Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:isoflavanones
go back to main search page
Accession:CHEBI:38741 term browser browse the term
Definition:Members of the class of isoflavans that have a 3,4-dihydro-3-aryl-2H-1-benzopyran-4-one skeleton and its substituted derivatives.
Synonyms:related_synonym: Formula=C15O2R12;   SMILES=[*]c1c([*])c([*])c(c([*])c1[*])C1([*])C(=O)c2c([*])c([*])c([*])c([*])c2OC1([*])[*]


show annotations for term's descendants           Sort by:
 
alpinumisoflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator affects localization ISO alpinumisoflavone affects the localization of BAX protein CTD PMID:23850732 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO alpinumisoflavone results in decreased expression of BCL2 protein CTD PMID:23850732 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bid BH3 interacting domain death agonist decreases expression ISO alpinumisoflavone results in decreased expression of BID protein CTD PMID:23850732 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
ISO [alpinumisoflavone results in increased expression of FAS protein] which results in increased cleavage of CASP3 protein
alpinumisoflavone results in increased cleavage of CASP3 protein
CTD PMID:23850732 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 increases cleavage
multiple interactions
ISO alpinumisoflavone results in increased cleavage of CASP9 protein
[alpinumisoflavone results in increased expression of FAS protein] which results in increased cleavage of CASP9 protein
CTD PMID:23850732 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex decreases expression ISO alpinumisoflavone results in decreased expression of CHUK protein CTD PMID:23850732 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Cycs cytochrome c, somatic affects localization ISO alpinumisoflavone affects the localization of CYCS protein CTD PMID:23850732 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
G Fas Fas cell surface death receptor multiple interactions
increases expression
ISO [alpinumisoflavone results in increased expression of FAS protein] which results in increased cleavage of CASP3 protein; [alpinumisoflavone results in increased expression of FAS protein] which results in increased cleavage of CASP9 protein CTD PMID:23850732 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO alpinumisoflavone inhibits the reaction [1,10-phenanthroline deficiency results in increased activity of HIF1A protein]; alpinumisoflavone inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein] CTD PMID:19091749 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO alpinumisoflavone results in increased cleavage of PARP1 protein CTD PMID:23850732 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO alpinumisoflavone results in decreased expression of RELA protein CTD PMID:23850732 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO alpinumisoflavone results in decreased phosphorylation of and results in decreased activity of STAT3 protein CTD PMID:23850732 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Stat5a signal transducer and activator of transcription 5A multiple interactions ISO alpinumisoflavone results in decreased phosphorylation of and results in decreased activity of STAT5A protein CTD PMID:23850732 NCBI chr10:88,764,732...88,789,060
Ensembl chr10:88,764,732...88,789,057
JBrowse link
G Stat6 signal transducer and activator of transcription 6 multiple interactions ISO alpinumisoflavone results in decreased phosphorylation of and results in decreased activity of STAT6 protein CTD PMID:23850732 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link
cajanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO [[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP3 protein; [[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP9 protein; [[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein CTD PMID:20638373 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO cajanol results in decreased expression of BCL2 protein
[[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP3 protein; [[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP9 protein; [[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein
CTD PMID:20638373 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO [[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP3 protein
cajanol results in increased activity of CASP3 protein
CTD PMID:20638373 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity
ISO [[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP9 protein
cajanol results in increased activity of CASP9 protein
CTD PMID:20638373 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cycs cytochrome c, somatic affects localization
multiple interactions
ISO cajanol affects the localization of CYCS protein
[[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP3 protein; [[[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein] which results in increased activity of CASP9 protein; [[cajanol results in decreased expression of BCL2 protein] co-treated with [cajanol results in increased expression of BAX protein]] affects the localization of CYCS protein
CTD PMID:20638373 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
JBrowse link
Deguelin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin multiple interactions ISO deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ADM mRNA] CTD PMID:22745725 NCBI chr 1:175,443,189...175,447,260
Ensembl chr 1:175,445,088...175,447,259
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO deguelin results in increased expression of and affects the localization of AIFM1 protein CTD PMID:26592500 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases expression
affects phosphorylation
increases phosphorylation
multiple interactions
decreases phosphorylation
ISO deguelin metabolite results in decreased expression of AKT1 protein; deguelin results in decreased expression of AKT1 protein
deguelin affects the phosphorylation of AKT1 protein
deguelin results in increased phosphorylation of AKT1 protein
deguelin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]
deguelin results in decreased phosphorylation of AKT1 protein
CTD PMID:16288123, PMID:17015749, PMID:18593368, PMID:19139008, PMID:19336726, PMID:19901985, PMID:25322282, PMID:29512685 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Angptl4 angiopoietin-like 4 multiple interactions ISO deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ANGPTL4 mRNA] CTD PMID:22745725 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
JBrowse link
G Ar androgen receptor multiple interactions ISO deguelin results in decreased expression of and affects the localization of AR protein CTD PMID:27255535 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Atm ATM serine/threonine kinase decreases expression ISO deguelin results in decreased expression of ATM mRNA CTD PMID:22227970 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atr ATR serine/threonine kinase decreases expression ISO deguelin results in decreased expression of ATR mRNA CTD PMID:22227970 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947
JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO deguelin results in increased expression of BAK1 protein CTD PMID:26592500 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO deguelin results in increased expression of BAX mRNA; deguelin results in increased expression of BAX protein CTD PMID:26592500, PMID:29512685 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO deguelin results in decreased expression of BCL2 mRNA; deguelin results in decreased expression of BCL2 protein
deguelin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]
CTD PMID:19365708, PMID:22623043, PMID:26592500, PMID:29512685 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
ISO deguelin inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]
deguelin results in decreased expression of BCL2L1 mRNA; deguelin results in decreased expression of BCL2L1 protein
CTD PMID:19365708, PMID:21472727, PMID:22623043, PMID:26592500 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO deguelin inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein] CTD PMID:17209049 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions
decreases expression
ISO deguelin inhibits the reaction [docetaxel results in increased expression of BIRC5 protein]; deguelin inhibits the reaction [Doxorubicin results in increased expression of BIRC5 protein]
deguelin results in decreased expression of BIRC5 protein
CTD PMID:17035597, PMID:18593368, PMID:21472727 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Brca1 BRCA1, DNA repair associated decreases expression ISO deguelin results in decreased expression of BRCA1 mRNA CTD PMID:22227970 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
JBrowse link
G Ca9 carbonic anhydrase 9 multiple interactions ISO deguelin inhibits the reaction [Oxygen deficiency results in increased expression of CA9 mRNA] CTD PMID:22745725 NCBI chr 5:59,008,277...59,015,535
Ensembl chr 5:59,008,933...59,015,528
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases activity
ISO deguelin results in increased cleavage of CASP3 protein
[NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased cleavage of CASP3 protein
deguelin results in increased activity of CASP3 protein
CTD PMID:18593368, PMID:19336726, PMID:22623043, PMID:22986522, PMID:25242579, PMID:26592500 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 multiple interactions ISO [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in decreased expression of and results in increased activity of CASP6 protein CTD PMID:25242579 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp7 caspase 7 increases expression ISO deguelin metabolite results in increased expression of CASP7 protein modified form; deguelin results in increased expression of CASP7 protein modified form CTD PMID:19139008 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 multiple interactions ISO [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in decreased expression of and results in increased activity of CASP8 protein CTD PMID:25242579 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP deguelin promotes the reaction [Oxygen deficiency results in increased expression of CCL2 mRNA] CTD PMID:22745725 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO deguelin inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA] CTD PMID:28529457 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO [deguelin results in increased degradation of CTNNB1 protein] which results in decreased expression of CCND1 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in decreased expression of CCND1 protein]; deguelin inhibits the reaction [TNF protein results in increased expression of CCND1 protein] CTD PMID:15960896, PMID:17015749, PMID:19861542, PMID:21472727 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO deguelin results in decreased expression of CCNE1 mRNA CTD PMID:29512685 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Cd14 CD14 molecule multiple interactions ISO [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased expression of CD14 protein CTD PMID:25242579 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd163 CD163 molecule multiple interactions EXP [deguelin co-treated with Oxygen deficiency] results in increased expression of CD163 mRNA CTD PMID:22745725 NCBI chr 4:156,752,063...156,785,467
Ensembl chr 4:156,752,082...156,785,467
JBrowse link
G Cd44 CD44 molecule (Indian blood group) decreases expression ISO deguelin results in decreased expression of CD44 mRNA; deguelin results in decreased expression of CD44 protein CTD PMID:26884827 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cdh1 cadherin 1 multiple interactions
affects localization
increases expression
ISO deguelin inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein]; deguelin promotes the reaction [CTNNB1 protein binds to CDH1 protein]
deguelin affects the localization of CDH1 protein
deguelin results in increased expression of CDH1 mRNA; deguelin results in increased expression of CDH1 protein
CTD PMID:22986522, PMID:28509438 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Cdh2 cadherin 2 decreases expression ISO deguelin results in decreased expression of CDH2 protein CTD PMID:22986522 NCBI chr18:8,146,971...8,366,037
Ensembl chr18:8,146,971...8,360,684
JBrowse link
G Cdh3 cadherin 3 increases expression ISO deguelin results in increased expression of CDH3 mRNA CTD PMID:19861542 NCBI chr19:38,668,957...38,719,801
Ensembl chr19:38,669,230...38,719,677
JBrowse link
G Cdh7 cadherin 7 increases expression ISO deguelin results in increased expression of CDH7 mRNA CTD PMID:19861542 NCBI chr13:31,081,064...31,228,884
Ensembl chr13:31,081,804...31,231,213
JBrowse link
G Cdh9 cadherin 9 increases expression ISO deguelin results in increased expression of CDH9 mRNA CTD PMID:19861542 NCBI chr 2:66,938,796...67,078,897
Ensembl chr 2:66,940,057...67,078,784
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO deguelin metabolite results in decreased expression of CDK4 protein; deguelin results in decreased expression of CDK4 protein CTD PMID:19139008, PMID:19336726 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
increases expression
ISO [deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of CDKN1A protein; deguelin metabolite results in decreased expression of CDKN1A protein; deguelin results in decreased expression of CDKN1A protein
deguelin results in increased expression of CDKN1A mRNA
CTD PMID:19139008, PMID:25242579, PMID:29512685 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression ISO [deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of CEBPA protein CTD PMID:25242579 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions
decreases expression
ISO deguelin inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA]
deguelin results in decreased expression of CFLAR mRNA
CTD PMID:22623043 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
JBrowse link
G Cldn2 claudin 2 increases expression ISO deguelin results in increased expression of CLDN2 mRNA CTD PMID:19861542 NCBI chr  X:111,122,552...111,133,188
Ensembl chr  X:111,122,552...111,137,769
JBrowse link
G Cldn5 claudin 5 increases expression ISO deguelin results in increased expression of CLDN5 mRNA CTD PMID:19861542 NCBI chr11:86,356,292...86,357,718
Ensembl chr11:86,356,294...86,357,718
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression
increases degradation
ISO [deguelin results in increased degradation of CTNNB1 protein] which results in decreased expression of CCND1 protein; [deguelin results in increased degradation of CTNNB1 protein] which results in decreased expression of MYC protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in decreased expression of CTNNB1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in increased degradation of CTNNB1 protein]; deguelin promotes the reaction [CTNNB1 protein binds to CDH1 protein] CTD PMID:21472727, PMID:22986522 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 multiple interactions ISO deguelin inhibits the reaction [Oxygen deficiency results in increased expression of CXCR4 mRNA] CTD PMID:22745725 NCBI chr13:45,314,952...45,318,856
Ensembl chr13:45,314,933...45,318,878
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO deguelin inhibits the reaction [1-nitropyrene results in increased stability of CYP1A1 mRNA] CTD PMID:19961161 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Dkk2 dickkopf WNT signaling pathway inhibitor 2 decreases expression ISO deguelin results in decreased expression of DKK2 mRNA CTD PMID:19861542 NCBI chr 2:237,148,918...237,240,883
Ensembl chr 2:237,148,941...237,241,350
JBrowse link
G Dkk4 dickkopf WNT signaling pathway inhibitor 4 increases expression ISO deguelin results in increased expression of DKK4 mRNA CTD PMID:19861542 NCBI chr16:74,260,551...74,264,142
Ensembl chr16:74,260,551...74,264,142
JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO deguelin metabolite results in decreased expression of EGFR protein; deguelin results in decreased expression of EGFR protein CTD PMID:19139008 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 multiple interactions ISO deguelin inhibits the reaction [Oxygen deficiency results in increased expression of EGLN3 mRNA] CTD PMID:22745725 NCBI chr 6:75,050,329...75,075,795
Ensembl chr 6:75,050,329...75,075,795
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 increases phosphorylation ISO deguelin results in increased phosphorylation of EIF2AK3 protein CTD PMID:25322282 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases expression
decreases phosphorylation
ISO deguelin metabolite results in decreased expression of EIF4EBP1 protein modified form; deguelin results in decreased expression of EIF4EBP1 protein modified form
deguelin results in decreased phosphorylation of EIF4EBP1 protein
CTD PMID:19139008, PMID:27255535 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Eno2 enolase 2 decreases secretion ISO deguelin results in decreased secretion of ENO2 protein CTD PMID:26884827 NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047
JBrowse link
G Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 multiple interactions ISO deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ENTPD1 protein] CTD PMID:27899277 NCBI chr 1:259,692,020...259,818,922
Ensembl chr 1:259,739,955...259,819,494
JBrowse link
G Epas1 endothelial PAS domain protein 1 decreases expression ISO deguelin results in decreased expression of EPAS1 protein CTD PMID:19336726 NCBI chr 6:10,306,508...10,385,239
Ensembl chr 6:10,306,405...10,387,265
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 decreases expression ISO deguelin results in decreased expression of ERN1 protein CTD PMID:25322282 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO deguelin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOS mRNA] CTD PMID:9270009 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Frzb frizzled-related protein increases expression ISO deguelin results in increased expression of FRZB mRNA CTD PMID:19861542 NCBI chr 3:67,635,604...67,668,772
Ensembl chr 3:67,635,607...67,668,772
JBrowse link
G Fzd10 frizzled class receptor 10 increases expression ISO deguelin results in increased expression of FZD10 mRNA CTD PMID:19861542 NCBI chr12:31,757,407...31,760,604
Ensembl chr12:31,757,407...31,760,604
JBrowse link
G Fzd4 frizzled class receptor 4 increases expression ISO deguelin results in increased expression of FZD4 mRNA CTD PMID:19861542 NCBI chr 1:153,589,471...153,598,376
Ensembl chr 1:153,589,471...153,598,375
JBrowse link
G Fzd8 frizzled class receptor 8 increases expression ISO deguelin results in increased expression of FZD8 mRNA CTD PMID:19861542 NCBI chr17:62,259,910...62,267,239
Ensembl chr17:62,262,129...62,265,113
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases phosphorylation ISO deguelin results in decreased phosphorylation of GSK3B protein CTD PMID:19336726, PMID:21472727 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases degradation
multiple interactions
ISO deguelin results in increased degradation of HIF1A protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in increased degradation of HIF1A protein]; deguelin inhibits the reaction [IGF1 protein results in increased expression of HIF1A protein]; deguelin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; deguelin metabolite inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]
CTD PMID:17764071, PMID:18575727, PMID:19139008, PMID:22745725, PMID:27899277 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ICAM1 mRNA]; deguelin inhibits the reaction [Oxygen deficiency results in increased expression of ICAM1 protein]; deguelin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:17015749, PMID:22745725 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifng interferon gamma multiple interactions EXP
ISO
deguelin inhibits the reaction [Perfadex results in increased expression of IFNG protein]
[deguelin co-treated with OVAL protein] results in increased expression of IFNG protein
CTD PMID:22745725, PMID:28529457 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO deguelin inhibits the reaction [IGF1 protein results in increased expression of HIF1A protein]; deguelin inhibits the reaction [IGF1 protein results in increased expression of VEGFA mRNA] CTD PMID:17764071 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf1r insulin-like growth factor 1 receptor decreases expression ISO deguelin metabolite results in decreased expression of IGF1R protein; deguelin results in decreased expression of IGF1R protein CTD PMID:19139008 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Ihh Indian hedgehog signaling molecule increases expression ISO deguelin results in increased expression of IHH mRNA CTD PMID:19861542 NCBI chr 9:82,208,223...82,214,440
Ensembl chr 9:82,208,223...82,214,440
JBrowse link
G Il10 interleukin 10 multiple interactions ISO deguelin inhibits the reaction [Oxygen deficiency results in increased expression of IL10 mRNA] CTD PMID:22745725 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il13 interleukin 13 multiple interactions ISO deguelin inhibits the reaction [OVAL protein results in increased expression of IL13 protein] CTD PMID:28529457 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il4 interleukin 4 multiple interactions EXP
ISO
deguelin inhibits the reaction [Oxygen deficiency results in decreased expression of IL4 mRNA]
deguelin inhibits the reaction [OVAL protein results in increased expression of IL4 mRNA]; deguelin inhibits the reaction [OVAL protein results in increased expression of IL4 protein]
CTD PMID:22745725, PMID:28529457 NCBI chr10:38,963,979...38,969,531
Ensembl chr10:38,963,979...38,969,531
JBrowse link
G Il5 interleukin 5 multiple interactions ISO deguelin inhibits the reaction [OVAL protein results in increased expression of IL5 protein] CTD PMID:28529457 NCBI chr10:39,066,716...39,069,587
Ensembl chr10:39,066,716...39,069,587
JBrowse link
G Il6 interleukin 6 multiple interactions EXP deguelin inhibits the reaction [Perfadex results in decreased expression of IL6 protein] CTD PMID:22745725 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased expression of ITGAM protein CTD PMID:25242579 NCBI chr 1:199,495,312...199,545,738
Ensembl chr 1:199,495,298...199,623,960
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit increases phosphorylation ISO deguelin results in increased phosphorylation of JUN protein CTD PMID:25322282 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Kdr kinase insert domain receptor decreases expression ISO deguelin metabolite results in decreased expression of KDR protein; deguelin results in decreased expression of KDR protein CTD PMID:19139008 NCBI chr14:34,727,677...34,787,127
Ensembl chr14:34,727,623...34,787,183
JBrowse link
G Krt18 keratin 18 increases expression
multiple interactions
ISO deguelin results in increased expression of KRT18 protein
deguelin inhibits the reaction [TGFB1 protein results in decreased expression of KRT18 protein]
CTD PMID:22986522 NCBI chr 7:143,629,455...143,633,131
Ensembl chr 7:143,629,455...143,633,131
JBrowse link
G Lox lysyl oxidase multiple interactions ISO deguelin inhibits the reaction [Oxygen deficiency results in increased expression of LOX mRNA] CTD PMID:22745725 NCBI chr18:47,500,320...47,577,819
Ensembl chr18:47,500,330...47,577,819
JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 decreases expression ISO deguelin metabolite results in decreased expression of MAP2K1 protein; deguelin results in decreased expression of MAP2K1 protein CTD PMID:19139008, PMID:19336726 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 decreases expression ISO deguelin results in decreased expression of MAP2K2 protein CTD PMID:19336726 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489
JBrowse link
G Map2k7 mitogen activated protein kinase kinase 7 decreases expression ISO deguelin results in decreased expression of MAP2K7 protein CTD PMID:25322282 NCBI chr12:2,546,278...2,555,310
Ensembl chr12:2,548,218...2,555,164
JBrowse link
G Map3k3 mitogen activated protein kinase kinase kinase 3 affects expression ISO deguelin affects the expression of MAP3K3 protein CTD PMID:25322282 NCBI chr10:94,280,703...94,349,372
Ensembl chr10:94,280,703...94,349,368
JBrowse link
G Mapk1 mitogen activated protein kinase 1 affects phosphorylation ISO deguelin affects the phosphorylation of MAPK1 protein CTD PMID:25322282 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 affects phosphorylation ISO deguelin affects the phosphorylation of MAPK3 protein CTD PMID:25322282 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO deguelin results in decreased expression of MCL1 protein CTD PMID:21472727 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mgmt O-6-methylguanine-DNA methyltransferase decreases expression ISO deguelin results in decreased expression of MGMT mRNA CTD PMID:22227970 NCBI chr 1:209,237,255...209,464,189
Ensembl chr 1:209,237,233...209,464,190
JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO deguelin results in decreased expression of MKI67 protein CTD PMID:22623043 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
JBrowse link
G Mmp1 matrix metallopeptidase 1 decreases expression ISO deguelin results in decreased expression of MMP1 protein CTD PMID:25322282 NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
JBrowse link
G Mmp13 matrix metallopeptidase 13 decreases expression ISO deguelin results in decreased expression of MMP13 protein CTD PMID:25322282 NCBI chr 8:5,522,739...5,533,018
Ensembl chr 8:5,522,739...5,533,018
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
ISO deguelin results in decreased expression of and results in decreased activity of MMP2 protein
deguelin results in decreased expression of MMP2 mRNA; deguelin results in decreased expression of MMP2 protein
CTD PMID:25322282, PMID:26884827 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO deguelin results in decreased expression of MMP7 mRNA CTD PMID:25322282 NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
decreases activity
ISO deguelin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]
deguelin results in decreased expression of MMP9 mRNA; deguelin results in decreased expression of MMP9 protein
deguelin results in decreased activity of MMP9 protein
CTD PMID:17015749, PMID:25322282, PMID:26884827 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mrc1 mannose receptor, C type 1 multiple interactions EXP deguelin promotes the reaction [Oxygen deficiency results in increased expression of MRC1 mRNA] CTD PMID:22745725 NCBI chr17:81,352,700...81,433,743
Ensembl chr17:81,352,700...81,433,743
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases expression
decreases phosphorylation
ISO deguelin metabolite results in decreased expression of MTOR protein; deguelin results in decreased expression of MTOR protein
deguelin results in decreased phosphorylation of MTOR protein
CTD PMID:19139008, PMID:27255535 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions ISO deguelin inhibits the reaction [OVAL protein results in increased expression of MUC5AC mRNA] CTD PMID:28529457 NCBI chr 1:214,725,482...214,756,653 JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions
decreases expression
ISO [deguelin results in increased degradation of CTNNB1 protein] which results in decreased expression of MYC protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [deguelin results in decreased expression of MYC protein]; deguelin inhibits the reaction [TNF protein results in increased expression of MYC protein]
deguelin inhibits the reaction [MYC protein results in increased activity of ODC1 protein]
CTD PMID:9270009, PMID:17015749, PMID:21472727 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Ncoa3 nuclear receptor coactivator 3 decreases expression ISO deguelin results in decreased expression of NCOA3 mRNA; deguelin results in decreased expression of NCOA3 protein CTD PMID:19365708 NCBI chr 3:162,692,176...162,788,582
Ensembl chr 3:162,692,185...162,787,548
JBrowse link
G Nek2 NIMA-related kinase 2 decreases expression ISO deguelin results in decreased expression of NEK2 mRNA; deguelin results in decreased expression of NEK2 protein CTD PMID:28509438 NCBI chr13:110,511,546...110,524,750
Ensembl chr13:110,511,668...110,522,769
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO deguelin inhibits the reaction [TNF protein results in increased degradation of and results in increased phosphorylation of NFKBIA protein]; deguelin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
deguelin inhibits the reaction [OVAL protein results in increased degradation of and results in increased phosphorylation of NFKBIA protein]
CTD PMID:17015749, PMID:22623043, PMID:28529457 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression
multiple interactions
ISO deguelin results in decreased expression of NOS2 protein
deguelin inhibits the reaction [OVAL protein results in increased expression of NOS2 mRNA]
CTD PMID:25322282, PMID:28529457 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 decreases expression ISO deguelin results in decreased expression of NOS3 protein CTD PMID:19336726 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Npm1 nucleophosmin 1 decreases expression
multiple interactions
increases response to substance
ISO [deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of CDKN1A protein; [deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of CEBPA protein; [deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of TP53 protein
[NPM1 protein mutant form results in increased susceptibility to deguelin] which results in decreased expression of and results in increased activity of CASP6 protein; [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in decreased expression of and results in increased activity of CASP8 protein; [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased cleavage of CASP3 protein; [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased cleavage of PARP1 protein; [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased expression of CD14 protein; [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased expression of ITGAM protein
CTD PMID:25242579 NCBI chr10:18,080,949...18,091,062
Ensembl chr10:18,080,950...18,090,950
JBrowse link
G Nt5e 5' nucleotidase, ecto multiple interactions ISO deguelin inhibits the reaction [Oxygen deficiency results in increased expression of NT5E protein] CTD PMID:27899277 NCBI chr 8:95,969,002...96,012,733
Ensembl chr 8:95,968,652...96,012,696
JBrowse link
G Nup98 nucleoporin 98 and 96 precursor decreases expression ISO deguelin results in decreased expression of NUP98 mRNA; deguelin results in decreased expression of NUP98 protein CTD PMID:17490514 NCBI chr 1:167,213,866...167,308,851
Ensembl chr 1:167,213,866...167,308,851
JBrowse link
G Odc1 ornithine decarboxylase 1 increases activity
multiple interactions
ISO deguelin results in increased activity of ODC1 protein
deguelin inhibits the reaction [MYC protein results in increased activity of ODC1 protein]; deguelin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of ODC1 mRNA]
CTD PMID:9270009, PMID:9834970 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
increases expression
ISO [NPM1 protein mutant form results in increased susceptibility to deguelin] which results in increased cleavage of PARP1 protein; deguelin inhibits the reaction [TNF protein results in increased cleavage of PARP1 protein]
deguelin results in increased cleavage of PARP1 protein
deguelin metabolite results in increased expression of PARP1 protein modified form; deguelin results in increased expression of PARP1 protein modified form
CTD PMID:17015749, PMID:17035597, PMID:19139008, PMID:22986522, PMID:25242579 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 decreases expression ISO deguelin metabolite results in decreased expression of PDK1 protein; deguelin results in decreased expression of PDK1 protein CTD PMID:19139008 NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha decreases expression ISO deguelin metabolite results in decreased expression of PIK3CA protein; deguelin results in decreased expression of PIK3CA protein CTD PMID:19139008 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Plcg1 phospholipase C, gamma 1 increases phosphorylation ISO deguelin results in increased phosphorylation of PLCG1 protein CTD PMID:19901985 NCBI chr 3:156,727,642...156,758,307
Ensembl chr 3:156,727,642...156,758,307
JBrowse link
G Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B multiple interactions ISO deguelin inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein] CTD PMID:17209049 NCBI chr10:86,303,727...86,312,770
Ensembl chr10:86,303,727...86,312,762
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 increases phosphorylation ISO deguelin results in increased phosphorylation of PRKAA1 protein CTD PMID:19901985 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit decreases expression ISO deguelin results in decreased expression of PRKDC mRNA CTD PMID:22227970 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
ISO deguelin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]
deguelin results in decreased expression of PTGS2 protein
CTD PMID:17015749, PMID:25322282 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases expression ISO deguelin results in decreased expression of PTK2 protein CTD PMID:25322282 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
JBrowse link
G Rac1 Rac family small GTPase 1 decreases expression ISO deguelin results in decreased expression of RAC1 protein CTD PMID:26884827 NCBI chr12:13,090,316...13,111,841
Ensembl chr12:13,090,172...13,111,873
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases expression ISO deguelin results in decreased expression of RB1 protein CTD PMID:15960896 NCBI chr15:55,081,582...55,209,060
Ensembl chr15:55,083,140...55,209,342
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression
multiple interactions
decreases phosphorylation
ISO deguelin results in decreased expression of RELA mRNA; deguelin results in decreased expression of RELA protein
deguelin inhibits the reaction [OVAL protein affects the localization of and results in increased phosphorylation of RELA protein]
deguelin results in decreased phosphorylation of RELA protein
deguelin inhibits the reaction [TNF protein affects the localization of and results in increased phosphorylation of RELA protein]; deguelin inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]
CTD PMID:17015749, PMID:19365708, PMID:22623043, PMID:28529457 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rhoa ras homolog family member A decreases expression ISO deguelin results in decreased expression of RHOA mRNA; deguelin results in decreased expression of RHOA protein CTD PMID:25322282 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rock1 Rho-associated coiled-coil containing protein kinase 1 decreases expression ISO deguelin results in decreased expression of ROCK1 protein CTD PMID:25322282, PMID:26884827 NCBI chr18:1,273,490...1,390,790
Ensembl chr18:1,273,453...1,390,190
JBrowse link
G Rps6 ribosomal protein S6 decreases expression
decreases phosphorylation
ISO deguelin metabolite results in decreased expression of RPS6 protein; deguelin metabolite results in decreased expression of RPS6 protein modified form; deguelin results in decreased expression of RPS6 protein; deguelin results in decreased expression of RPS6 protein modified form
deguelin results in decreased phosphorylation of RPS6 protein
CTD PMID:19139008, PMID:27255535 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases expression
decreases phosphorylation
ISO deguelin metabolite results in decreased expression of RPS6KB1 protein; deguelin results in decreased expression of RPS6KB1 protein
deguelin results in decreased phosphorylation of RPS6KB1 protein
CTD PMID:19139008, PMID:27255535 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Sele selectin E multiple interactions ISO deguelin inhibits the reaction [TNF protein results in increased expression of SELE mRNA]
deguelin inhibits the reaction [OVAL protein results in increased expression of SELE mRNA]
CTD PMID:28529457 NCBI chr13:82,355,234...82,365,323
Ensembl chr13:82,355,471...82,365,341
JBrowse link
G Serpinb3 serpin family B member 3 decreases secretion ISO deguelin results in decreased secretion of SERPINB3 protein CTD PMID:26884827 NCBI chr13:27,186,701...27,193,211
Ensembl chr13:27,187,130...27,192,592
JBrowse link
G Sfrp2 secreted frizzled-related protein 2 decreases expression ISO deguelin results in decreased expression of SFRP2 mRNA CTD PMID:19861542 NCBI chr 2:182,723,732...182,731,277
Ensembl chr 2:182,723,854...182,731,764
JBrowse link
G Smad3 SMAD family member 3 decreases phosphorylation ISO deguelin results in decreased phosphorylation of SMAD3 protein CTD PMID:22986522 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Smad4 SMAD family member 4 multiple interactions ISO deguelin inhibits the reaction [TGFB1 protein affects the localization of SMAD4 protein] CTD PMID:22986522 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression
multiple interactions
ISO deguelin results in decreased expression of SNAI1 mRNA; deguelin results in decreased expression of SNAI1 protein
deguelin inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]
CTD PMID:19861542, PMID:22986522 NCBI chr 3:164,274,710...164,279,199
Ensembl chr 3:164,274,710...164,279,378
JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 decreases expression ISO deguelin results in decreased expression of SOS1 protein CTD PMID:25322282 NCBI chr 6:3,105,443...3,182,977
Ensembl chr 6:3,104,861...3,182,996
JBrowse link
G Sox14 SRY-box transcription factor 14 increases expression ISO deguelin results in increased expression of SOX14 mRNA CTD PMID:19861542 NCBI chr 8:108,107,865...108,109,801
Ensembl chr 8:108,107,865...108,109,801
JBrowse link
G Sox30 SRY-box transcription factor 30 increases expression ISO deguelin results in increased expression of SOX30 mRNA CTD PMID:19861542 NCBI chr10:31,074,251...31,102,211
Ensembl chr10:31,074,251...31,102,169
JBrowse link
G Sox5 SRY-box transcription factor 5 increases expression ISO deguelin results in increased expression of SOX5 mRNA CTD PMID:19861542 NCBI chr 4:178,062,267...179,031,991
Ensembl chr 4:178,066,165...178,441,547
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase increases activity ISO deguelin metabolite results in increased activity of SRC protein; deguelin results in increased activity of SRC protein CTD PMID:19139008 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642
JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases activity ISO deguelin metabolite results in increased activity of STAT3 protein; deguelin results in increased activity of STAT3 protein CTD PMID:19139008 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
JBrowse link
G Stat6 signal transducer and activator of transcription 6 increases phosphorylation ISO deguelin metabolite results in increased phosphorylation of STAT6 protein; deguelin results in increased phosphorylation of STAT6 protein CTD PMID:19139008 NCBI chr 7:70,946,228...70,963,542
Ensembl chr 7:70,946,228...70,964,484
JBrowse link
G Sts steroid sulfatase multiple interactions ISO deguelin inhibits the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:45,420,418...45,428,748
Ensembl chr  X:45,420,596...45,428,750
JBrowse link
G Tcf4 transcription factor 4 increases expression ISO deguelin results in increased expression of TCF4 mRNA CTD PMID:19861542 NCBI chr18:65,285,320...65,507,983
Ensembl chr18:65,155,685...65,507,977
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO deguelin inhibits the reaction [TGFB1 protein affects the localization of SMAD4 protein]; deguelin inhibits the reaction [TGFB1 protein results in decreased expression of KRT18 protein]; deguelin inhibits the reaction [TGFB1 protein results in increased expression of CDH1 protein]; deguelin inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein] CTD PMID:22986522 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO deguelin results in increased expression of TIMP1 protein CTD PMID:25322282 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO deguelin results in increased expression of TIMP2 protein CTD PMID:25322282 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO deguelin inhibits the reaction [TNF protein affects the localization of and results in increased phosphorylation of RELA protein]; deguelin inhibits the reaction [TNF protein results in increased cleavage of PARP1 protein]; deguelin inhibits the reaction [TNF protein results in increased degradation of and results in increased phosphorylation of NFKBIA protein]; deguelin inhibits the reaction [TNF protein results in increased expression of BCL2 mRNA]; deguelin inhibits the reaction [TNF protein results in increased expression of BCL2L1 mRNA]; deguelin inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; deguelin inhibits the reaction [TNF protein results in increased expression of CCND1 protein]; deguelin inhibits the reaction [TNF protein results in increased expression of CFLAR mRNA]; deguelin inhibits the reaction [TNF protein results in increased expression of CXCL8 mRNA]; deguelin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; deguelin inhibits the reaction [TNF protein results in increased expression of MMP9 protein]; deguelin inhibits the reaction [TNF protein results in increased expression of MUC mRNA]; deguelin inhibits the reaction [TNF protein results in increased expression of MYC protein]; deguelin inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]; deguelin inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; deguelin inhibits the reaction [TNF protein results in increased expression of TSLP mRNA]; deguelin inhibits the reaction [TNF protein results in increased phosphorylation of and affects the localization of RELA protein]; deguelin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; deguelin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:17015749, PMID:22623043, PMID:28529457 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 decreases expression ISO [deguelin results in decreased expression of NPM1 protein mutant form] which results in decreased expression of TP53 protein; deguelin results in decreased expression of TP53 mRNA CTD PMID:22227970, PMID:25242579 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO deguelin inhibits the reaction [TNF protein results in increased expression of TSLP mRNA]
deguelin inhibits the reaction [OVAL protein results in increased expression of TSLP mRNA]; deguelin inhibits the reaction [OVAL protein results in increased expression of TSLP protein]
CTD PMID:28529457 NCBI chr18:25,613,601...25,618,066
Ensembl chr18:25,613,831...25,617,361
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions
decreases expression
decreases response to substance
ISO deguelin inhibits the reaction [IGF1 protein results in increased expression of VEGFA mRNA]; deguelin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; deguelin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA protein]
deguelin results in decreased expression of VEGFA protein
VEGFA protein results in decreased susceptibility to deguelin
CTD PMID:17764071, PMID:18575727, PMID:22623043, PMID:22745725, PMID:25322282 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Vim vimentin decreases expression ISO deguelin results in decreased expression of VIM protein CTD PMID:22986522, PMID:28509438 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
JBrowse link
G Wif1 Wnt inhibitory factor 1 increases expression ISO deguelin results in increased expression of WIF1 mRNA CTD PMID:19861542 NCBI chr 7:63,094,955...63,165,158
Ensembl chr 7:63,094,911...63,165,159
JBrowse link
G Wnt10a Wnt family member 10A increases expression ISO deguelin results in increased expression of WNT10A mRNA CTD PMID:19861542 NCBI chr 9:82,053,581...82,066,047
Ensembl chr 9:82,053,581...82,066,047
JBrowse link
G Wnt11 Wnt family member 11 increases expression ISO deguelin results in increased expression of WNT11 mRNA CTD PMID:19861542 NCBI chr 1:163,794,136...163,813,756
Ensembl chr 1:163,797,660...163,813,756
JBrowse link
G Wnt2 Wnt family member 2 increases expression ISO deguelin results in increased expression of WNT2 mRNA CTD PMID:19861542 NCBI chr 4:45,286,845...45,332,899
Ensembl chr 4:45,292,437...45,332,420
JBrowse link
G Wnt2b Wnt family member 2B decreases expression ISO deguelin results in decreased expression of WNT2B mRNA CTD PMID:19861542 NCBI chr 2:207,433,771...207,457,094
Ensembl chr 2:207,440,886...207,455,258
JBrowse link
G Wnt3a Wnt family member 3A decreases expression ISO deguelin results in decreased expression of WNT3A mRNA CTD PMID:19861542 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035
JBrowse link
G Wnt9a Wnt family member 9A decreases expression ISO deguelin results in decreased expression of WNT9A mRNA CTD PMID:19861542 NCBI chr10:45,659,045...45,686,103
Ensembl chr10:45,659,143...45,681,393
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO deguelin results in decreased expression of XIAP protein CTD PMID:17035597 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link
Osajin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acly ATP citrate lyase increases expression ISO osajin results in increased expression of ACLY mRNA CTD PMID:20706672 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Aqp1 aquaporin 1 increases expression ISO osajin results in increased expression of AQP1 mRNA CTD PMID:20706672 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) increases expression ISO osajin results in increased expression of AQP3 mRNA CTD PMID:20706672 NCBI chr 5:57,423,735...57,429,252
Ensembl chr 5:57,423,734...57,429,245
JBrowse link
G Ar androgen receptor decreases expression ISO osajin results in decreased expression of AR mRNA CTD PMID:20706672 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO osajin results in increased expression of CD44 mRNA CTD PMID:20706672 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cdh1 cadherin 1 increases expression ISO osajin results in increased expression of CDH1 mRNA CTD PMID:20706672 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO osajin results in increased expression of COL1A1 mRNA CTD PMID:20706672 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cygb cytoglobin decreases expression ISO osajin results in decreased expression of CYGB mRNA CTD PMID:20706672 NCBI chr10:105,618,325...105,628,091
Ensembl chr10:105,618,326...105,628,091
JBrowse link
G Dsg3 desmoglein 3 decreases expression ISO osajin results in decreased expression of DSG3 mRNA CTD PMID:20706672 NCBI chr18:15,652,948...15,688,605
Ensembl chr18:15,650,526...15,688,284
JBrowse link
G Egf epidermal growth factor decreases expression ISO osajin results in decreased expression of EGF mRNA CTD PMID:20706672 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Esr2 estrogen receptor 2 decreases expression ISO osajin results in decreased expression of ESR2 mRNA CTD PMID:20706672 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression ISO osajin results in increased expression of FGF1 mRNA CTD PMID:20706672 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Grn granulin precursor increases expression ISO osajin results in increased expression of GRN mRNA CTD PMID:20706672 NCBI chr10:90,377,103...90,383,207
Ensembl chr10:90,376,933...90,383,205
JBrowse link
G Has1 hyaluronan synthase 1 decreases expression ISO osajin results in decreased expression of HAS1 mRNA CTD PMID:20706672 NCBI chr 1:59,720,612...59,732,409
Ensembl chr 1:59,720,612...59,732,409
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO osajin results in increased expression of HSPB1 mRNA CTD PMID:20706672 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO osajin results in decreased expression of IGF1 mRNA CTD PMID:20706672 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO osajin results in decreased expression of IL1A mRNA CTD PMID:20706672 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Kl Klotho decreases expression ISO osajin results in decreased expression of KL mRNA CTD PMID:20706672 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551
JBrowse link
G Krt5 keratin 5 increases expression ISO osajin results in increased expression of KRT5 mRNA CTD PMID:20706672 NCBI chr 7:143,320,142...143,324,536
Ensembl chr 7:143,316,920...143,453,546
JBrowse link
G Mc1r melanocortin 1 receptor decreases expression ISO osajin results in decreased expression of MC1R mRNA CTD PMID:20706672 NCBI chr19:56,215,420...56,219,987 JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I increases expression ISO osajin results in increased expression of COX1 mRNA CTD PMID:20706672 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression ISO osajin results in decreased expression of NOS2 mRNA CTD PMID:20706672 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO osajin results in increased expression of NOS3 mRNA CTD PMID:20706672 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Pgr progesterone receptor decreases expression ISO osajin results in decreased expression of PGR mRNA CTD PMID:20706672 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 increases expression ISO osajin results in increased expression of PLOD3 mRNA CTD PMID:20706672 NCBI chr12:22,716,421...22,726,982
Ensembl chr12:22,716,423...22,726,982
JBrowse link
G Pomc proopiomelanocortin decreases expression ISO osajin results in decreased expression of POMC mRNA CTD PMID:20706672 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO osajin results in decreased expression of PPARG mRNA CTD PMID:20706672 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptger1 prostaglandin E receptor 1 decreases expression ISO osajin results in decreased expression of PTGER1 mRNA CTD PMID:20706672 NCBI chr19:24,799,422...24,803,373
Ensembl chr19:24,800,072...24,803,373
JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein decreases expression ISO osajin results in decreased expression of RAD23A mRNA CTD PMID:20706672 NCBI chr19:25,949,488...25,956,677
Ensembl chr19:25,949,490...25,955,391
JBrowse link
G Rara retinoic acid receptor, alpha increases expression ISO osajin results in increased expression of RARA mRNA CTD PMID:20706672 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Rxra retinoid X receptor alpha decreases expression ISO osajin results in decreased expression of RXRA mRNA CTD PMID:20706672 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Sod3 superoxide dismutase 3 decreases expression ISO osajin results in decreased expression of SOD3 mRNA CTD PMID:20706672 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 decreases expression ISO osajin results in decreased expression of SRD5A2 mRNA CTD PMID:20706672 NCBI chr 6:25,279,635...25,315,501
Ensembl chr 6:25,279,626...25,315,511
JBrowse link
G Tert telomerase reverse transcriptase decreases expression ISO osajin results in decreased expression of TERT mRNA CTD PMID:20706672 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 increases expression ISO osajin results in increased expression of TPT1 mRNA CTD PMID:20706672 NCBI chr15:57,891,680...57,894,504
Ensembl chr15:57,891,680...57,894,504
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO osajin results in increased expression of TXN mRNA CTD PMID:20706672 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
Pomiferin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acly ATP citrate lyase increases expression ISO pomiferin results in increased expression of ACLY mRNA CTD PMID:20706672 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Aqp1 aquaporin 1 increases expression ISO pomiferin results in increased expression of AQP1 mRNA CTD PMID:20706672 NCBI chr 4:85,551,503...85,563,683
Ensembl chr 4:85,551,502...85,569,360
JBrowse link
G Aqp3 aquaporin 3 (Gill blood group) increases expression ISO pomiferin results in increased expression of AQP3 mRNA CTD PMID:20706672 NCBI chr 5:57,423,735...57,429,252
Ensembl chr 5:57,423,734...57,429,245
JBrowse link
G Ar androgen receptor decreases expression ISO pomiferin results in decreased expression of AR mRNA CTD PMID:20706672 NCBI chr  X:67,656,253...67,828,998
Ensembl chr  X:67,656,253...67,829,026
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO pomiferin results in increased expression of CD44 mRNA CTD PMID:20706672 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
JBrowse link
G Cdh1 cadherin 1 increases expression ISO pomiferin results in increased expression of CDH1 mRNA CTD PMID:20706672 NCBI chr19:38,768,467...38,838,395
Ensembl chr19:38,768,467...38,838,395
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO pomiferin results in increased expression of COL1A1 mRNA CTD PMID:20706672 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
JBrowse link
G Cygb cytoglobin decreases expression ISO pomiferin results in decreased expression of CYGB mRNA CTD PMID:20706672 NCBI chr10:105,618,325...105,628,091
Ensembl chr10:105,618,326...105,628,091
JBrowse link
G Egf epidermal growth factor decreases expression ISO pomiferin results in decreased expression of EGF mRNA CTD PMID:20706672 NCBI chr 2:68,820,616...68,895,537 JBrowse link
G Esr2 estrogen receptor 2 decreases expression ISO pomiferin results in decreased expression of ESR2 mRNA CTD PMID:20706672 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fbn1 fibrillin 1 decreases expression ISO pomiferin results in decreased expression of FBN1 mRNA CTD PMID:20706672 NCBI chr 3:117,569,708...117,766,160
Ensembl chr 3:117,569,697...117,766,120
JBrowse link
G Fgf1 fibroblast growth factor 1 increases expression ISO pomiferin results in increased expression of FGF1 mRNA CTD PMID:20706672 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Grn granulin precursor increases expression ISO pomiferin results in increased expression of GRN mRNA CTD PMID:20706672 NCBI chr10:90,377,103...90,383,207
Ensembl chr10:90,376,933...90,383,205
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 increases expression ISO pomiferin results in increased expression of HSPB1 mRNA CTD PMID:20706672 NCBI chr12:23,839,390...23,841,051
Ensembl chr12:23,839,399...23,841,049
JBrowse link
G Igf1 insulin-like growth factor 1 decreases expression ISO pomiferin results in decreased expression of IGF1 mRNA CTD PMID:20706672 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Kl Klotho decreases expression ISO pomiferin results in decreased expression of KL mRNA CTD PMID:20706672 NCBI chr12:942,974...987,206
Ensembl chr12:943,006...987,551
JBrowse link
G Krt5 keratin 5 increases expression ISO pomiferin results in increased expression of KRT5 mRNA CTD PMID:20706672 NCBI chr 7:143,320,142...143,324,536
Ensembl chr 7:143,316,920...143,453,546
JBrowse link
G Mc1r melanocortin 1 receptor decreases expression ISO pomiferin results in decreased expression of MC1R mRNA CTD PMID:20706672 NCBI chr19:56,215,420...56,219,987 JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I increases expression ISO pomiferin results in increased expression of COX1 mRNA CTD PMID:20706672 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression ISO pomiferin results in increased expression of NOS3 mRNA CTD PMID:20706672 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Pgr progesterone receptor decreases expression ISO pomiferin results in decreased expression of PGR mRNA CTD PMID:20706672 NCBI chr 8:7,128,656...7,187,796
Ensembl chr 8:7,128,656...7,187,796
JBrowse link
G Plod3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 increases expression ISO pomiferin results in increased expression of PLOD3 mRNA CTD PMID:20706672 NCBI chr12:22,716,421...22,726,982
Ensembl chr12:22,716,423...22,726,982
JBrowse link
G Pomc proopiomelanocortin decreases expression ISO pomiferin results in decreased expression of POMC mRNA CTD PMID:20706672 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression ISO pomiferin results in decreased expression of PPARG mRNA CTD PMID:20706672 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ptger1 prostaglandin E receptor 1 decreases expression ISO pomiferin results in decreased expression of PTGER1 mRNA CTD PMID:20706672 NCBI chr19:24,799,422...24,803,373
Ensembl chr19:24,800,072...24,803,373
JBrowse link
G Rad23a RAD23 homolog A, nucleotide excision repair protein decreases expression ISO pomiferin results in decreased expression of RAD23A mRNA CTD PMID:20706672 NCBI chr19:25,949,488...25,956,677
Ensembl chr19:25,949,490...25,955,391
JBrowse link
G Rara retinoic acid receptor, alpha increases expression ISO pomiferin results in increased expression of RARA mRNA CTD PMID:20706672 NCBI chr10:86,838,819...86,884,224
Ensembl chr10:86,860,685...86,884,210
JBrowse link
G Sod3 superoxide dismutase 3 decreases expression ISO pomiferin results in decreased expression of SOD3 mRNA CTD PMID:20706672 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Srd5a2 steroid 5 alpha-reductase 2 decreases expression ISO pomiferin results in decreased expression of SRD5A2 mRNA CTD PMID:20706672 NCBI chr 6:25,279,635...25,315,501
Ensembl chr 6:25,279,626...25,315,511
JBrowse link
G Tert telomerase reverse transcriptase decreases expression ISO pomiferin results in decreased expression of TERT mRNA CTD PMID:20706672 NCBI chr 1:32,250,876...32,275,330
Ensembl chr 1:32,251,714...32,272,476
JBrowse link
G Tpt1 tumor protein, translationally-controlled 1 increases expression ISO pomiferin results in increased expression of TPT1 mRNA CTD PMID:20706672 NCBI chr15:57,891,680...57,894,504
Ensembl chr15:57,891,680...57,894,504
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO pomiferin results in increased expression of TXN mRNA CTD PMID:20706672 NCBI chr 5:75,049,735...75,057,731
Ensembl chr 5:75,049,747...75,057,752
JBrowse link
G Tyrp1 tyrosinase-related protein 1 decreases expression ISO pomiferin results in decreased expression of TYRP1 mRNA CTD PMID:20706672 NCBI chr 5:98,387,291...98,406,083
Ensembl chr 5:98,387,291...98,406,083
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    chemical entity 19787
      group 19698
        inorganic group 19148
          oxo group 18391
            organic oxo compound 18391
              carbonyl compound 18391
                ketone 16144
                  cyclic ketone 13813
                    isoflavanones 184
                      (+)-Sophorol 0
                      (+-)-5-Deoxykievitone 0
                      (-)-Sophorol 0
                      3-(1,3-benzodioxol-5-yl)-5,7-dihydroxy-6-(3-methylbut-2-enyl)-1-benzopyran-4-one 0
                      7-(1,3-benzodioxol-5-yl)-5-methoxy-2,2-dimethyl-6-pyrano[3,2-g][1]benzopyranone 0
                      Cyclokievitone 0
                      Deguelin 146
                      Euchretin A 0
                      Lachnoisoflavones A, (rac)- 0
                      Lachnoisoflavones B 0
                      Licoagroisoflavone 0
                      Millettone 0
                      Osajin 36
                      Pomiferin 33
                      Sumatrol 0
                      Toxicarol 0
                      alpinumisoflavone 14
                      hydroxyisoflavanone + 5
                      isoflavanone + 5
                      methoxyisoflavanone + 5
                      sophoraisoflavanone B 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  oxacycle 17185
                                    benzopyran 10135
                                      1-benzopyran 9851
                                        isoflavonoid 3793
                                          isoflavans 220
                                            isoflavanones 184
                                              (+)-Sophorol 0
                                              (+-)-5-Deoxykievitone 0
                                              (-)-Sophorol 0
                                              3-(1,3-benzodioxol-5-yl)-5,7-dihydroxy-6-(3-methylbut-2-enyl)-1-benzopyran-4-one 0
                                              7-(1,3-benzodioxol-5-yl)-5-methoxy-2,2-dimethyl-6-pyrano[3,2-g][1]benzopyranone 0
                                              Cyclokievitone 0
                                              Deguelin 146
                                              Euchretin A 0
                                              Lachnoisoflavones A, (rac)- 0
                                              Lachnoisoflavones B 0
                                              Licoagroisoflavone 0
                                              Millettone 0
                                              Osajin 36
                                              Pomiferin 33
                                              Sumatrol 0
                                              Toxicarol 0
                                              alpinumisoflavone 14
                                              hydroxyisoflavanone + 5
                                              isoflavanone + 5
                                              methoxyisoflavanone + 5
                                              sophoraisoflavanone B 0
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.