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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70982
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
Acc ID: CHEBI:33216
Term: bisphenol A
Definition: A bisphenol that is 4,4'-methanediyldiphenol in which the methylene hydrogens are replaced by two methyl groups.
Chemical ID: MESH:C006780
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsk3bdecreases expressionEXP 6480464CTDbisphenol A results in decreased expression of GSK3B mRNAPMID:26186136
Gsk3bdecreases phosphorylationEXP 6480464CTDbisphenol A results in decreased phosphorylation of GSK3B proteinPMID:25112833 PMID:25963729 PMID:28739533 PMID:33315269
Gsk3bincreases expressionEXP 6480464CTDbisphenol A results in increased expression of GSK3B mRNAPMID:25181051 PMID:25381574 PMID:25963729 PMID:29097150
Gsk3bincreases methylationEXP 6480464CTDbisphenol A results in increased methylation of GSK3B genePMID:28505145
Gsk3bmultiple interactionsEXP 6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of GSK3B mRNA; bisphenol A promotes the reaction [Dietary Fats results in decreased phosphorylation of GSK3B protein]; bisphenol A results in increased expression of and results in decreased phosphorylation of GSK3B protein; Curcumin inhibits the reaction [bisphenol A results in decreased phosphorylation of GSK3B protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of GSK3B mRNA]; Curcumin inhibits the reaction [bisphenol A results in increased phosphorylation of and affects the localization of GSK3B protein]; Dietary Fats promotes the reaction [bisphenol A results in decreased phosphorylation of GSK3B protein]; GSK3B mutant form inhibits the reaction [bisphenol A results in increased phosphorylation of and affects the localization of GSK3B protein]; Nigella sativa oil inhibits the reaction [bisphenol A results in decreased phosphorylation of GSK3B protein]; thymoquinone inhibits the reaction [bisphenol A results in decreased phosphorylation of GSK3B protein]; WNT3A protein affects the reaction [bisphenol A results in increased expression of and results in decreased phosphorylation of GSK3B protein]PMID:25112833 PMID:25381574 PMID:25963729 PMID:33315269 PMID:36041667
Gsk3baffects bindingISOGSK3B (Homo sapiens)6480464CTDbisphenol A binds to GSK3B proteinPMID:34706627
Gsk3bdecreases expressionISOGsk3b (Mus musculus)6480464CTDbisphenol A results in decreased expression of GSK3B mRNAPMID:35489422
Gsk3bdecreases methylationISOGSK3B (Homo sapiens)6480464CTDbisphenol A results in decreased methylation of GSK3B genePMID:31601247
Gsk3bdecreases phosphorylationISOGsk3b (Mus musculus)6480464CTDbisphenol A results in decreased phosphorylation of GSK3B proteinPMID:25637671 PMID:26779933 PMID:35489422
Gsk3bincreases expressionISOGSK3B (Homo sapiens)6480464CTDbisphenol A results in increased expression of GSK3B proteinPMID:34186270
Gsk3bincreases phosphorylationISOGSK3B (Homo sapiens)6480464CTDbisphenol A results in increased phosphorylation of GSK3B proteinPMID:36232920
Gsk3bincreases phosphorylationISOGsk3b (Mus musculus)6480464CTDbisphenol A results in increased phosphorylation of GSK3B proteinPMID:26923231
Gsk3bmultiple interactionsISOGSK3B (Homo sapiens)6480464CTD[bisphenol A co-treated with Fulvestrant] results in increased methylation of GSK3B genePMID:31601247
Gsk3bmultiple interactionsISOGsk3b (Mus musculus)6480464CTD[bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in decreased expression of GSK3B mRNA; [bisphenol A co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased phosphorylation of GSK3B protein; bisphenol A affects the phosphorylation of and results in increased activity of GSK3B protein; bisphenol A inhibits the reaction [INS1 protein results in increased phosphorylation of GSK3B protein]; bisphenol A results in increased activity of and results in decreased phosphorylation of GSK3B protein; HDAC2 protein affects the reaction [bisphenol A results in increased activity of and results in decreased phosphorylation of GSK3B protein]PMID:28483554 PMID:30665118 PMID:32278051 PMID:37372067
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