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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70982
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
Acc ID: CHEBI:31767
Term: lead diacetate
Definition: A lead coordination entity in which a central lead(2+) atom is coordinated to two acetate ions.
Chemical ID: MESH:C008261
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsk3bincreases phosphorylationEXP 6480464CTDlead acetate results in increased phosphorylation of GSK3B proteinPMID:27012722
Gsk3bincreases expressionISOGsk3b (Mus musculus)6480464CTDlead acetate results in increased expression of GSK3B proteinPMID:37385299
Gsk3bmultiple interactionsISOGsk3b (Mus musculus)6480464CTD3,4-di-O-caffeoylquinic acid inhibits the reaction [lead acetate results in increased expression of GSK3B protein]; [lead acetate results in increased abundance of Lead] which results in decreased phosphorylation of GSK3B proteinPMID:37385299 PMID:37436718
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