RGD Reference Report - Recruitment of active glycogen synthase kinase-3 into neuronal lipid rafts. - Rat Genome Database

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Recruitment of active glycogen synthase kinase-3 into neuronal lipid rafts.

Authors: Sui, Z  Kovacs, AD  Maggirwar, SB 
Citation: Sui Z, etal., Biochem Biophys Res Commun. 2006 Jul 14;345(4):1643-8. Epub 2006 May 24.
RGD ID: 1641884
Pubmed: PMID:16735023   (View Abstract at PubMed)
DOI: DOI:10.1016/j.bbrc.2006.05.087   (Journal Full-text)

Glycogen synthase kinase (GSK)-3beta has emerged as a key molecule that regulates neuronal apoptosis. To examine the molecular mechanism(s) through which GSK-3beta regulates this process, we studied the subcellular localization of GSK-3beta following exposure of the cells to well-characterized apoptotic stimuli. Here, we report that the induction of apoptosis by withdrawal of serum and potassium triggers dephosphorylation of GSK-3beta at serine 9 and subsequent translocation of these molecules into neuronal lipid raft microdomains. Inhibition of GSK-3beta by small molecule inhibitors blocks specific phosphorylation of lipid raft associated protein Tau. Consistent with the notion that the lipid raft domains may serve as a platform for the cellular signaling complexes, disruption of lipid rafts protected neurons from apoptosis induced by withdrawal of serum and potassium as well as by HIV-1 Tat. Our observations reveal novel interaction of GSK-3beta and raft domains, and suggest that such interaction could contribute to neuronal apoptosis.

Gene Ontology Annotations    Click to see Annotation Detail View

Molecular Function
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
tau protein binding  IDA 1641884 RGD 
tau-protein kinase activity  IDA 1641884 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gsk3b  (glycogen synthase kinase 3 beta)


Additional Information