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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70982
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
Acc ID: CHEBI:5063
Term: fipronil
Definition: A racemate comprising equimolar amounts of (R)- and (S)-fipronil.
Chemical ID: MESH:C082360
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsk3baffects response to substanceISOGSK3B (Homo sapiens)6480464CTDGSK3B protein affects the susceptibility to fipronilPMID:21296133
Gsk3bdecreases phosphorylationISOGSK3B (Homo sapiens)6480464CTDfipronil results in decreased phosphorylation of GSK3B proteinPMID:21296133
Gsk3bmultiple interactionsISOGSK3B (Homo sapiens)6480464CTDkenpaullone inhibits the reaction [fipronil results in decreased phosphorylation of GSK3B protein]; Lithium Chloride inhibits the reaction [fipronil results in decreased phosphorylation of GSK3B protein]PMID:21296133
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