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phosphatidic acid - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:phosphatidic acid
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Accession:CHEBI:16337 term browser browse the term
Definition:A derivative of glycerol in which one hydroxy group, commonly but not necessarily primary, is esterified with phosphoric acid and the other two are esterified with fatty acids.
Synonyms:related_synonym: 1,2-Diacyl-sn-glycerol 3-phosphate;   3-sn-Phosphatidate;   Formula=C5H7O8PR2;   Phosphatidate;   SMILES=OP(O)(=O)OCC(COC([*])=O)OC([*])=O;   phosphatidic acids
 alt_id: CHEBI:14795;   CHEBI:26023;   CHEBI:8122;   MESH:D010712
 xref: KEGG:C00416
 xref_mesh: MESH:D010712
 cyclic_relationship: is_conjugate_acid_of CHEBI:57739


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phosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen increases abundance EXP AGT protein results in increased abundance of Phosphatidic Acids CTD PMID:14613874 NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO
EXP
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Phosphatidic Acids results in increased phosphorylation of AKT1 protein]
R 59949 inhibits the reaction [Phosphatidic Acids results in increased phosphorylation of AKT1 protein]
CTD PMID:15525798 PMID:16354768 NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Avp arginine vasopressin increases abundance
multiple interactions
EXP AVP protein results in increased abundance of Phosphatidic Acids
2-(4-amylcinnamoyl)amino-4-chlorobenzoic acid inhibits the reaction [AVP protein results in increased abundance of Phosphatidic Acids]
CTD PMID:11356622 NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases activity ISO Phosphatidic Acids results in increased activity of BGLAP protein CTD PMID:16857255 NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Egf epidermal growth factor multiple interactions
increases abundance
EXP 1-Butanol inhibits the reaction [EGF protein results in increased abundance of Phosphatidic Acids] CTD PMID:11134345 NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase increases activity ISO Phosphatidic Acids results in increased activity of FGR protein CTD PMID:11078731 NCBI chr 5:150,473,767...150,503,524
Ensembl chr 5:145,189,841...145,217,326
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion
ISO alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Phosphatidic Acids results in increased secretion of IL1B protein] CTD PMID:16354768 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion
ISO alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Phosphatidic Acids results in increased secretion of IL6 protein] CTD PMID:16354768 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Jak2 Janus kinase 2 increases phosphorylation ISO Phosphatidic Acids results in increased phosphorylation of JAK2 protein CTD PMID:16354768 NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Phosphatidic Acids inhibits the reaction [Ethanol results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]; Phosphatidic Acids results in increased phosphorylation of and results in increased activity of MAPK1 protein; U 0126 inhibits the reaction [Phosphatidic Acids results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:18358832 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Phosphatidic Acids inhibits the reaction [Ethanol results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]; Phosphatidic Acids results in increased phosphorylation of and results in increased activity of MAPK3 protein; U 0126 inhibits the reaction [Phosphatidic Acids results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:18358832 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp2 matrix metallopeptidase 2 increases activity
multiple interactions
ISO Phosphatidic Acids results in increased activity of MMP2 protein
Quercetin inhibits the reaction [Phosphatidic Acids results in increased activity of MMP2 protein]
CTD PMID:21867678 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases activity
ISO MTOR protein affects the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein]
Phosphatidic Acids results in increased activity of MTOR protein
CTD PMID:12087098 PMID:16537399 NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions EXP [1-Butanol inhibits the reaction [PLD2 protein results in increased chemical synthesis of Phosphatidic Acids]] affects the reaction [PENK protein binds to and results in increased activity of OPRM1 protein] CTD PMID:14720217 NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Penk proenkephalin multiple interactions EXP [1-Butanol inhibits the reaction [PLD2 protein results in increased chemical synthesis of Phosphatidic Acids]] affects the reaction [PENK protein binds to and results in increased activity of OPRM1 protein] CTD PMID:14720217 NCBI chr 5:21,981,381...21,987,074
Ensembl chr 5:17,183,806...17,189,129
JBrowse link
G Pld1 phospholipase D1 increases activity ISO Phosphatidic Acids results in increased activity of PLD1 protein CTD PMID:16857255 NCBI chr 2:112,777,820...112,975,857
Ensembl chr 2:110,893,608...111,047,692
JBrowse link
G Pld2 phospholipase D2 multiple interactions EXP 1-Butanol inhibits the reaction [PLD2 protein results in increased chemical synthesis of Phosphatidic Acids]; [1-Butanol inhibits the reaction [PLD2 protein results in increased chemical synthesis of Phosphatidic Acids]] affects the reaction [PENK protein binds to and results in increased activity of OPRM1 protein] CTD PMID:14720217 NCBI chr10:55,754,957...55,772,819
Ensembl chr10:55,256,359...55,272,808
JBrowse link
G Prkcz protein kinase C, zeta increases activity
multiple interactions
EXP
ISO
Phosphatidic Acids results in increased activity of PRKCZ protein
Phosphatidic Acids results in increased phosphorylation of and results in increased activity of PRKCZ protein
CTD PMID:11978788 PMID:15255942 NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Phosphatidic Acids results in increased expression of PTGS2 protein
Phosphatidic Acids results in increased expression of PTGS2 mRNA
CTD PMID:12872987 PMID:15210717 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO Phosphatidic Acids results in increased phosphorylation of and results in increased activity of RPS6KB1 protein CTD PMID:15255942 NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 multiple interactions
increases activity
ISO MTOR protein affects the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein]; Sirolimus inhibits the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein]; wortmannin inhibits the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein] CTD PMID:12087098 NCBI chr 1:210,880,824...210,887,556
Ensembl chr 1:201,451,265...201,458,078
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Phosphatidic Acids results in increased phosphorylation of and affects the localization of STAT1 protein CTD PMID:16354768 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Phosphatidic Acids results in increased phosphorylation of and affects the localization of STAT3 protein CTD PMID:16354768 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Sts steroid sulfatase multiple interactions ISO Phosphatidic Acids promotes the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:46,102,524...46,110,868
Ensembl chr  X:42,225,372...42,233,402
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion
ISO TNF protein inhibits the reaction [Carbachol results in increased abundance of Phosphatidic Acids]
Phosphatidic Acids results in increased secretion of TNF protein
CTD PMID:11245595 PMID:16354768 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
JBrowse link
1,2-dioctanoyl-sn-glycero-3-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO dioctanoylphosphatidic acid results in increased expression of PTGS2 protein CTD PMID:11854442 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
JBrowse link
dioleoyl phosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plek pleckstrin multiple interactions ISO dioleoylphosphatidic acid analog promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased phosphorylation of PLEK protein] CTD PMID:8928743 NCBI chr14:95,598,650...95,631,326
Ensembl chr14:91,397,019...91,454,131
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [1,2-oleoylphosphatidylcholine co-treated with dioleoylphosphatidic acid] binds to SOD1 protein; [1,2-oleoylphosphatidylcholine co-treated with dioleoylphosphatidic acid] binds to SOD1 protein mutant form; [1,2-oleoylphosphatidylcholine co-treated with dioleoylphosphatidic acid] promotes the reaction [SOD1 protein binds to SOD1 protein]; [1,2-oleoylphosphatidylcholine co-treated with dioleoylphosphatidic acid] promotes the reaction [SOD1 protein mutant form binds to SOD1 protein mutant form] CTD PMID:29649360 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
JBrowse link
phosphatidylethanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plek pleckstrin multiple interactions ISO phosphatidylethanol analog promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased phosphorylation of PLEK protein] CTD PMID:8928743 NCBI chr14:95,598,650...95,631,326
Ensembl chr14:91,397,019...91,454,131
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19887
    role 19858
      biological role 19856
        osmolyte 3454
          glycerol 3185
            glycerolipid 1793
              glycerophospholipid 218
                phosphatidic acid 27
                  1,2-Distearoyl-sn-glycero-3-phosphate (sodium salt) 0
                  1,2-diacyl-sn-glycerol 3-phosphate + 1
                  1,2-dioctadecanoyl-sn-glycerol-3-phosphate 0
                  1-decanoyl-2-stearoyl-sn-phosphatidic acid 0
                  1-stearoyl-2-arachidonoylphosphatidic acid 0
                  PA(14:0/18:3(6Z,9Z,12Z)) 0
                  PA(16:0/18:1(11Z)) 0
                  PA(18:0/22:4) 0
                  PA(18:1(11Z)/18:1(11Z)) 0
                  PA(18:1(11Z)/18:1(9Z)) 0
                  PA(20:3(5Z,8Z,11Z)/22:5(4Z,7Z,10Z,13Z,16Z)) 0
                  didecanoylphosphatidic acid 0
                  dihexadecanoyl phosphatidic acid 0
                  dimyristoyl phosphatidic acid 0
                  phosphatidic acid (16:0/18:1) 0
                  phosphatidic acid 14:0 0
                  phosphatidic acid 16:0 0
                  phosphatidic acid 18:0 0
                  phosphatidic acid 18:3 0
                  phosphatidic acid 30:1 + 0
                  phosphatidic acid 32:5 + 0
                  phosphatidic acid 32:7 0
                  phosphatidic acid 34:3 + 0
                  phosphatidic acid 36:2 + 2
                  phosphatidic acid 36:3 + 0
                  phosphatidic acid 36:4 0
                  phosphatidic acid 36:5 + 0
                  phosphatidic acid 36:6 + 0
                  phosphatidic acid 37:0 0
                  phosphatidic acid 38:0 0
                  phosphatidic acid 38:4 + 0
                  phosphatidic acid 39:1 0
                  phosphatidic acid 39:2 0
                  phosphatidic acid 39:5 0
                  phosphatidic acid 40:2 0
                  phosphatidic acid 40:6 + 0
                  phosphatidic acid 41:1 0
                  phosphatidic acid 41:2 0
                  phosphatidic acid 41:3 0
                  phosphatidic acid 41:5 0
                  phosphatidic acid 43:5 0
                  phosphatidic acid 44:6 0
                  phosphatidyl group 0
                  phosphatidylethanol + 1
Path 2
Term Annotations click to browse term
  CHEBI ontology 19887
    subatomic particle 19885
      composite particle 19885
        hadron 19885
          baryon 19885
            nucleon 19885
              atomic nucleus 19885
                atom 19885
                  main group element atom 19824
                    p-block element atom 19824
                      chalcogen 19580
                        oxygen atom 19551
                          oxygen molecular entity 19551
                            hydroxides 19361
                              oxoacid 18797
                                pnictogen oxoacid 15018
                                  phosphorus oxoacid 14577
                                    phosphoric acids 13927
                                      phosphoric acid 13927
                                        phosphoric acid derivative 13839
                                          phosphate 13838
                                            organic phosphate 13838
                                              phospholipid 326
                                                glycerophospholipid 218
                                                  phosphatidic acid 27
                                                    1,2-Distearoyl-sn-glycero-3-phosphate (sodium salt) 0
                                                    1,2-diacyl-sn-glycerol 3-phosphate + 1
                                                    1,2-dioctadecanoyl-sn-glycerol-3-phosphate 0
                                                    1-decanoyl-2-stearoyl-sn-phosphatidic acid 0
                                                    1-stearoyl-2-arachidonoylphosphatidic acid 0
                                                    PA(14:0/18:3(6Z,9Z,12Z)) 0
                                                    PA(16:0/18:1(11Z)) 0
                                                    PA(18:0/22:4) 0
                                                    PA(18:1(11Z)/18:1(11Z)) 0
                                                    PA(18:1(11Z)/18:1(9Z)) 0
                                                    PA(20:3(5Z,8Z,11Z)/22:5(4Z,7Z,10Z,13Z,16Z)) 0
                                                    didecanoylphosphatidic acid 0
                                                    dihexadecanoyl phosphatidic acid 0
                                                    dimyristoyl phosphatidic acid 0
                                                    phosphatidic acid (16:0/18:1) 0
                                                    phosphatidic acid 14:0 0
                                                    phosphatidic acid 16:0 0
                                                    phosphatidic acid 18:0 0
                                                    phosphatidic acid 18:3 0
                                                    phosphatidic acid 30:1 + 0
                                                    phosphatidic acid 32:5 + 0
                                                    phosphatidic acid 32:7 0
                                                    phosphatidic acid 34:3 + 0
                                                    phosphatidic acid 36:2 + 2
                                                    phosphatidic acid 36:3 + 0
                                                    phosphatidic acid 36:4 0
                                                    phosphatidic acid 36:5 + 0
                                                    phosphatidic acid 36:6 + 0
                                                    phosphatidic acid 37:0 0
                                                    phosphatidic acid 38:0 0
                                                    phosphatidic acid 38:4 + 0
                                                    phosphatidic acid 39:1 0
                                                    phosphatidic acid 39:2 0
                                                    phosphatidic acid 39:5 0
                                                    phosphatidic acid 40:2 0
                                                    phosphatidic acid 40:6 + 0
                                                    phosphatidic acid 41:1 0
                                                    phosphatidic acid 41:2 0
                                                    phosphatidic acid 41:3 0
                                                    phosphatidic acid 41:5 0
                                                    phosphatidic acid 43:5 0
                                                    phosphatidic acid 44:6 0
                                                    phosphatidyl group 0
                                                    phosphatidylethanol + 1
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