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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70982
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
Acc ID: CHEBI:30145
Term: lithium atom
Definition: An alkali metal atom that has formula Li.
Chemical ID: MESH:D008094
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsk3bdecreases activityEXP 6480464CTDLithium results in decreased activity of GSK3B proteinPMID:16288908
Gsk3bdecreases phosphorylationEXP 6480464CTDLithium results in decreased phosphorylation of GSK3B proteinPMID:25433145
Gsk3bincreases expressionEXP 6480464CTDLithium results in increased expression of GSK3B mRNA; Lithium results in increased expression of GSK3B proteinPMID:18296634 PMID:19359144
Gsk3bincreases phosphorylationEXP 6480464CTDLithium results in increased phosphorylation of GSK3B proteinPMID:18296634
Gsk3bmultiple interactionsEXP 6480464CTDLithium results in increased phosphorylation of and results in decreased activity of GSK3B proteinPMID:15950778 PMID:21711903
Gsk3bdecreases activityISOGSK3B (Homo sapiens)6480464CTDLithium results in decreased activity of GSK3B proteinPMID:10998351
Gsk3bdecreases activityISOGsk3b (Mus musculus)6480464CTDLithium results in decreased activity of GSK3B proteinPMID:19621015
Gsk3bincreases phosphorylationISOGSK3B (Homo sapiens)6480464CTDLithium results in increased phosphorylation of GSK3B proteinPMID:15475000 PMID:19440698
Gsk3bmultiple interactionsISOGSK3B (Homo sapiens)6480464CTDLithium inhibits the reaction [GSK3B protein binds to TP53 protein]; Lithium promotes the reaction [sodium arsenite results in increased phosphorylation of GSK3B protein]; Magnesium affects the reaction [Lithium results in decreased activity of GSK3B protein]PMID:10998351 PMID:15475000 PMID:17849503
Gsk3bmultiple interactionsISOGsk3b (Mus musculus)6480464CTD[Lithium results in decreased activity of GSK3B protein] which results in increased activity of MTOR protein; [Lithium results in decreased activity of GSK3B protein] which results in increased activity of NFE2L2 protein; Lithium results in increased phosphorylation of and results in decreased activity of GSK3B proteinPMID:17921520 PMID:18619545 PMID:19328817
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