RGD Reference Report - Nuclear expression of glycogen synthase kinase-3ß and lack of membranous ß-catenin is correlated with poor survival in colon cancer. - Rat Genome Database

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Nuclear expression of glycogen synthase kinase-3ß and lack of membranous ß-catenin is correlated with poor survival in colon cancer.

Authors: Salim, Tavga  Sjölander, Anita  Sand-Dejmek, Janna 
Citation: Salim T, etal., Int J Cancer. 2013 Aug 15;133(4):807-15. doi: 10.1002/ijc.28074. Epub 2013 Mar 9.
RGD ID: 13210769
Pubmed: PMID:23389968   (View Abstract at PubMed)
DOI: DOI:10.1002/ijc.28074   (Journal Full-text)

Dysregulation of Wnt/ß-catenin signaling is a hallmark of colon cancer. Glycogen synthase kinase-3ß (GSK-3ß) can be a positive regulator of survival and proliferation of cultured colon cancer cell but its role in clinical colon cancer is unknown. Our objectives were to evaluate the role of GSK-3ß in colon cancer. A tumor tissue microarray of primary colon cancers and metastases was used to evaluate expression and subcellular localization of GSK-3ß and ß-catenin. In total, 85 primary colon cancer samples were evaluated by immunohistochemistry. Immunoreactivity was correlated to known markers of adverse prognosis. Overall survival was the primary end-point. We found nuclear accumulation of GSK-3ß in 39% (33/85) of evaluated tumors. Nuclear GSK-3ß was significantly associated with shorter overall survival (p¿=¿0.008), larger tumor size (p¿=¿0.015), distant metastasis (p¿=¿0.029) and loss of membranous ß-catenin (p¿=¿0.007). Loss of membranous ß-catenin occurred in 37% (30/82) of the tumors and was associated with poor survival (p¿=¿0.016). The combination of nuclear GSK-3ß and lack of membrane ß-catenin occurred in a total of 26% of the studied tumors (21/61) and was significantly and independently associated with poor prognosis. Our results suggest that nuclear expression of GSK-3ß and loss of membrane ß-catenin identify a subset of colon carcinomas with worse prognosis.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Colonic Neoplasms disease_progressionIEP 13210769protein:increased expression:nucleusRGD 
Colonic Neoplasms disease_progressionISOGSK3B (Homo sapiens)13210769; 13210769protein:increased expression:nucleusRGD 

Objects Annotated

Genes (Rattus norvegicus)
Gsk3b  (glycogen synthase kinase 3 beta)

Genes (Mus musculus)
Gsk3b  (glycogen synthase kinase 3 beta)

Genes (Homo sapiens)
GSK3B  (glycogen synthase kinase 3 beta)


Additional Information