Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70982
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsk3bdecreases phosphorylationISOGsk3b (Mus musculus)6480464CTDDoxorubicin results in decreased phosphorylation of GSK3B proteinPMID:18037988
Gsk3bincreases phosphorylationISOGSK3B (Homo sapiens)6480464CTDDoxorubicin results in increased phosphorylation of GSK3B proteinPMID:17339365
Gsk3bmultiple interactionsISOGSK3B (Homo sapiens)6480464CTDmethylselenic acid inhibits the reaction [Doxorubicin results in increased phosphorylation of GSK3B protein]; Selenium inhibits the reaction [Doxorubicin results in increased phosphorylation of GSK3B protein]PMID:17339365
Gsk3bmultiple interactionsISOGsk3b (Mus musculus)6480464CTDCarbon Monoxide inhibits the reaction [Doxorubicin results in decreased phosphorylation of GSK3B protein]PMID:18037988
Go Back to source page   Continue to Ontology report