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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70982
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsk3baffects expressionEXP 6480464CTDAcetaminophen affects the expression of GSK3B mRNAPMID:16701773
Gsk3bdecreases phosphorylationEXP 6480464CTDAcetaminophen results in decreased phosphorylation of GSK3B proteinPMID:26767949
Gsk3bmultiple interactionsEXP 6480464CTDmorin inhibits the reaction [Acetaminophen results in decreased phosphorylation of GSK3B protein]PMID:26767949
Gsk3bincreases expressionISOGsk3b (Mus musculus)6480464CTDAcetaminophen results in increased expression of GSK3B protein modified formPMID:19679878
Gsk3bincreases phosphorylationISOGsk3b (Mus musculus)6480464CTDAcetaminophen results in increased phosphorylation of GSK3B proteinPMID:22687999 PMID:25752611 PMID:34668565
Gsk3bmultiple interactionsISOGsk3b (Mus musculus)6480464CTDcoenzyme Q10 promotes the reaction [Acetaminophen results in increased phosphorylation of GSK3B protein]; GSTM1 gene mutant form inhibits the reaction [Acetaminophen results in increased phosphorylation of GSK3B protein]; PRKN gene mutant form affects the reaction [Acetaminophen results in increased phosphorylation of GSK3B protein]PMID:22687999 PMID:25752611 PMID:34668565
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