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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70982
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gsk3b
Name: glycogen synthase kinase 3 beta
Acc ID: CHEBI:64317
Term: isoprenaline
Definition: A secondary amino compound that is noradrenaline in which one of the hydrogens attached to the nitrogen is replaced by an isopropyl group. A sympathomimetic acting almost exclusively on beta-adrenergic receptors, it is used (mainly as the hydrochloride salt) as a bronghodilator and heart stimulant for the management of a variety of cardiac disorders.
Chemical ID: MESH:D007545
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsk3bdecreases phosphorylationEXP 6480464CTDIsoproterenol results in decreased phosphorylation of GSK3B proteinPMID:18806606
Gsk3bincreases phosphorylationEXP 6480464CTDIsoproterenol results in increased phosphorylation of GSK3B proteinPMID:15951400 PMID:16716347 PMID:31009642
Gsk3bmultiple interactionsEXP 6480464CTD2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one inhibits the reaction [Isoproterenol results in decreased phosphorylation of GSK3B protein]; 2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one inhibits the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein]; 2-((2-piperidin-1-ylethyl)thio)quinazolin-4(3H)-one promotes the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein]; Enalapril inhibits the reaction [Isoproterenol results in decreased phosphorylation of GSK3B protein]; plantamajoside inhibits the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein]; Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein]PMID:15951400 PMID:16716347 PMID:18806606 PMID:31009642
Gsk3bincreases phosphorylationISOGsk3b (Mus musculus)6480464CTDIsoproterenol results in increased phosphorylation of GSK3B proteinPMID:31009642
Gsk3bmultiple interactionsISOGsk3b (Mus musculus)6480464CTDplantamajoside inhibits the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein]; Valsartan inhibits the reaction [Isoproterenol results in increased phosphorylation of GSK3B protein]PMID:31009642
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