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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70982
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsk3bmultiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [[Methylnitrosourea co-treated with Testosterone] results in decreased expression of GSK3B protein]; Quercetin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of GSK3B protein]; Quercetin inhibits the reaction [[Warfarin co-treated with Vitamin K] results in increased phosphorylation of GSK3B protein]PMID:23117658 PMID:25164625 PMID:34922902
Gsk3bdecreases activityISOGSK3B (Homo sapiens)6480464CTDQuercetin results in decreased activity of GSK3B proteinPMID:16968061
Gsk3bdecreases expressionISOGSK3B (Homo sapiens)6480464CTDQuercetin results in decreased expression of GSK3B mRNA; Quercetin results in decreased expression of GSK3B proteinPMID:16968065 PMID:23727915
Gsk3bdecreases phosphorylationISOGSK3B (Homo sapiens)6480464CTDQuercetin results in decreased phosphorylation of GSK3B proteinPMID:35688186
Gsk3bmultiple interactionsISOGSK3B (Homo sapiens)6480464CTDQuercetin promotes the reaction [arctigenin results in decreased phosphorylation of GSK3B protein]PMID:25380086
Gsk3bmultiple interactionsISOGsk3b (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Quercetin inhibits the reaction [Okadaic Acid affects the phosphorylation of GSK3B protein]]; Quercetin inhibits the reaction [Dietary Fats results in increased expression of GSK3B mRNA]; Quercetin inhibits the reaction [Okadaic Acid affects the phosphorylation of GSK3B protein]PMID:27050422 PMID:27260466
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