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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:phospholipid
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Accession:CHEBI:16247 term browser browse the term
Definition:A lipid containing phosphoric acid as a mono- or di-ester. The term encompasses phosphatidic acids and phosphoglycerides.
Synonyms:related_synonym: a phospholipid derivative;   phospholipids
 alt_id: CHEBI:14816;   CHEBI:26063;   CHEBI:8150
 xref: KEGG:C00865
 cyclic_relationship: is_conjugate_acid_of CHEBI:62643


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1,2-dihexadecanoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6 interleukin 6 multiple interactions ISO 1,2-Dipalmitoylphosphatidylcholine inhibits the reaction [Asbestos, Crocidolite results in increased secretion of IL6 protein] CTD PMID:19041333 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Prnp prion protein multiple interactions
affects folding		 ISO Copper affects the reaction [1,2-Dipalmitoylphosphatidylcholine affects the folding of PRNP protein modified form] CTD PMID:20936829 NCBI chr 3:119,186,073...119,201,513
Ensembl chr 3:119,177,485...119,203,937 		JBrowse link
1,2-dioctanoyl-sn-glycero-3-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO dioctanoylphosphatidic acid results in increased expression of PTGS2 protein CTD PMID:11854442 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
1-hexadecanoyl-2-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fech ferrochelatase affects abundance ISO FECH protein affects the abundance of 1-palmitoyl-2-docosahexaenoyl-sn-glycero-3-phosphocholine CTD PMID:29906468 NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348 		JBrowse link
1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fech ferrochelatase affects abundance ISO FECH protein affects the abundance of 1-palmitoyl-2-linoleoylphosphatidylcholine CTD PMID:29906468 NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348 		JBrowse link
1-O-oleoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions ISO [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of 1-oleoyl lysophosphatidylcholine CTD PMID:29515023 NCBI chr13:48,313,634...48,433,494
Ensembl chr13:48,316,301...48,433,326 		JBrowse link
G Smad3 SMAD family member 3 decreases abundance ISO SMAD3 protein results in decreased abundance of 1-oleoyl lysophosphatidylcholine CTD PMID:23034213 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of AGTR1 mRNA CTD PMID:16386258 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of ALOX5 mRNA CTD PMID:16386258 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of CCR2 mRNA CTD PMID:16386258 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Cd68 Cd68 molecule increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of CD68 mRNA CTD PMID:16386258 NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697 		JBrowse link
G Crp C-reactive protein increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of CRP mRNA CTD PMID:16386258 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions
increases phosphorylation		 EXP AG 1879 inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of GJA1 protein]; resveratrol inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of GJA1 protein] CTD PMID:24079413 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of IL1A mRNA CTD PMID:16386258 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of IL1B mRNA CTD PMID:16386258 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Kcnab2 potassium voltage-gated channel subfamily A regulatory beta subunit 2 multiple interactions EXP [KCNAB2 protein co-treated with NADP] results in increased reduction of 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine CTD PMID:21296056 NCBI chr 5:162,899,511...162,988,057
Ensembl chr 5:162,901,896...162,988,243 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions		 EXP 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of MAPK1 protein
resveratrol inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of MAPK1 protein]		 CTD PMID:24079413 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP resveratrol inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of MAPK3 protein] CTD PMID:24079413 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of OLR1 mRNA CTD PMID:16386258 NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523 		JBrowse link
G Ptafr platelet-activating factor receptor affects binding
multiple interactions		 ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine binds to PTAFR protein
1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]		 CTD PMID:16386258 NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of PTGS1 mRNA CTD PMID:16386258 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of PTGS2 mRNA CTD PMID:16386258 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Sele selectin E increases expression
increases secretion		 ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of SELE mRNA
1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased secretion of SELE protein		 CTD PMID:16386258 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions
increases phosphorylation		 EXP resveratrol inhibits the reaction [1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased phosphorylation of SRC protein] CTD PMID:24079413 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476 		JBrowse link
G Timp4 TIMP metallopeptidase inhibitor 4 increases expression ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of TIMP4 mRNA CTD PMID:16386258 NCBI chr 4:148,306,021...148,312,558
Ensembl chr 4:148,304,490...148,312,558 		JBrowse link
G Tnf tumor necrosis factor increases expression
increases secretion		 ISO 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased expression of TNF mRNA
1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine results in increased secretion of TNF protein		 CTD PMID:16386258 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
1-octadec-9-enoylglycero-3-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle increases expression
multiple interactions		 ISO lysophosphatidic acid results in increased expression of ACTA2 mRNA
N-(4-chlorophenyl)-1-((3-(furan-2-yl)phenyl)carbonyl)piperidine-3-carboxamide inhibits the reaction [lysophosphatidic acid results in increased expression of ACTA2 mRNA]		 CTD PMID:24706986 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation		 ISO
EXP		 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of AKT1 protein]; Resveratrol inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of AKT1 protein]
1-Butanol inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of AKT1 protein]; exoenzyme C3, Clostridium botulinum inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of AKT1 protein]		 CTD PMID:14769825 PMID:17550345 PMID:20103642 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions ISO ALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide]; Masoprocol inhibits the reaction [ALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide]]; zileuton inhibits the reaction [ALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide]] CTD PMID:10698703 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO [Lithocholic Acid co-treated with lysophosphatidic acid] results in increased activity of ALPL protein CTD PMID:19646460 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Bcar1 BCAR1 scaffold protein, Cas family member increases phosphorylation ISO lysophosphatidic acid results in increased phosphorylation of BCAR1 protein CTD PMID:11792571 NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907 		JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression ISO lysophosphatidic acid analog results in increased expression of BCL2 protein; lysophosphatidic acid results in increased expression of BCL2 protein CTD PMID:23251428 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G C5 complement C5 increases expression ISO lysophosphatidic acid results in increased expression of HC protein CTD PMID:25822713 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO lysophosphatidic acid analog inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]; lysophosphatidic acid inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein] CTD PMID:23251428 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccl12 C-C motif chemokine ligand 12 increases expression
multiple interactions		 ISO lysophosphatidic acid results in increased expression of CCL12 protein
3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid inhibits the reaction [lysophosphatidic acid results in increased expression of CCL12 protein]		 CTD PMID:25822713 NCBI chr10:67,070,230...67,071,780
Ensembl chr10:67,070,230...67,071,780 		JBrowse link
G Ccl28 C-C motif chemokine ligand 28 multiple interactions
increases expression		 ISO 3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid inhibits the reaction [lysophosphatidic acid results in increased expression of CCL28 protein] CTD PMID:25822713 NCBI chr 2:51,601,354...51,625,999
Ensembl chr 2:51,601,331...51,625,997 		JBrowse link
G Ccn1 cellular communication network factor 1 multiple interactions
increases expression		 ISO 3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid inhibits the reaction [lysophosphatidic acid results in increased expression of CCN1 protein] CTD PMID:25822713 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Ccn2 cellular communication network factor 2 increases expression
multiple interactions		 EXP
ISO		 lysophosphatidic acid results in increased expression of CCN2 protein
N-(4-chlorophenyl)-1-((3-(furan-2-yl)phenyl)carbonyl)piperidine-3-carboxamide inhibits the reaction [lysophosphatidic acid results in increased expression of CCN2 mRNA]
Simvastatin inhibits the reaction [lysophosphatidic acid results in increased expression of CCN2 protein]; Y 27632 inhibits the reaction [lysophosphatidic acid results in increased expression of CCN2 protein]		 CTD PMID:15200425 PMID:24706986 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Col1a2 collagen type I alpha 2 chain increases expression
multiple interactions		 ISO lysophosphatidic acid results in increased expression of COL1A2 mRNA
N-(4-chlorophenyl)-1-((3-(furan-2-yl)phenyl)carbonyl)piperidine-3-carboxamide inhibits the reaction [lysophosphatidic acid results in increased expression of COL1A2 mRNA]		 CTD PMID:24706986 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867 		JBrowse link
G Csf1 colony stimulating factor 1 increases expression ISO lysophosphatidic acid results in increased expression of CSF1 protein CTD PMID:25822713 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression
multiple interactions		 ISO lysophosphatidic acid results in increased expression of CXCL12 protein
3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid inhibits the reaction [lysophosphatidic acid results in increased expression of CXCL12 protein]		 CTD PMID:25822713 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cxcl16 C-X-C motif chemokine ligand 16 increases expression
multiple interactions		 ISO lysophosphatidic acid results in increased expression of CXCL16 protein
3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid inhibits the reaction [lysophosphatidic acid results in increased expression of CXCL16 protein]		 CTD PMID:25822713 NCBI chr10:55,166,721...55,171,316
Ensembl chr10:55,166,723...55,171,592 		JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 multiple interactions
decreases expression		 ISO lysophosphatidic acid inhibits the reaction [CXCR1 protein binds to LPAR1 protein]; lysophosphatidic acid results in decreased expression of [CXCR1 protein binds to LPAR1 protein]
lysophosphatidic acid results in decreased expression of CXCR1 mRNA		 CTD PMID:16224106 NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084 		JBrowse link
G Dgka diacylglycerol kinase, alpha multiple interactions ISO DGKA protein promotes the reaction [lysophosphatidic acid results in increased activity of PIP5K1A protein] CTD PMID:10913605 NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
increases phosphorylation		 ISO GNA13 mutant form inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of EGFR protein]; Pertussis Toxin inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of EGFR protein]; resveratrol inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of EGFR protein] CTD PMID:23127547 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions
increases phosphorylation		 EXP 1-Butanol inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of EIF4EBP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of EIF4EBP1 protein]; 2-butanol inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of EIF4EBP1 protein]; exoenzyme C3, Clostridium botulinum inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:14769825 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984 		JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 multiple interactions
decreases expression		 ISO
EXP		 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]; 3-(2-methoxybenzylamino)-2-phenylpiperidine inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]; [[Capsaicin results in increased chemical synthesis of Lysophosphatidylcholines] which results in increased secretion of Lysophosphatidylcholines] promotes the reaction [ENPP2 results in increased chemical synthesis of lysophosphatidic acid]; [[ONO-8430506 results in decreased activity of ENPP2 protein] which results in decreased abundance of lysophosphatidic acid] which results in decreased expression of NFE2L2; [[ONO-8430506 results in decreased activity of ENPP2 protein] which results in decreased chemical synthesis of and results in decreased abundance of lysophosphatidic acid] which results in increased expression of ENPP2 mRNA; [ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid; [ENPP2 protein co-treated with Lysophosphatidylcholines] results in increased chemical synthesis of lysophosphatidic acid; [ONO-8430506 results in decreased activity of ENPP2 protein] which results in decreased abundance of lysophosphatidic acid; [ONO-8430506 results in decreased activity of ENPP2 protein] which results in decreased chemical synthesis of and results in decreased abundance of lysophosphatidic acid; arachidonyltrifluoromethane inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]; bisindolylmaleimide I inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]; Dizocilpine Maleate inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]; IL1B protein inhibits the reaction [lysophosphatidic acid results in decreased expression of ENPP2 protein]; TNF protein inhibits the reaction [lysophosphatidic acid results in decreased expression of ENPP2 protein]; U 0126 inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]; xestospongin C inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]
lysophosphatidic acid inhibits the reaction [ENPP2 mutant form results in decreased expression of MBP mRNA]		 CTD PMID:18594965 PMID:19014389 PMID:24599971 PMID:24747415 PMID:25398768 More... NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827 		JBrowse link
G Epo erythropoietin multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]; [lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of GATA1 mRNA; [lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC mRNA; [lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein; lysophosphatidic acid promotes the reaction [[KITLG protein co-treated with EPO protein] results in increased expression of GATA1 mRNA]; lysophosphatidic acid promotes the reaction [[KITLG protein co-treated with EPO protein] results in increased expression of GYPA mRNA]; lysophosphatidic acid promotes the reaction [[KITLG protein co-treated with EPO protein] results in increased expression of TFRC mRNA]; lysophosphatidic acid promotes the reaction [[KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]; Quercetin inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of GATA1 mRNA]; Quercetin inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC mRNA]; Quercetin inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]; WP1066 inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein] CTD PMID:21915944 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Gata1 GATA binding protein 1 multiple interactions ISO [lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of GATA1 mRNA; lysophosphatidic acid promotes the reaction [[KITLG protein co-treated with EPO protein] results in increased expression of GATA1 mRNA]; Quercetin inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of GATA1 mRNA] CTD PMID:21915944 NCBI chr  X:14,529,706...14,537,530
Ensembl chr  X:14,529,702...14,537,530 		JBrowse link
G Gna13 G protein subunit alpha 13 multiple interactions ISO GNA13 mutant form inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of EGFR protein] CTD PMID:23127547 NCBI chr10:94,337,939...94,370,774
Ensembl chr10:94,337,725...94,370,774 		JBrowse link
G Gypa glycophorin A multiple interactions ISO lysophosphatidic acid promotes the reaction [[KITLG protein co-treated with EPO protein] results in increased expression of GYPA mRNA] CTD PMID:21915944 NCBI chr19:27,450,304...27,465,940
Ensembl chr19:27,450,308...27,465,822 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression		 ISO L-4F peptide inhibits the reaction [lysophosphatidic acid results in increased expression of HIF1A protein]; resveratrol inhibits the reaction [lysophosphatidic acid results in increased expression of HIF1A protein]
[lysophosphatidic acid results in increased expression of HIF1A protein] which results in increased expression of VEGFA mRNA; [lysophosphatidic acid results in increased expression of HIF1A protein] which results in increased expression of VEGFA protein; lysophosphatidic acid results in increased expression of HIF1A protein		 CTD PMID:17919812 PMID:22537771 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hspb1 heat shock protein family B (small) member 1 multiple interactions
increases phosphorylation		 EXP MK2i peptide inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of HSPB1 protein]; SB 203580 inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of HSPB1 protein] CTD PMID:20864298 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO IL1B protein inhibits the reaction [lysophosphatidic acid results in decreased expression of ENPP2 protein] CTD PMID:25896349 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases secretion ISO lysophosphatidic acid results in increased secretion of IL6 protein CTD PMID:21821728 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Il6st interleukin 6 cytokine family signal transducer multiple interactions
increases expression		 ISO 3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid inhibits the reaction [lysophosphatidic acid results in increased expression of IL6ST protein] CTD PMID:25822713 NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936 		JBrowse link
G Kitlg KIT ligand multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]; [lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of GATA1 mRNA; [lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC mRNA; [lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein; lysophosphatidic acid promotes the reaction [[KITLG protein co-treated with EPO protein] results in increased expression of GATA1 mRNA]; lysophosphatidic acid promotes the reaction [[KITLG protein co-treated with EPO protein] results in increased expression of GYPA mRNA]; lysophosphatidic acid promotes the reaction [[KITLG protein co-treated with EPO protein] results in increased expression of TFRC mRNA]; lysophosphatidic acid promotes the reaction [[KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]; Quercetin inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of GATA1 mRNA]; Quercetin inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC mRNA]; Quercetin inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]; WP1066 inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein] CTD PMID:21915944 NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214 		JBrowse link
G Kng1 kininogen 1 multiple interactions EXP KNG1 protein inhibits the reaction [[Wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein] CTD PMID:10537051 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Lama3 laminin subunit alpha 3 increases expression ISO lysophosphatidic acid results in increased expression of LAMA3 mRNA CTD PMID:15541073 NCBI chr18:3,523,168...3,751,722
Ensembl chr18:3,523,133...3,751,353 		JBrowse link
G Lamb3 laminin subunit beta 3 increases expression ISO lysophosphatidic acid results in increased expression of LAMB3 mRNA CTD PMID:15541073 NCBI chr13:104,833,810...104,875,405
Ensembl chr13:104,833,873...104,875,405 		JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression ISO lysophosphatidic acid results in increased expression of LAMC2 mRNA CTD PMID:15541073 NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200 		JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 increases response to substance
multiple interactions		 ISO LPAR1 protein results in increased susceptibility to lysophosphatidic acid
LPAR1 protein affects the reaction [lysophosphatidic acid results in increased stability of and affects the localization of NFE2L2 protein]; lysophosphatidic acid inhibits the reaction [CXCR1 protein binds to LPAR1 protein]; lysophosphatidic acid results in decreased expression of [CXCR1 protein binds to LPAR1 protein]		 CTD PMID:16224106 PMID:16809448 PMID:25398768 NCBI chr 5:73,229,047...73,347,874
Ensembl chr 5:73,229,625...73,369,895 		JBrowse link
G Lpar3 lysophosphatidic acid receptor 3 multiple interactions ISO Endocannabinoids inhibits the reaction [lysophosphatidic acid binds to and results in increased activity of LPAR3 protein]; lysophosphatidic acid binds to and results in increased activity of LPAR3 protein CTD PMID:30102254 NCBI chr 2:235,125,234...235,193,916
Ensembl chr 2:235,149,065...235,193,357 		JBrowse link
G Lpar5 lysophosphatidic acid receptor 5 multiple interactions ISO Endocannabinoids inhibits the reaction [lysophosphatidic acid binds to and results in increased activity of LPAR5 protein]; lysophosphatidic acid binds to and results in increased activity of LPAR5 protein CTD PMID:30102254 NCBI chr 4:157,870,493...157,883,979
Ensembl chr 4:157,881,796...157,882,950 		JBrowse link
G Lpar6 lysophosphatidic acid receptor 6 multiple interactions ISO lysophosphatidic acid binds to and results in increased activity of LPAR6 protein CTD PMID:18297070 NCBI chr15:48,416,548...48,418,357
Ensembl chr15:48,416,544...48,422,331 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO
EXP		 Hydrogen Peroxide promotes the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK1 protein]; resveratrol inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK1 protein]
1-Butanol inhibits the reaction [PLD1 protein affects the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK1 protein]; Pertussis Toxin inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK1 protein]; PLD1 protein affects the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK1 protein]		 CTD PMID:11243883 PMID:12657697 PMID:15081308 PMID:17919812 PMID:21179406 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO
EXP		 Hydrogen Peroxide promotes the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK3 protein]; resveratrol inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK3 protein]
1-Butanol inhibits the reaction [PLD1 protein affects the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK3 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK3 protein]; Pertussis Toxin inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK3 protein]; PLD1 protein affects the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK3 protein]		 CTD PMID:11243883 PMID:12657697 PMID:15081308 PMID:17919812 PMID:21179406 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mbp myelin basic protein multiple interactions EXP lysophosphatidic acid inhibits the reaction [ENPP2 mutant form results in decreased expression of MBP mRNA] CTD PMID:18594965 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases expression		 ISO gefitinib inhibits the reaction [lysophosphatidic acid results in increased expression of MMP9 mRNA]; gefitinib promotes the reaction [resveratrol inhibits the reaction [lysophosphatidic acid results in increased expression of MMP9 mRNA]]; resveratrol inhibits the reaction [lysophosphatidic acid results in increased expression of MMP9 mRNA]; resveratrol promotes the reaction [gefitinib inhibits the reaction [lysophosphatidic acid results in increased expression of MMP9 mRNA]] CTD PMID:23127547 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mtor mechanistic target of rapamycin kinase increases phosphorylation EXP lysophosphatidic acid results in increased phosphorylation of MTOR protein CTD PMID:14769825 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myl9 myosin light chain 9 increases phosphorylation
multiple interactions		 ISO lysophosphatidic acid results in increased phosphorylation of MYL9 protein
Farnesol analog inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of MYL9 protein]; geranylgeraniol analog inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of MYL9 protein]		 CTD PMID:24587105 NCBI chr 3:145,281,943...145,288,333
Ensembl chr 3:145,281,937...145,288,333 		JBrowse link
G Mylk myosin light chain kinase affects response to substance ISO MYLK protein affects the susceptibility to lysophosphatidic acid CTD PMID:10640419 NCBI chr11:65,783,008...66,030,239
Ensembl chr11:65,783,008...66,030,261 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO LPAR1 protein affects the reaction [lysophosphatidic acid results in increased stability of and affects the localization of NFE2L2 protein]; lysophosphatidic acid results in increased stability of and affects the localization of NFE2L2 protein
[[ONO-8430506 results in decreased activity of ENPP2 protein] which results in decreased abundance of lysophosphatidic acid] which results in decreased expression of NFE2L2		 CTD PMID:25398768 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nppa natriuretic peptide A multiple interactions
increases expression		 EXP Pertussis Toxin inhibits the reaction [lysophosphatidic acid results in increased expression of NPPA protein]; Y 27632 inhibits the reaction [lysophosphatidic acid results in increased expression of NPPA protein] CTD PMID:15081308 PMID:25449040 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351 		JBrowse link
G Pip5k1a phosphatidylinositol-4-phosphate 5-kinase, type 1, alpha multiple interactions
increases activity		 ISO 1-Butanol inhibits the reaction [lysophosphatidic acid results in increased activity of PIP5K1A protein]; DGKA protein promotes the reaction [lysophosphatidic acid results in increased activity of PIP5K1A protein] CTD PMID:10913605 NCBI chr 2:182,628,299...182,671,584
Ensembl chr 2:182,628,300...182,671,598 		JBrowse link
G Plau plasminogen activator, urokinase multiple interactions
increases expression		 ISO gefitinib inhibits the reaction [lysophosphatidic acid results in increased expression of PLAU mRNA]; gefitinib promotes the reaction [resveratrol inhibits the reaction [lysophosphatidic acid results in increased expression of PLAU mRNA]]; resveratrol inhibits the reaction [lysophosphatidic acid results in increased expression of PLAU mRNA]; resveratrol promotes the reaction [gefitinib inhibits the reaction [lysophosphatidic acid results in increased expression of PLAU mRNA]] CTD PMID:23127547 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Pld1 phospholipase D1 multiple interactions
increases activity		 EXP 1-Butanol inhibits the reaction [PLD1 protein affects the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK1 protein]]; 1-Butanol inhibits the reaction [PLD1 protein affects the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK3 protein]]; bisindolylmaleimide I inhibits the reaction [lysophosphatidic acid results in increased activity of PLD1 protein]; Pertussis Toxin inhibits the reaction [lysophosphatidic acid results in increased activity of PLD1 protein]; PLD1 protein affects the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK1 protein]; PLD1 protein affects the reaction [lysophosphatidic acid results in increased phosphorylation of MAPK3 protein]; toxB protein, Clostridium difficile inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of PLD1 protein] CTD PMID:11243883 PMID:14769825 NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692 		JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A increases phosphorylation
multiple interactions		 EXP lysophosphatidic acid results in increased phosphorylation of PPP1R12A protein
Y 27632 inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of PPP1R12A protein]		 CTD PMID:25449040 NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425 		JBrowse link
G Ptk2 protein tyrosine kinase 2 increases phosphorylation
multiple interactions		 ISO
EXP		 lysophosphatidic acid results in increased phosphorylation of PTK2 protein
[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein; KNG1 protein inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]
[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]]; oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]		 CTD PMID:10537051 PMID:11792571 NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta increases phosphorylation ISO lysophosphatidic acid results in increased phosphorylation of PTK2B protein CTD PMID:11792571 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
G Rhoa ras homolog family member A increases activity
multiple interactions		 EXP
ISO		 lysophosphatidic acid results in increased activity of RHOA protein
Farnesol analog inhibits the reaction [lysophosphatidic acid results in increased activity of RHOA protein]; geranylgeraniol analog inhibits the reaction [lysophosphatidic acid results in increased activity of RHOA protein]		 CTD PMID:15081308 PMID:24587105 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Rhoc ras homolog family member C multiple interactions
increases activity		 ISO Farnesol analog inhibits the reaction [lysophosphatidic acid results in increased activity of RHOC protein]; geranylgeraniol analog inhibits the reaction [lysophosphatidic acid results in increased activity of RHOC protein] CTD PMID:24587105 NCBI chr 2:192,287,065...192,293,292
Ensembl chr 2:192,287,130...192,295,306 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 increases phosphorylation
multiple interactions		 ISO
EXP		 lysophosphatidic acid results in increased phosphorylation of RPS6KB1 protein
resveratrol inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of RPS6KB1 protein]
1-Butanol inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of RPS6KB1 protein]; exoenzyme C3, Clostridium botulinum inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of RPS6KB1 protein]		 CTD PMID:14769825 PMID:17919812 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Tfrc transferrin receptor multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]; [lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC mRNA; [lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein; lysophosphatidic acid promotes the reaction [[KITLG protein co-treated with EPO protein] results in increased expression of TFRC mRNA]; lysophosphatidic acid promotes the reaction [[KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]; Quercetin inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC mRNA]; Quercetin inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]; WP1066 inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein] CTD PMID:21915944 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
increases expression		 ISO 3-(4-(4-((1-(2-chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acid inhibits the reaction [lysophosphatidic acid results in increased expression of TIMP1 protein] CTD PMID:25822713 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO TNF protein inhibits the reaction [lysophosphatidic acid results in decreased expression of ENPP2 protein] CTD PMID:25896349 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression
multiple interactions		 ISO [lysophosphatidic acid results in increased expression of HIF1A protein] which results in increased expression of VEGFA mRNA; [lysophosphatidic acid results in increased expression of HIF1A protein] which results in increased expression of VEGFA protein
resveratrol inhibits the reaction [lysophosphatidic acid results in increased expression of VEGFA protein]		 CTD PMID:17919812 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipg lipase G, endothelial type increases hydrolysis ISO LIPG protein results in increased hydrolysis of 1-O-hexadecyl-2-arachidonyl-sn-glycero-3-phosphocholine CTD PMID:15953354 NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260 		JBrowse link
1-stearoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipc lipase C, hepatic type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of stearoyl alpha-lysolecithin CTD PMID:24777581 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464 		JBrowse link
G Lipg lipase G, endothelial type multiple interactions ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of stearoyl alpha-lysolecithin CTD PMID:24777581 NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260 		JBrowse link
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agtr1a angiotensin II receptor, type 1a increases expression ISO Platelet Activating Factor results in increased expression of AGTR1 mRNA CTD PMID:16386258 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type increases expression ISO Platelet Activating Factor results in increased expression of ALOX12 mRNA CTD PMID:16386258 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions
increases expression		 ISO [sodium arsenite co-treated with Platelet Activating Factor co-treated with Arachidonic Acid] results in increased phosphorylation of and results in increased activity of ALOX5 protein; [zileuton results in decreased activity of ALOX5 protein] inhibits the reaction [Calcimycin results in increased abundance of Platelet Activating Factor]
Platelet Activating Factor results in increased expression of ALOX5 mRNA		 CTD PMID:8387780 PMID:10779545 PMID:16386258 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions
increases secretion		 ISO Foropafant inhibits the reaction [Platelet Activating Factor results in increased secretion of CCL2 protein] CTD PMID:15149885 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccr2 C-C motif chemokine receptor 2 increases expression ISO Platelet Activating Factor results in increased expression of CCR2 mRNA CTD PMID:16386258 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100 		JBrowse link
G Crp C-reactive protein increases expression ISO Platelet Activating Factor results in increased expression of CRP mRNA CTD PMID:16386258 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 increases expression ISO Platelet Activating Factor results in increased expression of CX3CR1 mRNA CTD PMID:16386258 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014 		JBrowse link
G Edn1 endothelin 1 multiple interactions
increases abundance		 EXP Carbon Tetrachloride promotes the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]; EDNRB protein affects the reaction [Carbon Tetrachloride promotes the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]]; EDNRB protein affects the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor] CTD PMID:18205269 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Ednrb endothelin receptor type B multiple interactions EXP EDNRB protein affects the reaction [Carbon Tetrachloride promotes the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor]]; EDNRB protein affects the reaction [EDN1 protein results in increased abundance of Platelet Activating Factor] CTD PMID:18205269 NCBI chr15:80,640,839...80,672,115
Ensembl chr15:80,643,043...80,672,115 		JBrowse link
G Egr1 early growth response 1 increases expression ISO Platelet Activating Factor results in increased expression of EGR1 mRNA CTD PMID:16386258 NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766 		JBrowse link
G Gusb glucuronidase, beta multiple interactions EXP [Platelet Activating Factor co-treated with Cytochalasin B] results in increased secretion of GUSB protein; IMMLG5521 inhibits the reaction [[Platelet Activating Factor co-treated with Cytochalasin B] results in increased secretion of GUSB protein] CTD PMID:23850278 NCBI chr12:26,701,188...26,714,718
Ensembl chr12:26,697,951...26,726,905 		JBrowse link
G Il1a interleukin 1 alpha increases expression ISO Platelet Activating Factor results in increased expression of IL1A mRNA CTD PMID:16386258 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta increases expression
increases secretion
multiple interactions		 ISO Platelet Activating Factor results in increased expression of IL1B mRNA
Platelet Activating Factor results in increased secretion of IL1B protein
[Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of IL1B protein; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of IL1B protein]		 CTD PMID:16386258 PMID:32830409 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion		 ISO [Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of IL6 protein; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of IL6 protein] CTD PMID:32830409 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgam integrin subunit alpha M multiple interactions
increases expression		 ISO Foropafant inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein]; Isoproterenol promotes the reaction [Theophylline inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein]]; Theophylline inhibits the reaction [Platelet Activating Factor results in increased expression of ITGAM protein] CTD PMID:9762784 PMID:11116075 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Ltb4r leukotriene B4 receptor affects response to substance ISO LTB4R1 protein affects the susceptibility to Platelet Activating Factor CTD PMID:10934231 NCBI chr15:29,263,199...29,265,716 JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression ISO Platelet Activating Factor results in increased expression of MMP13 mRNA CTD PMID:16386258 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor increases expression
multiple interactions		 ISO Platelet Activating Factor results in increased expression of MYD88 protein
PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased expression of MYD88 protein]		 CTD PMID:32830409 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nceh1 neutral cholesterol ester hydrolase 1 multiple interactions ISO NCEH1 protein inhibits the reaction [[Chlorpyrifos metabolite co-treated with Cytidine Diphosphate Choline] results in increased abundance of Platelet Activating Factor] CTD PMID:18164358 NCBI chr 2:110,074,985...110,135,592
Ensembl chr 2:110,074,957...110,135,588 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
increases degradation		 ISO Acetylcysteine inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; BN 50739 inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; Genistein inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; herbimycin inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; pyrrolidine dithiocarbamic acid inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein]; Vitamin E inhibits the reaction [Platelet Activating Factor results in increased degradation of NFKBIA protein] CTD PMID:10921504 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 increases expression ISO Platelet Activating Factor results in increased expression of OLR1 mRNA CTD PMID:16386258 NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523 		JBrowse link
G Pla2g7 phospholipase A2 group VII multiple interactions
increases expression		 ISO [lipopolysaccharide, Escherichia coli O111 B4 co-treated with Platelet Activating Factor] results in increased expression of PLA2G7 mRNA; bepafant inhibits the reaction [Platelet Activating Factor results in increased expression of PLA2G7 mRNA] CTD PMID:21432021 NCBI chr 9:17,362,214...17,404,476
Ensembl chr 9:17,362,225...17,404,476 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha decreases expression ISO Platelet Activating Factor results in decreased expression of PPARA mRNA CTD PMID:16386258 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ptafr platelet-activating factor receptor multiple interactions
increases expression
increases phosphorylation
affects binding		 ISO
EXP		 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; BN 50730 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; BN 50739 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; CMI 392 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; MK 287 inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]; zileuton inhibits the reaction [Platelet Activating Factor binds to PTAFR protein]
Platelet Activating Factor results in increased expression of PTAFR mRNA
Platelet Activating Factor results in increased phosphorylation of PTAFR protein
bepafant inhibits the reaction [Platelet Activating Factor results in increased expression of PTAFR mRNA]; Carbon Tetrachloride promotes the reaction [Platelet Activating Factor binds to PTAFR protein]; RGS4 protein inhibits the reaction [Platelet Activating Factor results in increased phosphorylation of PTAFR protein]; TNF protein affects the reaction [Platelet Activating Factor results in increased expression of PTAFR mRNA]		 CTD PMID:9065783 PMID:10447766 PMID:11297424 PMID:11529688 PMID:16386258 More... NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases expression ISO Platelet Activating Factor results in increased expression of PTGS1 mRNA CTD PMID:16386258 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Platelet Activating Factor results in increased expression of PTGS2 mRNA CTD PMID:16386258 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pvt1 Pvt1 oncogene increases expression
multiple interactions		 ISO Platelet Activating Factor results in increased expression of PVT1 mRNA
[Platelet Activating Factor co-treated with PVT1 mRNA] affects the expression of MIR149 mRNA; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased expression of MYD88 protein]; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of IL1B protein]; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of IL6 protein]; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of TNF protein]		 CTD PMID:32830409 NCBI chr 7:93,656,528...93,879,938 JBrowse link
G Rgs4 regulator of G-protein signaling 4 multiple interactions EXP RGS4 protein inhibits the reaction [Platelet Activating Factor results in increased phosphorylation of PTAFR protein] CTD PMID:11297424 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068 		JBrowse link
G Sele selectin E increases expression ISO Platelet Activating Factor results in increased expression of SELE mRNA CTD PMID:16386258 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Sell selectin L multiple interactions
increases secretion		 ISO Isoproterenol promotes the reaction [Theophylline inhibits the reaction [Platelet Activating Factor results in increased secretion of SELL protein]]; Theophylline inhibits the reaction [Platelet Activating Factor results in increased secretion of SELL protein] CTD PMID:9762784 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456 		JBrowse link
G Selp selectin P multiple interactions
increases expression		 ISO Foropafant inhibits the reaction [Platelet Activating Factor results in increased expression of SELP protein] CTD PMID:11116075 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G Timp4 TIMP metallopeptidase inhibitor 4 increases expression ISO Platelet Activating Factor results in increased expression of TIMP4 mRNA CTD PMID:16386258 NCBI chr 4:148,306,021...148,312,558
Ensembl chr 4:148,304,490...148,312,558 		JBrowse link
G Tnf tumor necrosis factor increases secretion
multiple interactions
increases expression		 ISO
EXP		 Platelet Activating Factor results in increased secretion of TNF protein
[Platelet Activating Factor co-treated with MIR149 mRNA] affects the secretion of TNF protein; PVT1 mRNA affects the reaction [Platelet Activating Factor results in increased secretion of TNF protein]
TNF protein affects the reaction [Platelet Activating Factor results in increased expression of PTAFR mRNA]
Platelet Activating Factor results in increased expression of TNF mRNA
Acetylcysteine inhibits the reaction [Platelet Activating Factor results in increased expression of TNF mRNA]; BN 50739 inhibits the reaction [Platelet Activating Factor results in increased expression of TNF mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Platelet Activating Factor results in increased expression of TNF mRNA]; Vitamin E inhibits the reaction [Platelet Activating Factor results in increased expression of TNF mRNA]		 CTD PMID:9065783 PMID:10921504 PMID:16386258 PMID:32830409 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
2-O-acetyl-1-O-octadecyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Tnf tumor necrosis factor increases expression EXP platelet-activating factor increases expression of Tnf protein in portal stenosis rat plasma RGD PMID:10452877 RGD:38508900 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
2-trans,6-trans,10-trans-geranylgeranyl diphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [kuwanon G results in increased expression of ABCB1 protein] CTD PMID:29355567 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [kuwanon G results in increased expression of ABCG1 protein] CTD PMID:29355567 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of AKT1 mRNA]
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]		 CTD PMID:18031796 PMID:33034787 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of BCL2 mRNA] CTD PMID:18031796 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in decreased expression of BIRC5 protein] CTD PMID:17472962 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]] CTD PMID:18310456 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP		 geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin results in increased activity of CASP3 protein]; geranylgeranyl pyrophosphate inhibits the reaction [cerivastatin results in increased activity of CASP3 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased activity of CASP3 protein] CTD PMID:15200425 PMID:16470222 PMID:18766339 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TGFB1 results in increased expression of CCN2 mRNA]] CTD PMID:15298857 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Ccna2 cyclin A2 multiple interactions EXP geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CCNA2 protein] CTD PMID:26577051 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577 		JBrowse link
G Ccne1 cyclin E1 multiple interactions EXP geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CCNE1 protein] CTD PMID:26577051 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cd40 CD40 molecule multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]] CTD PMID:17507688 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions EXP geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CDK1 protein] CTD PMID:26577051 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions EXP geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CDK2 protein] CTD PMID:26577051 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of CDKN1A protein] CTD PMID:18625202 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of COL1A1 mRNA] CTD PMID:16575855 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Crp C-reactive protein multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein]] CTD PMID:18023360 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions EXP geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CYP17A1 mRNA] CTD PMID:21918126 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [resveratrol results in increased expression of CYP7A1 mRNA] CTD PMID:22607622 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of F3 mRNA] CTD PMID:18031796 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Fbxo32 F-box protein 32 multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of FBXO32 mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of FBXO32 protein] CTD PMID:19406843 NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436 		JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of and affects the localization of FOXO1 protein] CTD PMID:33034787 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Ggps1 geranylgeranyl diphosphate synthase 1 decreases activity ISO geranylgeranyl pyrophosphate analog results in decreased activity of GGPS1 protein CTD PMID:16787319 NCBI chr17:51,263,262...51,282,471
Ensembl chr17:51,263,263...51,276,220 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO [Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of geranylgeranyl pyrophosphate CTD PMID:17208200 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]] CTD PMID:18625914 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]] CTD PMID:10946302 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CD40 protein]] CTD PMID:17507688 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B protein] CTD PMID:15187114 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO
EXP		 geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in increased abundance of Nitric Oxide]]		 CTD PMID:15705589 PMID:15728660 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]] CTD PMID:10946302 PMID:17075836 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]]
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]]		 CTD PMID:16511915 PMID:17075836 PMID:17729120 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Irf4 interferon regulatory factor 4 multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of IRF4 mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of IRF4 protein] CTD PMID:33034787 NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070 		JBrowse link
G Lep leptin multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of LEP mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased secretion of LEP protein] CTD PMID:19254925 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK1 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]] CTD PMID:16470222 PMID:18625914 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin results in decreased phosphorylation of MAPK3 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]] CTD PMID:16470222 PMID:18625914 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mbp myelin basic protein multiple interactions EXP geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of MBP mRNA] CTD PMID:20578043 NCBI chr18:75,855,878...75,966,404
Ensembl chr18:75,855,878...75,966,404 		JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased expression of MMP1]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of MMP1 mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of MMP1 protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased secretion of MMP1 protein] CTD PMID:17303772 PMID:18625914 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO
EXP		 geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]]
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased expression of MMP9 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased expression of MMP9]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased secretion of MMP9 protein]]		 CTD PMID:15728660 PMID:19299917 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mstn myostatin multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of MSTN mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of MSTN protein] CTD PMID:33034787 NCBI chr 9:48,452,533...48,458,933
Ensembl chr 9:48,452,533...48,458,933 		JBrowse link
G Mvk mevalonate kinase multiple interactions
decreases chemical synthesis
decreases activity		 ISO geranylgeranyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; geranylgeranyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]
MVK protein mutant form results in decreased chemical synthesis of geranylgeranyl pyrophosphate
geranylgeranyl pyrophosphate results in decreased activity of MVK protein		 CTD PMID:9392419 PMID:24073415 NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]] CTD PMID:17075836 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [IL1A results in decreased expression of NOS2 protein]] CTD PMID:15705589 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 decreases activity ISO geranylgeranyl pyrophosphate results in decreased activity of NR1H3 protein CTD PMID:22607622 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of NR4A3 mRNA] CTD PMID:16005304 NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [TNFSF10 protein promotes the reaction [Simvastatin results in increased cleavage of PARP1 protein]] CTD PMID:21910007 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pdgfb platelet derived growth factor subunit B multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]] CTD PMID:15728660 NCBI chr 7:111,539,444...111,557,984
Ensembl chr 7:111,540,345...111,557,984 		JBrowse link
G Plat plasminogen activator, tissue type multiple interactions EXP geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PLAT protein] CTD PMID:10412747 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA] CTD PMID:14500290 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PPARG mRNA] CTD PMID:20578043 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions EXP geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of PTEN mRNA] CTD PMID:20578043 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin inhibits the reaction [Glucose results in increased localization of RAC1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of RAC1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of RAC1 protein]] CTD PMID:17279352 PMID:18625914 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Retn resistin multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein]] CTD PMID:18023360 NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620 		JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin results in decreased activity of RHOA protein]; geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin results in increased localization of RHOA protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin affects the localization of and results in decreased activity of RHOA protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in decreased activity of RHOA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased activity of RHOA protein]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased localization of RHOA protein]; Simvastatin inhibits the reaction [geranylgeranyl pyrophosphate affects the localization of RHOA protein]
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]]		 CTD PMID:16005304 PMID:16470222 PMID:17075836 PMID:18031796 PMID:18310456 More... NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]] CTD PMID:18310456 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Sele selectin E multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]] CTD PMID:10946302 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Sox10 SRY-box transcription factor 10 multiple interactions EXP geranylgeranyl pyrophosphate inhibits the reaction [Lovastatin results in increased expression of SOX10 mRNA] CTD PMID:20578043 NCBI chr 7:110,725,274...110,734,651
Ensembl chr 7:110,725,274...110,735,544 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions
increases expression		 ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of STAT1 mRNA]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of STAT1 protein]
geranylgeranyl pyrophosphate results in increased expression of STAT1 protein		 CTD PMID:17507688 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TGFB1 results in increased expression of CCN2 mRNA]] CTD PMID:15298857 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CXCL8 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]]
geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased abundance of Nitric Oxide]]; geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [[Lipopolysaccharides co-treated with TNF] results in increased expression of IL6 protein]]		 CTD PMID:16511915 PMID:17075836 PMID:17729120 PMID:18310456 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]]; geranylgeranyl pyrophosphate inhibits the reaction [TNFSF10 protein promotes the reaction [Simvastatin results in increased cleavage of PARP1 protein]] CTD PMID:21910007 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO geranylgeranyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of VEGFA mRNA] CTD PMID:18356691 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
2-trans,6-trans-farnesyl diphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein] CTD PMID:33034787 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Lovastatin results in decreased expression of BIRC5 protein] CTD PMID:17472962 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]] CTD PMID:18310456 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP		 farnesyl pyrophosphate inhibits the reaction [Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein]
farnesyl pyrophosphate inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]		 CTD PMID:15200425 PMID:18766339 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions EXP farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CYP17A1 mRNA] CTD PMID:21918126 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Fnta farnesyltransferase, CAAX box, alpha multiple interactions EXP [FNTA protein binds to FNTB protein] binds to [farnesyl pyrophosphate analog co-treated with KRAS protein] CTD PMID:10673434 NCBI chr16:66,065,131...66,083,460
Ensembl chr16:66,065,132...66,083,460 		JBrowse link
G Fntb farnesyltransferase, CAAX box, beta multiple interactions EXP [FNTA protein binds to FNTB protein] binds to [farnesyl pyrophosphate analog co-treated with KRAS protein] CTD PMID:10673434 NCBI chr 6:95,536,540...95,619,587
Ensembl chr 6:95,470,683...95,619,586 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of FOS mRNA] CTD PMID:16005304 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of FOXO1 protein] CTD PMID:33034787 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO [Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of farnesyl pyrophosphate CTD PMID:17208200 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of HRAS protein]] CTD PMID:18625914 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]] CTD PMID:10946302 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B protein] CTD PMID:15187114 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]] CTD PMID:10946302 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions EXP [FNTA protein binds to FNTB protein] binds to [farnesyl pyrophosphate analog co-treated with KRAS protein] CTD PMID:10673434 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK1 protein]] CTD PMID:18310456 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK3 protein]] CTD PMID:18310456 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK8 protein]] CTD PMID:18310456 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased expression of MMP9 mRNA]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased secretion of MMP9 protein]] CTD PMID:19299917 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mvk mevalonate kinase decreases activity
decreases chemical synthesis
multiple interactions		 ISO farnesyl pyrophosphate results in decreased activity of MVK protein
MVK protein mutant form results in decreased chemical synthesis of farnesyl pyrophosphate
farnesyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; farnesyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]		 CTD PMID:9392419 PMID:24073415 NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA]; farnesyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA] CTD PMID:14500290 PMID:15690306 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of RAC1 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of RAC1 protein]] CTD PMID:18625914 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in decreased activity of RHOA protein]]
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]]		 CTD PMID:18310456 PMID:18625914 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]] CTD PMID:18310456 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Sele selectin E multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]] CTD PMID:10946302 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK1 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK3 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK8 protein]] CTD PMID:18310456 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
ceramide 1-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cerk ceramide kinase affects abundance ISO CERK protein affects the abundance of ceramide 1-phosphate CTD PMID:15899891 NCBI chr 7:117,225,855...117,269,436
Ensembl chr 7:117,225,855...117,268,759 		JBrowse link
dioleoyl phosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plek pleckstrin multiple interactions ISO dioleoylphosphatidic acid analog promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased phosphorylation of PLEK protein] CTD PMID:8928743 NCBI chr14:91,397,015...91,429,693
Ensembl chr14:91,397,019...91,454,131 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions ISO [1,2-oleoylphosphatidylcholine co-treated with dioleoylphosphatidic acid] binds to SOD1 protein; [1,2-oleoylphosphatidylcholine co-treated with dioleoylphosphatidic acid] binds to SOD1 protein mutant form; [1,2-oleoylphosphatidylcholine co-treated with dioleoylphosphatidic acid] promotes the reaction [SOD1 protein binds to SOD1 protein]; [1,2-oleoylphosphatidylcholine co-treated with dioleoylphosphatidic acid] promotes the reaction [SOD1 protein mutant form binds to SOD1 protein mutant form] CTD PMID:29649360 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
dipalmitoyl phosphatidylglycerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pon1 paraoxonase 1 multiple interactions ISO 1,2-dipalmitoylphosphatidylglycerol inhibits the reaction [Copper promotes the reaction [Ascorbic Acid results in decreased activity of PON1 protein]] CTD PMID:15104111 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
dolichyl phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mvk mevalonate kinase decreases activity
multiple interactions		 ISO dolichol monophosphate results in decreased activity of MVK protein
dolichol monophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; dolichol monophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]		 CTD PMID:9392419 NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882 		JBrowse link
edelfosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO edelfosine inhibits the reaction [Nicotine results in increased phosphorylation of BCL2 protein]; edelfosine inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2 protein]; edelfosine promotes the reaction [Cytarabine results in decreased expression of BCL2 protein] CTD PMID:9295281 PMID:12421819 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 multiple interactions ISO edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]; edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]] CTD PMID:17571167 NCBI chr 2:26,772,274...26,785,226
Ensembl chr 2:26,772,278...26,785,226 		JBrowse link
G Lep leptin multiple interactions ISO edelfosine inhibits the reaction [LEP protein results in increased transport of Calcium] CTD PMID:20107083 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Plcb2 phospholipase C, beta 2 multiple interactions ISO edelfosine inhibits the reaction [Cytarabine affects the localization of PLCB2 protein]; edelfosine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PLCB2 protein] CTD PMID:9295281 NCBI chr 3:105,683,676...105,704,384
Ensembl chr 3:105,684,815...105,704,302 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO edelfosine results in increased expression of PTGS2 protein CTD PMID:12485854 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions ISO edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]]; edelfosine inhibits the reaction [F2RL1 protein promotes the reaction [cinnamaldehyde results in increased activity of TRPA1 protein]] CTD PMID:17571167 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
eritoran term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gpt glutamic--pyruvic transaminase multiple interactions ISO eritoran inhibits the reaction [Azathioprine results in increased expression of GPT protein]; eritoran inhibits the reaction [Diclofenac results in increased expression of GPT protein]; eritoran inhibits the reaction [Dicloxacillin results in increased expression of GPT protein]; eritoran inhibits the reaction [Halothane results in increased expression of GPT protein] CTD PMID:24184165 PMID:24747151 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
farnesyl diphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein] CTD PMID:33034787 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Lovastatin results in decreased expression of BIRC5 protein] CTD PMID:17472962 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380 		JBrowse link
G Bmp2 bone morphogenetic protein 2 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]] CTD PMID:18310456 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP		 farnesyl pyrophosphate inhibits the reaction [Lovastatin results in increased activity of and results in increased cleavage of CASP3 protein]
farnesyl pyrophosphate inhibits the reaction [Simvastatin results in increased activity of CASP3 protein]		 CTD PMID:15200425 PMID:18766339 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions EXP farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of CYP17A1 mRNA] CTD PMID:21918126 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Fnta farnesyltransferase, CAAX box, alpha multiple interactions EXP [FNTA protein binds to FNTB protein] binds to [farnesyl pyrophosphate analog co-treated with KRAS protein] CTD PMID:10673434 NCBI chr16:66,065,131...66,083,460
Ensembl chr16:66,065,132...66,083,460 		JBrowse link
G Fntb farnesyltransferase, CAAX box, beta multiple interactions EXP [FNTA protein binds to FNTB protein] binds to [farnesyl pyrophosphate analog co-treated with KRAS protein] CTD PMID:10673434 NCBI chr 6:95,536,540...95,619,587
Ensembl chr 6:95,470,683...95,619,586 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased expression of FOS mRNA] CTD PMID:16005304 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin results in decreased phosphorylation of FOXO1 protein] CTD PMID:33034787 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions ISO [Lovastatin results in decreased activity of HMGCR protein] which results in decreased abundance of farnesyl pyrophosphate CTD PMID:17208200 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of HRAS protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of HRAS protein]] CTD PMID:18625914 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]] CTD PMID:10946302 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL12B protein] CTD PMID:15187114 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]] CTD PMID:10946302 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions EXP [FNTA protein binds to FNTB protein] binds to [farnesyl pyrophosphate analog co-treated with KRAS protein] CTD PMID:10673434 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK1 protein]] CTD PMID:18310456 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK3 protein]] CTD PMID:18310456 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK8 protein]] CTD PMID:18310456 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased expression of MMP9 mRNA]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Smoke analog results in increased secretion of MMP9 protein]] CTD PMID:19299917 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mvk mevalonate kinase decreases activity
decreases chemical synthesis
multiple interactions		 ISO farnesyl pyrophosphate results in decreased activity of MVK protein
MVK protein mutant form results in decreased chemical synthesis of farnesyl pyrophosphate
farnesyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; farnesyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]		 CTD PMID:9392419 PMID:24073415 NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA]; farnesyl pyrophosphate inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA] CTD PMID:14500290 PMID:15690306 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Rac1 Rac family small GTPase 1 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of RAC1 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of RAC1 protein]] CTD PMID:18625914 NCBI chr12:11,037,028...11,057,251
Ensembl chr12:11,036,698...11,057,251 		JBrowse link
G Rhoa ras homolog family member A multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in decreased activity of RHOA protein]]
farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]]		 CTD PMID:18310456 PMID:18625914 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]] CTD PMID:18310456 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Sele selectin E multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]] CTD PMID:10946302 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF affects the localization of RHOA protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF protein inhibits the reaction [BMP2 results in increased expression of RUNX2 mRNA]]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK1 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK3 protein]]; farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased phosphorylation of MAPK8 protein]] CTD PMID:18310456 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
geranyl diphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases abundance		 ISO [geranylgeraniol co-treated with geranyl pyrophosphate] results in decreased expression of HMGCR protein; Lovastatin inhibits the reaction [HMGCR protein results in increased abundance of geranyl diphosphate] CTD PMID:19819230 PMID:19856009 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Mvk mevalonate kinase decreases activity
multiple interactions		 ISO geranyl diphosphate results in decreased activity of MVK protein
geranyl diphosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; geranyl diphosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]		 CTD PMID:9392419 NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882 		JBrowse link
G Rap1a RAP1A, member of RAS oncogene family multiple interactions ISO [geranylgeraniol co-treated with geranyl pyrophosphate] results in decreased expression of RAP1A protein modified form CTD PMID:19819230 NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501 		JBrowse link
glycerylphosphorylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gdpd5 glycerophosphodiester phosphodiesterase domain containing 5 affects abundance ISO GDPD5 protein affects the abundance of Glycerylphosphorylcholine CTD PMID:33617914 NCBI chr 1:153,679,718...153,761,452
Ensembl chr 1:153,679,718...153,761,446 		JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 affects abundance ISO PNPLA6 protein affects the abundance of Glycerylphosphorylcholine CTD PMID:36336212 NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734 		JBrowse link
isopentenyl diphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccr5 C-C motif chemokine receptor 5 decreases expression ISO isopentenyl pyrophosphate results in decreased expression of CCR5 protein CTD PMID:11994442 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Fdps farnesyl diphosphate synthase multiple interactions ISO [zoledronic acid results in decreased activity of FDPS protein] which results in increased abundance of isopentenyl pyrophosphate CTD PMID:19699819 NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776 		JBrowse link
G Fgf9 fibroblast growth factor 9 increases expression ISO isopentenyl pyrophosphate results in increased expression of FGF9 mRNA; isopentenyl pyrophosphate results in increased expression of FGF9 protein CTD PMID:14704367 NCBI chr15:32,208,993...32,254,952
Ensembl chr15:32,210,074...32,253,309 		JBrowse link
G Ifng interferon gamma multiple interactions
increases expression		 ISO Calcitriol inhibits the reaction [isopentenyl pyrophosphate results in increased expression of IFNG protein] CTD PMID:15879110 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il2ra interleukin 2 receptor subunit alpha multiple interactions
increases expression		 ISO Calcitriol inhibits the reaction [isopentenyl pyrophosphate results in increased expression of IL2RA protein] CTD PMID:15879110 NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697 		JBrowse link
G Mvk mevalonate kinase multiple interactions
decreases activity		 ISO isopentenyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; isopentenyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]
isopentenyl pyrophosphate results in decreased activity of MVK protein		 CTD PMID:9392419 NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882 		JBrowse link
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 multiple interactions ISO isopentenyl pyrophosphate inhibits the reaction [cinnamaldehyde results in increased activity of TRPA1 protein] CTD PMID:21353389 NCBI chr 5:4,379,862...4,434,133
Ensembl chr 5:4,379,999...4,433,570 		JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 multiple interactions ISO isopentenyl pyrophosphate inhibits the reaction [Camphor results in increased activity of TRPV3 protein] CTD PMID:21353389 NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296 		JBrowse link
G Vdr vitamin D receptor multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [isopentenyl pyrophosphate results in increased expression of VDR protein]; Go 6976 inhibits the reaction [isopentenyl pyrophosphate results in increased expression of VDR protein]; U 0126 inhibits the reaction [isopentenyl pyrophosphate results in increased expression of VDR protein] CTD PMID:15879110 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
lipid As term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl3 C-C motif chemokine ligand 3 increases expression
multiple interactions		 ISO Lipid A results in increased expression of CCL3 mRNA
anacetrapib inhibits the reaction [Lipid A results in increased expression of CCL3 mRNA]		 CTD PMID:20448206 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ifng interferon gamma multiple interactions
increases expression		 ISO [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IFNG mRNA; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IFNG protein; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipid A] results in increased expression of IFNG mRNA; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipid A] results in increased expression of IFNG protein
Lipid A results in increased expression of IFNG mRNA; Lipid A results in increased expression of IFNG protein		 CTD PMID:16299289 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il12a interleukin 12A multiple interactions
increases expression		 ISO [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of [IL12A protein binds to IL12B protein]; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IL12A mRNA; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipid A] results in increased expression of [IL12A protein binds to IL12B protein]; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipid A] results in increased expression of IL12A mRNA; Lipid A results in increased expression of [IL12A protein binds to IL12B protein]
Lipid A results in increased expression of IL12A mRNA		 CTD PMID:16299289 NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734 		JBrowse link
G Il12b interleukin 12B multiple interactions
increases expression		 ISO [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of [IL12A protein binds to IL12B protein]; [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IL12B mRNA; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipid A] results in increased expression of [IL12A protein binds to IL12B protein]; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipid A] results in increased expression of IL12B mRNA; Lipid A results in increased expression of [IL12A protein binds to IL12B protein]
Lipid A results in increased expression of IL12B mRNA		 CTD PMID:16299289 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il15 interleukin 15 multiple interactions
increases expression		 ISO [Acetylmuramyl-Alanyl-Isoglutamine co-treated with Lipid A] results in increased expression of IL15 mRNA; [heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine co-treated with Lipid A] results in increased expression of IL15 mRNA
Lipid A results in increased expression of IL15 mRNA		 CTD PMID:16299289 NCBI chr19:25,640,025...25,706,818
Ensembl chr19:25,640,251...25,706,820 		JBrowse link
G Il18 interleukin 18 increases expression ISO Lipid A results in increased expression of IL18 mRNA CTD PMID:16299289 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO anacetrapib inhibits the reaction [Lipid A results in increased expression of IL6 mRNA] CTD PMID:20448206 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO anacetrapib inhibits the reaction [Lipid A results in increased expression of TNF mRNA] CTD PMID:20448206 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
lipoarabinomannan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Csf2 colony stimulating factor 2 multiple interactions ISO CSF2 protein promotes the reaction [lipoarabinomannan results in increased secretion of CXCL8 protein] CTD PMID:12176910 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199 		JBrowse link
G Cxcr2 C-X-C motif chemokine receptor 2 decreases expression ISO lipoarabinomannan results in decreased expression of CXCR2 protein CTD PMID:10950785 NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO lipoarabinomannan inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B protein] CTD PMID:16263713 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO lipoarabinomannan inhibits the reaction [IRAK1 protein binds to TRAF6 protein] CTD PMID:16263713 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521 		JBrowse link
G Irak3 interleukin-1 receptor-associated kinase 3 increases expression
increases expression 		ISO lipoarabinomannan results in increased expression of IRAK3 protein
Lipoarabinomannan increases expression of Irak3 mRNA and protein in macrophages		 CTD
RGD		 PMID:16263713 PMID:16263713 RGD:36049804 NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases activity ISO lipoarabinomannan results in increased activity of MMP9 protein CTD PMID:11839551 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO lipoarabinomannan results in decreased localization of and results in decreased activity of NFKB1 protein CTD PMID:16263713 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases phosphorylation ISO lipoarabinomannan results in decreased phosphorylation of NFKBIA protein CTD PMID:16263713 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Rel REL proto-oncogene, NF-kB subunit multiple interactions ISO lipoarabinomannan results in decreased localization of and results in decreased activity of REL protein CTD PMID:16263713 NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892 		JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO lipoarabinomannan inhibits the reaction [IRAK1 protein binds to TRAF6 protein] CTD PMID:16263713 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
lipophosphoglycan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd14 CD14 molecule multiple interactions ISO CD14 protein promotes the reaction [lipopeptidophosphoglycan results in increased activity of TLR2 protein]; CD14 protein promotes the reaction [lipopeptidophosphoglycan results in increased activity of TLR4 protein] CTD PMID:15910421 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of IL10 protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL10 protein CTD PMID:15910421 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of IL12B protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL12B protein CTD PMID:15910421 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] results in increased activity of [NFKB1 protein binds to RELA protein]; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] results in increased activity of [NFKB1 protein binds to RELA protein] CTD PMID:15910421 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] results in increased activity of [NFKB1 protein binds to RELA protein]; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] results in increased activity of [NFKB1 protein binds to RELA protein] CTD PMID:15910421 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions
increases response to substance		 ISO [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] results in increased activity of [NFKB1 protein binds to RELA protein]; [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of CXCL8 protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of IL10 protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of IL12B protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of TNF protein; CD14 protein promotes the reaction [lipopeptidophosphoglycan results in increased activity of TLR2 protein]; lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein
TLR2 protein results in increased susceptibility to lipopeptidophosphoglycan		 CTD PMID:15910421 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions
increases response to substance		 ISO [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] results in increased activity of [NFKB1 protein binds to RELA protein]; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of CXCL8 protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL10 protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL12B protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of TNF protein; CD14 protein promotes the reaction [lipopeptidophosphoglycan results in increased activity of TLR4 protein]; lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein
TLR4 protein results in increased susceptibility to lipopeptidophosphoglycan		 CTD PMID:15910421 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO [lipopeptidophosphoglycan binds to and results in increased activity of TLR2 protein] which results in increased secretion of TNF protein; [lipopeptidophosphoglycan binds to and results in increased activity of TLR4 protein] which results in increased secretion of TNF protein CTD PMID:15910421 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
lysophosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ddr1 discoidin domain receptor tyrosine kinase 1 ISO lysophosphatidic acid increased expression of Ddr1 in 3T3 and GD25 cells RGD PMID:28199848 RGD:151347403 NCBI chr20:3,042,494...3,064,442
Ensembl chr20:3,044,320...3,064,468 		JBrowse link
G Prkd1 protein kinase D1 increases phosphorylation EXP LPA increases phosphorylation of Prkd1 protein in neonatal ventricular myocytes RGD PMID:16648482 RGD:243065275 NCBI chr 6:67,725,193...68,039,002
Ensembl chr 6:67,725,905...68,039,042 		JBrowse link
lysophosphatidylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bmal1 basic helix-loop-helix ARNT like 1 affects abundance ISO BMAL1 gene mutant form affects the abundance of Lysophosphatidylcholines CTD PMID:27056296 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions		 ISO Lysophosphatidylcholines results in increased expression of CASP3 protein
GPR4 protein promotes the reaction [Lysophosphatidylcholines results in increased expression of CASP3 protein]		 CTD PMID:34293432 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cav1 caveolin 1 multiple interactions
increases expression		 ISO alpha-Tocopherol inhibits the reaction [Lysophosphatidylcholines results in increased expression of CAV1 mRNA]; quercetin 3-O-glucuronide inhibits the reaction [Lysophosphatidylcholines results in increased expression of CAV1 mRNA]; Quercetin inhibits the reaction [Lysophosphatidylcholines results in increased expression of CAV1 mRNA]; Quercetin inhibits the reaction [Lysophosphatidylcholines results in increased expression of CAV1 protein]
Lysophosphatidylcholines results in increased expression of CAV1 mRNA; Lysophosphatidylcholines results in increased expression of CAV1 protein		 CTD PMID:27257344 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 multiple interactions ISO [[Capsaicin results in increased chemical synthesis of Lysophosphatidylcholines] which results in increased secretion of Lysophosphatidylcholines] promotes the reaction [ENPP2 results in increased chemical synthesis of lysophosphatidic acid]; [ENPP2 protein co-treated with Lysophosphatidylcholines] results in increased chemical synthesis of lysophosphatidic acid CTD PMID:19014389 NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827 		JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 increases hydrolysis ISO ENPP7 protein results in increased hydrolysis of Lysophosphatidylcholines CTD PMID:12885774 NCBI chr10:104,242,169...104,247,185
Ensembl chr10:104,242,223...104,246,589 		JBrowse link
G Fscn1 fascin actin-bundling protein 1 increases expression ISO Lysophosphatidylcholines results in increased expression of FSCN1 mRNA CTD PMID:22102721 NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211 		JBrowse link
G Gja1 gap junction protein, alpha 1 increases ubiquitination
multiple interactions		 EXP Lysophosphatidylcholines results in increased ubiquitination of GJA1 protein
Lysophosphatidylcholines affects the localization of and results in increased phosphorylation of GJA1 protein; PRKCE affects the reaction [Lysophosphatidylcholines results in increased phosphorylation of GJA1 protein]		 CTD PMID:23973256 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582 		JBrowse link
G Gpr4 G protein-coupled receptor 4 increases expression
multiple interactions		 ISO Lysophosphatidylcholines results in increased expression of GPR4 mRNA; Lysophosphatidylcholines results in increased expression of GPR4 protein
GPR4 protein promotes the reaction [Lysophosphatidylcholines results in increased expression of CASP3 protein]; GPR4 protein promotes the reaction [Lysophosphatidylcholines results in increased expression of IL18 protein]; GPR4 protein promotes the reaction [Lysophosphatidylcholines results in increased expression of IL1B protein]; GPR4 protein promotes the reaction [Lysophosphatidylcholines results in increased expression of IL33 protein]; GPR4 protein promotes the reaction [Lysophosphatidylcholines results in increased expression of NLRP3 protein]		 CTD PMID:34293432 NCBI chr 1:78,865,376...78,877,126
Ensembl chr 1:78,865,409...78,876,599 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Lysophosphatidylcholines results in increased expression of HMOX1 mRNA CTD PMID:9808084 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Icam1 intercellular adhesion molecule 1 increases expression
multiple interactions		 ISO Lysophosphatidylcholines results in increased expression of ICAM1 mRNA
quercetin 3-O-glucuronide inhibits the reaction [Lysophosphatidylcholines results in increased expression of ICAM1 mRNA]; Quercetin inhibits the reaction [Lysophosphatidylcholines results in increased expression of ICAM1 mRNA]		 CTD PMID:27257344 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Il18 interleukin 18 increases expression
multiple interactions		 ISO Lysophosphatidylcholines results in increased expression of IL18 protein
GPR4 protein promotes the reaction [Lysophosphatidylcholines results in increased expression of IL18 protein]		 CTD PMID:34293432 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 ISO Lysophosphatidylcholines results in increased expression of IL1B protein
GPR4 protein promotes the reaction [Lysophosphatidylcholines results in increased expression of IL1B protein]		 CTD PMID:34293432 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il33 interleukin 33 increases expression
multiple interactions		 ISO Lysophosphatidylcholines results in increased expression of IL33 protein
GPR4 protein promotes the reaction [Lysophosphatidylcholines results in increased expression of IL33 protein]		 CTD PMID:34293432 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Lama3 laminin subunit alpha 3 increases expression ISO Lysophosphatidylcholines results in increased expression of LAMA3 mRNA CTD PMID:15541073 NCBI chr18:3,523,168...3,751,722
Ensembl chr18:3,523,133...3,751,353 		JBrowse link
G Lamb3 laminin subunit beta 3 increases expression ISO Lysophosphatidylcholines results in increased expression of LAMB3 mRNA CTD PMID:15541073 NCBI chr13:104,833,810...104,875,405
Ensembl chr13:104,833,873...104,875,405 		JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression ISO Lysophosphatidylcholines results in increased expression of LAMC2 mRNA CTD PMID:15541073 NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lysophosphatidylcholines results in increased phosphorylation of MAPK1 protein]; resveratrol inhibits the reaction [Lysophosphatidylcholines results in increased phosphorylation of MAPK1 protein] CTD PMID:20564508 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lysophosphatidylcholines results in increased phosphorylation of MAPK3 protein]; resveratrol inhibits the reaction [Lysophosphatidylcholines results in increased phosphorylation of MAPK3 protein] CTD PMID:20564508 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mfsd2a MFSD2 lysolipid transporter A, lysophospholipid increases transport ISO MFSD2A results in increased transport of Lysophosphatidylcholines CTD PMID:26005865 NCBI chr 5:135,225,801...135,240,744
Ensembl chr 5:135,225,816...135,240,690 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions
increases expression		 ISO GPR4 protein promotes the reaction [Lysophosphatidylcholines results in increased expression of NLRP3 protein] CTD PMID:34293432 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
increases expression		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lysophosphatidylcholines results in increased expression of NOS2 mRNA]; Resveratrol inhibits the reaction [Lysophosphatidylcholines results in increased expression of NOS2 mRNA] CTD PMID:20564508 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
decreases expression		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lysophosphatidylcholines results in decreased expression of NOS3 mRNA]; resveratrol inhibits the reaction [Lysophosphatidylcholines results in decreased expression of NOS3 mRNA] CTD PMID:20564508 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions ISO [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Lysophosphatidylcholines CTD PMID:29515023 NCBI chr13:48,313,634...48,433,494
Ensembl chr13:48,316,301...48,433,326 		JBrowse link
G Pah phenylalanine hydroxylase multiple interactions ISO Lysophosphatidylcholines results in increased activity of [PAH protein binds to PAH protein binds to PAH protein binds to PAH protein] CTD PMID:19367645 NCBI chr 7:21,933,179...21,998,134
Ensembl chr 7:21,933,179...21,998,130 		JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 affects abundance ISO PNPLA6 protein affects the abundance of Lysophosphatidylcholines CTD PMID:36336212 NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734 		JBrowse link
G Prkce protein kinase C, epsilon multiple interactions EXP PRKCE affects the reaction [Lysophosphatidylcholines results in increased phosphorylation of GJA1 protein] CTD PMID:23973256 NCBI chr 6:7,965,048...8,451,966
Ensembl chr 6:7,965,048...8,451,719 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 decreases expression
multiple interactions		 EXP Lysophosphatidylcholines results in decreased expression of PTGS1 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lysophosphatidylcholines results in decreased expression of PTGS1 mRNA]; resveratrol inhibits the reaction [Lysophosphatidylcholines results in decreased expression of PTGS1 mRNA]		 CTD PMID:20564508 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Lysophosphatidylcholines results in increased expression of PTGS2 mRNA]; resveratrol inhibits the reaction [Lysophosphatidylcholines results in increased expression of PTGS2 mRNA] CTD PMID:20564508 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of Lysophosphatidylcholines CTD PMID:30258081 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trpc5 transient receptor potential cation channel, subfamily C, member 5 multiple interactions ISO Lysophosphatidylcholines promotes the reaction [TRPC5 protein results in increased transport of Calcium]; resveratrol inhibits the reaction [Lysophosphatidylcholines promotes the reaction [TRPC5 protein results in increased transport of Calcium]] CTD PMID:21127073 NCBI chr  X:107,946,163...108,230,991
Ensembl chr  X:107,939,131...108,230,991 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 increases expression ISO Lysophosphatidylcholines results in increased expression of VCAM1 mRNA CTD PMID:27257344 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
lysophosphatidylethanolamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Birc3 baculoviral IAP repeat-containing 3 multiple interactions ISO lysophosphatidylethanolamine analog inhibits the reaction [cobaltous chloride results in decreased expression of BIRC3 protein] CTD PMID:25125499 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO lysophosphatidylethanolamine analog inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]
lysophosphatidylethanolamine analog inhibits the reaction [Glycochenodeoxycholic Acid results in increased cleavage of CASP3 protein]		 CTD PMID:25125499 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions
increases expression		 ISO lysophosphatidylethanolamine analog inhibits the reaction [cobaltous chloride results in decreased expression of CFLAR mRNA]
lysophosphatidylethanolamine analog results in increased expression of CFLAR protein
Glycochenodeoxycholic Acid promotes the reaction [lysophosphatidylethanolamine analog results in increased expression of CFLAR protein]; lysophosphatidylethanolamine analog promotes the reaction [Glycochenodeoxycholic Acid results in increased expression of CFLAR protein]
lysophosphatidylethanolamine analog results in increased expression of CFLAR mRNA; lysophosphatidylethanolamine analog results in increased expression of CFLAR protein		 CTD PMID:25125499 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [lysophosphatidylethanolamine analog co-treated with cobaltous chloride] results in increased phosphorylation of GSK3B protein CTD PMID:25125499 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
increases expression		 ISO lysophosphatidylethanolamine analog inhibits the reaction [cobaltous chloride results in decreased expression of and results in increased degradation of MCL1 protein]
lysophosphatidylethanolamine analog results in increased expression of MCL1 protein
lysophosphatidylethanolamine analog inhibits the reaction [Glycochenodeoxycholic Acid results in decreased expression of and results in increased degradation of MCL1 protein]		 CTD PMID:25125499 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions ISO [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of lysophosphatidylethanolamine; [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of lysophosphatidylethanolamine analog CTD PMID:29515023 NCBI chr13:48,313,634...48,433,494
Ensembl chr13:48,316,301...48,433,326 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO lysophosphatidylethanolamine analog inhibits the reaction [cobaltous chloride results in increased activity of PARP1 protein] CTD PMID:25125499 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO [TP53 protein mutant form results in increased susceptibility to Niclosamide] which results in increased abundance of lysophosphatidylethanolamine CTD PMID:30258081 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
lysophosphatidylglycerol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pon1 paraoxonase 1 decreases activity
multiple interactions		 ISO lysophosphatidylglycerol results in decreased activity of PON1 protein
lysophosphatidylglycerol inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon]		 CTD PMID:15375178 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
miltefosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases response to substance
multiple interactions		 ISO ABCB1 protein results in decreased susceptibility to miltefosine
miltefosine binds to and results in decreased activity of ABCB1 protein		 CTD PMID:11355955 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Prkca protein kinase C, alpha decreases phosphorylation ISO miltefosine results in decreased phosphorylation of PRKCA protein CTD PMID:31265827 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012 		JBrowse link
perifosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO [perifosine co-treated with Butyrates] results in increased secretion of AIFM1 protein; [perifosine co-treated with trichostatin A] results in increased secretion of AIFM1 protein; [perifosine co-treated with vorinostat] results in increased secretion of AIFM1 protein CTD PMID:15781658 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation		 ISO [perifosine co-treated with Butyrates] results in decreased activity of AKT1 protein; [perifosine co-treated with trichostatin A] results in decreased activity of AKT1 protein; [perifosine co-treated with Vorinostat] results in decreased activity of AKT1 protein; AKT1 protein modified form results in decreased activity of [perifosine co-treated with Butyrates]; AKT1 protein modified form results in decreased activity of [perifosine co-treated with trichostatin A]; AKT1 protein modified form results in decreased activity of [perifosine co-treated with Vorinostat]; perifosine inhibits the reaction [cyadox results in increased phosphorylation of AKT1 protein]
perifosine results in decreased phosphorylation of AKT1 protein
[perifosine co-treated with temsirolimus] results in decreased activity of AKT1 protein		 CTD PMID:15781658 PMID:21267448 PMID:30265530 PMID:31445927 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions ISO [perifosine co-treated with Butyrates] results in decreased expression of BAK1 protein; [perifosine co-treated with trichostatin A] results in decreased expression of BAK1 protein; [perifosine co-treated with vorinostat] results in decreased expression of BAK1 protein CTD PMID:15781658 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [perifosine co-treated with Butyrates] results in increased activity of BAX protein; [perifosine co-treated with trichostatin A] results in increased activity of BAX protein; [perifosine co-treated with vorinostat] results in increased activity of BAX protein CTD PMID:15781658 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Casp3 caspase 3 multiple interactions
decreases expression		 ISO [perifosine co-treated with Butyrates] results in increased activity of CASP3 protein; [perifosine co-treated with trichostatin A] results in increased activity of CASP3 protein; [perifosine co-treated with vorinostat] results in increased activity of CASP3 protein
perifosine results in decreased expression of CASP3 protein		 CTD PMID:15781658 PMID:25416439 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions
increases expression		 ISO [perifosine co-treated with Butyrates] results in increased activity of CASP8 protein; [perifosine co-treated with trichostatin A] results in increased activity of CASP8 protein; [perifosine co-treated with Vorinostat] results in increased activity of CASP8 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [perifosine results in increased expression of CASP8 protein modified form]; LAT2 protein inhibits the reaction [perifosine results in increased expression of CASP8 protein modified form] CTD PMID:15781658 PMID:32587277 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO perifosine inhibits the reaction [Mitomycin results in increased expression of CDKN1A protein] CTD PMID:34624459 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [perifosine co-treated with Butyrates] affects the localization of CYCS protein; [perifosine co-treated with trichostatin A] affects the localization of CYCS protein; [perifosine co-treated with vorinostat] affects the localization of CYCS protein CTD PMID:15781658 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Egf epidermal growth factor multiple interactions ISO perifosine inhibits the reaction [cyadox results in increased expression of EGF]; perifosine inhibits the reaction [Hydrogen Peroxide results in increased expression of EGF] CTD PMID:30265530 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Fas Fas cell surface death receptor affects response to substance ISO perifosine affects the susceptibility to FAS protein CTD PMID:31445927 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO [perifosine co-treated with cyadox] results in increased expression of FOXO1 mRNA; [perifosine co-treated with Hydrogen Peroxide] results in increased expression of FOXO1 mRNA
perifosine inhibits the reaction [cyanoginosin LR results in increased phosphorylation of FOXO1 protein]		 CTD PMID:30265530 PMID:33078829 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790 		JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions ISO perifosine inhibits the reaction [Mitomycin results in increased activity of GLB1 protein] CTD PMID:34624459 NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127 		JBrowse link
G Lat2 linker for activation of T cells family, member 2 multiple interactions
decreases response to substance
decreases expression		 ISO ixazomib inhibits the reaction [perifosine results in decreased expression of LAT2 protein]; LAT2 protein inhibits the reaction [perifosine results in increased cleavage of PARP1 protein]; LAT2 protein inhibits the reaction [perifosine results in increased expression of CASP8 protein modified form]
LAT2 protein results in decreased susceptibility to perifosine		 CTD PMID:23001822 PMID:32587277 NCBI chr12:22,104,173...22,118,294
Ensembl chr12:22,104,219...22,118,288 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with Butyrates]; MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with trichostatin A]; MAP2K1 protein mutant form results in decreased activity of [perifosine co-treated with vorinostat] CTD PMID:15781658 NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [perifosine co-treated with Butyrates] results in decreased activity of MAPK1 protein; [perifosine co-treated with trichostatin A] results in decreased activity of MAPK1 protein; [perifosine co-treated with vorinostat] results in decreased activity of MAPK1 protein CTD PMID:15781658 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [perifosine co-treated with Butyrates] results in decreased activity of MAPK3 protein; [perifosine co-treated with trichostatin A] results in decreased activity of MAPK3 protein; [perifosine co-treated with vorinostat] results in decreased activity of MAPK3 protein CTD PMID:15781658 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [perifosine co-treated with Butyrates] results in increased activity of MAPK8 protein; [perifosine co-treated with trichostatin A] results in increased activity of MAPK8 protein; [perifosine co-treated with vorinostat] results in increased activity of MAPK8 protein CTD PMID:15781658 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO [perifosine co-treated with temsirolimus] results in decreased activity of MTOR protein CTD PMID:21267448 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [perifosine results in increased cleavage of PARP1 protein]; LAT2 protein inhibits the reaction [perifosine results in increased cleavage of PARP1 protein] CTD PMID:32587277 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Tnf tumor necrosis factor increases response to substance ISO perifosine results in increased susceptibility to TNF protein CTD PMID:31445927 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO perifosine inhibits the reaction [cyadox results in increased expression of TP53 mRNA]; perifosine inhibits the reaction [cyadox results in increased expression of TP53 protein]; perifosine inhibits the reaction [Hydrogen Peroxide results in increased expression of TP53 mRNA] CTD PMID:30265530 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
phosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agt angiotensinogen increases abundance EXP AGT protein results in increased abundance of Phosphatidic Acids CTD PMID:14613874 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO
EXP		 alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Phosphatidic Acids results in increased phosphorylation of AKT1 protein]
R 59949 inhibits the reaction [Phosphatidic Acids results in increased phosphorylation of AKT1 protein]		 CTD PMID:15525798 PMID:16354768 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Avp arginine vasopressin increases abundance
multiple interactions		 EXP AVP protein results in increased abundance of Phosphatidic Acids
2-(4-amylcinnamoyl)amino-4-chlorobenzoic acid inhibits the reaction [AVP protein results in increased abundance of Phosphatidic Acids]		 CTD PMID:11356622 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases activity ISO Phosphatidic Acids results in increased activity of BGLAP protein CTD PMID:16857255 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495 		JBrowse link
G Egf epidermal growth factor multiple interactions
increases abundance		 EXP 1-Butanol inhibits the reaction [EGF protein results in increased abundance of Phosphatidic Acids] CTD PMID:11134345 NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064 		JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase increases activity ISO Phosphatidic Acids results in increased activity of FGR protein CTD PMID:11078731 NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases secretion		 ISO alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Phosphatidic Acids results in increased secretion of IL1B protein] CTD PMID:16354768 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases secretion		 ISO alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Phosphatidic Acids results in increased secretion of IL6 protein] CTD PMID:16354768 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jak2 Janus kinase 2 increases phosphorylation ISO Phosphatidic Acids results in increased phosphorylation of JAK2 protein CTD PMID:16354768 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO Phosphatidic Acids inhibits the reaction [Ethanol results in decreased phosphorylation of and results in decreased activity of MAPK1 protein]; Phosphatidic Acids results in increased phosphorylation of and results in increased activity of MAPK1 protein; U 0126 inhibits the reaction [Phosphatidic Acids results in increased phosphorylation of and results in increased activity of MAPK1 protein] CTD PMID:18358832 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO Phosphatidic Acids inhibits the reaction [Ethanol results in decreased phosphorylation of and results in decreased activity of MAPK3 protein]; Phosphatidic Acids results in increased phosphorylation of and results in increased activity of MAPK3 protein; U 0126 inhibits the reaction [Phosphatidic Acids results in increased phosphorylation of and results in increased activity of MAPK3 protein] CTD PMID:18358832 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases activity
multiple interactions		 ISO Phosphatidic Acids results in increased activity of MMP2 protein
Quercetin inhibits the reaction [Phosphatidic Acids results in increased activity of MMP2 protein]		 CTD PMID:21867678 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
increases activity		 ISO MTOR protein affects the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein]
Phosphatidic Acids results in increased activity of MTOR protein		 CTD PMID:12087098 PMID:16537399 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Oprm1 opioid receptor, mu 1 multiple interactions EXP [1-Butanol inhibits the reaction [PLD2 protein results in increased chemical synthesis of Phosphatidic Acids]] affects the reaction [PENK protein binds to and results in increased activity of OPRM1 protein] CTD PMID:14720217 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409 		JBrowse link
G Penk proenkephalin multiple interactions EXP [1-Butanol inhibits the reaction [PLD2 protein results in increased chemical synthesis of Phosphatidic Acids]] affects the reaction [PENK protein binds to and results in increased activity of OPRM1 protein] CTD PMID:14720217 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129 		JBrowse link
G Pld1 phospholipase D1 increases activity ISO Phosphatidic Acids results in increased activity of PLD1 protein CTD PMID:16857255 NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692 		JBrowse link
G Pld2 phospholipase D2 multiple interactions EXP 1-Butanol inhibits the reaction [PLD2 protein results in increased chemical synthesis of Phosphatidic Acids]; [1-Butanol inhibits the reaction [PLD2 protein results in increased chemical synthesis of Phosphatidic Acids]] affects the reaction [PENK protein binds to and results in increased activity of OPRM1 protein] CTD PMID:14720217 NCBI chr10:55,256,326...55,274,192
Ensembl chr10:55,256,359...55,272,808 		JBrowse link
G Prkcz protein kinase C, zeta increases activity
multiple interactions		 EXP
ISO		 Phosphatidic Acids results in increased activity of PRKCZ protein
Phosphatidic Acids results in increased phosphorylation of and results in increased activity of PRKCZ protein		 CTD PMID:11978788 PMID:15255942 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression ISO Phosphatidic Acids results in increased expression of PTGS2 protein
Phosphatidic Acids results in increased expression of PTGS2 mRNA		 CTD PMID:12872987 PMID:15210717 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO Phosphatidic Acids results in increased phosphorylation of and results in increased activity of RPS6KB1 protein CTD PMID:15255942 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G Rps6kb2 ribosomal protein S6 kinase B2 multiple interactions
increases activity		 ISO MTOR protein affects the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein]; Sirolimus inhibits the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein]; wortmannin inhibits the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein] CTD PMID:12087098 NCBI chr 1:201,451,265...201,458,096
Ensembl chr 1:201,451,265...201,458,078 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO Phosphatidic Acids results in increased phosphorylation of and affects the localization of STAT1 protein CTD PMID:16354768 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO Phosphatidic Acids results in increased phosphorylation of and affects the localization of STAT3 protein CTD PMID:16354768 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Sts steroid sulfatase multiple interactions ISO Phosphatidic Acids promotes the reaction [Tretinoin results in increased activity of STS protein] CTD PMID:16178010 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases secretion		 ISO TNF protein inhibits the reaction [Carbachol results in increased abundance of Phosphatidic Acids]
Phosphatidic Acids results in increased secretion of TNF protein		 CTD PMID:11245595 PMID:16354768 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
phosphatidylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 increases secretion ISO ABCB11 protein results in increased secretion of Phosphatidylcholines CTD PMID:14570929 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A affects export
affects transport		 ISO ABCB1 protein affects the export of Phosphatidylcholines
ABCB1 protein affects the transport of Phosphatidylcholines		 CTD PMID:11147995 PMID:11745043 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 affects transport
affects export		 ISO ABCB4 protein affects the transport of Phosphatidylcholines
ABCB4 protein affects the export of Phosphatidylcholines		 CTD PMID:11745043 PMID:15696852 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202 		JBrowse link
G Acat1 acetyl-CoA acetyltransferase 1 decreases activity EXP Phosphatidylcholines results in decreased activity of ACAT1 protein CTD PMID:12559476 NCBI chr 8:53,979,813...54,008,861
Ensembl chr 8:53,979,813...54,008,855 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression ISO Phosphatidylcholines results in decreased expression of ADIPOQ mRNA CTD PMID:23911798 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
increases abundance		 ISO PEMT protein promotes the reaction [AHR protein results in increased abundance of Phosphatidylcholines] CTD PMID:29416063 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in increased expression of AIFM1 protein CTD PMID:21695227 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256 		JBrowse link
G App amyloid beta precursor protein multiple interactions ISO [[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide; [[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines; Edetic Acid inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide]; Penicillamine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide]; Trientine inhibits the reaction [[[[APP protein modified form binds to Copper] which co-treated with Ascorbic Acid] results in increased oxidation of Phosphatidylcholines] which results in increased chemical synthesis of phosphatidylcholine hydroperoxide] CTD PMID:17964426 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G As3mt arsenite methyltransferase affects metabolic processing ISO AS3MT gene mutant form affects the metabolism of Phosphatidylcholines CTD PMID:27591999 NCBI chr 1:245,595,939...245,628,921
Ensembl chr 1:245,596,108...245,627,872 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in increased expression of BAX protein CTD PMID:21695227 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in decreased expression of BCL2 protein CTD PMID:21695227 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bmal1 basic helix-loop-helix ARNT like 1 increases abundance ISO BMAL1 gene mutant form results in increased abundance of Phosphatidylcholines CTD PMID:27056296 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in increased expression of CASP3 protein CTD PMID:21695227 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in increased expression of CASP8 protein CTD PMID:21695227 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in increased expression of CASP9 protein CTD PMID:21695227 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression ISO Phosphatidylcholines results in increased expression of CCL2 mRNA CTD PMID:23911798 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in decreased expression of CCND1 protein CTD PMID:21695227 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccne1 cyclin E1 multiple interactions ISO Phosphatidylcholines promotes the reaction [rubitecan results in decreased expression of CCNE1 protein] CTD PMID:21695227 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in decreased expression of CDK2 protein CTD PMID:21695227 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in increased expression of CDKN1A protein CTD PMID:21695227 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO [rubitecan co-treated with Phosphatidylcholines] results in increased expression of CDKN1B protein CTD PMID:21695227 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982 		JBrowse link
G Ces1d carboxylesterase 1D decreases expression ISO Phosphatidylcholines results in decreased expression of CES1D mRNA CTD PMID:23911798 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions EXP [silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of COL1A1 mRNA] CTD PMID:16169303 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Crp C-reactive protein affects binding
decreases activity		 ISO CRP protein binds to Phosphatidylcholines
Phosphatidylcholines results in decreased activity of CRP protein		 CTD PMID:16962105 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects activity ISO Phosphatidylcholines affects the activity of CYP1A2 protein CTD PMID:15966743 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases activity EXP Phosphatidylcholines results in increased activity of CYP7A1 protein CTD PMID:12559476 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688 		JBrowse link
G Enpp7 ectonucleotide pyrophosphatase/phosphodiesterase 7 increases hydrolysis ISO ENPP7 protein results in increased hydrolysis of Phosphatidylcholines CTD PMID:12885774 NCBI chr10:104,242,169...104,247,185
Ensembl chr10:104,242,223...104,246,589 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO [orlistat results in decreased activity of FASN protein] which results in decreased abundance of Phosphatidylcholines CTD PMID:18723500 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fgf19 fibroblast growth factor 19 decreases abundance ISO FGF19 protein results in decreased abundance of Phosphatidylcholines CTD PMID:29416063 NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287 		JBrowse link
G Gpx4 glutathione peroxidase 4 multiple interactions ISO GPX4 mutant form promotes the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite]; GPX4 protein inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite] CTD PMID:22433871 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase increases activity EXP Phosphatidylcholines results in increased activity of HMGCR protein CTD PMID:12559476 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703 		JBrowse link
G Igf1 insulin-like growth factor 1 increases degradation ISO IGF1 protein results in increased degradation of Phosphatidylcholines CTD PMID:2120207 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il10 interleukin 10 increases expression ISO Phosphatidylcholines results in increased expression of IL10 mRNA CTD PMID:23911798 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions		 ISO Phosphatidylcholines results in increased expression of IL1B mRNA
Phosphatidylcholines results in increased expression of and results in increased secretion of IL1B protein		 CTD PMID:23911798 PMID:30958839 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 increases expression ISO Phosphatidylcholines results in increased expression of IL6 mRNA CTD PMID:23911798 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Lep leptin decreases expression ISO Phosphatidylcholines results in decreased expression of LEP mRNA CTD PMID:23911798 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lipc lipase C, hepatic type multiple interactions
increases abundance		 ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of Phosphatidylcholines
LIPC gene mutant form results in increased abundance of Phosphatidylcholines		 CTD PMID:24777581 NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464 		JBrowse link
G Lipe lipase E, hormone sensitive type increases expression ISO Phosphatidylcholines results in increased expression of LIPE mRNA CTD PMID:23911798 NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310 		JBrowse link
G Lipg lipase G, endothelial type multiple interactions
increases abundance		 ISO [LIPC gene mutant form co-treated with LIPG gene mutant form] results in increased abundance of Phosphatidylcholines
LIPG gene mutant form results in increased abundance of Phosphatidylcholines		 CTD PMID:24777581 NCBI chr18:68,514,923...68,536,105
Ensembl chr18:68,514,923...68,536,260 		JBrowse link
G Ltf lactotransferrin multiple interactions ISO [LTF protein co-treated with Phosphatidylcholines co-treated with Phytosterols] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:16141546 NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions EXP [silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of MMP2 mRNA] CTD PMID:16169303 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO NOX4 mutant form inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite] CTD PMID:22433871 NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases abundance ISO NR0B2 protein results in decreased abundance of Phosphatidylcholines CTD PMID:29416063 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609 		JBrowse link
G Nr5a2 nuclear receptor subfamily 5, group A, member 2 multiple interactions ISO [NR5A2 gene mutant form results in increased susceptibility to Dietary Fats] which results in increased abundance of Phosphatidylcholines CTD PMID:29515023 NCBI chr13:48,313,634...48,433,494
Ensembl chr13:48,316,301...48,433,326 		JBrowse link
G Pafah1b1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 multiple interactions
increases secretion		 EXP PAFAH1B1 protein promotes the reaction [Terbutaline results in increased secretion of Phosphatidylcholines]; PAFAH1B1 protein promotes the reaction [Tetradecanoylphorbol Acetate results in increased secretion of Phosphatidylcholines]
PAFAH1B1 protein results in increased secretion of Phosphatidylcholines		 CTD PMID:12013527 NCBI chr10:59,533,042...59,591,808
Ensembl chr10:59,534,117...59,591,808 		JBrowse link
G Pafah2 platelet-activating factor acetylhydrolase 2 multiple interactions ISO PAFAH2 inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite] CTD PMID:22433871 NCBI chr 5:146,607,050...146,636,203
Ensembl chr 5:146,613,498...146,634,943 		JBrowse link
G Pcyt1a phosphate cytidylyltransferase 1A, choline multiple interactions ISO PCYT1A protein promotes the reaction [PLPP6 protein results in increased chemical synthesis of Phosphatidylcholines] CTD PMID:18930839 NCBI chr11:68,313,860...68,357,828
Ensembl chr11:68,313,882...68,357,357 		JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase multiple interactions ISO PEMT protein promotes the reaction [AHR protein results in increased abundance of Phosphatidylcholines] CTD PMID:29416063 NCBI chr10:44,775,910...44,849,990
Ensembl chr10:44,775,911...44,850,013 		JBrowse link
G Plin1 perilipin 1 increases expression ISO Phosphatidylcholines results in increased expression of PLIN1 mRNA CTD PMID:23911798 NCBI chr 1:133,664,294...133,676,854
Ensembl chr 1:133,664,892...133,676,828 		JBrowse link
G Plpp6 phospholipid phosphatase 6 multiple interactions
increases chemical synthesis		 ISO PCYT1A protein promotes the reaction [PLPP6 protein results in increased chemical synthesis of Phosphatidylcholines] CTD PMID:18930839 NCBI chr 1:226,679,100...226,681,952
Ensembl chr 1:226,679,100...226,681,949 		JBrowse link
G Pnpla2 patatin-like phospholipase domain containing 2 decreases expression ISO Phosphatidylcholines results in decreased expression of PNPLA2 mRNA CTD PMID:23911798 NCBI chr 1:196,552,723...196,557,805
Ensembl chr 1:196,552,723...196,557,805 		JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 affects abundance ISO PNPLA6 protein affects the abundance of Phosphatidylcholines CTD PMID:36336212 NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734 		JBrowse link
G Pon2 paraoxonase 2 increases activity
increases expression		 ISO Phosphatidylcholines results in increased activity of PON2 protein
Phosphatidylcholines results in increased expression of PON2 mRNA		 CTD PMID:12615656 NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248 		JBrowse link
G Pon3 paraoxonase 3 multiple interactions ISO Phosphatidylcholines inhibits the reaction [PON3 protein results in increased metabolism of Lovastatin] CTD PMID:12615656 NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO Phosphatidylcholines results in increased expression of PPARG mRNA CTD PMID:23911798 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ppargc1b PPARG coactivator 1 beta increases abundance ISO PPARGC1B results in increased abundance of Phosphatidylcholines CTD PMID:17932310 NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194 		JBrowse link
G Pten phosphatase and tensin homolog affects binding
multiple interactions		 ISO PTEN protein binds to Phosphatidylcholines
[TXN protein binds to PTEN protein] inhibits the reaction [PTEN protein binds to Phosphatidylcholines]		 CTD PMID:15313215 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Retn resistin decreases expression ISO Phosphatidylcholines results in decreased expression of RETN mRNA CTD PMID:23911798 NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620 		JBrowse link
G Sftpa1 surfactant protein A1 multiple interactions ISO [SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]; Ozone inhibits the reaction [[SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]]; Ozone inhibits the reaction [SFTPA1 protein polymorphism inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]] CTD PMID:15065867 NCBI chr16:17,008,180...17,011,686
Ensembl chr16:17,008,180...17,011,685 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFB1 mRNA] CTD PMID:16169303 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP [silybin co-treated with Phosphatidylcholines co-treated with Vitamin E] inhibits the reaction [Dimethylnitrosamine results in increased expression of TIMP1 mRNA] CTD PMID:16169303 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
increases abundance		 ISO GPX4 mutant form promotes the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite]; GPX4 protein inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite]; NOX4 mutant form inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite]; PAFAH2 inhibits the reaction [TNF protein results in increased abundance of Phosphatidylcholines metabolite]
Phosphatidylcholines results in increased expression of TNF mRNA
[LTF protein co-treated with Phosphatidylcholines co-treated with Phytosterols] inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Phosphatidylcholines results in increased expression of and results in increased secretion of TNF protein		 CTD PMID:16141546 PMID:22433871 PMID:23911798 PMID:30958839 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 multiple interactions ISO Phosphatidylcholines inhibits the reaction [rubitecan results in increased expression of TP53 protein] CTD PMID:21695227 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO [TXN protein binds to PTEN protein] inhibits the reaction [PTEN protein binds to Phosphatidylcholines] CTD PMID:15313215 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
phosphatidylethanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plek pleckstrin multiple interactions ISO phosphatidylethanol analog promotes the reaction [Guanosine 5'-O-(3-Thiotriphosphate) results in increased phosphorylation of PLEK protein] CTD PMID:8928743 NCBI chr14:91,397,015...91,429,693
Ensembl chr14:91,397,019...91,454,131 		JBrowse link
phosphatidylethanolamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor decreases abundance ISO AHR protein results in decreased abundance of phosphatidylethanolamine CTD PMID:29416063 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO phosphatidylethanolamine results in increased stability of and results in increased activity of CYP1A2 protein CTD PMID:15966743 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Fgf19 fibroblast growth factor 19 increases abundance ISO FGF19 protein results in increased abundance of phosphatidylethanolamine CTD PMID:29416063 NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO calpeptin inhibits the reaction [dehydroeburicoic acid promotes the reaction [MAP1LC3B protein binds to phosphatidylethanolamine]]; dehydroeburicoic acid promotes the reaction [MAP1LC3B protein binds to phosphatidylethanolamine] CTD PMID:19848398 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Ppargc1b PPARG coactivator 1 beta increases abundance ISO PPARGC1B results in increased abundance of phosphatidylethanolamine CTD PMID:17932310 NCBI chr18:54,758,891...54,861,103
Ensembl chr18:54,758,902...54,861,194 		JBrowse link
G Pten phosphatase and tensin homolog multiple interactions
affects binding		 ISO [TXN protein binds to PTEN protein] inhibits the reaction [PTEN protein binds to phosphatidylethanolamine] CTD PMID:15313215 NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838 		JBrowse link
G Txn1 thioredoxin 1 multiple interactions ISO [TXN protein binds to PTEN protein] inhibits the reaction [PTEN protein binds to phosphatidylethanolamine] CTD PMID:15313215 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629 		JBrowse link
phosphatidylinositol 4-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G F2 coagulation factor II, thrombin multiple interactions
increases abundance		 ISO resveratrol inhibits the reaction [F2 protein results in increased abundance of phosphatidylinositol 4-phosphate] CTD PMID:16051184 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G Ncs1 neuronal calcium sensor 1 increases phosphorylation
multiple interactions		 EXP NCS1 protein results in increased phosphorylation of phosphatidylinositol 4-phosphate
wortmannin inhibits the reaction [NCS1 protein results in increased phosphorylation of phosphatidylinositol 4-phosphate]		 CTD PMID:12471042 NCBI chr 3:14,523,220...14,568,829
Ensembl chr 3:14,523,220...14,568,829 		JBrowse link
phosphatidylinositol dimannoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il6 interleukin 6 multiple interactions ISO [phosphatidylinositol dimannoside analog co-treated with Thioglycolates] results in increased expression of IL6 protein; phosphatidylinositol dimannoside analog inhibits the reaction [[Lipopolysaccharides co-treated with Thioglycolates] results in increased expression of IL6 protein]; phosphatidylinositol dimannoside analog promotes the reaction [[Lipopolysaccharides co-treated with Thioglycolates] results in increased expression of IL6 protein]; TLR4 gene mutant form inhibits the reaction [[phosphatidylinositol dimannoside analog co-treated with Thioglycolates] results in increased expression of IL6 protein] CTD PMID:21936536 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO TLR4 gene mutant form inhibits the reaction [[phosphatidylinositol dimannoside analog co-treated with Thioglycolates] results in increased expression of IL6 protein] CTD PMID:21936536 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
prenyl diphosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Il12rb1 interleukin 12 receptor subunit beta 1 increases expression ISO 3,3-dimethylallyl pyrophosphate results in increased expression of IL12RB1 protein CTD PMID:12932289 NCBI chr16:18,620,228...18,633,207
Ensembl chr16:18,620,770...18,632,769 		JBrowse link
G Mvk mevalonate kinase decreases activity
multiple interactions		 ISO 3,3-dimethylallyl pyrophosphate results in decreased activity of MVK protein
3,3-dimethylallyl pyrophosphate inhibits the reaction [MVK protein results in increased hydrolysis of Adenosine Triphosphate]; 3,3-dimethylallyl pyrophosphate inhibits the reaction [MVK protein results in increased phosphorylation of Mevalonic Acid]		 CTD PMID:9392419 NCBI chr12:42,141,391...42,158,893
Ensembl chr12:42,141,384...42,158,882 		JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B increases expression ISO 3,3-dimethylallyl pyrophosphate results in increased expression of TNFRSF1B protein CTD PMID:12932289 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206 		JBrowse link
rosuvastatin calcium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 decreases expression
multiple interactions		 ISO Rosuvastatin Calcium results in decreased expression of ABCA1 mRNA
Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of ABCA1 mRNA]		 CTD PMID:18192897 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions ISO
EXP		 Rosuvastatin Calcium inhibits the reaction [ABCB11 protein affects the import of Taurocholic Acid]
[Cyclosporine results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium; [Glyburide results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium; [troglitazone results in decreased activity of ABCB11 protein] which results in decreased secretion of Rosuvastatin Calcium		 CTD PMID:15901796 PMID:19853032 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730 		JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression
affects secretion		 ISO
EXP		 ABCC2 protein binds to and results in increased uptake of Rosuvastatin Calcium analog; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]
Rosuvastatin Calcium results in increased expression of ABCC2 protein
[Benzbromarone results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; [Probenecid results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; [Sulfasalazine results in decreased activity of ABCC2 protein] which results in decreased secretion of Rosuvastatin Calcium; ABCC2 protein binds to and results in increased uptake of Rosuvastatin Calcium analog; Rosuvastatin Calcium analog inhibits the reaction [ABCC2 protein binds to and results in increased uptake of 5(6)-carboxy-2',7'-dichlorofluorescein]; Rosuvastatin Calcium promotes the reaction [ABCC2 protein results in increased export of 5(6)-carboxy-2',7'-dichlorofluorescein]
ABCC2 protein affects the secretion of Rosuvastatin Calcium		 CTD PMID:19853032 PMID:23562342 PMID:24909372 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238 		JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP Rosuvastatin Calcium results in increased expression of ABCC3 protein CTD PMID:24909372 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression ISO Rosuvastatin Calcium results in decreased expression of ABCG1 mRNA CTD PMID:18192897 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
increases activity		 EXP
ISO		 [Novobiocin results in decreased activity of ABCG2 protein] which results in decreased secretion of Rosuvastatin Calcium
Rosuvastatin Calcium results in increased activity of ABCG2 protein		 CTD PMID:19853032 PMID:30083819 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409 		JBrowse link
G Ache acetylcholinesterase multiple interactions EXP [Piracetam co-treated with Rosuvastatin Calcium] inhibits the reaction [[Sodium Chloride, Dietary co-treated with Cholesterol, Dietary co-treated with Coconut Oil] results in increased activity of ACHE protein]; Rosuvastatin Calcium inhibits the reaction [[Sodium Chloride, Dietary co-treated with Cholesterol, Dietary co-treated with Coconut Oil] results in increased activity of ACHE protein] CTD PMID:28441890 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 affects phosphorylation EXP Rosuvastatin Calcium affects the phosphorylation of AKT1 protein CTD PMID:27815113 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Apoa1 apolipoprotein A1 multiple interactions
increases expression		 ISO Niacin promotes the reaction [Rosuvastatin Calcium results in increased expression of APOA1 protein] CTD PMID:12767421 PMID:15539964 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Apob apolipoprotein B decreases expression ISO Rosuvastatin Calcium results in decreased expression of APOB protein CTD PMID:15539964 PMID:18702965 NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of BAX mRNA] CTD PMID:32007421 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO Rosuvastatin Calcium results in decreased expression of BCL2 protein CTD PMID:20852871 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G C3 complement C3 decreases expression ISO Rosuvastatin Calcium results in decreased expression of C3 mRNA CTD PMID:32771489 NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429 		JBrowse link
G Casp3 caspase 3 increases activity
increases expression		 ISO Rosuvastatin Calcium results in increased activity of CASP3 protein
Rosuvastatin Calcium results in increased expression of CASP3 protein		 CTD PMID:21478229 PMID:32771489 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase increases activity
multiple interactions		 EXP Rosuvastatin Calcium results in increased activity of CAT protein
[Rosuvastatin Calcium co-treated with Isoproterenol] inhibits the reaction [Interleukin-6 results in increased expression of CAT protein]; Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]		 CTD PMID:20146376 PMID:32007421 PMID:35130744 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression EXP Rosuvastatin Calcium results in decreased expression of CCL2 mRNA CTD PMID:15681303 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Creb5 cAMP responsive element binding protein 5 decreases expression ISO Rosuvastatin Calcium results in decreased expression of CREB5 mRNA CTD PMID:18192897 NCBI chr 4:82,393,091...82,794,320
Ensembl chr 4:82,393,730...82,790,325 		JBrowse link
G Crp C-reactive protein multiple interactions ISO Rosuvastatin Calcium inhibits the reaction [CRP protein results in decreased expression of NOS3] CTD PMID:21562509 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Cyba cytochrome b-245 alpha chain multiple interactions
decreases expression		 EXP [[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species CTD PMID:21562509 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions
decreases expression		 ISO
EXP		 Rosuvastatin Calcium inhibits the reaction [Nitroglycerin results in increased expression of CYBB mRNA]
[[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species		 CTD PMID:16633368 PMID:21562509 NCBI chr  X:13,358,101...13,392,570
Ensembl chr  X:13,359,430...13,392,586 		JBrowse link
G Esr1 estrogen receptor 1 decreases expression ISO Rosuvastatin Calcium results in decreased expression of ESR1 protein CTD PMID:32771489 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions		 ISO Rosuvastatin Calcium results in increased expression of GCLC mRNA
[Tetradecanoylphorbol Acetate co-treated with Rosuvastatin Calcium] results in increased expression of GCLC mRNA		 CTD PMID:18154958 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gpr183 G protein-coupled receptor 183 multiple interactions
increases expression		 ISO Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in increased expression of GPR183 mRNA] CTD PMID:18192897 NCBI chr15:99,037,764...99,050,550
Ensembl chr15:99,036,367...99,050,559 		JBrowse link
G Gzmk granzyme K multiple interactions
increases expression		 ISO Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in increased expression of GZMK mRNA] CTD PMID:18192897 NCBI chr 2:44,840,811...44,848,829
Ensembl chr 2:44,840,811...44,848,894 		JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha increases secretion ISO HNF4A protein results in increased secretion of Rosuvastatin Calcium CTD PMID:27160211 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320 		JBrowse link
G Il18rap interleukin 18 receptor accessory protein decreases expression
multiple interactions		 ISO Rosuvastatin Calcium results in decreased expression of IL18RAP mRNA
Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of IL18RAP mRNA]		 CTD PMID:18192897 NCBI chr 9:42,768,112...42,800,964
Ensembl chr 9:42,768,220...42,800,959 		JBrowse link
G Il1b interleukin 1 beta decreases expression EXP Rosuvastatin Calcium results in decreased expression of IL1B mRNA CTD PMID:15681303 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Rosuvastatin Calcium results in decreased activity of KCNH2 protein CTD PMID:28551711 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008 		JBrowse link
G Kcnj15 potassium inwardly-rectifying channel, subfamily J, member 15 decreases expression ISO Rosuvastatin Calcium results in decreased expression of KCNJ15 mRNA CTD PMID:18192897 NCBI chr11:34,577,397...34,621,725
Ensembl chr11:34,577,363...34,621,952 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of KDR protein] CTD PMID:27097221 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Mb myoglobin affects expression EXP Rosuvastatin Calcium affects the expression of MB protein CTD PMID:27815113 NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383 		JBrowse link
G Mstn myostatin increases expression ISO Rosuvastatin Calcium results in increased expression of MSTN protein CTD PMID:33034787 NCBI chr 9:48,452,533...48,458,933
Ensembl chr 9:48,452,533...48,458,933 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in decreased expression of NFE2L2 mRNA] CTD PMID:32007421 PMID:35130744 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions		 EXP Rosuvastatin Calcium results in increased expression of NOS2 mRNA
Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of NOS2 mRNA]		 CTD PMID:21443142 PMID:32007421 PMID:35130744 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions
increases expression
affects response to substance		 ISO
EXP		 Rosuvastatin Calcium inhibits the reaction [CRP protein results in decreased expression of NOS3]; Rosuvastatin Calcium results in increased phosphorylation of and results in increased activity of NOS3 protein
Rosuvastatin Calcium results in increased expression of NOS3 mRNA
NOS3 protein affects the susceptibility to Rosuvastatin Calcium		 CTD PMID:12354446 PMID:15681303 PMID:18162361 PMID:21562509 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Orm1 orosomucoid 1 multiple interactions
decreases expression		 ISO Lipopolysaccharides inhibits the reaction [Rosuvastatin Calcium results in decreased expression of ORM1 mRNA] CTD PMID:18192897 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 multiple interactions ISO Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of PECAM1 protein] CTD PMID:27097221 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Selp selectin P decreases expression EXP Rosuvastatin Calcium results in decreased expression of SELP mRNA CTD PMID:15681303 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G Serpine2 serpin family E member 2 multiple interactions ISO Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SERPINE2 protein]; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein] CTD PMID:27097221 NCBI chr 9:81,124,746...81,188,866
Ensembl chr 9:81,124,804...81,188,826 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions
increases uptake
decreases expression
affects transport		 EXP
ISO		 Fusidic Acid inhibits the reaction [SLCO1A4 protein results in increased uptake of Rosuvastatin Calcium]
diosmetin inhibits the reaction [SLCO1A2 protein results in increased uptake of Rosuvastatin Calcium]
Rosuvastatin Calcium results in decreased expression of SLCO1A4 protein
SLCO1A4 protein affects the transport of Rosuvastatin Calcium		 CTD PMID:19833843 PMID:24909372 PMID:26888941 PMID:28867436 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions
increases uptake		 EXP
ISO		 Fusidic Acid inhibits the reaction [SLCO1B2 protein results in increased uptake of Rosuvastatin Calcium]
Fusidic Acid inhibits the reaction [SLCO1B3 protein results in increased uptake of Rosuvastatin Calcium]		 CTD PMID:26888941 PMID:31299240 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Slco2b1 solute carrier organic anion transporter family, member 2b1 increases uptake
multiple interactions		 ISO SLCO2B1 protein results in increased uptake of Rosuvastatin Calcium
Rutin promotes the reaction [SLCO2B1 protein results in increased uptake of Rosuvastatin Calcium]		 CTD PMID:24285294 NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression		 EXP [[[Rosuvastatin Calcium results in decreased expression of CYBB] co-treated with [Rosuvastatin Calcium results in decreased expression of CYBA]] co-treated with [Rosuvastatin Calcium results in increased expression of SOD1]] results in decreased abundance of Reactive Oxygen Species CTD PMID:21562509 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Tff1 trefoil factor 1 decreases expression ISO Rosuvastatin Calcium results in decreased expression of TFF1 mRNA CTD PMID:32771489 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression		 ISO
EXP		 Rosuvastatin Calcium inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of TGFB1 protein]; Rosuvastatin Calcium inhibits the reaction [[TGFB1 protein co-treated with Serotonin] results in increased secretion of SERPINE2 protein]
Rosuvastatin Calcium results in decreased expression of TGFB1 mRNA		 CTD PMID:15681303 PMID:27097221 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions		 EXP Rosuvastatin Calcium results in decreased expression of TNF mRNA
Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of TNF protein]		 CTD PMID:15681303 PMID:32007421 PMID:35130744 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnni3 troponin I3, cardiac type multiple interactions EXP Rosuvastatin Calcium inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein] CTD PMID:32007421 PMID:35130744 NCBI chr 1:69,299,900...69,303,582
Ensembl chr 1:69,299,900...69,303,580 		JBrowse link
G Vnn3 vanin 3 decreases expression ISO Rosuvastatin Calcium results in decreased expression of VNN3P mRNA CTD PMID:18192897 NCBI chr 1:21,571,364...21,583,626
Ensembl chr 1:21,571,364...21,583,626 		JBrowse link
G Wt1 WT1 transcription factor increases expression EXP Rosuvastatin Calcium results in increased expression of WT1 mRNA CTD PMID:21443142 NCBI chr 3:91,566,540...91,613,653
Ensembl chr 3:91,567,001...91,613,643 		JBrowse link
sphinganine 1-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 ISO dihydrosphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; dihydrosphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 protein]; dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 protein]
dihydrosphingosine 1-phosphate results in increased expression of PTGS2 mRNA; dihydrosphingosine 1-phosphate results in increased expression of PTGS2 protein		 CTD PMID:18612546 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Spns2 SPNS lysolipid transporter 2, sphingosine-1-phosphate decreases abundance ISO SPNS2 protein results in decreased abundance of dihydrosphingosine 1-phosphate CTD PMID:29772789 NCBI chr10:57,067,348...57,105,969
Ensembl chr10:57,066,897...57,105,957 		JBrowse link
sphingosine 1-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acta2 actin alpha 2, smooth muscle multiple interactions
increases expression		 EXP sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of ACTA2 mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of ACTA2 protein]
sphingosine 1-phosphate results in increased expression of ACTA2 mRNA; sphingosine 1-phosphate results in increased expression of ACTA2 protein		 CTD PMID:37169277 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation		 ISO sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of AKT1 protein
sphingosine 1-phosphate results in increased phosphorylation of AKT1 protein		 CTD PMID:15946935 PMID:16365044 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Atg5 autophagy related 5 increases expression
multiple interactions		 EXP sphingosine 1-phosphate results in increased expression of ATG5 mRNA; sphingosine 1-phosphate results in increased expression of ATG5 protein
3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of ATG5 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of ATG5 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of ATG5 mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of ATG5 protein]		 CTD PMID:37169277 NCBI chr20:47,798,217...47,889,216
Ensembl chr20:47,798,290...47,889,209 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
multiple interactions		 ISO sphingosine 1-phosphate results in decreased expression of BAX mRNA
sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX mRNA]		 CTD PMID:24399507 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BCL2 mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of BCL2 protein] CTD PMID:24399507 PMID:24420784 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Becn1 beclin 1 increases expression
multiple interactions		 EXP sphingosine 1-phosphate results in increased expression of BECN1 mRNA; sphingosine 1-phosphate results in increased expression of BECN1 protein
sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of BECN1 mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of BECN1 protein]		 CTD PMID:37169277 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp1 caspase 1 multiple interactions EXP sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of and results in increased cleavage of CASP1 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of CASP1 mRNA] CTD PMID:37169277 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Ccn2 cellular communication network factor 2 increases expression ISO sphingosine 1-phosphate results in increased expression of CCN2 mRNA CTD PMID:25690654 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression
multiple interactions		 EXP sphingosine 1-phosphate results in increased expression of COL1A1 mRNA; sphingosine 1-phosphate results in increased expression of COL1A1 protein
3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of COL1A1 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of COL1A1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [sphingosine 1-phosphate results in increased expression of COL1A1 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of COL1A1 mRNA]		 CTD PMID:37169277 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions		 ISO sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of CREB1 protein]		 CTD PMID:18612546 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816 		JBrowse link
G Cxcr1 C-X-C motif chemokine receptor 1 decreases expression ISO sphingosine 1-phosphate results in decreased expression of CXCR1 mRNA CTD PMID:16224106 NCBI chr 9:75,766,894...75,771,079
Ensembl chr 9:75,766,770...75,771,084 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO sphingosine 1-phosphate results in increased expression of CYP17A1 mRNA CTD PMID:15666826 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Egfr epidermal growth factor receptor increases phosphorylation
multiple interactions		 ISO sphingosine 1-phosphate results in increased phosphorylation of EGFR protein
JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of EGFR protein]		 CTD PMID:26518876 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Fn1 fibronectin 1 multiple interactions
increases expression		 EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of and results in increased lipidation of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein; [sphingosine 1-phosphate results in increased activity of S1PR2 protein] which results in increased expression of FN1; Curcumin inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; SB 203580 inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of FN1 protein] CTD PMID:21998146 PMID:22406263 PMID:37169277 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Gnaq G protein subunit alpha q multiple interactions
increases expression		 ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of GNAQ protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of GNAQ protein] CTD PMID:25980589 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672 		JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3A protein]; Wortmannin inhibits the reaction [sphingosine 1-phosphate inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3A protein]] CTD PMID:25769802 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO sphingosine 1-phosphate affects the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3B protein]; Wortmannin affects the reaction [sphingosine 1-phosphate affects the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3B protein]] CTD PMID:25769802 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646 		JBrowse link
G Hgf hepatocyte growth factor increases expression ISO sphingosine 1-phosphate results in increased expression of HGF mRNA CTD PMID:19349368 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409 		JBrowse link
G Hrk harakiri, BCL2 interacting protein multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HRK mRNA]; sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in increased expression of HRK mRNA] CTD PMID:24399507 PMID:24420784 NCBI chr12:38,387,484...38,409,652 JBrowse link
G Hsf1 heat shock transcription factor 1 increases activity ISO sphingosine 1-phosphate results in increased activity of HSF1 protein CTD PMID:34170685 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011 		JBrowse link
G Igf1 insulin-like growth factor 1 increases expression ISO sphingosine 1-phosphate results in increased expression of IGF1 mRNA CTD PMID:19349368 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296 		JBrowse link
G Il18 interleukin 18 multiple interactions EXP 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL18 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL18 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL18 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of IL18 protein] CTD PMID:37169277 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta increases expression
multiple interactions
increases secretion		 ISO sphingosine 1-phosphate results in increased expression of IL1B mRNA
Janus Kinase Inhibitors inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]; Janus Kinase Inhibitors inhibits the reaction [sphingosine 1-phosphate results in increased secretion of IL1B protein]; S1PR1 protein affects the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]; STAT3 protein affects the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]; STAT3 protein affects the reaction [sphingosine 1-phosphate results in increased secretion of IL1B protein]		 CTD PMID:32401414 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL6 mRNA] CTD PMID:26518876 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jak2 Janus kinase 2 increases phosphorylation ISO sphingosine 1-phosphate results in increased phosphorylation of JAK2 protein CTD PMID:32401414 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of KDR mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of KDR mRNA] CTD PMID:15741222 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Lama3 laminin subunit alpha 3 increases expression ISO sphingosine 1-phosphate results in increased expression of LAMA3 mRNA CTD PMID:15541073 NCBI chr18:3,523,168...3,751,722
Ensembl chr18:3,523,133...3,751,353 		JBrowse link
G Lamb3 laminin subunit beta 3 increases expression ISO sphingosine 1-phosphate results in increased expression of LAMB3 mRNA CTD PMID:15541073 NCBI chr13:104,833,810...104,875,405
Ensembl chr13:104,833,873...104,875,405 		JBrowse link
G Lamc2 laminin subunit gamma 2 increases expression ISO sphingosine 1-phosphate results in increased expression of LAMC2 mRNA CTD PMID:15541073 NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression		 EXP JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of and results in increased lipidation of MAP1LC3B protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of MAP1LC3B mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased phosphorylation of and results in increased lipidation of MAP1LC3B protein]; sphingosine 1-phosphate results in increased phosphorylation of and results in increased lipidation of MAP1LC3B protein
sphingosine 1-phosphate results in increased expression of MAP1LC3B mRNA		 CTD PMID:37169277 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO
EXP		 JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]; Plant Extracts inhibits the reaction [sphingosine 1-phosphate results in increased activity of and results in increased phosphorylation of MAPK1 protein]; sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of MAPK1 protein; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK1 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK1 protein modified form]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK1 protein modified form		 CTD PMID:16365044 PMID:18612546 PMID:22251058 PMID:22406263 PMID:26518876 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases phosphorylation		 ISO
EXP		 JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]; Plant Extracts inhibits the reaction [sphingosine 1-phosphate results in increased activity of and results in increased phosphorylation of MAPK3 protein]; sphingosine 1-phosphate results in increased phosphorylation of and results in increased activity of MAPK3 protein; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of MAPK3 protein]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK3 protein modified form]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK3 protein modified form		 CTD PMID:16365044 PMID:18612546 PMID:22251058 PMID:22406263 PMID:26518876 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
increases expression		 ISO JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP2 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP2 protein]
sphingosine 1-phosphate results in increased expression of MMP2 mRNA; sphingosine 1-phosphate results in increased expression of MMP2 protein		 CTD PMID:26518876 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases expression		 ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 mRNA]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of MMP9 protein]
sphingosine 1-phosphate results in increased expression of MMP9 mRNA; sphingosine 1-phosphate results in increased expression of MMP9 protein		 CTD PMID:25980589 PMID:26518876 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of NLRP3 protein]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of NLRP3 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [sphingosine 1-phosphate results in increased expression of NLRP3 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of NLRP3 mRNA]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of NLRP3 protein] CTD PMID:37169277 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nrp1 neuropilin 1 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP1 mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP1 mRNA] CTD PMID:15741222 NCBI chr19:56,359,455...56,514,628
Ensembl chr19:56,359,455...56,513,633 		JBrowse link
G Nrp2 neuropilin 2 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [N-acetylsphingosine results in decreased expression of NRP2 mRNA]; sphingosine 1-phosphate inhibits the reaction [Thalidomide results in decreased expression of NRP2 mRNA] CTD PMID:15741222 NCBI chr 9:64,122,815...64,238,007
Ensembl chr 9:64,123,132...64,237,958 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 increases expression ISO sphingosine 1-phosphate results in increased expression of PECAM1 protein CTD PMID:19349368 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Plcb4 phospholipase C, beta 4 increases expression
multiple interactions		 ISO sphingosine 1-phosphate results in increased expression of PLCB4 protein
Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of PLCB4 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of PLCB4 protein]		 CTD PMID:25980589 NCBI chr 3:122,952,965...123,322,522
Ensembl chr 3:122,953,196...123,322,392 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions EXP [Bezafibrate results in increased activity of PPARA protein] which results in decreased abundance of sphingosine 1-phosphate CTD PMID:18024222 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression		 ISO dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; dihydrosphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; JTE 013 inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; JTE 013 promotes the reaction [Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; MK 2206 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; S1PR2 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; S1PR3 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [dihydrosphingosine 1-phosphate results in increased expression of PTGS2 protein]; sphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; sphingosine 1-phosphate inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 protein]; Suramin inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]; Suramin inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]; Suramin promotes the reaction [JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]]
sphingosine 1-phosphate results in increased expression of PTGS2 mRNA; sphingosine 1-phosphate results in increased expression of PTGS2 protein		 CTD PMID:18612546 PMID:26518876 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization		 ISO JTE 013 inhibits the reaction [sphingosine 1-phosphate affects the localization of RELA protein modified form] CTD PMID:26518876 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 increases response to substance
multiple interactions
increases expression		 EXP
ISO		 S1PR1 protein results in increased susceptibility to sphingosine 1-phosphate
S1PR1 protein affects the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]
sphingosine 1-phosphate results in increased expression of S1PR1 mRNA
sphingosine 1-phosphate binds to and results in increased activity of S1PR1 protein		 CTD PMID:20844107 PMID:24399507 PMID:32401414 NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681 		JBrowse link
G S1pr2 sphingosine-1-phosphate receptor 2 multiple interactions
increases expression
increases uptake
increases activity		 ISO
EXP		 S1PR2 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]
sphingosine 1-phosphate results in increased expression of S1PR2 protein
sphingosine 1-phosphate results in increased uptake of S1PR2 protein
sphingosine 1-phosphate results in increased activity of S1PR2 protein
[JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] results in decreased susceptibility to [sphingosine 1-phosphate co-treated with Glucose]; [JTE 013 binds to and results in decreased activity of S1PR2 protein] which results in decreased susceptibility to sphingosine 1-phosphate; [sphingosine 1-phosphate results in increased activity of S1PR2 protein] which results in increased expression of FN1; JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR2 protein]; sphingosine 1-phosphate promotes the reaction [dibutyldichlorotin results in increased expression of S1PR2 protein]		 CTD PMID:18612546 PMID:22406263 PMID:26518876 PMID:37169277 NCBI chr 8:19,503,276...19,514,169
Ensembl chr 8:19,502,627...19,523,574 		JBrowse link
G S1pr3 sphingosine-1-phosphate receptor 3 multiple interactions
increases expression		 ISO Fingolimod Hydrochloride inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR3 protein]; Phytochemicals analog inhibits the reaction [sphingosine 1-phosphate results in increased expression of S1PR3 protein]; S1PR3 mutant form inhibits the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA] CTD PMID:18612546 PMID:25980589 NCBI chr17:13,781,050...13,794,408
Ensembl chr17:13,781,050...13,794,505 		JBrowse link
G S1pr5 sphingosine-1-phosphate receptor 5 multiple interactions ISO Endocannabinoids inhibits the reaction [sphingosine 1-phosphate binds to and results in increased activity of S1PR5 protein]; sphingosine 1-phosphate binds to and results in increased activity of S1PR5 protein CTD PMID:30102254 NCBI chr 8:19,786,676...19,791,862
Ensembl chr 8:19,786,663...19,791,795 		JBrowse link
G Smad3 SMAD family member 3 increases phosphorylation EXP sphingosine 1-phosphate results in increased phosphorylation of SMAD3 protein CTD PMID:37169277 NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960 		JBrowse link
G Smpd2 sphingomyelin phosphodiesterase 2 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [Thalidomide results in increased activity of SMPD2 protein] CTD PMID:15741222 NCBI chr20:44,986,229...44,989,343
Ensembl chr20:44,986,231...44,989,441 		JBrowse link
G Sphk1 sphingosine kinase 1 increases chemical synthesis
multiple interactions		 ISO SPHK1 protein results in increased chemical synthesis of sphingosine 1-phosphate
[resveratrol affects the localization of and results in decreased activity of SPHK1 protein] which results in decreased abundance of sphingosine 1-phosphate; sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 mRNA]; sphingosine 1-phosphate inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SPHK1 protein]		 CTD PMID:22251058 PMID:24399507 PMID:26045781 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240 		JBrowse link
G Spns2 SPNS lysolipid transporter 2, sphingosine-1-phosphate increases secretion
multiple interactions		 ISO SPNS2 protein results in increased secretion of sphingosine 1-phosphate
TGFB2 protein promotes the reaction [SPNS2 protein results in increased secretion of sphingosine 1-phosphate]		 CTD PMID:29772789 NCBI chr10:57,067,348...57,105,969
Ensembl chr10:57,066,897...57,105,957 		JBrowse link
G Sqstm1 sequestosome 1 decreases expression EXP sphingosine 1-phosphate results in decreased expression of SQSTM1 protein CTD PMID:37169277 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases phosphorylation
multiple interactions		 ISO sphingosine 1-phosphate results in increased phosphorylation of STAT3 protein
Janus Kinase Inhibitors inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of STAT3 protein]; STAT3 protein affects the reaction [sphingosine 1-phosphate results in increased expression of IL1B mRNA]; STAT3 protein affects the reaction [sphingosine 1-phosphate results in increased secretion of IL1B protein]		 CTD PMID:32401414 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Tgfb2 transforming growth factor, beta 2 multiple interactions ISO TGFB2 protein promotes the reaction [SPNS2 protein results in increased secretion of sphingosine 1-phosphate] CTD PMID:29772789 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO JTE 013 inhibits the reaction [sphingosine 1-phosphate results in increased expression of TNF mRNA]; sphingosine 1-phosphate inhibits the reaction [TNF results in increased expression of VCAM1] CTD PMID:18981156 PMID:26518876 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO sphingosine 1-phosphate inhibits the reaction [TNF results in increased expression of VCAM1] CTD PMID:18981156 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
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Path 1
Term Annotations click to browse term
  CHEBI ontology 19876
    chemical entity 19905
      atom 19905
        nonmetal atom 19810
          carbon atom 19764
            organic molecular entity 19764
              lipid 17884
                phospholipid 316
                  C30 phosphomycoketide 0
                  C32 phosphomycoketide + 0
                  aminophospholipid + 0
                  glycerophospholipid + 211
                  glycophospholipid + 23
                  isoprenoid phosphate + 75
                  miltefosine 2
                  olefinic phospholipid + 0
                  oxidised phospholipid + 0
                  perifosine 21
                  phosphosphingolipid + 98
Path 2
Term Annotations click to browse term
  CHEBI ontology 19876
    subatomic particle 19874
      composite particle 19874
        hadron 19874
          baryon 19874
            nucleon 19874
              atomic nucleus 19905
                atom 19905
                  main group element atom 19821
                    p-block element atom 19821
                      chalcogen 19570
                        oxygen atom 19543
                          oxygen molecular entity 19543
                            hydroxides 19342
                              oxoacid 18721
                                pnictogen oxoacid 13168
                                  phosphorus oxoacid 12413
                                    phosphoric acids 11416
                                      phosphoric acid 11416
                                        phosphoric acid derivative 11225
                                          phosphate 11224
                                            organic phosphate 11224
                                              phospholipid 316
                                                C30 phosphomycoketide 0
                                                C32 phosphomycoketide + 0
                                                aminophospholipid + 0
                                                glycerophospholipid + 211
                                                glycophospholipid + 23
                                                isoprenoid phosphate + 75
                                                miltefosine 2
                                                olefinic phospholipid + 0
                                                oxidised phospholipid + 0
                                                perifosine 21
                                                phosphosphingolipid + 98
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