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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70982 Species: Rattus norvegicus RGD Object: Gene Symbol: Gsk3b Name: glycogen synthase kinase 3 beta

Acc ID: CHEBI:40303 Term: lovastatin Definition: A fatty acid ester that has formula C24H36O5. CasRN: 75330-75-5 Chemical ID: MESH:D008148

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
decreases phosphorylation	ISO	RGD:733891	6480464	CTD	Lovastatin results in decreased phosphorylation of GSK3B protein	PMID:17234346
increases phosphorylation	EXP		6480464	CTD	Lovastatin results in increased phosphorylation of GSK3B protein	PMID:19741129