RGD Reference Report - Association analysis of the GSK-3beta T-50C gene polymorphism with schizophrenia and bipolar disorder. - Rat Genome Database

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Association analysis of the GSK-3beta T-50C gene polymorphism with schizophrenia and bipolar disorder.

Authors: Szczepankiewicz, A  Skibinska, M  Hauser, J  Slopien, A  Leszczynska-Rodziewicz, A  Kapelski, P  Dmitrzak-Weglarz, M  Czerski, PM  Rybakowski, JK 
Citation: Szczepankiewicz A, etal., Neuropsychobiology. 2006;53(1):51-6. Epub 2006 Jan 4.
RGD ID: 1641931
Pubmed: PMID:16397405   (View Abstract at PubMed)
DOI: DOI:10.1159/000090704   (Journal Full-text)

Glycogen synthase kinase-3beta (GSK-3beta) has been implicated in the pathogenesis of major psychoses. In this paper, the T-50C polymorphism of the GSK-3beta gene has been studied in patients with schizophrenia (n=432), patients with bipolar disorder (n=416) and in a healthy control group (n=408). Consensus diagnosis by at least two psychiatrists was made for each patient, according to DSM-IV and ICD-10 criteria, using the Structured Clinical Interview for DSM-IV Axis I Disorders. Genotypes were established by the polymerase chain reaction-restriction fragment length polymorphism method. We have found a trend towards an association for the C allele in the whole group of schizophrenic patients (p=0.088) and for the heterozygous T/C genotype of bipolar patients (0.095). Significant differences of genotype distribution and allele frequencies of the T-50C polymorphism were found in the female group of bipolar II patients (p=0.015 for genotypes and p=0.009 for alleles). In conclusion, this polymorphism may be associated with female gender in bipolar II disorder.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
bipolar disorder  IAGP 1641931 RGD 
bipolar disorder  ISOGSK3B (Homo sapiens)1641931; 1641931 RGD 
schizophrenia  IAGP 1641931 RGD 
schizophrenia  ISOGSK3B (Homo sapiens)1641931; 1641931 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Gsk3b  (glycogen synthase kinase 3 beta)

Genes (Mus musculus)
Gsk3b  (glycogen synthase kinase 3 beta)

Genes (Homo sapiens)
GSK3B  (glycogen synthase kinase 3 beta)


Additional Information