Gsk3b (glycogen synthase kinase 3 beta) - Rat Genome Database

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Gene: Gsk3b (glycogen synthase kinase 3 beta) Chinchilla lanigera
Analyze
Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
RGD ID: 8797936
Description: ENCODES a protein that exhibits ATP binding (ortholog); beta-catenin binding (ortholog); dynactin binding (ortholog); INVOLVED IN animal organ morphogenesis (ortholog); autosome genomic imprinting (ortholog); axon extension (ortholog); PARTICIPATES IN Bone morphogenetic proteins signaling pathway; glycogen biosynthetic pathway; Hedgehog signaling pathway; ASSOCIATED WITH Aberrant Crypt Foci (ortholog); acute kidney failure (ortholog); acute myocardial infarction (ortholog); FOUND IN axon (ortholog); beta-catenin destruction complex (ortholog); centrosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: glycogen synthase kinase-3 beta
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542719,495,422 - 19,671,137 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542719,489,972 - 19,671,137 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Aberrant Crypt Foci  (ISO)
acute kidney failure  (ISO)
acute myocardial infarction  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
bipolar disorder  (ISO)
Brain Injuries  (ISO)
Breast Neoplasms  (ISO)
Burns  (ISO)
Cardiomegaly  (ISO)
cognitive disorder  (ISO)
colon cancer  (ISO)
Colonic Neoplasms  (ISO)
colorectal adenocarcinoma  (ISO)
congestive heart failure  (ISO)
degenerative disc disease  (ISO)
depressive disorder  (ISO)
diabetic encephalopathy  (ISO)
Diabetic Nephropathies  (ISO)
dilated cardiomyopathy  (ISO)
Drug-Induced Dyskinesia  (ISO)
endometrial carcinoma  (ISO)
Endometrial Neoplasms  (ISO)
Experimental Arthritis  (ISO)
Experimental Mammary Neoplasms  (ISO)
genetic disease  (ISO)
Hearing Loss, Cisplatin-Induced  (ISO)
heart disease  (ISO)
hypertension  (ISO)
Intestinal Neoplasms  (ISO)
Liver Reperfusion Injury  (ISO)
mantle cell lymphoma  (ISO)
middle cerebral artery infarction  (ISO)
Multiple Abnormalities  (ISO)
muscular atrophy  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplastic Cell Transformation  (ISO)
neuronal ceroid lipofuscinosis 6A  (ISO)
oral squamous cell carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
Parkinson's disease  (ISO)
peritonitis  (ISO)
Poisoning  (ISO)
Prostatic Neoplasms  (ISO)
schizophrenia  (ISO)
sciatic neuropathy  (ISO)
Sepsis  (ISO)
status epilepticus  (ISO)
Subarachnoid Hemorrhage  (ISO)
substance-related disorder  (ISO)
Tachycardia  (ISO)
tauopathy  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
vascular dementia  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ morphogenesis  (ISO)
autosome genomic imprinting  (ISO)
axon extension  (ISO)
axonogenesis  (ISO)
bone remodeling  (ISO)
canonical Wnt signaling pathway  (ISO)
cell growth involved in cardiac muscle cell development  (ISO)
cell migration  (ISO)
cellular response to amyloid-beta  (ISO)
cellular response to dopamine  (ISO)
cellular response to erythropoietin  (ISO)
cellular response to glucocorticoid stimulus  (ISO)
cellular response to hepatocyte growth factor stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to interleukin-3  (ISO)
cellular response to iron(II) ion  (ISO)
cellular response to lithium ion  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to retinoic acid  (ISO)
circadian rhythm  (ISO)
epithelial to mesenchymal transition  (ISO)
ER overload response  (ISO)
establishment of cell polarity  (ISO)
establishment or maintenance of cell polarity  (ISO)
extrinsic apoptotic signaling pathway  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
fat cell differentiation  (ISO)
glycogen metabolic process  (ISO)
hepatic stellate cell activation  (ISO)
hepatocyte apoptotic process  (ISO)
hippocampus development  (ISO)
insulin receptor signaling pathway  (ISO)
intracellular signal transduction  (ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (ISO)
maintenance of cell polarity  (ISO)
meiosis I  (ISO)
mitochondrion organization  (ISO)
myoblast fusion  (ISO)
myotube differentiation  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of calcineurin-NFAT signaling cascade  (ISO)
negative regulation of canonical Wnt signaling pathway  (ISO)
negative regulation of cardiac muscle hypertrophy  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of dendrite development  (ISO)
negative regulation of dendrite morphogenesis  (ISO)
negative regulation of dopaminergic neuron differentiation  (ISO)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of insulin receptor signaling pathway  (ISO)
negative regulation of MAP kinase activity  (ISO)
negative regulation of mesenchymal stem cell differentiation  (ISO)
negative regulation of neuron maturation  (ISO)
negative regulation of neuron migration  (ISO)
negative regulation of neuron projection development  (ISO)
negative regulation of nitric-oxide synthase activity  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of protein acetylation  (ISO)
negative regulation of protein localization to centrosome  (ISO)
negative regulation of protein localization to nucleus  (ISO)
negative regulation of protein-containing complex assembly  (ISO)
negative regulation of smooth muscle cell apoptotic process  (ISO)
negative regulation of synaptic assembly at neuromuscular junction  (ISO)
negative regulation of TOR signaling  (ISO)
neuron projection development  (ISO)
neuron projection organization  (ISO)
phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of autophagy  (ISO)
positive regulation of axon extension  (ISO)
positive regulation of cardiac muscle cell differentiation  (ISO)
positive regulation of cell differentiation  (ISO)
positive regulation of cell-matrix adhesion  (ISO)
positive regulation of cilium assembly  (ISO)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of excitatory postsynaptic potential  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of mitochondrial membrane potential  (ISO)
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of osteoblast proliferation  (ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of osteoclast proliferation  (ISO)
positive regulation of peptidyl-threonine phosphorylation  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (ISO)
positive regulation of protein catabolic process  (ISO)
positive regulation of protein export from nucleus  (ISO)
positive regulation of protein localization to centrosome  (ISO)
positive regulation of protein localization to cilium  (ISO)
positive regulation of protein ubiquitination  (ISO)
positive regulation of protein-containing complex assembly  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of stem cell differentiation  (ISO)
positive regulation of synaptic assembly at neuromuscular junction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
presynaptic modulation of chemical synaptic transmission  (ISO)
protein export from nucleus  (ISO)
protein localization to microtubule  (ISO)
protein phosphorylation  (ISO)
re-entry into mitotic cell cycle  (ISO)
regulation of apoptotic process  (ISO)
regulation of axon extension  (ISO)
regulation of axonogenesis  (ISO)
regulation of cell growth  (ISO)
regulation of circadian rhythm  (ISO)
regulation of dendrite morphogenesis  (ISO)
regulation of long-term synaptic potentiation  (ISO)
regulation of microtubule anchoring at centrosome  (ISO)
regulation of microtubule cytoskeleton organization  (ISO)
regulation of microtubule-based process  (ISO)
regulation of modification of postsynaptic structure  (ISO)
regulation of neuron projection development  (ISO)
regulation of neuronal synaptic plasticity  (ISO)
regulation of neurotransmitter receptor localization to postsynaptic specialization membrane  (ISO)
regulation of osteoblast differentiation  (ISO)
regulation of protein export from nucleus  (ISO)
response to activity  (ISO)
response to angiotensin  (ISO)
response to epinephrine  (ISO)
response to estradiol  (ISO)
response to insulin  (ISO)
response to insulin-like growth factor stimulus  (ISO)
response to L-glutamate  (ISO)
response to ultrasound  (ISO)
response to xenobiotic stimulus  (ISO)
response to zinc ion  (ISO)
stem cell differentiation  (ISO)
superior temporal gyrus development  (ISO)
transcription by RNA polymerase II  (ISO)
Wnt signaling pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Gsk3b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542719,495,422 - 19,671,137 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542719,489,972 - 19,671,137 (-)NCBIChiLan1.0ChiLan1.0
GSK3B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383119,821,321 - 120,094,447 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3119,821,321 - 120,094,994 (-)EnsemblGRCh38hg38GRCh38
GRCh373119,540,168 - 119,813,294 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363121,028,233 - 121,295,203 (-)NCBINCBI36Build 36hg18NCBI36
Build 343121,028,237 - 121,295,203NCBI
Celera3117,949,905 - 118,223,017 (-)NCBICelera
Cytogenetic Map3q13.33NCBI
HuRef3116,916,542 - 117,189,344 (-)NCBIHuRef
CHM1_13119,504,331 - 119,776,722 (-)NCBICHM1_1
T2T-CHM13v2.03122,541,048 - 122,814,129 (-)NCBIT2T-CHM13v2.0
Gsk3b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391637,909,363 - 38,066,446 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1637,909,363 - 38,066,446 (+)EnsemblGRCm39 Ensembl
GRCm381638,089,001 - 38,246,084 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1638,089,001 - 38,246,084 (+)EnsemblGRCm38mm10GRCm38
MGSCv371638,089,087 - 38,246,165 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361638,008,240 - 38,165,318 (+)NCBIMGSCv36mm8
Celera1638,497,488 - 38,655,086 (+)NCBICelera
Cytogenetic Map16B3NCBI
cM Map1626.54NCBI
Gsk3b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81176,004,502 - 76,154,665 (-)NCBIGRCr8
mRatBN7.21162,498,997 - 62,648,665 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1162,504,316 - 62,648,646 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1171,316,816 - 71,460,263 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01163,979,039 - 64,122,494 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01163,029,506 - 63,172,937 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01165,060,884 - 65,208,842 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1165,066,235 - 65,209,268 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01166,873,291 - 67,016,640 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41164,284,731 - 64,428,698 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11164,342,319 - 64,486,287 (-)NCBI
Celera1162,004,680 - 62,147,081 (-)NCBICelera
RH 3.4 Map11501.41RGD
Cytogenetic Map11q21NCBI
GSK3B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22117,803,084 - 118,069,881 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13117,803,362 - 118,073,878 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03116,943,205 - 117,215,001 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13123,856,047 - 124,126,747 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3123,861,379 - 124,126,771 (-)Ensemblpanpan1.1panPan2
GSK3B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13323,458,369 - 23,659,878 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3323,463,767 - 23,659,666 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3323,488,457 - 23,689,804 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03323,696,164 - 23,823,688 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3323,714,581 - 23,900,333 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13323,500,322 - 23,702,303 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03323,541,326 - 23,742,436 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03324,104,403 - 24,306,119 (-)NCBIUU_Cfam_GSD_1.0
Gsk3b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602130,628,163 - 130,791,946 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365366,730,062 - 6,894,303 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365366,730,070 - 6,893,818 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSK3B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13140,136,158 - 140,369,569 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113140,136,109 - 140,370,197 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213149,599,661 - 149,702,154 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.213149,431,156 - 149,510,315 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GSK3B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12260,732,449 - 61,002,735 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2260,733,465 - 60,997,239 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041105,307,531 - 105,584,674 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gsk3b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473128,178,628 - 28,366,420 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473128,178,647 - 28,368,784 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000015942   ⟹   ENSCLAP00000015779
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542719,495,422 - 19,671,137 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000015943   ⟹   ENSCLAP00000015780
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495542719,495,422 - 19,671,135 (-)Ensembl
RefSeq Acc Id: XM_005386460   ⟹   XP_005386517
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542719,489,972 - 19,671,137 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005386461   ⟹   XP_005386518
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542719,489,972 - 19,671,135 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013515157   ⟹   XP_013370611
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495542719,489,972 - 19,663,793 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005386517 (Get FASTA)   NCBI Sequence Viewer  
  XP_005386518 (Get FASTA)   NCBI Sequence Viewer  
  XP_013370611 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000015779
  ENSCLAP00000015779.1
  ENSCLAP00000015780
  ENSCLAP00000015780.1
Reference Protein Sequences
RefSeq Acc Id: XP_005386518   ⟸   XM_005386461
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VHL3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005386517   ⟸   XM_005386460
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VHR1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013370611   ⟸   XM_013515157
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: ENSCLAP00000015779   ⟸   ENSCLAT00000015942
RefSeq Acc Id: ENSCLAP00000015780   ⟸   ENSCLAT00000015943
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000010847 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000015942 ENTREZGENE
  ENSCLAT00000015942.1 UniProtKB/TrEMBL
  ENSCLAT00000015943 ENTREZGENE
  ENSCLAT00000015943.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  STKc_GSK3 UniProtKB/TrEMBL
NCBI Gene Gsk3b ENTREZGENE
PANTHER GLYCOGEN SYNTHASE KINASE-3 ALPHA UniProtKB/TrEMBL
  PTHR24057:SF8 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A8C2VHL3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VHR1 ENTREZGENE, UniProtKB/TrEMBL