Gene:	Gsk3b ( Rattus norvegicus ) glycogen synthase kinase 3 beta
Description:	mediates Par6-atypical protein kinase C (aPKC) complex regulation of cell polarity; may induce apoptosis
ArrayIDs:	X53428cds_s_at; 6124787; 5942438; X73653_at; 1370267_at; 6182274; 6561825; 6421908; GE21138; A_42_P620042; 5956937; 6724512; 5823188; 5662376; 5796702; 5816130; 6623971; 5748776; 6041274; 6494535;  (details...)
Gene Type:	protein-coding
Additional Data
primer pair:	635145
Homologs
Homo sapiens: GSK3B     See the Human gene in context in:     UCSC     NCBI MapViewer
Mus musculus: Gsk3b     See the Mouse gene in context in:     UCSC     NCBI MapViewer
Comparative Map Data Species Symbol Map Name Chr. Position Rattus norvegicus Gsk3b genome assembly 3.1 11 64342319 - 64486287     Rat Celera Assembly 11 62004680 - 62147081     RH 3.4 11 501.41     RGSC genome assembly v3.4 11 64284731 - 64428698     Cytogenetic 11 q21 Mus musculus Gsk3b Mouse genome assembly build 36.1 16 38089087 - 38246165     Cytogenetic 16 16 B4 Homo sapiens GSK3B human genome assembly 3 121028237 - 121295203     Human genome assembly build 36.2 3 121028233 - 121295203     Cytogenetic 3 q13.3   View comparative maps:      NCBI MapViewer
Genome
View:
Browsers:	Select a browser to viewGene (GBrowse)Gene and SNPs (GBrowse)UCSCVCMAPEnsemblNCBIECRVISTAVISTA+UCSC
Annotation
Molecular Function	Note Reference phosphorylates several substrates, including b-catenin, glycogen synthase, transcriptional factors and the translation initiation factor Eif2b 70606 serine/threonine kinase 70606 Gene Ontology ionotropic glutamate receptor binding,  NF-kappaB binding,  tau protein binding ...  (details...)
Biological Process	Note Reference regulates apoptosis downstream of PI3-kinase/Akt signaling 70606 plays a role in coupling metabolism and protein synthesis to growth factor stimulation 70606 Gene Ontology re-entry into mitotic cell cycle,  response to stress,  negative regulation of MAP kinase activity ...  (details...)
Cellular Component	Gene Ontology protein complex,  nucleus,  membrane raft ...  (details...)
Disease	Ontology Alzheimer Disease (details...)
Phenotype	Ontology liver degeneration,  prenatal lethality,  neurodegeneration (details...)
Behavior	Ontology Schizophrenia,  Bipolar Disorder (details...)
Pathway	Ontology glycogen biosynthetic pathway,  long term depression,  Alzheimer disease pathway ...  (details...)
External Links
Databases	DATABASE ID SOURCE SMART: S_TKc IPI PROSITE: PROTEIN_KINASE_ST IPI PROSITE: PROTEIN_KINASE_ATP IPI PROSITE: PROTEIN_KINASE_DOM IPI UNIPARC: UPI000012DDC0 IPI KEGG Report: rno:84027 ENTREZGENE HomoloGene Group ID: 55629 ENTREZGENE Germonline: 70982 Pfam: Pkinase IPI KEGG Pathway: 04340 ENTREZGENE KEGG Pathway: 05010 ENTREZGENE KEGG Pathway: 04360 ENTREZGENE KEGG Pathway: 04662 ENTREZGENE KEGG Pathway: 05217 ENTREZGENE KEGG Pathway: 04110 ENTREZGENE KEGG Pathway: 05210 ENTREZGENE KEGG Pathway: 05213 ENTREZGENE KEGG Pathway: 04012 ENTREZGENE KEGG Pathway: 04510 ENTREZGENE KEGG Pathway: 04910 ENTREZGENE KEGG Pathway: 04916 ENTREZGENE KEGG Pathway: 05215 ENTREZGENE KEGG Pathway: 04310 ENTREZGENE InterPro: Ser/Thr_prot_kinase_AS. IPI InterPro: Ser/Thr_prot_kinase_dom. IPI InterPro: Se/Thr_prot_kinase-like_dom. IPI InterPro: Kinase-like_dom. IPI InterPro: Prot_kinase_cat_dom. IPI InterPro: Protein_kinase_ATP_BS. IPI IPI: IPI00324168 IPI Ensembl Protein: ENSRNOP00000003867 IPI Entrez Gene: Gsk3b ENTREZGENE UniProt: GSK3B_RAT IPI Ensembl Genes: ENSRNOG00000002833 IPI Superfamily-SCOP: Kinase_like IPI
Sequences	Nucleotide: CH473967 Get FASTA Search GEO Profiles Nucleotide: X53428 Get FASTA Search GEO Profiles Nucleotide: X73653 Get FASTA Search GEO Profiles Nucleotide: NM_032080 Get FASTA Search GEO Profiles (View all 4 Nucleotide Accessions) Protein: CAA52020 Get FASTA Protein: NP_114469 Get FASTA Protein: CAA37519 Get FASTA Protein: EDM11234 Get FASTA Protein: EDM11233 Get FASTA Protein: EDM11232 Get FASTA Protein: P18266 Get FASTA (View all 7 Protein Accessions)
Clusters	UniGene: 10426
References
Curated References	33 references in RGD related to Gsk3b
Other References	104 other references at PubMed related to Gsk3b
Database Information
RGD ID	70982
History	Date Current Symbol Current Name Previous Symbol Previous name Status Description Reference 09-JUL-02: Gsk3b glycogen synthase kinase 3 beta APPROVED Symbol and Name updated to reflect Human and Mouse nomenclature 70877