphorylation of SRC protein] auriculasin results in decreased expression of VEGFA protein |
CTD |
PMID:30236598 |
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NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641
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