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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:isoflavans
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Accession:CHEBI:72572 term browser browse the term
Definition:Any isoflavonoid with a 3,4-dihydro-3-aryl-2H-1-benzopyran skeleton and its substituted derivatives.
Synonyms:related_synonym: Formula=C15HOR13;   SMILES=[*]c1c([*])c([*])c(C2C([*])([*])Oc3c([*])c([*])c([*])c([*])c3C2([*])[*])c([*])c1[*]


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alpinumisoflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator affects localization ISO alpinumisoflavone affects the localization of BAX protein CTD PMID:23850732 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO alpinumisoflavone results in decreased expression of BCL2 protein CTD PMID:23850732 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bid BH3 interacting domain death agonist decreases expression ISO alpinumisoflavone results in decreased expression of BID protein CTD PMID:23850732 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO [alpinumisoflavone results in increased expression of FAS protein] which results in increased cleavage of CASP3 protein
alpinumisoflavone results in increased cleavage of CASP3 protein
CTD PMID:23850732 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions
ISO alpinumisoflavone results in increased cleavage of CASP9 protein
[alpinumisoflavone results in increased expression of FAS protein] which results in increased cleavage of CASP9 protein
CTD PMID:23850732 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex decreases expression ISO alpinumisoflavone results in decreased expression of CHUK protein CTD PMID:23850732 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Cycs cytochrome c, somatic affects localization ISO alpinumisoflavone affects the localization of CYCS protein CTD PMID:23850732 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression
ISO [alpinumisoflavone results in increased expression of FAS protein] which results in increased cleavage of CASP3 protein; [alpinumisoflavone results in increased expression of FAS protein] which results in increased cleavage of CASP9 protein CTD PMID:23850732 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO alpinumisoflavone inhibits the reaction [1,10-phenanthroline deficiency results in increased activity of HIF1A protein]; alpinumisoflavone inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein] CTD PMID:19091749 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO alpinumisoflavone results in increased cleavage of PARP1 protein CTD PMID:23850732 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO alpinumisoflavone results in decreased expression of RELA protein CTD PMID:23850732 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO alpinumisoflavone results in decreased phosphorylation of and results in decreased activity of STAT3 protein CTD PMID:23850732 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions ISO alpinumisoflavone results in decreased phosphorylation of and results in decreased activity of STAT5A protein CTD PMID:23850732 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057
JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions ISO alpinumisoflavone results in decreased phosphorylation of and results in decreased activity of STAT6 protein CTD PMID:23850732 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link
cajanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO [[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP3 protein; [[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP9 protein; [[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein CTD PMID:20638373 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO cajanol results in decreased expression of BCL2 protein
[[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP3 protein; [[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP9 protein; [[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein
CTD PMID:20638373 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO [[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP3 protein
cajanol results in increased activity of CASP3 protein
CTD PMID:20638373 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO [[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP9 protein
cajanol results in increased activity of CASP9 protein
CTD PMID:20638373 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cycs cytochrome c, somatic affects localization
multiple interactions
ISO cajanol affects the localization of CYCS protein
[[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP3 protein; [[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP9 protein; [[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein
CTD PMID:20638373 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
Deguelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin multiple interactions ISO deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ADM mRNA] CTD PMID:22745725 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO deguelin results in increased expression of and affects the localization of AIFM1 protein CTD PMID:26592500 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases expression
affects phosphorylation
increases phosphorylation
multiple interactions
decreases phosphorylation
ISO deguelin metabolite results in decreased expression of AKT1 protein; deguelin results in decreased expression of AKT1 protein
deguelin affects the phosphorylation of AKT1 protein
deguelin results in increased phosphorylation of AKT1 protein
deguelin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]
deguelin results in decreased phosphorylation of AKT1 protein
CTD PMID:16288123 PMID:17015749 PMID:18593368 PMID:19139008 PMID:19336726 PMID:19901985 PMID:25322282 PMID:29512685 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Angptl4 angiopoietin-like 4 multiple interactions ISO deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ANGPTL4 mRNA] CTD PMID:22745725 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
JBrowse link
G Ar androgen receptor multiple interactions ISO deguelin results in decreased expression of and affects the localization of AR protein CTD PMID:27255535 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Atm ATM serine/threonine kinase decreases expression ISO deguelin results in decreased expression of ATM mRNA CTD PMID:22227970 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atr ATR serine/threonine kinase decreases expression ISO deguelin results in decreased expression of ATR mRNA CTD PMID:22227970 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO deguelin results in increased expression of BAK1 protein CTD PMID:26592500 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO deguelin results in increased expression of BAX mRNA; deguelin results in increased expression of BAX protein CTD PMID:26592500 PMID:29512685 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO deguelin results in decreased expression of BCL2 mRNA; deguelin results in decreased expression of BCL2 protein
deguelin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]
CTD PMID:19365708 PMID:22623043 PMID:26592500 PMID:29512685 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
ISO deguelin inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]
deguelin results in decreased expression of BCL2L1 mRNA; deguelin results in decreased expression of BCL2L1 protein
CTD PMID:19365708 PMID:21472727 PMID:22623043 PMID:26592500 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO deguelin inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein] CTD PMID:17209049 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression
ISO deguelin inhibits the reaction [docetaxel results in increased expression of BIRC5 protein]; deguelin inhibits the reaction [Doxorubicin results in increased expression of BIRC5 protein]
deguelin results in decreased expression of BIRC5 protein
CTD PMID:17035597 PMID:18593368 PMID:21472727 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression ISO deguelin results in decreased expression of BRCA1 mRNA CTD PMID:22227970 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Ca9 carbonic anhydrase 9 multiple interactions ISO deguelin inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA] CTD PMID:22745725 NCBI chr 5:59,008,277...59,015,535
Ensembl chr 5:59,008,933...59,015,528
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases activity
ISO deguelin results in increased cleavage of CASP3 protein
[NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased cleavage of CASP3 protein
deguelin results in increased activity of CASP3 protein
CTD PMID:18593368 PMID:19336726 PMID:22623043 PMID:22986522 PMID:25242579 PMID:26592500 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 multiple interactions ISO [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in decreased expression of and results in increased activity of CASP6 protein CTD PMID:25242579 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp7 caspase 7 increases expression ISO deguelin metabolite results in increased expression of CASP7 protein modified form; deguelin results in increased expression of CASP7 protein modified form CTD PMID:19139008 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in decreased expression of and results in increased activity of CASP8 protein CTD PMID:25242579 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP deguelin promotes the reaction [Oxygen deficiency results in increased expression of CCL2 mRNA] CTD PMID:22745725 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO deguelin inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA] CTD PMID:28529457 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO [deguelin results in increased degradation of CTNNB1 protein] which results in decreased expression of CCND1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in decreased expression of CCND1 protein]; deguelin inhibits the reaction [TNF protein results in increased expression of CCND1 protein] CTD PMID:15960896 PMID:17015749 PMID:19861542 PMID:21472727 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO deguelin results in decreased expression of CCNE1 mRNA CTD PMID:29512685 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cd14 CD14 molecule multiple interactions ISO [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased expression of CD14 protein CTD PMID:25242579 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd163 CD163 molecule multiple interactions EXP [deguelin co-treated with Oxygen deficiency] results in increased expression of CD163 mRNA CTD PMID:22745725 NCBI chr 4:156,752,063...156,785,467
Ensembl chr 4:156,752,082...156,785,467
JBrowse link
G Cd44 CD44 molecule (Indian blood group) decreases expression ISO deguelin results in decreased expression of CD44 mRNA; deguelin results in decreased expression of CD44 protein CTD PMID:26884827 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cdh1 cadherin 1 multiple interactions
affects localization
increases expression
ISO deguelin inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein]; deguelin promotes the reaction [CTNNB1 protein binds to CDH1 protein]
deguelin affects the localization of CDH1 protein
deguelin results in increased expression of CDH1 mRNA; deguelin results in increased expression of CDH1 protein
CTD PMID:22986522 PMID:28509438 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh2 cadherin 2 decreases expression ISO deguelin results in decreased expression of CDH2 protein CTD PMID:22986522 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdh3 cadherin 3 increases expression ISO deguelin results in increased expression of CDH3 mRNA CTD PMID:19861542 NCBI chr19:38,668,957...38,719,801
Ensembl chr19:38,669,230...38,719,677
JBrowse link
G Cdh7 cadherin 7 increases expression ISO deguelin results in increased expression of CDH7 mRNA CTD PMID:19861542 NCBI chr13:31,081,064...31,228,884
Ensembl chr13:31,081,804...31,231,213
JBrowse link
G Cdh9 cadherin 9 increases expression ISO deguelin results in increased expression of CDH9 mRNA CTD PMID:19861542 NCBI chr 2:66,938,796...67,078,897
Ensembl chr 2:66,940,057...67,078,784
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO deguelin metabolite results in decreased expression of CDK4 protein; deguelin results in decreased expression of CDK4 protein CTD PMID:19139008 PMID:19336726 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
increases expression
ISO [deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of CDKN1A protein; deguelin metabolite results in decreased expression of CDKN1A protein; deguelin results in decreased expression of CDKN1A protein
deguelin results in increased expression of CDKN1A mRNA
CTD PMID:19139008 PMID:25242579 PMID:29512685 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression ISO [deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of CEBPA protein CTD PMID:25242579 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions
decreases expression
ISO deguelin inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA]
deguelin results in decreased expression of CFLAR mRNA
CTD PMID:22623043 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Cldn2 claudin 2 increases expression ISO deguelin results in increased expression of CLDN2 mRNA CTD PMID:19861542 NCBI chr  X:111,122,552...111,133,188
Ensembl chr  X:111,122,552...111,137,769
JBrowse link
G Cldn5 claudin 5 increases expression ISO deguelin results in increased expression of CLDN5 mRNA CTD PMID:19861542 NCBI chr11:86,356,292...86,357,718
Ensembl chr11:86,356,294...86,357,718
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression
increases degradation
ISO [deguelin results in increased degradation of CTNNB1 protein] which results in decreased expression of CCND1 protein; [deguelin results in increased degradation of CTNNB1 protein] which results in decreased expression of MYC protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in decreased expression of CTNNB1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in increased degradation of CTNNB1 protein]; deguelin promotes the reaction [CTNNB1 protein binds to CDH1 protein] CTD PMID:21472727 PMID:22986522 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions ISO deguelin inhibits the reaction [Oxygen deficiency results in increased expression of CXCR4 mRNA] CTD PMID:22745725 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO deguelin inhibits the reaction [1-nitropyrene results in increased stability of CYP1A1 mRNA] CTD PMID:19961161 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Dkk2 dickkopf WNT signaling pathway inhibitor 2 decreases expression ISO deguelin results in decreased expression of DKK2 mRNA CTD PMID:19861542 NCBI chr 2:237,148,918...237,240,883
Ensembl chr 2:237,148,941...237,241,350
JBrowse link
G Dkk4 dickkopf WNT signaling pathway inhibitor 4 increases expression ISO deguelin results in increased expression of DKK4 mRNA CTD PMID:19861542 NCBI chr16:74,260,551...74,264,142
Ensembl chr16:74,260,551...74,264,142
JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO deguelin metabolite results in decreased expression of EGFR protein; deguelin results in decreased expression of EGFR protein CTD PMID:19139008 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 multiple interactions ISO deguelin inhibits the reaction [Oxygen deficiency results in increased expression of EGLN3 mRNA] CTD PMID:22745725 NCBI chr 6:75,050,329...75,075,795
Ensembl chr 6:75,050,329...75,075,795
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation ISO deguelin results in increased phosphorylation of EIF2AK3 protein CTD PMID:25322282 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases expression
decreases phosphorylation
ISO deguelin metabolite results in decreased expression of EIF4EBP1 protein modified form; deguelin results in decreased expression of EIF4EBP1 protein modified form
deguelin results in decreased phosphorylation of EIF4EBP1 protein
CTD PMID:19139008 PMID:27255535 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Eno2 enolase 2 decreases secretion ISO deguelin results in decreased secretion of ENO2 protein CTD PMID:26884827 NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047
JBrowse link
G Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 multiple interactions ISO deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ENTPD1 protein] CTD PMID:27899277 NCBI chr 1:259,692,020...259,818,922
Ensembl chr 1:259,739,955...259,819,494
JBrowse link
G Epas1 endothelial PAS domain protein 1 decreases expression ISO deguelin results in decreased expression of EPAS1 protein CTD PMID:19336726 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 decreases expression ISO deguelin results in decreased expression of ERN1 protein CTD PMID:25322282 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO deguelin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOS mRNA] CTD PMID:9270009 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Frzb frizzled-related protein increases expression ISO deguelin results in increased expression of FRZB mRNA CTD PMID:19861542 NCBI chr 3:67,635,604...67,668,772
Ensembl chr 3:67,635,607...67,668,772
JBrowse link
G Fzd10 frizzled class receptor 10 increases expression ISO deguelin results in increased expression of FZD10 mRNA CTD PMID:19861542 NCBI chr12:31,757,407...31,760,604
Ensembl chr12:31,757,407...31,760,604
JBrowse link
G Fzd4 frizzled class receptor 4 increases expression ISO deguelin results in increased expression of FZD4 mRNA CTD PMID:19861542 NCBI chr 1:153,589,471...153,598,376
Ensembl chr 1:153,589,471...153,598,375
JBrowse link
G Fzd8 frizzled class receptor 8 increases expression ISO deguelin results in increased expression of FZD8 mRNA CTD PMID:19861542 NCBI chr17:62,259,910...62,267,239
Ensembl chr17:62,262,129...62,265,113
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation ISO deguelin results in decreased phosphorylation of GSK3B protein CTD PMID:19336726 PMID:21472727 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases degradation
multiple interactions
ISO deguelin results in increased degradation of HIF1A protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in increased degradation of HIF1A protein]; deguelin inhibits the reaction [IGF1 protein results in increased expression of HIF1A protein]; deguelin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; deguelin metabolite inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]
CTD PMID:17764071 PMID:18575727 PMID:19139008 PMID:22745725 PMID:27899277 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ICAM1 mRNA]; deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ICAM1 protein]; deguelin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:17015749 PMID:22745725 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions EXP
ISO
deguelin inhibits the reaction [Perfadex results in increased expression of IFNG protein]
[deguelin co-treated with OVAL protein] results in increased expression of IFNG protein
CTD PMID:22745725 PMID:28529457 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO deguelin inhibits the reaction [IGF1 protein results in increased expression of HIF1A protein]; deguelin inhibits the reaction [IGF1 protein results in increased expression of VEGFA mRNA] CTD PMID:17764071 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression ISO deguelin metabolite results in decreased expression of IGF1R protein; deguelin results in decreased expression of IGF1R protein CTD PMID:19139008 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Ihh Indian hedgehog signaling molecule increases expression ISO deguelin results in increased expression of IHH mRNA CTD PMID:19861542 NCBI chr 9:82,208,223...82,214,440
Ensembl chr 9:82,208,223...82,214,440
JBrowse link
G Il10 interleukin 10 multiple interactions ISO deguelin inhibits the reaction [Oxygen deficiency results in increased expression of IL10 mRNA] CTD PMID:22745725 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il13 interleukin 13 multiple interactions ISO deguelin inhibits the reaction [OVAL protein results in increased expression of IL13 protein] CTD PMID:28529457 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il4 interleukin 4 multiple interactions EXP
ISO
deguelin inhibits the reaction [Oxygen deficiency results in decreased expression of IL4 mRNA]
deguelin inhibits the reaction [OVAL protein results in increased expression of IL4 mRNA]; deguelin inhibits the reaction [OVAL protein results in increased expression of IL4 protein]
CTD PMID:22745725 PMID:28529457 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 multiple interactions ISO deguelin inhibits the reaction [OVAL protein results in increased expression of IL5 protein] CTD PMID:28529457 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 multiple interactions EXP deguelin inhibits the reaction [Perfadex results in decreased expression of IL6 protein] CTD PMID:22745725 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased expression of ITGAM protein CTD PMID:25242579 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation ISO deguelin results in increased phosphorylation of JUN protein CTD PMID:25322282 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kdr kinase insert domain receptor decreases expression ISO deguelin metabolite results in decreased expression of KDR protein; deguelin results in decreased expression of KDR protein CTD PMID:19139008 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Krt18 keratin 18 increases expression
multiple interactions
ISO deguelin results in increased expression of KRT18 protein
deguelin inhibits the reaction [TGFB1 protein results in decreased expression of KRT18 protein]
CTD PMID:22986522 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Lox lysyl oxidase multiple interactions ISO deguelin inhibits the reaction [Oxygen deficiency results in increased expression of LOX mRNA] CTD PMID:22745725 NCBI chr18:47,500,320...47,577,819
Ensembl chr18:47,500,330...47,577,819
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 decreases expression ISO deguelin metabolite results in decreased expression of MAP2K1 protein; deguelin results in decreased expression of MAP2K1 protein CTD PMID:19139008 PMID:19336726 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 decreases expression ISO deguelin results in decreased expression of MAP2K2 protein CTD PMID:19336726 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489
JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 decreases expression ISO deguelin results in decreased expression of MAP2K7 protein CTD PMID:25322282 NCBI chr12:2,546,278...2,555,310
Ensembl chr12:2,548,218...2,555,164
JBrowse link
G Map3k3 mitogen activated protein kinase kinase kinase 3 affects expression ISO deguelin affects the expression of MAP3K3 protein CTD PMID:25322282 NCBI chr10:94,280,703...94,349,372
Ensembl chr10:94,280,703...94,349,368
JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects phosphorylation ISO deguelin affects the phosphorylation of MAPK1 protein CTD PMID:25322282 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 affects phosphorylation ISO deguelin affects the phosphorylation of MAPK3 protein CTD PMID:25322282 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO deguelin results in decreased expression of MCL1 protein CTD PMID:21472727 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression ISO deguelin results in decreased expression of MGMT mRNA CTD PMID:22227970 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO deguelin results in decreased expression of MKI67 protein CTD PMID:22623043 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mmp1 matrix metallopeptidase 1 decreases expression ISO deguelin results in decreased expression of MMP1 protein CTD PMID:25322282 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp13 matrix metallopeptidase 13 decreases expression ISO deguelin results in decreased expression of MMP13 protein CTD PMID:25322282 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
ISO deguelin results in decreased expression of and results in decreased activity of MMP2 protein
deguelin results in decreased expression of MMP2 mRNA; deguelin results in decreased expression of MMP2 protein
CTD PMID:25322282 PMID:26884827 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO deguelin results in decreased expression of MMP7 mRNA CTD PMID:25322282 NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
decreases activity
ISO deguelin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]
deguelin results in decreased expression of MMP9 mRNA; deguelin results in decreased expression of MMP9 protein
deguelin results in decreased activity of MMP9 protein
CTD PMID:17015749 PMID:25322282 PMID:26884827 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mrc1 mannose receptor, C type 1 multiple interactions EXP deguelin promotes the reaction [Oxygen deficiency results in increased expression of MRC1 mRNA] CTD PMID:22745725 NCBI chr17:81,352,700...81,433,743
Ensembl chr17:81,352,700...81,433,743
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression
decreases phosphorylation
ISO deguelin metabolite results in decreased expression of MTOR protein; deguelin results in decreased expression of MTOR protein
deguelin results in decreased phosphorylation of MTOR protein
CTD PMID:19139008 PMID:27255535 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO deguelin inhibits the reaction [OVAL protein results in increased expression of MUC5AC mRNA] CTD PMID:28529457 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases expression
ISO [deguelin results in increased degradation of CTNNB1 protein] which results in decreased expression of MYC protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in decreased expression of MYC protein]; deguelin inhibits the reaction [TNF protein results in increased expression of MYC protein]
deguelin inhibits the reaction [MYC protein results in increased activity of ODC1 protein]
CTD PMID:9270009 PMID:17015749 PMID:21472727 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ncoa3 nuclear receptor coactivator 3 decreases expression ISO deguelin results in decreased expression of NCOA3 mRNA; deguelin results in decreased expression of NCOA3 protein CTD PMID:19365708 NCBI chr 3:162,692,176...162,788,582
Ensembl chr 3:162,692,185...162,787,548
JBrowse link
G Nek2 NIMA-related kinase 2 decreases expression ISO deguelin results in decreased expression of NEK2 mRNA; deguelin results in decreased expression of NEK2 protein CTD PMID:28509438 NCBI chr13:110,511,546...110,524,750
Ensembl chr13:110,511,668...110,522,769
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO deguelin inhibits the reaction [TNF protein results in increased degradation of and results in increased phosphorylation of NFKBIA protein]; deguelin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
deguelin inhibits the reaction [OVAL protein results in increased degradation of and results in increased phosphorylation of NFKBIA protein]
CTD PMID:17015749 PMID:22623043 PMID:28529457 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
ISO deguelin results in decreased expression of NOS2 protein
deguelin inhibits the reaction [OVAL protein results in increased expression of NOS2 mRNA]
CTD PMID:25322282 PMID:28529457 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression ISO deguelin results in decreased expression of NOS3 protein CTD PMID:19336726 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Npm1 nucleophosmin 1 decreases expression
multiple interactions
increases response to substance
ISO [deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of CDKN1A protein; [deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of CEBPA protein; [deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of TP53 protein
[NPM1 protein mutant form results in increased susceptibility to deguelin] which results in decreased expression of and results in increased activity of CASP6 protein; [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in decreased expression of and results in increased activity of CASP8 protein; [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased cleavage of CASP3 protein; [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased cleavage of PARP1 protein; [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased expression of CD14 protein; [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased expression of ITGAM protein
CTD PMID:25242579 NCBI chr10:18,080,949...18,091,062
Ensembl chr10:18,080,950...18,090,950
JBrowse link
G Nt5e 5' nucleotidase, ecto multiple interactions ISO deguelin inhibits the reaction [Oxygen deficiency results in increased expression of NT5E protein] CTD PMID:27899277 NCBI chr 8:95,969,002...96,012,733
Ensembl chr 8:95,968,652...96,012,696
JBrowse link
G Nup98 nucleoporin 98 and 96 precursor decreases expression ISO deguelin results in decreased expression of NUP98 mRNA; deguelin results in decreased expression of NUP98 protein CTD PMID:17490514 NCBI chr 1:167,213,866...167,308,851
Ensembl chr 1:167,213,866...167,308,851
JBrowse link
G Odc1 ornithine decarboxylase 1 increases activity
multiple interactions
ISO deguelin results in increased activity of ODC1 protein
deguelin inhibits the reaction [MYC protein results in increased activity of ODC1 protein]; deguelin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ODC1 mRNA]
CTD PMID:9270009 PMID:9834970 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
increases expression
ISO [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased cleavage of PARP1 protein; deguelin inhibits the reaction [TNF protein results in increased cleavage of PARP1 protein]
deguelin results in increased cleavage of PARP1 protein
deguelin metabolite results in increased expression of PARP1 protein modified form; deguelin results in increased expression of PARP1 protein modified form
CTD PMID:17015749 PMID:17035597 PMID:19139008 PMID:22986522 PMID:25242579 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 decreases expression ISO deguelin metabolite results in decreased expression of PDK1 protein; deguelin results in decreased expression of PDK1 protein CTD PMID:19139008 NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha decreases expression ISO deguelin metabolite results in decreased expression of PIK3CA protein; deguelin results in decreased expression of PIK3CA protein CTD PMID:19139008 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Plcg1 phospholipase C, gamma 1 increases phosphorylation ISO deguelin results in increased phosphorylation of PLCG1 protein CTD PMID:19901985 NCBI chr 3:156,727,642...156,758,307
Ensembl chr 3:156,727,642...156,758,307
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B multiple interactions ISO deguelin inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein] CTD PMID:17209049 NCBI chr10:86,303,727...86,312,770
Ensembl chr10:86,303,727...86,312,762
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation ISO deguelin results in increased phosphorylation of PRKAA1 protein CTD PMID:19901985 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit decreases expression ISO deguelin results in decreased expression of PRKDC mRNA CTD PMID:22227970 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
ISO deguelin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
deguelin results in decreased expression of PTGS2 protein
CTD PMID:17015749 PMID:25322282 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases expression ISO deguelin results in decreased expression of PTK2 protein CTD PMID:25322282 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Rac1 Rac family small GTPase 1 decreases expression ISO deguelin results in decreased expression of RAC1 protein CTD PMID:26884827 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO deguelin results in decreased expression of RB1 protein CTD PMID:15960896 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression
multiple interactions
decreases phosphorylation
ISO deguelin results in decreased expression of RELA mRNA; deguelin results in decreased expression of RELA protein
deguelin inhibits the reaction [OVAL protein affects the localization of and results in increased phosphorylation of RELA protein]
deguelin results in decreased phosphorylation of RELA protein
deguelin inhibits the reaction [TNF protein affects the localization of and results in increased phosphorylation of RELA protein]; deguelin inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]
CTD PMID:17015749 PMID:19365708 PMID:22623043 PMID:28529457 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rhoa ras homolog family member A decreases expression ISO deguelin results in decreased expression of RHOA mRNA; deguelin results in decreased expression of RHOA protein CTD PMID:25322282 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 decreases expression ISO deguelin results in decreased expression of ROCK1 protein CTD PMID:25322282 PMID:26884827 NCBI chr18:1,273,490...1,390,790
Ensembl chr18:1,273,453...1,390,190
JBrowse link
G Rps6 ribosomal protein S6 decreases expression
decreases phosphorylation
ISO deguelin metabolite results in decreased expression of RPS6 protein; deguelin metabolite results in decreased expression of RPS6 protein modified form; deguelin results in decreased expression of RPS6 protein; deguelin results in decreased expression of RPS6 protein modified form
deguelin results in decreased phosphorylation of RPS6 protein
CTD PMID:19139008 PMID:27255535 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases expression
decreases phosphorylation
ISO deguelin metabolite results in decreased expression of RPS6KB1 protein; deguelin results in decreased expression of RPS6KB1 protein
deguelin results in decreased phosphorylation of RPS6KB1 protein
CTD PMID:19139008 PMID:27255535 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Sele selectin E multiple interactions ISO deguelin inhibits the reaction [TNF protein results in increased expression of SELE mRNA]
deguelin inhibits the reaction [OVAL protein results in increased expression of SELE mRNA]
CTD PMID:28529457 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Serpinb3 serpin family B member 3 decreases secretion ISO deguelin results in decreased secretion of SERPINB3 protein CTD PMID:26884827 NCBI chr13:27,186,701...27,193,211
Ensembl chr13:27,187,130...27,192,592
JBrowse link
G Sfrp2 secreted frizzled-related protein 2 decreases expression ISO deguelin results in decreased expression of SFRP2 mRNA CTD PMID:19861542 NCBI chr 2:182,723,732...182,731,277
Ensembl chr 2:182,723,854...182,731,764
JBrowse link
G Smad3 SMAD family member 3 decreases phosphorylation ISO deguelin results in decreased phosphorylation of SMAD3 protein CTD PMID:22986522 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Smad4 SMAD family member 4 multiple interactions ISO deguelin inhibits the reaction [TGFB1 protein affects the localization of SMAD4 protein] CTD PMID:22986522 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression
multiple interactions
ISO deguelin results in decreased expression of SNAI1 mRNA; deguelin results in decreased expression of SNAI1 protein
deguelin inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]
CTD PMID:19861542 PMID:22986522 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 decreases expression ISO deguelin results in decreased expression of SOS1 protein CTD PMID:25322282 NCBI chr 6:3,105,443...3,182,977
Ensembl chr 6:3,104,861...3,182,996
JBrowse link
G Sox14 SRY-box transcription factor 14 increases expression ISO deguelin results in increased expression of SOX14 mRNA CTD PMID:19861542 NCBI chr 8:108,107,865...108,109,801
Ensembl chr 8:108,107,865...108,109,801
JBrowse link
G Sox30 SRY-box transcription factor 30 increases expression ISO deguelin results in increased expression of SOX30 mRNA CTD PMID:19861542 NCBI chr10:31,074,251...31,102,211
Ensembl chr10:31,074,251...31,102,169
JBrowse link
G Sox5 SRY-box transcription factor 5 increases expression ISO deguelin results in increased expression of SOX5 mRNA CTD PMID:19861542 NCBI chr 4:178,062,267...179,031,991
Ensembl chr 4:178,066,165...178,441,547
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase increases activity ISO deguelin metabolite results in increased activity of SRC protein; deguelin results in increased activity of SRC protein CTD PMID:19139008 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases activity ISO deguelin metabolite results in increased activity of STAT3 protein; deguelin results in increased activity of STAT3 protein CTD PMID:19139008 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Stat6 signal transducer and activator of transcription 6 increases phosphorylation ISO deguelin metabolite results in increased phosphorylation of STAT6 protein; deguelin results in increased phosphorylation of STAT6 protein CTD PMID:19139008 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link
G Sts steroid sulfatase multiple interactions ISO deguelin inhibits the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750
JBrowse link
G Tcf4 transcription factor 4 increases expression ISO deguelin results in increased expression of TCF4 mRNA CTD PMID:19861542 NCBI chr18:65,285,320...65,507,983
Ensembl chr18:65,155,685...65,507,977
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO deguelin inhibits the reaction [TGFB1 protein affects the localization of SMAD4 protein]; deguelin inhibits the reaction [TGFB1 protein results in decreased expression of KRT18 protein]; deguelin inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein]; deguelin inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein] CTD PMID:22986522 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO deguelin results in increased expression of TIMP1 protein CTD PMID:25322282 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO deguelin results in increased expression of TIMP2 protein CTD PMID:25322282 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO deguelin inhibits the reaction [TNF protein affects the localization of and results in increased phosphorylation of RELA protein]; deguelin inhibits the reaction [TNF protein results in increased cleavage of PARP1 protein]; deguelin inhibits the reaction [TNF protein results in increased degradation of and results in increased phosphorylation of NFKBIA protein]; deguelin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; deguelin inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; deguelin inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; deguelin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; deguelin inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA]; deguelin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; deguelin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; deguelin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; deguelin inhibits the reaction [TNF protein results in increased expression of MUC mRNA]; deguelin inhibits the reaction [TNF protein results in increased expression of MYC protein]; deguelin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; deguelin inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; deguelin inhibits the reaction [TNF protein results in increased expression of TSLP mRNA]; deguelin inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]; deguelin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; deguelin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:17015749 PMID:22623043 PMID:28529457 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 decreases expression ISO [deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of TP53 protein; deguelin results in decreased expression of TP53 mRNA CTD PMID:22227970 PMID:25242579 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO deguelin inhibits the reaction [TNF protein results in increased expression of TSLP mRNA]
deguelin inhibits the reaction [OVAL protein results in increased expression of TSLP mRNA]; deguelin inhibits the reaction [OVAL protein results in increased expression of TSLP protein]
CTD PMID:28529457 NCBI chr18:25,613,601...25,618,066
Ensembl chr18:25,613,831...25,617,361
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
decreases response to substance
ISO deguelin inhibits the reaction [IGF1 protein results in increased expression of VEGFA mRNA]; deguelin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; deguelin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]
deguelin results in decreased expression of VEGFA protein
VEGFA protein results in decreased susceptibility to deguelin
CTD PMID:17764071 PMID:18575727 PMID:22623043 PMID:22745725 PMID:25322282 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vim vimentin decreases expression ISO deguelin results in decreased expression of VIM protein CTD PMID:22986522 PMID:28509438 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Wif1 Wnt inhibitory factor 1 increases expression ISO deguelin results in increased expression of WIF1 mRNA CTD PMID:19861542 NCBI chr 7:63,094,955...63,165,158
Ensembl chr 7:63,094,911...63,165,159
JBrowse link
G Wnt10a Wnt family member 10A increases expression ISO deguelin results in increased expression of WNT10A mRNA CTD PMID:19861542 NCBI chr 9:82,053,581...82,066,047
Ensembl chr 9:82,053,581...82,066,047
JBrowse link
G Wnt11 Wnt family member 11 increases expression ISO deguelin results in increased expression of WNT11 mRNA CTD PMID:19861542 NCBI chr 1:163,794,136...163,813,756
Ensembl chr 1:163,797,660...163,813,756
JBrowse link
G Wnt2 Wnt family member 2 increases expression ISO deguelin results in increased expression of WNT2 mRNA CTD PMID:19861542 NCBI chr 4:45,286,845...45,332,899
Ensembl chr 4:45,292,437...45,332,420
JBrowse link
G Wnt2b Wnt family member 2B decreases expression ISO deguelin results in decreased expression of WNT2B mRNA CTD PMID:19861542 NCBI chr 2:207,433,771...207,457,094
Ensembl chr 2:207,440,886...207,455,258
JBrowse link
G Wnt3a Wnt family member 3A decreases expression ISO deguelin results in decreased expression of WNT3A mRNA CTD PMID:19861542 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035
JBrowse link
G Wnt9a Wnt family member 9A decreases expression ISO deguelin results in decreased expression of WNT9A mRNA CTD PMID:19861542 NCBI chr10:45,659,045...45,686,103
Ensembl chr10:45,659,143...45,681,393
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO deguelin results in decreased expression of XIAP protein CTD PMID:17035597 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
equol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein affects binding EXP Equol binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr14:19,141,755...19,159,919
Ensembl chr14:19,141,755...19,159,923
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO Equol results in increased phosphorylation of AKT1 protein CTD PMID:16840783 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Alpg alkaline phosphatase, germ cell increases expression ISO Equol results in increased expression of ALPG mRNA CTD PMID:15993745 NCBI chr 9:94,164,667...94,184,972
Ensembl chr 9:94,178,221...94,181,010
JBrowse link
G Ar androgen receptor affects binding EXP Equol binds to AR protein CTD PMID:14565775 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Casp3 caspase 3 increases activity ISO Equol results in increased activity of CASP3 protein CTD PMID:18973749 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 increases cleavage ISO Equol results in increased cleavage of CASP6 protein CTD PMID:18973749 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp7 caspase 7 increases cleavage ISO Equol results in increased cleavage of CASP7 protein CTD PMID:18973749 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp9 caspase 9 increases cleavage ISO Equol results in increased cleavage of CASP9 protein CTD PMID:18973749 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cav1 caveolin 1 multiple interactions ISO Equol inhibits the reaction [NOS3 protein binds to CAV1 protein] CTD PMID:16840783 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO Equol results in decreased expression of CCNA2 mRNA CTD PMID:16865672 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
JBrowse link
G Ccnb2 cyclin B2 decreases expression ISO Equol results in decreased expression of CCNB2 mRNA CTD PMID:16865672 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Cd86 CD86 molecule multiple interactions ISO Equol inhibits the reaction [Lipopolysaccharides results in increased expression of CD86 protein] CTD PMID:21945492 NCBI chr11:67,060,305...67,117,990
Ensembl chr11:67,082,193...67,118,795
JBrowse link
G Cdc25b cell division cycle 25B decreases expression ISO Equol results in decreased expression of CDC25B mRNA CTD PMID:16865672 NCBI chr 3:123,731,539...123,741,696
Ensembl chr 3:123,731,539...123,741,339
JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO Equol results in decreased expression of CDC25C mRNA CTD PMID:16865672 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
JBrowse link
G Cga glycoprotein hormones, alpha polypeptide decreases expression EXP Equol results in decreased expression of CGA mRNA CTD PMID:23220561 NCBI chr 5:50,362,491...50,393,368
Ensembl chr 5:50,381,244...50,393,367
JBrowse link
G Chek1 checkpoint kinase 1 decreases expression ISO Equol results in decreased expression of CHEK1 mRNA CTD PMID:16865672 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Cycs cytochrome c, somatic affects localization ISO Equol affects the localization of CYCS protein CTD PMID:18973749 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression ISO Equol results in decreased expression of CYP11A1 mRNA CTD PMID:26876617 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression ISO Equol results in decreased expression of CYP17A1 mRNA CTD PMID:26876617 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases expression ISO Equol results in decreased expression of CYP19A1 mRNA CTD PMID:26876617 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Dbf4 DBF4 zinc finger decreases expression ISO Equol results in decreased expression of DBF4 mRNA CTD PMID:16865672 NCBI chr 4:22,898,527...22,914,091
Ensembl chr 4:22,898,527...22,914,177
JBrowse link
G Dffa DNA fragmentation factor subunit alpha increases activity ISO Equol results in increased activity of DFFA protein CTD PMID:18973749 NCBI chr 5:165,922,893...165,935,822
Ensembl chr 5:165,922,915...165,935,821
JBrowse link
G Dusp4 dual specificity phosphatase 4 decreases expression ISO Equol results in decreased expression of DUSP4 mRNA CTD PMID:16865672 NCBI chr16:61,080,767...61,090,973
Ensembl chr16:61,078,175...61,091,169
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Equol results in increased chemical synthesis of Oxygen]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Equol results in increased phosphorylation of and results in increased activity of NOS3 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Equol results in increased phosphorylation of MAPK1 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Equol results in increased phosphorylation of MAPK3 protein] CTD PMID:21300668 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases expression
increases activity
affects binding
ISO
EXP
[afimoxifene binds to and results in decreased activity of ESR1 protein] which results in decreased susceptibility to Equol; [fulvestrant binds to and results in decreased activity of ESR1 protein] which results in decreased susceptibility to Equol; Equol binds to and results in increased activity of ESR1 protein; Estradiol affects the reaction [Equol affects the activity of ESR1 protein]
Equol results in increased expression of ESR1 mRNA; Equol results in increased expression of ESR1 mRNA alternative form
Equol results in increased activity of ESR1 protein
Equol binds to ESR1 protein
CTD PMID:15876408 PMID:15993745 PMID:16118406 PMID:16965913 PMID:19427779 PMID:19913605 PMID:20074635 PMID:20362049 PMID:20435135 PMID:23220561 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases activity
affects binding
ISO Equol binds to and results in increased activity of ESR2 protein; Equol inhibits the reaction [KAT5 protein results in decreased activity of ESR2 protein]; Equol inhibits the reaction [KAT5 protein results in increased activity of ESR2 protein]; Estradiol affects the reaction [Equol affects the activity of ESR2 protein]
Equol results in increased activity of ESR2 protein
Equol binds to ESR2 protein
CTD PMID:12224631 PMID:15084758 PMID:15993745 PMID:16118406 PMID:16965913 PMID:19913605 PMID:23857583 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Gnrhr gonadotropin releasing hormone receptor decreases expression EXP Equol results in decreased expression of GNRHR mRNA CTD PMID:23220561 NCBI chr14:23,480,462...23,498,450
Ensembl chr14:23,480,462...23,498,450
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression ISO Equol results in decreased expression of IGF1R mRNA CTD PMID:16865672 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Il4 interleukin 4 increases expression ISO Equol results in increased expression of IL4 mRNA; Equol results in increased expression of IL4 protein CTD PMID:16108819 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Kat5 lysine acetyltransferase 5 multiple interactions ISO Equol inhibits the reaction [KAT5 protein results in decreased activity of ESR2 protein]; Equol inhibits the reaction [KAT5 protein results in increased activity of ESR2 protein] CTD PMID:23857583 NCBI chr 1:220,967,795...220,974,596
Ensembl chr 1:220,967,796...220,974,597
JBrowse link
G Lhb luteinizing hormone subunit beta decreases expression EXP Equol results in decreased expression of LHB protein CTD PMID:23220561 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation
ISO [AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Equol results in increased phosphorylation of MAPK1 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Equol results in increased phosphorylation of MAPK1 protein]; [U 0126 results in decreased phosphorylation of [MAPK1 protein co-treated with MAPK3 protein]] which results in decreased susceptibility to Equol; AG 1879 inhibits the reaction [Equol results in increased phosphorylation of MAPK1 protein]; Equol results in increased activity of and results in increased phosphorylation of MAPK1 protein; Pertussis Toxin inhibits the reaction [Equol results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Equol results in increased activity of and results in increased phosphorylation of MAPK1 protein] CTD PMID:16840783 PMID:19427779 PMID:21300668 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation
ISO [AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Equol results in increased phosphorylation of MAPK3 protein]; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Equol results in increased phosphorylation of MAPK3 protein]; [U 0126 results in decreased phosphorylation of [MAPK1 protein co-treated with MAPK3 protein]] which results in decreased susceptibility to Equol; AG 1879 inhibits the reaction [Equol results in increased phosphorylation of MAPK3 protein]; Equol results in increased activity of and results in increased phosphorylation of MAPK3 protein; Pertussis Toxin inhibits the reaction [Equol results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Equol results in increased activity of and results in increased phosphorylation of MAPK3 protein] CTD PMID:16840783 PMID:19427779 PMID:21300668 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 decreases expression ISO Equol results in decreased expression of MCM4 mRNA CTD PMID:16865672 NCBI chr11:89,511,191...89,524,892
Ensembl chr11:89,511,191...89,524,892
JBrowse link
G Me1 malic enzyme 1 increases expression ISO Equol results in increased expression of ME1 mRNA CTD PMID:16865672 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Nkx3-1 NK3 homeobox 1 decreases expression ISO Equol results in decreased expression of NKX3-1 mRNA CTD PMID:16865672 NCBI chr15:51,065,316...51,067,908
Ensembl chr15:51,065,316...51,068,421
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO [AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Equol results in increased activity of and results in increased phosphorylation of NOS3 protein]; [Equol results in increased chemical synthesis of Superoxides] which results in increased activity of and results in increased phosphorylation of NOS3 protein; [RTKI cpd results in decreased activity of EGFR protein] inhibits the reaction [Equol results in increased phosphorylation of and results in increased activity of NOS3 protein]; Equol inhibits the reaction [NOS3 protein binds to CAV1 protein]; Equol results in increased activity of and results in increased phosphorylation of NOS3 protein; Equol results in increased phosphorylation of and results in increased activity of NOS3 protein; Manganese inhibits the reaction [Equol results in increased activity of and results in increased phosphorylation of NOS3 protein]; Pertussis Toxin inhibits the reaction [Equol results in increased activity of and results in increased phosphorylation of NOS3 protein]; Rotenone inhibits the reaction [Equol results in increased phosphorylation of and results in increased activity of NOS3 protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Equol results in increased chemical synthesis of Superoxides] which results in increased phosphorylation of NOS3 protein] CTD PMID:16840783 PMID:21300668 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Prim2 DNA primase subunit 2 decreases expression ISO Equol results in decreased expression of PRIM2 mRNA CTD PMID:16865672 NCBI chr 9:38,535,435...38,745,058
Ensembl chr 9:38,536,920...38,745,099
JBrowse link
G Prl prolactin increases expression EXP Equol results in increased expression of PRL protein CTD PMID:23220561 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Equol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]; Equol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] CTD PMID:16870006 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO Equol binds to SHBG protein CTD PMID:25349334 NCBI chr10:56,219,861...56,237,354
Ensembl chr10:56,219,858...56,223,245
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO [AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Equol results in increased activity of and results in increased phosphorylation of NOS3 protein]; [AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Equol results in increased phosphorylation of MAPK1 protein]; [AG 1879 results in decreased activity of SRC protein] inhibits the reaction [Equol results in increased phosphorylation of MAPK3 protein] CTD PMID:21300668 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Stk39 serine threonine kinase 39 decreases expression ISO Equol results in decreased expression of STK39 mRNA CTD PMID:16865672 NCBI chr 3:54,359,449...54,625,702
Ensembl chr 3:54,359,451...54,625,414
JBrowse link
G Tff1 trefoil factor 1 increases expression ISO Equol results in increased expression of TFF1 mRNA CTD PMID:16965913 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
JBrowse link
G Thbs1 thrombospondin 1 decreases expression ISO Equol results in decreased expression of THBS1 mRNA CTD PMID:16865672 NCBI chr 3:109,862,120...109,873,466
Ensembl chr 3:109,862,117...109,873,466
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Equol CTD PMID:14557274 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of Equol CTD PMID:14557274 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Equol CTD PMID:14557274 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases expression ISO Equol results in increased expression of UGT2B17 mRNA CTD PMID:16865672 NCBI chr14:22,724,399...22,736,148
Ensembl chr14:22,724,070...22,825,444
JBrowse link
glabridin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp8 caspase 8 increases cleavage ISO glabridin results in increased cleavage of CASP8 protein CTD PMID:29663662 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 increases cleavage ISO glabridin results in increased cleavage of CASP9 protein CTD PMID:29663662 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO glabridin inhibits the reaction [Antimycin A affects the localization of CYCS protein] CTD PMID:21621525 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO glabridin results in increased phosphorylation of MAPK1 protein CTD PMID:29663662 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO glabridin results in increased phosphorylation of MAPK3 protein CTD PMID:29663662 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO glabridin results in increased cleavage of PARP1 protein CTD PMID:29663662 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of glabridin CTD PMID:25765239 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of glabridin CTD PMID:25765239 NCBI chr 9:95,285,592...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of glabridin CTD PMID:25765239 NCBI chr 9:95,221,474...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of glabridin CTD PMID:25765239 NCBI chr 9:95,161,157...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Ugt2b7 UDP glucuronosyltransferase family 2 member B7 increases glucuronidation ISO UGT2B7 protein results in increased glucuronidation of glabridin CTD PMID:25765239 NCBI chr14:22,597,103...22,619,968 JBrowse link
glycyrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A decreases activity ISO glycyrin results in decreased activity of DYRK1A protein CTD PMID:31838052 NCBI chr11:34,858,339...34,958,733
Ensembl chr11:34,865,532...34,956,536
JBrowse link
licoricidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO [gemcitabine co-treated with licoricidin] results in decreased phosphorylation of AKT1 protein; [licoricidin co-treated with gemcitabine] results in decreased phosphorylation of AKT1 protein
licoricidin results in decreased phosphorylation of AKT1 protein
CTD PMID:29782821 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO licoricidin promotes the reaction [gemcitabine results in increased activity of CASP3 protein]; licoricidin promotes the reaction [gemcitabine results in increased expression of and results in increased activity of CASP3 protein]; licoricidin results in increased expression of and results in increased activity of CASP3 protein
licoricidin results in increased activity of CASP3 protein
CTD PMID:29782821 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases phosphorylation
ISO licoricidin inhibits the reaction [gemcitabine results in increased phosphorylation of RELA protein]
licoricidin results in decreased phosphorylation of RELA protein
CTD PMID:29782821 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
Osajin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acly ATP citrate lyase increases expression ISO osajin results in increased expression of ACLY mRNA CTD PMID:20706672 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Aqp1 aquaporin 1 increases expression ISO osajin results in increased expression of AQP1 mRNA CTD PMID:20706672 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) increases expression ISO osajin results in increased expression of AQP3 mRNA CTD PMID:20706672 NCBI chr 5:57,423,735...57,429,252
Ensembl chr 5:57,423,734...57,429,245
JBrowse link
G Ar androgen receptor decreases expression ISO osajin results in decreased expression of AR mRNA CTD PMID:20706672 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO osajin results in increased expression of CD44 mRNA CTD PMID:20706672 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cdh1 cadherin 1 increases expression ISO osajin results in increased expression of CDH1 mRNA CTD PMID:20706672 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO osajin results in increased expression of COL1A1 mRNA CTD PMID:20706672 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cygb cytoglobin decreases expression ISO osajin results in decreased expression of CYGB mRNA CTD PMID:20706672 NCBI chr10:105,618,325...105,628,091
Ensembl chr10:105,618,326...105,628,091
JBrowse link
G Dsg3 desmoglein 3 decreases expression ISO osajin results in decreased expression of DSG3 mRNA CTD PMID:20706672 NCBI chr18:15,652,948...15,688,605
Ensembl chr18:15,650,526...15,688,284
JBrowse link
G Egf epidermal growth factor decreases expression ISO osajin results in decreased expression of EGF mRNA CTD PMID:20706672 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Esr2 estrogen receptor 2 decreases expression ISO osajin results in decreased expression of ESR2 mRNA CTD PMID:20706672 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression ISO osajin results in increased expression of FGF1 mRNA CTD PMID:20706672 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Grn granulin precursor increases expression ISO osajin results in increased expression of GRN mRNA CTD PMID:20706672 NCBI chr10:90,377,103...90,383,207
Ensembl chr10:90,376,933...90,383,205
JBrowse link
G Has1 hyaluronan synthase 1 decreases expression ISO osajin results in decreased expression of HAS1 mRNA CTD PMID:20706672 NCBI chr 1:59,720,612...59,732,409
Ensembl chr 1:59,720,612...59,732,409
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO osajin results in increased expression of HSPB1 mRNA CTD PMID:20706672 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO osajin results in decreased expression of IGF1 mRNA CTD PMID:20706672 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO osajin results in decreased expression of IL1A mRNA CTD PMID:20706672 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Kl Klotho decreases expression ISO osajin results in decreased expression of KL mRNA CTD PMID:20706672 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551
JBrowse link
G Krt5 keratin 5 increases expression ISO osajin results in increased expression of KRT5 mRNA CTD PMID:20706672 NCBI chr 7:143,320,142...143,324,536
Ensembl chr 7:143,316,920...143,453,546
JBrowse link
G Mc1r melanocortin 1 receptor decreases expression ISO osajin results in decreased expression of MC1R mRNA CTD PMID:20706672 NCBI chr19:56,215,420...56,219,987 JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I increases expression ISO osajin results in increased expression of COX1 mRNA CTD PMID:20706672 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression ISO osajin results in decreased expression of NOS2 mRNA CTD PMID:20706672 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO osajin results in increased expression of NOS3 mRNA CTD PMID:20706672 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Pgr progesterone receptor decreases expression ISO osajin results in decreased expression of PGR mRNA CTD PMID:20706672 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 increases expression ISO osajin results in increased expression of PLOD3 mRNA CTD PMID:20706672 NCBI chr12:22,716,421...22,726,982
Ensembl chr12:22,716,423...22,726,982
JBrowse link
G Pomc proopiomelanocortin decreases expression ISO osajin results in decreased expression of POMC mRNA CTD PMID:20706672 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO osajin results in decreased expression of PPARG mRNA CTD PMID:20706672 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptger1 prostaglandin E receptor 1 decreases expression ISO osajin results in decreased expression of PTGER1 mRNA CTD PMID:20706672 NCBI chr19:24,799,422...24,803,373
Ensembl chr19:24,800,072...24,803,373
JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein decreases expression ISO osajin results in decreased expression of RAD23A mRNA CTD PMID:20706672 NCBI chr19:25,949,488...25,956,677
Ensembl chr19:25,949,490...25,955,391
JBrowse link
G Rara retinoic acid receptor, alpha increases expression ISO osajin results in increased expression of RARA mRNA CTD PMID:20706672 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rxra retinoid X receptor alpha decreases expression ISO osajin results in decreased expression of RXRA mRNA CTD PMID:20706672 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Sod3 superoxide dismutase 3 decreases expression ISO osajin results in decreased expression of SOD3 mRNA CTD PMID:20706672 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 decreases expression ISO osajin results in decreased expression of SRD5A2 mRNA CTD PMID:20706672 NCBI chr 6:25,279,635...25,315,501
Ensembl chr 6:25,279,626...25,315,511
JBrowse link
G Tert telomerase reverse transcriptase decreases expression ISO osajin results in decreased expression of TERT mRNA CTD PMID:20706672 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 increases expression ISO osajin results in increased expression of TPT1 mRNA CTD PMID:20706672 NCBI chr15:57,891,680...57,894,504
Ensembl chr15:57,891,680...57,894,504
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO osajin results in increased expression of TXN mRNA CTD PMID:20706672 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
Pomiferin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acly ATP citrate lyase increases expression ISO pomiferin results in increased expression of ACLY mRNA CTD PMID:20706672 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Aqp1 aquaporin 1 increases expression ISO pomiferin results in increased expression of AQP1 mRNA CTD PMID:20706672 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) increases expression ISO pomiferin results in increased expression of AQP3 mRNA CTD PMID:20706672 NCBI chr 5:57,423,735...57,429,252
Ensembl chr 5:57,423,734...57,429,245
JBrowse link
G Ar androgen receptor decreases expression ISO pomiferin results in decreased expression of AR mRNA CTD PMID:20706672 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO pomiferin results in increased expression of CD44 mRNA CTD PMID:20706672 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cdh1 cadherin 1 increases expression ISO pomiferin results in increased expression of CDH1 mRNA CTD PMID:20706672 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO pomiferin results in increased expression of COL1A1 mRNA CTD PMID:20706672 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cygb cytoglobin decreases expression ISO pomiferin results in decreased expression of CYGB mRNA CTD PMID:20706672 NCBI chr10:105,618,325...105,628,091
Ensembl chr10:105,618,326...105,628,091
JBrowse link
G Egf epidermal growth factor decreases expression ISO pomiferin results in decreased expression of EGF mRNA CTD PMID:20706672 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Esr2 estrogen receptor 2 decreases expression ISO pomiferin results in decreased expression of ESR2 mRNA CTD PMID:20706672 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fbn1 fibrillin 1 decreases expression ISO pomiferin results in decreased expression of FBN1 mRNA CTD PMID:20706672 NCBI chr 3:117,569,708...117,766,160
Ensembl chr 3:117,569,697...117,766,120
JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression ISO pomiferin results in increased expression of FGF1 mRNA CTD PMID:20706672 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Grn granulin precursor increases expression ISO pomiferin results in increased expression of GRN mRNA CTD PMID:20706672 NCBI chr10:90,377,103...90,383,207
Ensembl chr10:90,376,933...90,383,205
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO pomiferin results in increased expression of HSPB1 mRNA CTD PMID:20706672 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO pomiferin results in decreased expression of IGF1 mRNA CTD PMID:20706672 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Kl Klotho decreases expression ISO pomiferin results in decreased expression of KL mRNA CTD PMID:20706672 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551
JBrowse link
G Krt5 keratin 5 increases expression ISO pomiferin results in increased expression of KRT5 mRNA CTD PMID:20706672 NCBI chr 7:143,320,142...143,324,536
Ensembl chr 7:143,316,920...143,453,546
JBrowse link
G Mc1r melanocortin 1 receptor decreases expression ISO pomiferin results in decreased expression of MC1R mRNA CTD PMID:20706672 NCBI chr19:56,215,420...56,219,987 JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I increases expression ISO pomiferin results in increased expression of COX1 mRNA CTD PMID:20706672 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO pomiferin results in increased expression of NOS3 mRNA CTD PMID:20706672 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Pgr progesterone receptor decreases expression ISO pomiferin results in decreased expression of PGR mRNA CTD PMID:20706672 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 increases expression ISO pomiferin results in increased expression of PLOD3 mRNA CTD PMID:20706672 NCBI chr12:22,716,421...22,726,982
Ensembl chr12:22,716,423...22,726,982
JBrowse link
G Pomc proopiomelanocortin decreases expression ISO pomiferin results in decreased expression of POMC mRNA CTD PMID:20706672 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO pomiferin results in decreased expression of PPARG mRNA CTD PMID:20706672 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptger1 prostaglandin E receptor 1 decreases expression ISO pomiferin results in decreased expression of PTGER1 mRNA CTD PMID:20706672 NCBI chr19:24,799,422...24,803,373
Ensembl chr19:24,800,072...24,803,373
JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein decreases expression ISO pomiferin results in decreased expression of RAD23A mRNA CTD PMID:20706672 NCBI chr19:25,949,488...25,956,677
Ensembl chr19:25,949,490...25,955,391
JBrowse link
G Rara retinoic acid receptor, alpha increases expression ISO pomiferin results in increased expression of RARA mRNA CTD PMID:20706672 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Sod3 superoxide dismutase 3 decreases expression ISO pomiferin results in decreased expression of SOD3 mRNA CTD PMID:20706672 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 decreases expression ISO pomiferin results in decreased expression of SRD5A2 mRNA CTD PMID:20706672 NCBI chr 6:25,279,635...25,315,501
Ensembl chr 6:25,279,626...25,315,511
JBrowse link
G Tert telomerase reverse transcriptase decreases expression ISO pomiferin results in decreased expression of TERT mRNA CTD PMID:20706672 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 increases expression ISO pomiferin results in increased expression of TPT1 mRNA CTD PMID:20706672 NCBI chr15:57,891,680...57,894,504
Ensembl chr15:57,891,680...57,894,504
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO pomiferin results in increased expression of TXN mRNA CTD PMID:20706672 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Tyrp1 tyrosinase-related protein 1 decreases expression ISO pomiferin results in decreased expression of TYRP1 mRNA CTD PMID:20706672 NCBI chr 5:98,387,291...98,406,083
Ensembl chr 5:98,387,291...98,406,083
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    chemical entity 19810
      atom 19808
        nonmetal atom 19683
          oxygen atom 19353
            oxygen molecular entity 19353
              flavonoids 10507
                isoflavonoid 3806
                  isoflavans 220
                    hydroxyisoflavans + 55
                    isoflavan + 11
                    isoflavanones + 184
                    methoxyisoflavan + 3
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic molecule 19514
                              organic cyclic compound 19311
                                organic heterocyclic compound 18425
                                  oxacycle 17200
                                    benzopyran 10149
                                      1-benzopyran 9865
                                        isoflavonoid 3806
                                          isoflavans 220
                                            hydroxyisoflavans + 55
                                            isoflavan + 11
                                            isoflavanones + 184
                                            methoxyisoflavan + 3
paths to the root