Esr2 (estrogen receptor 2) - Rat Genome Database

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Gene: Esr2 (estrogen receptor 2) Rattus norvegicus
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Symbol: Esr2
Name: estrogen receptor 2
RGD ID: 2582
Description: Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; estrogen response element binding activity; and steroid binding activity. Involved in several processes, including brain development; regulation of transcription by RNA polymerase II; and reproductive structure development. Located in mitochondrion; perikaryon; and perinuclear region of cytoplasm. Part of protein-DNA complex. Used to study several diseases, including hypertension (multiple); obesity; peritonitis; prostate carcinoma in situ; and transient cerebral ischemia. Biomarker of asthma; brain ischemia; colitis; cystitis; and osteoporosis. Human ortholog(s) of this gene implicated in several diseases, including Graves' disease; artery disease (multiple); arthritis (multiple); hypospadias; and neurodegenerative disease (multiple). Orthologous to human ESR2 (estrogen receptor 2); PARTICIPATES IN estrogen signaling pathway; bisphenol A response pathway; tamoxifen pharmacodynamics pathway; INTERACTS WITH (R,R,R)-alpha-tocopherol; (S)-naringenin; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ER-beta; Erb2; ERbeta; estrogen receptor 2 (beta); estrogen receptor 2 (ER beta); estrogen receptor 2 beta; estrogen receptor beta; nuclear receptor subfamily 3 group A member 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Esr2em1Soar
Genetic Models: SD-Esr2em1Soar
Candidate Gene For: Schws8
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86100,589,553 - 100,645,240 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6100,545,206 - 100,644,709 (-)EnsemblGRCr8
mRatBN7.2694,858,438 - 94,909,630 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl694,809,547 - 94,908,919 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx695,252,364 - 95,302,093 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0695,550,861 - 95,600,589 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0694,979,673 - 95,029,407 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0699,163,953 - 99,214,711 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl699,164,357 - 99,214,251 (-)Ensemblrn6Rnor6.0
Rnor_5.06108,576,398 - 108,626,196 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4698,691,167 - 98,775,299 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera693,284,596 - 93,334,744 (-)NCBICelera
RGSC_v3.1698,694,622 - 98,778,755 (-)NCBI
RH 3.4 Map6686.1RGD
Cytogenetic Map6q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
adenocarcinoma  (ISO)
adenoma  (ISO)
alopecia  (ISO)
Alzheimer's disease  (ISO)
Animal Mammary Neoplasms  (ISO)
anxiety disorder  (IDA)
aortic valve stenosis  (ISO)
asthma  (IEP)
atherosclerosis  (ISO)
atrial fibrillation  (ISO)
Blast Crisis  (ISO)
brain ischemia  (IEP)
breast cancer  (IDA,ISO)
Breast Neoplasms  (ISO)
carcinoma  (ISO)
Cardiac Arrhythmias  (ISO)
Cocaine-Related Disorders  (ISO)
Cognitive Dysfunction  (ISO)
colitis  (IEP,ISO)
colon cancer  (IDA)
colorectal cancer  (ISO)
Colorectal Neoplasms  (ISO)
contact dermatitis  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
COVID-19  (ISO)
Crohn's disease  (ISO)
cystitis  (IEP)
Deafness  (ISO)
depressive disorder  (IDA)
Endometrial Neoplasms  (ISO)
endometriosis  (ISO)
Experimental Arthritis  (IDA)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Mammary Neoplasms  (IDA,IEP,ISO)
Experimental Melanoma  (ISO)
familial medullary thyroid carcinoma  (ISO)
Female Infertility  (IMP,ISO)
glomerulosclerosis  (ISO)
Graves' disease  (ISO)
Hand Osteoarthritis  (ISO)
Hashimoto Disease  (ISO)
Hearing Loss  (ISO)
Hemorrhagic Shock  (IDA)
Hot Flashes  (IDA)
Hyperalgesia  (IDA,ISO)
hypertension  (IMP,ISO)
hypospadias  (ISO)
in situ carcinoma  (ISO)
inflammatory bowel disease  (IDA)
Insulin Resistance  (ISO)
interstitial cystitis  (ISO)
Knee Osteoarthritis  (ISO)
Left Ventricular Hypertrophy  (ISO)
Lithiasis  (ISO)
Lung Injury  (IDA)
malignant astrocytoma  (ISO)
medulloblastoma  (ISO)
melanoma  (ISO)
myasthenia gravis  (ISO)
myeloid leukemia  (ISO)
Myocardial Reperfusion Injury  (ISO)
Neoplastic Cell Transformation  (ISO)
obesity  (IDA)
osteoarthritis  (ISO)
osteoporosis  (IEP,ISO)
Osteoporotic Fractures  (IEP,ISO)
ovarian dysgenesis 8  (ISO)
Parkinson's disease  (ISO)
peritonitis  (IDA)
Pituitary Neoplasms  (ISO)
Postmenopausal Osteoporosis  (ISO)
pre-eclampsia  (ISO)
primary open angle glaucoma  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (IDA,ISO)
prostatic hypertrophy  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary hypertension  (IDA)
retinal degeneration  (ISO)
rheumatoid arthritis  (ISO)
Sepsis  (IDA)
Spinal Cord Injuries  (IEP)
Splenomegaly  (ISO)
stroke  (IDA)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
transient cerebral ischemia  (IMP)
transitional cell carcinoma  (ISO)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
Urination Disorders  (IDA)
Varicose Ulcer  (ISO)
Vulvar Lichen Sclerosus  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
(24S)-24-hydroxycholesterol  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(3-phenoxyphenyl)methanol  (ISO)
(R,R,R)-alpha-tocopherol  (EXP)
(S)-naringenin  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP,ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-bromopropane  (ISO)
1-Hydroxypyrene  (ISO)
1-naphthol  (ISO)
10H-phenothiazine  (ISO)
16-Ketoestrone  (ISO)
17alpha-estradiol  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17alpha-hydroxyprogesterone  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2'-Bisphenol F  (ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,2,2-trichloroethanol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,4,5-Tetrachloro-4'-biphenylol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (EXP,ISO)
2,4,5-trichlorophenol  (ISO)
2,4,6-Trimethylbenzaldehyde  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP,ISO)
2,4-dichlorophenol  (ISO)
2,4-Dihydroxybenzophenone  (ISO)
2,6-diisopropylnaphthalene  (ISO)
2,6-dimethylnaphthalene  (ISO)
2-benzyl-4-chlorophenol  (ISO)
2-hydroxy-17beta-estradiol  (EXP,ISO)
2-hydroxyestrone  (ISO)
2-tert-butylhydroquinone  (ISO)
2-tert-Butylphenol  (ISO)
22-Hydroxycholesterol  (ISO)
25-hydroxycholesterol  (ISO)
26-hydroxycholesterol  (ISO)
3',5'-cyclic AMP  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-diindolylmethane  (ISO)
3,3'-Dimethylbenzidine  (ISO)
3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-1-decanol  (ISO)
3,4-dihydroxybenzoic acid  (EXP)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-Benzylidene camphor  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-Methyl-4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one  (ISO)
3-phenoxybenzoic acid  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4,4'-thiodiphenol  (ISO)
4-Androstenediol  (EXP)
4-chloro-3,5-dimethylphenol  (ISO)
4-ethylphenol  (ISO)
4-hydroxy-17beta-estradiol  (EXP,ISO)
4-Hydroxybenzophenone  (ISO)
4-nitro-m-cresol  (ISO)
4-nitrophenol  (EXP)
4-nitrotoluene  (ISO)
4-nonylphenol  (ISO)
4-octylphenol  (ISO)
4-Propylphenol  (ISO)
4-tert-butylphenol  (ISO)
4-tert-Octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5alpha-androstane-3alpha,17beta-diol  (EXP)
5alpha-androstane-3beta,17beta-diol  (EXP)
6-oxocampestanol  (ISO)
7,12-dimethyltetraphene  (EXP,ISO)
8-Br-cAMP  (ISO)
9-cis-retinoic acid  (ISO)
9-phenanthrol  (ISO)
acetochlor  (ISO)
acetophenone  (ISO)
acrylamide  (ISO)
adenosine  (ISO)
afimoxifene  (EXP,ISO)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
all-trans-phytoene  (ISO)
all-trans-phytofluene  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (ISO)
alpha-naphthoflavone  (EXP)
alpha-Zearalanol  (EXP,ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (EXP)
androgen antagonist  (EXP)
androst-4-ene-3,17-dione  (ISO)
androst-5-ene-3beta,17beta-diol  (EXP,ISO)
androstane-3,17-diol  (EXP,ISO)
anilines  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
Aroclor 1254  (EXP,ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
azadirachtin A  (ISO)
Azoxymethane  (EXP)
bazedoxifene  (ISO)
benzo[a]pyrene  (ISO)
benzophenone  (ISO)
benzyl benzoate  (ISO)
Benzyl parahydroxybenzoate  (ISO)
Benzyl salicylate  (ISO)
beta-carotene  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (EXP)
beta-tocopherol  (EXP)
beta-Zearalanol  (EXP)
bexarotene  (EXP,ISO)
bicalutamide  (ISO)
bifenthrin  (ISO)
biochanin A  (EXP,ISO)
biphenyl-2-ol  (ISO)
biphenyl-4-ol  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol A dimethacrylate  (ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP,ISO)
Bisphenol Z  (ISO)
bortezomib  (ISO)
brassinolide  (ISO)
Bromofos  (ISO)
Bromophos-ethyl  (ISO)
butanal  (ISO)
butylated hydroxyanisole  (ISO)
butylbenzene  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (EXP,ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
camptothecin  (ISO)
captan  (ISO)
carbaryl  (ISO)
carbendazim  (EXP)
carbon nanotube  (ISO)
carfilzomib  (ISO)
cedrol  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chlorogenic acid  (EXP)
chloropropylate  (ISO)
chlorpyrifos  (ISO)
chlorpyrifos-methyl  (ISO)
chromium(6+)  (EXP)
chrysin  (ISO)
cisplatin  (ISO)
citral  (ISO)
clomiphene  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
coumaphos  (ISO)
coumestrol  (EXP,IPI,ISO)
Cuprizon  (EXP)
cyanazine  (ISO)
Cyanofenphos  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyhalothrin  (ISO)
cypermethrin  (ISO)
cyproterone acetate  (ISO)
D-aspartic acid  (ISO)
D-glucose  (ISO)
daidzein  (EXP,ISO)
daidzein 7-O-beta-D-glucoside  (EXP)
DDD  (ISO)
DDE  (EXP,ISO)
DDT  (EXP,ISO)
Decamethylcyclopentasiloxane  (ISO)
dehydroepiandrosterone  (EXP,ISO)
delta-hexachlorocyclohexane  (ISO)
delta-tocopherol  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
Di-n-hexyl phthalate  (ISO)
Di-n-octyl phthalate  (ISO)
diarsenic trioxide  (ISO)
diarylheptanoid  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
Dichlofenthion  (ISO)
dicofol  (ISO)
Dicyclohexyl phthalate  (ISO)
dieldrin  (ISO)
dienestrol  (EXP)
diethyl phthalate  (ISO)
diethylstilbestrol  (EXP,ISO)
digitoxin  (ISO)
diheptyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dimethoate  (ISO)
diniconazole  (ISO)
dioscin  (ISO)
diosgenin  (ISO)
dioxygen  (EXP,ISO)
dipentyl phthalate  (ISO)
diphenylmethanol  (ISO)
dipropyl phthalate  (ISO)
disodium selenite  (ISO)
diuron  (ISO)
dodecylamine  (ISO)
doxorubicin  (ISO)
dronedarone  (ISO)
emetine  (ISO)
emodin  (ISO)
endosulfan  (EXP,ISO)
endrin  (ISO)
enilconazole  (ISO)
enzacamene  (EXP,ISO)
EPN  (ISO)
equilin  (ISO)
equol  (ISO)
estradiol  (EXP)
estriol  (EXP,ISO)
estrone  (EXP,ISO)
estrone 3-sulfate  (EXP)
ethanol  (EXP)
ethion  (ISO)
Ethyl cinnamate  (ISO)
ethyl myristate  (ISO)
ethylparaben  (EXP,ISO)
etoposide  (ISO)
eugenol  (ISO)
Evodiamine  (ISO)
fenamiphos  (ISO)
fenarimol  (ISO)
fenbuconazole  (ISO)
fenhexamid  (ISO)
fenitrothion  (ISO)
fenpyroximate  (ISO)
fenthion  (ISO)
fentin chloride  (ISO)
fenvalerate  (ISO)
finasteride  (ISO)
fingolimod hydrochloride  (ISO)
fipronil  (ISO)
flavone  (ISO)
flavonoids  (ISO)
fludioxonil  (ISO)
flumethrin  (ISO)
fluoranthene  (ISO)
fluoxastrobin  (ISO)
flutamide  (EXP,ISO)
formononetin  (ISO)
fulvestrant  (EXP,ISO)
galaxolide  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gamma-tocopherol  (EXP)
gefitinib  (ISO)
genistein  (EXP,ISO)
genistein 7-O-beta-D-glucoside  (EXP)
geranial  (ISO)
geraniol  (ISO)
glucose  (ISO)
glycitein  (EXP,ISO)
glycitin  (EXP)
glyphosate  (EXP,ISO)
heptachlor  (ISO)
Heptachlor epoxide  (ISO)
herbicide  (ISO)
hexachlorobenzene  (ISO)
hexestrol  (EXP,ISO)
hydrogencarbonate  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
ibuprofen  (ISO)
Icaritin  (ISO)
ICI-164384  (EXP)
imidacloprid  (ISO)
indinavir  (ISO)
indoles  (ISO)
ipriflavone  (ISO)
iprodione  (ISO)
irilone  (ISO)
Isobutylparaben  (EXP,ISO)
isoflavones  (EXP,ISO)
Isopropylparaben  (ISO)
isorhamnetin  (ISO)
isotretinoin  (EXP)
kaempferol  (EXP,ISO)
kresoxim-methyl  (ISO)
L-ascorbic acid  (EXP)
lamivudine  (ISO)
lasofoxifene  (EXP)
leptophos  (ISO)
linuron  (ISO)
lipopolysaccharide  (ISO)
liquiritigenin  (ISO)
luteolin  (ISO)
luteolin 7-O-beta-D-glucoside  (ISO)
lycopene  (ISO)
M1  (ISO)
mancozeb  (ISO)
melatonin  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
mestranol  (ISO)
metconazole  (ISO)
metformin  (EXP)
methimazole  (ISO)
methiocarb  (ISO)
methoxyacetic acid  (EXP,ISO)
methoxychlor  (EXP,ISO)
methyl laurate  (ISO)
Methyl palmitate  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
methyltestosterone  (ISO)
metolachlor  (ISO)
mifepristone  (EXP,ISO)
Mitotane  (ISO)
MK 571  (ISO)
Moniliformin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
monoethyl phthalate  (ISO)
Moxestrol  (EXP)
mycophenolic acid  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-butylbenzenesulfonamide  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP)
n-propyl gallate  (ISO)
Nafoxidine  (EXP)
nandrolone  (EXP)
Nandrolone decanoate  (EXP)
napropamide  (ISO)
naringin  (EXP)
nebivolol  (ISO)
Nonylphenol  (EXP,ISO)
norethisterone  (ISO)
Norethynodrel  (EXP)
notoginsenoside R1  (EXP)
nuarimol  (ISO)
O-Desmethylangolensin  (ISO)
octocrylene  (ISO)
ormeloxifene  (EXP)
oryzalin  (ISO)
Osajin  (ISO)
Oxadiazon  (ISO)
oxybenzone  (EXP,ISO)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
p-tolualdehyde  (ISO)
paclitaxel  (ISO)
parathion-methyl  (ISO)
pendimethalin  (EXP,ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (ISO)
phenanthrene  (ISO)
phenothrin  (ISO)
PhIP  (EXP)
phloretin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phthalic acid  (ISO)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
Pomiferin  (ISO)
potassium dichromate  (EXP)
prallethrin  (ISO)
prochloraz  (ISO)
procymidone  (ISO)
progesterone  (EXP,ISO)
propamocarb  (ISO)
propargite  (ISO)
propiconazole  (ISO)
propylparaben  (EXP,ISO)
propyzamide  (ISO)
prothiofos  (ISO)
pterostilbene  (ISO)
puerarin  (EXP,ISO)
pyrazoles  (ISO)
pyrene  (ISO)
pyridaben  (ISO)
quercetin  (ISO)
quinalphos  (ISO)
raloxifene  (EXP,ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rhapontigenin  (ISO)
rifapentine  (ISO)
Rosavin  (ISO)
rotenone  (ISO)
royal jelly  (ISO)
rubitecan  (ISO)
rutin  (EXP)
salicylates  (ISO)
saquinavir  (ISO)
SB 203580  (ISO)
serpentine asbestos  (ISO)
silibinin  (EXP,ISO)
sodium arsenite  (ISO)
sodium hypochlorite  (ISO)
sophoraflavanone B  (EXP,ISO)
staurosporine  (ISO)
streptozocin  (ISO)
tamoxifen  (EXP,ISO)
teniposide  (ISO)
testosterone  (EXP,ISO)
Testosterone propionate  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (EXP)
tetrachlorvinphos  (ISO)
tetradifon  (ISO)
tetralin  (ISO)
tetramethrin  (EXP)
tetramethylpyrazine  (ISO)
tibolone  (ISO)
tolclofos-methyl  (ISO)
topotecan  (ISO)
toremifene  (ISO)
toxaphene  (EXP,ISO)
trans-piceid  (ISO)
Tri-2-ethylhexyl trimellitate  (ISO)
tributylstannane  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (EXP,ISO)
trifloxystrobin  (ISO)
trifluralin  (ISO)
trifluridine  (ISO)
trilostane  (ISO)
triphenyl phosphate  (ISO)
Triphenylethylene  (ISO)
triptonide  (ISO)
triticonazole  (ISO)
undecan-2-one  (ISO)
Urolithin A  (ISO)
valinomycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP,ISO)
vincristine  (ISO)
vinyl carbamate  (ISO)
vitamin D  (ISO)
zearalenone  (EXP,ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
amygdala development  (IEP)
behavioral fear response  (IDA)
brain development  (ISO)
cellular response to estradiol stimulus  (IEA,IEP,ISO)
cellular response to hormone stimulus  (IEA)
cellular response to lipopolysaccharide  (IMP)
cellular response to magnetism  (IEP)
cellular response to xenobiotic stimulus  (IEP)
cerebellum development  (IEP)
DNA-templated transcription  (IEA)
epithelial cell maturation involved in prostate gland development  (ISO)
estrogen receptor signaling pathway  (IBA,IEA,ISO,TAS)
estrous cycle  (IMP)
female gonad development  (IEP)
hormone-mediated apoptotic signaling pathway  (ISO)
hypothalamus development  (IEP)
intracellular receptor signaling pathway  (IEA)
learning or memory  (IMP)
male gonad development  (IEP)
negative regulation of androgen receptor signaling pathway  (ISO)
negative regulation of behavior  (IDA)
negative regulation of cell population proliferation  (ISO)
negative regulation of epithelial cell proliferation  (IDA,ISO)
negative regulation of feeding behavior  (IMP)
negative regulation of neuron apoptotic process  (IDA,IEA)
negative regulation of reactive oxygen species metabolic process  (IMP)
negative regulation of smooth muscle cell proliferation  (IMP)
negative regulation of transcription by RNA polymerase II  (IDA,IEA,ISO)
neuron migration  (ISO)
nuclear receptor-mediated steroid hormone signaling pathway  (IDA,IEA)
ovarian follicle development  (IEP,ISO)
positive regulation of apoptotic process  (IDA)
positive regulation of DNA-templated transcription  (IDA,IEA,ISO)
positive regulation of epidermal growth factor receptor signaling pathway  (IEA,IMP)
positive regulation of ERK1 and ERK2 cascade  (IDA,IEA,IMP)
positive regulation of transcription by RNA polymerase II  (IDA,ISO)
prostate gland development  (IEP)
prostate gland epithelium morphogenesis  (ISO)
regulation of cell population proliferation  (ISO)
regulation of DNA-templated transcription  (IEA)
regulation of epithelial cell proliferation  (IEA)
regulation of transcription by RNA polymerase II  (IBA)
response to activity  (IEP)
response to bisphenol A  (IEP)
response to dexamethasone  (IEP)
response to estradiol  (IEP)
response to estrogen  (IEA,IEP)
response to ethanol  (IEP)
response to genistein  (IEP)
response to hormone  (IEP)
response to human chorionic gonadotropin  (IEP)
response to insecticide  (IEP)
response to lipid  (IEA)
response to nicotine  (IEP)
response to nutrient levels  (IEP)
response to salt  (IEP)
response to testosterone  (IEP,IMP)
response to xenobiotic stimulus  (IEP)
Sertoli cell development  (IEA,IEP)
Sertoli cell proliferation  (IEA,IMP)
uterus development  (ISO)
vagina development  (ISO)
vasodilation  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
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35. Androgens' effects to enhance learning may be mediated in part through actions at estrogen receptor-beta in the hippocampus. Edinger KL and Frye CA, Neurobiol Learn Mem. 2007 Jan;87(1):78-85. Epub 2006 Aug 14.
36. Quantitative analysis of estrogen receptor-alpha and -beta messenger RNA expression in normal and malignant thyroid tissues by real-time polymerase chain reaction. Egawa C, etal., Oncology. 2001;61(4):293-8.
37. Estrogen receptor beta protects against in vivo injury in RPE cells. Elliot SJ, etal., Exp Eye Res. 2010 Jan;90(1):10-6. doi: 10.1016/j.exer.2009.09.001. Epub 2009 Sep 30.
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66. Estrogen receptor beta-deficient female mice develop a bladder phenotype resembling human interstitial cystitis. Imamov O, etal., Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9806-9. Epub 2007 May 23.
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68. Estrogen receptors activate atrial natriuretic peptide in the rat heart. Jankowski M, etal., Proc Natl Acad Sci U S A 2001 Sep 25;98(20):11765-70.
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75. Gene expression profile of amyloid beta protein-injected mouse model for Alzheimer disease. Kong LN, etal., Acta Pharmacol Sin. 2005 Jun;26(6):666-72.
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80. Response element sequence modulates estrogen receptor alpha and beta affinity and activity. Kulakosky PC, etal., J Mol Endocrinol. 2002 Aug;29(1):137-52.
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92. Estrogen receptor beta gene (ESRbeta) 3'-UTR variants in Alzheimer disease. Luckhaus C, etal., Alzheimer Dis Assoc Disord. 2006 Oct-Dec;20(4):322-3.
93. Novel actions of estrogen receptor-beta on anxiety-related behaviors. Lund TD, etal., Endocrinology. 2005 Feb;146(2):797-807. Epub 2004 Oct 28.
94. Estrogen receptor beta gene polymorphism and intraocular pressure elevation in female patients with primary open-angle glaucoma. Mabuchi F, etal., Am J Ophthalmol. 2010 May;149(5):826-30.e1-2. doi: 10.1016/j.ajo.2009.12.030.
95. Estrogen receptor alpha/beta ratio and estrogen receptor beta as predictors of endocrine therapy responsiveness-a randomized neoadjuvant trial comparison between anastrozole and tamoxifen for the treatment of postmenopausal breast cancer. Madeira M, etal., BMC Cancer. 2013 Sep 18;13:425. doi: 10.1186/1471-2407-13-425.
96. Impact of estrogen receptor beta activation on functional recovery after experimental stroke. Madinier A, etal., Behav Brain Res. 2014 Mar 15;261:282-8. doi: 10.1016/j.bbr.2013.12.046. Epub 2014 Jan 6.
97. Estrogen receptor beta (ESR2) polymorphisms in familial and sporadic breast cancer. Maguire P, etal., Breast Cancer Res Treat. 2005 Nov;94(2):145-52.
98. Simultaneous disruption of estrogen receptor and Wnt/beta-catenin signaling is involved in methyl amooranin-mediated chemoprevention of mammary gland carcinogenesis in rats. Mandal A, etal., Mol Cell Biochem. 2013 Sep 29.
99. Genetic polymorphisms of estrogen receptors in patients with premature coronary artery disease. Mansur Ade P, etal., Arch Med Res. 2005 Sep-Oct;36(5):511-7.
100. Association study using single nucleotide polymorphisms in the estrogen receptor beta (ESR2) gene for preeclampsia. Maruyama A, etal., Hypertens Res. 2004 Dec;27(12):903-9.
101. A novel isoform of rat estrogen receptor beta with 18 amino acid insertion in the ligand binding domain as a putative dominant negative regular of estrogen action. Maruyama K, etal., Biochem Biophys Res Commun 1998 May 8;246(1):142-7.
102. Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia. Massinen S, etal., Hum Mol Genet. 2009 Aug 1;18(15):2802-12. doi: 10.1093/hmg/ddp215. Epub 2009 May 7.
103. Novel ligands balance estrogen receptor beta and alpha agonism for safe and effective suppression of the vasomotor response in the ovariectomized female rat model of menopause. McGregor C, etal., Endocrinology. 2014 Jul;155(7):2480-91. doi: 10.1210/en.2013-1976. Epub 2014 May 13.
104. Essential role for estrogen receptor beta in stromal-epithelial regulation of prostatic hyperplasia. McPherson SJ, etal., Endocrinology. 2007 Feb;148(2):566-74. Epub 2006 Oct 26.
105. Estrogen receptor alpha and beta immunoreactive neurons in normal adult and aged female rat hippocampus: a qualitative and quantitative study. Mehra RD, etal., Brain Res. 2005 Sep 14;1056(1):22-35.
106. Estrogen receptor beta protects against acoustic trauma in mice. Meltser I, etal., J Clin Invest. 2008 Apr;118(4):1563-70. doi: 10.1172/JCI32796.
107. Estrogen-related genes and postmenopausal osteoporosis risk. Mendoza N, etal., Climacteric. 2012 Dec;15(6):587-93. doi: 10.3109/13697137.2012.656160. Epub 2012 Feb 15.
108. Estrogen stimulates galanin expression within luteinizing hormone-releasing hormone-immunoreactive (LHRH-i) neurons via estrogen receptor-beta (ERbeta) in the female rat brain. Merchenthaler I Neuropeptides. 2005 Jun;39(3):341-3.
109. Estrogen and estrogen receptor-{beta} (ER{beta})-selective ligands induce galanin expression within gonadotropin hormone-releasing hormone-immunoreactive neurons in the female rat brain. Merchenthaler I, etal., Endocrinology. 2005 Jun;146(6):2760-5. Epub 2005 Mar 24.
110. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
111. Estrogen receptor (ER)beta isoforms rather than ERalpha regulate corticotropin-releasing hormone promoter activity through an alternate pathway. Miller WJ, etal., J Neurosci. 2004 Nov 24;24(47):10628-35.
112. Multilocus analysis of estrogen-related genes in Spanish postmenopausal women suggests an interactive role of ESR1, ESR2 and NRIP1 genes in the pathogenesis of osteoporosis. Moron FJ, etal., Bone. 2006 Jul;39(1):213-21. Epub 2006 Mar 10.
113. Differential estrogen receptor expression in autoimmune myasthenia gravis. Nancy P and Berrih-Aknin S, Endocrinology. 2005 May;146(5):2345-53. Epub 2005 Jan 20.
114. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
115. Polymorphisms in genes of the steroid receptor superfamily modify postmenopausal breast cancer risk associated with menopausal hormone therapy. NO_AUTHOR Int J Cancer. 2010 Jun 15;126(12):2935-46. doi: 10.1002/ijc.24892.
116. Immunohistochemical expression of estrogen receptors alpha and beta in lobular neoplasia. Nonni A, etal., Virchows Arch. 2007 Nov;451(5):893-7. Epub 2007 Oct 9.
117. Upregulation of myocardial estrogen receptors in human aortic stenosis. Nordmeyer J, etal., Circulation. 2004 Nov 16;110(20):3270-5. Epub 2004 Nov 8.
118. Association of estrogen receptor beta (ESR2) gene polymorphism with blood pressure. Ogawa S, etal., J Hum Genet. 2000;45(6):327-30.
119. Mating changes the subcellular distribution and the functionality of estrogen receptors in the rat oviduct. Orihuela PA, etal., Reprod Biol Endocrinol. 2009 Nov 30;7:139.
120. Sex and region-specific regulation of oestrogen receptor beta in the rat hypothalamus. Orikasa C and Sakuma Y, J Neuroendocrinol. 2004 Dec;16(12):964-9.
121. Sexually dimorphic expression of estrogen receptor beta in the anteroventral periventricular nucleus of the rat preoptic area: implication in luteinizing hormone surge. Orikasa C, etal., Proc Natl Acad Sci U S A. 2002 Mar 5;99(5):3306-11. Epub 2002 Feb 19.
122. Potential role of estrogen in regulation of the insulin-like growth factor2-H19 locus in the rat testis. Pathak S, etal., Mol Cell Endocrinol. 2010 Jan 15;314(1):110-7. doi: 10.1016/j.mce.2009.08.005. Epub 2009 Aug 14.
123. Anxiogenic effects of developmental bisphenol A exposure are associated with gene expression changes in the juvenile rat amygdala and mitigated by soy. Patisaul HB, etal., PLoS One. 2012;7(9):e43890. doi: 10.1371/journal.pone.0043890. Epub 2012 Sep 5.
124. Association of estrogen receptor beta gene polymorphisms with left ventricular mass and wall thickness in women. Peter I, etal., Am J Hypertens. 2005 Nov;18(11):1388-95.
125. Estrogen receptor beta gene variants are associated with increased risk of Alzheimer's disease in women. Pirskanen M, etal., Eur J Hum Genet. 2005 Sep;13(9):1000-6.
126. Estrogen-related abnormalities in glomerulosclerosis-prone mice: reduced mesangial cell estrogen receptor expression and prosclerotic response to estrogens. Potier M, etal., Am J Pathol. 2002 May;160(5):1877-85.
127. Estrogen receptor-beta messenger ribonucleic acid ontogeny in the prostate of normal and neonatally estrogenized rats. Prins GS, etal., Endocrinology. 1998 Mar;139(3):874-83.
128. Steroid hormone receptor expression and proliferation in rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Qiu C, etal., Carcinogenesis. 2005 Apr;26(4):763-9. Epub 2005 Jan 6.
129. Feeding soy protein isolate and treatment with estradiol have different effects on mammary gland morphology and gene expression in weanling male and female rats. Racine Miousse I, etal., Physiol Genomics. 2013 Sep 17.
130. Soy isoflavones modulate azoxymethane-induced rat colon carcinogenesis exposed pre- and postnatally and inhibit growth of DLD-1 human colon adenocarcinoma cells by increasing the expression of estrogen receptor-beta. Raju J, etal., J Nutr. 2009 Mar;139(3):474-81. doi: 10.3945/jn.108.099200. Epub 2009 Jan 13.
131. Periodic 17beta-estradiol pretreatment protects rat brain from cerebral ischemic damage via estrogen receptor-beta. Raval AP, etal., PLoS One. 2013 Apr 12;8(4):e60716. doi: 10.1371/journal.pone.0060716. Print 2013.
132. Selected variants of the steroid-5-alpha-reductase isoforms SRD5A1 and SRD5A2 and the sex steroid hormone receptors ESR1, ESR2 and PGR: no association with female pattern hair loss identified. Redler S, etal., Exp Dermatol. 2012 May;21(5):390-3. doi: 10.1111/j.1600-0625.2012.01469.x.
133. A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Revankar CM, etal., Science. 2005 Mar 11;307(5715):1625-30. Epub 2005 Feb 10.
134. Bisphenol A and human chronic diseases: Current evidences, possible mechanisms, and future perspectives. Rezg R, etal., Environ Int. 2014 Mar;64C:83-90. doi: 10.1016/j.envint.2013.12.007. Epub 2013 Dec 29.
135. GOA pipeline RGD automated data pipeline
136. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
137. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
138. Disruption of estrogen receptor beta gene impairs spatial learning in female mice. Rissman EF, etal., Proc Natl Acad Sci U S A 2002 Mar 19;99(6):3996-4001. Epub 2002 Mar 12.
139. Estrogen receptor beta (ESR2) polymorphisms in interaction with estrogen receptor alpha (ESR1) and insulin-like growth factor I (IGF1) variants influence the risk of fracture in postmenopausal women. Rivadeneira F, etal., J Bone Miner Res. 2006 Sep;21(9):1443-56.
140. Evaluation of estrogen receptor alpha and beta and progesterone receptor expression and correlation with clinicopathologic factors and proliferative marker Ki-67 in breast cancers. Rosa FE, etal., Hum Pathol. 2008 Jan 29;.
141. Defining the Role of Estrogen Receptor β in the Regulation of Female Fertility. Rumi MAK, etal., Endocrinology. 2017 Jul 1;158(7):2330-2343. doi: 10.1210/en.2016-1916.
142. An ADIOL-ERbeta-CtBP transrepression pathway negatively regulates microglia-mediated inflammation. Saijo K, etal., Cell. 2011 May 13;145(4):584-95.
143. Exposure of neonatal rats to the endocrine disrupter Bisphenol A affects ontogenic expression pattern of testicular steroid receptors and their coregulators. Salian-Mehta S, etal., J Appl Toxicol. 2013 Apr 26. doi: 10.1002/jat.2882.
144. Differential expression of estrogen receptor-beta and estrogen receptor-alpha in the rat ovary. Sar M and Welsch F, Endocrinology. 1999 Feb;140(2):963-71.
145. Association of Rsa polymorphism of the estrogen receptor-beta gene with rheumatoid arthritis. Sato H, etal., Rheumatol Int. 2011 Apr 27.
146. Ciliated epithelial-specific and regional-specific expression and regulation of the estrogen receptor-beta2 in the fallopian tubes of immature rats: a possible mechanism for estrogen-mediated transport process in vivo. Shao R, etal., Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E147-58. Epub 2007 Mar 20.
147. Estradiol receptors agonists induced effects in rat intestinal microcirculation during sepsis. Sharawy N, etal., Microvasc Res. 2013 Jan;85:118-27. doi: 10.1016/j.mvr.2012.10.002. Epub 2012 Oct 11.
148. Notoginsenoside Ft1 activates both glucocorticoid and estrogen receptors to induce endothelium-dependent, nitric oxide-mediated relaxations in rat mesenteric arteries. Shen K, etal., Biochem Pharmacol. 2014 Mar 1;88(1):66-74. doi: 10.1016/j.bcp.2014.01.007. Epub 2014 Jan 16.
149. Disruption of the estrogen receptor beta gene in mice causes myeloproliferative disease resembling chronic myeloid leukemia with lymphoid blast crisis. Shim GJ, etal., Proc Natl Acad Sci U S A 2003 May 27;100(11):6694-9. Epub 2003 May 9.
150. Downregulation of androgen, estrogen and progesterone receptor genes and protein is involved in aging-related erectile dysfunction. Shirai M, etal., Int J Impot Res. 2003 Dec;15(6):391-6.
151. Inner ear pathology and loss of hearing in estrogen receptor-beta deficient mice. Simonoska R, etal., J Endocrinol. 2009 Jun;201(3):397-406. doi: 10.1677/JOE-09-0060. Epub 2009 Mar 17.
152. Estrogen or estrogen receptor agonist inhibits lipopolysaccharide induced microglial activation and death. Smith JA, etal., Neurochem Res. 2011 Sep;36(9):1587-93. Epub 2010 Dec 3.
153. Depletion of oestrogen receptor-beta expression in magnocellular arginine vasopressin neurones by hypovolaemia and dehydration. Somponpun SJ and Sladek CD, J Neuroendocrinol. 2004 Jun;16(6):544-9.
154. Osmotic regulation of estrogen receptor-beta in rat vasopressin and oxytocin neurons. Somponpun SJ and Sladek CD, J Neurosci. 2003 May 15;23(10):4261-9.
155. The protective association of high plasma enterolactone with breast cancer is reasonably robust in women with polymorphisms in the estrogen receptor alpha and beta genes. Sonestedt E, etal., J Nutr. 2009 May;139(5):993-1001. doi: 10.3945/jn.108.101691. Epub 2009 Mar 25.
156. Expression of estrogen receptor ESR1 and its 46-kDa variant in the gubernaculum testis. Staub C, etal., Biol Reprod. 2005 Oct;73(4):703-12. Epub 2005 Jun 8.
157. The affinity and activity of the multiple hormone response element in the proximal promoter of the human oxytocin gene. Stedronsky K, etal., J Neuroendocrinol. 2002 Jun;14(6):472-85.
158. Attenuation of Atherogenesis via the Anti-inflammatory Effects of the Selective Estrogen Receptor Beta Modulator 8beta-VE2. Sun J, etal., J Cardiovasc Pharmacol. 2011 Oct;58(4):399-405.
159. Regulation of estrogen receptor-beta expression in the female rat hypothalamus: differential effects of dexamethasone and estradiol. Suzuki S and Handa RJ, Endocrinology. 2004 Aug;145(8):3658-70. Epub 2004 Apr 15.
160. Histological observation of the development of follicles and follicular atresia in immature rat ovaries. Takagi K, etal., Acta Med Okayama. 2007 Oct;61(5):283-98.
161. Differential expression of oestrogen receptor isoforms and androgen receptor in the normal vulva and vagina compared with vulval lichen sclerosus and chronic vaginitis. Taylor AH, etal., Br J Dermatol. 2008 Feb;158(2):319-28. Epub 2007 Dec 11.
162. Polymorphisms in the promoter region of ESR2 gene and breast cancer susceptibility. Treeck O, etal., J Steroid Biochem Mol Biol. 2009 Apr;114(3-5):207-11. doi: 10.1016/j.jsbmb.2009.02.012. Epub 2009 Mar 3.
163. Association of repeat polymorphisms in the estrogen receptors alpha, beta (ESR1, ESR2) and androgen receptor (AR) genes with the occurrence of breast cancer. Tsezou A, etal., Breast. 2008 Apr;17(2):159-66. Epub 2007 Sep 29.
164. Estrogen Rescues Pre-existing Severe Pulmonary Hypertension in Rats. Umar S, etal., Am J Respir Crit Care Med. 2011 Jun 23.
165. Expression of estrogen receptor subtypes in rat pituitary gland during pregnancy and lactation. Vaillant C, etal., Endocrinology 2002 Nov;143(11):4249-58.
166. Progestin activation of nongenomic pathways via cross talk of progesterone receptor with estrogen receptor beta induces proliferation of endometrial stromal cells. Vallejo G, etal., Mol Endocrinol. 2005 Dec;19(12):3023-37. Epub 2005 Jul 14.
167. Progesterone withdrawal, and not increased circulating relaxin, mediates the decrease in myometrial relaxin receptor (RXFP1) expression in late gestation in rats. Vodstrcil LA, etal., Biol Reprod. 2010 Nov;83(5):825-32. doi: 10.1095/biolreprod.110.084301. Epub 2010 Aug 4.
168. Association of estrogen and aromatase gene polymorphisms with systemic lupus erythematosus. Wang J, etal., Lupus. 2010 May;19(6):734-40. Epub 2010 Mar 19.
169. [Effects of static magnetic field with different exposure time on the maturation of rat osteoblasts in vitro and the expression of the estrogen receptor gene]. Wang JQ, etal., Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2013 Feb;35(1):58-63. doi: 10.3881/j.issn.1000-503X.2013.01.011.
170. Estrogen receptor (ER)beta knockout mice reveal a role for ERbeta in migration of cortical neurons in the developing brain. Wang L, etal., Proc Natl Acad Sci U S A 2003 Jan 21;100(2):703-8. Epub 2003 Jan 6.
171. Prepubertal physical activity up-regulates estrogen receptor beta, BRCA1 and p53 mRNA expression in the rat mammary gland. Wang M, etal., Breast Cancer Res Treat. 2009 May;115(1):213-20. doi: 10.1007/s10549-008-0062-x. Epub 2008 May 31.
172. Estrogen receptor beta mediates acute myocardial protection following ischemia. Wang M, etal., Surgery. 2008 Aug;144(2):233-8. Epub 2008 May 9.
173. Impact of estradiol, ER subtype specific agonists and genistein on energy homeostasis in a rat model of nutrition induced obesity. Weigt C, etal., Mol Cell Endocrinol. 2012 Apr 4;351(2):227-38. doi: 10.1016/j.mce.2011.12.013. Epub 2011 Dec 30.
174. A role for estrogen receptor beta in the regulation of growth of the ventral prostate. Weihua Z, etal., Proc Natl Acad Sci U S A 2001 May 22;98(11):6330-5.
175. An endocrine pathway in the prostate, ERbeta, AR, 5alpha -androstane-3beta,17beta -diol, and CYP7B1, regulates prostate growth. Weihua Z, etal., Proc Natl Acad Sci U S A 2002 Oct 15;99(21):13589-94.
176. Association between the estrogen receptor beta gene and age of onset of Parkinson's disease. Westberg L, etal., Psychoneuroendocrinology. 2004 Sep;29(8):993-8.
177. The relationship of estrogen receptor-alpha and -beta genes with osteoarthritis of the hand. Wise BL, etal., J Rheumatol. 2009 Dec;36(12):2772-9. doi: 10.3899/jrheum.081208. Epub 2009 Nov 2.
178. Characterization of bacterially expressed rat estrogen receptor beta ligand binding domain by mass spectrometry: structural comparison with estrogen receptor alpha. Witkowska HE, etal., Steroids. 1997 Aug-Sep;62(8-9):621-31.
179. The role of peroxisome proliferator-activated receptor-gamma and estrogen receptors in genistein-induced regulation of vascular tone in female rat aortas. Xiang Q, etal., Pharmacology. 2010;86(2):117-24. doi: 10.1159/000315065. Epub 2010 Aug 6.
180. Estrogen receptor-beta in the paraventricular nucleus and rostroventrolateral medulla plays an essential protective role in aldosterone/salt-induced hypertension in female rats. Xue B, etal., Hypertension. 2013 Jun;61(6):1255-62. doi: 10.1161/HYPERTENSIONAHA.111.00903. Epub 2013 Apr 22.
181. Estrogen receptor genotype and risk of cognitive impairment in elders: findings from the Health ABC study. Yaffe K, etal., Neurobiol Aging. 2009 Apr;30(4):607-14. Epub 2007 Sep 21.
182. Estradiol decreases rat depressive behavior by estrogen receptor beta but not alpha: no correlation with plasma corticosterone. Yang F, etal., Neuroreport. 2014 Jan 22;25(2):100-4. doi: 10.1097/WNR.0000000000000052.
183. Expression of oestrogen receptor-alpha and oestrogen receptor-beta in prostate cancer. Yang GS, etal., Chin Med J (Engl). 2007 Sep 20;120(18):1611-5.
184. Mitochondrial localization of estrogen receptor beta. Yang SH, etal., Proc Natl Acad Sci U S A. 2004 Mar 23;101(12):4130-5. Epub 2004 Mar 15.
185. Association analysis of oestrogen receptor beta gene (ESR2) polymorphisms with female pattern hair loss. Yip L, etal., Br J Dermatol. 2012 May;166(5):1131-4. doi: 10.1111/j.1365-2133.2011.10702.x. Epub 2012 Mar 5.
186. Diffusion weighted imaging evaluated the early therapy effect of tamoxifen in an MNU-induced mammary cancer rat model. Zhai G, etal., PLoS One. 2013 May 21;8(5):e64445. doi: 10.1371/journal.pone.0064445. Print 2013.
187. [Effects of naringin on proliferation, differentiation and maturation of rat calvarial osteoblasts in vitro]. Zhai YK, etal., Zhongguo Zhong Yao Za Zhi. 2013 Jan;38(1):105-11.
188. C terminus of Hsc70-interacting protein (CHIP)-mediated degradation of hippocampal estrogen receptor-alpha and the critical period hypothesis of estrogen neuroprotection. Zhang QG, etal., Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):E617-24. doi: 10.1073/pnas.1104391108. Epub 2011 Aug 1.
189. 4-Nitrophenol induces Leydig cells hyperplasia, which may contribute to the differential modulation of the androgen receptor and estrogen receptor-alpha and -beta expression in male rat testes. Zhang Y, etal., Toxicol Lett. 2013 Sep 23. pii: S0378-4274(13)01325-8. doi: 10.1016/j.toxlet.2013.09.011.
190. Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons. Zhao L, etal., Brain Res. 2004 Jun 4;1010(1-2):22-34.
191. Joint effect of estrogen receptor beta sequence variants and endogenous estrogen exposure on breast cancer risk in Chinese women. Zheng SL, etal., Cancer Res. 2003 Nov 15;63(22):7624-9.
192. Microsatellites in the estrogen receptor (ESR1, ESR2) and androgen receptor (AR) genes and breast cancer risk in African American and Nigerian women. Zheng Y, etal., PLoS One. 2012;7(7):e40494. doi: 10.1371/journal.pone.0040494. Epub 2012 Jul 11.
193. [The relationship of vitamin D endocrine system and estrogen receptor expression with bone mineral density in initial systemic lupus erythematosus]. Zheng YJ, etal., Zhonghua Nei Ke Za Zhi. 2010 Apr;49(4):309-12.
194. Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta. Zhu Y, etal., Science 2002 Jan 18;295(5554):505-8.
Additional References at PubMed
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Genomics

Comparative Map Data
Esr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86100,589,553 - 100,645,240 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6100,545,206 - 100,644,709 (-)EnsemblGRCr8
mRatBN7.2694,858,438 - 94,909,630 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl694,809,547 - 94,908,919 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx695,252,364 - 95,302,093 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0695,550,861 - 95,600,589 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0694,979,673 - 95,029,407 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0699,163,953 - 99,214,711 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl699,164,357 - 99,214,251 (-)Ensemblrn6Rnor6.0
Rnor_5.06108,576,398 - 108,626,196 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4698,691,167 - 98,775,299 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera693,284,596 - 93,334,744 (-)NCBICelera
RGSC_v3.1698,694,622 - 98,778,755 (-)NCBI
RH 3.4 Map6686.1RGD
Cytogenetic Map6q24NCBI
ESR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381464,226,707 - 64,338,613 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1464,084,232 - 64,338,112 (-)Ensemblhg38GRCh38
GRCh371464,693,425 - 64,805,331 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361463,763,504 - 63,875,021 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341463,769,607 - 63,830,831NCBI
Celera1444,751,460 - 44,862,976 (-)NCBICelera
Cytogenetic Map14q23.2-q23.3NCBI
HuRef1444,866,333 - 44,977,880 (-)NCBIHuRef
CHM1_11464,633,573 - 64,745,077 (-)NCBICHM1_1
T2T-CHM13v2.01458,434,422 - 58,546,317 (-)NCBIT2T-CHM13v2.0
Esr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391276,167,193 - 76,224,033 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1276,167,193 - 76,224,033 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381276,120,419 - 76,177,259 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1276,120,419 - 76,177,259 (-)Ensemblmm10GRCm38
MGSCv371277,221,406 - 77,278,246 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361277,039,259 - 77,096,099 (-)NCBIMGSCv36mm8
Celera1277,215,189 - 77,271,340 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1233.52NCBI
Esr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554665,575,088 - 5,638,946 (+)Ensembl
ChiLan1.0NW_0049554665,587,003 - 5,644,765 (+)NCBIChiLan1.0ChiLan1.0
ESR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21565,338,719 - 65,450,191 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11464,555,234 - 64,666,706 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01444,807,875 - 44,919,780 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11463,064,397 - 63,175,303 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1463,064,402 - 63,131,303 (-)EnsemblpanPan2panpan1.1
ESR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1838,645,917 - 38,715,347 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl838,645,430 - 38,702,691 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha838,338,303 - 38,407,225 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0838,869,013 - 38,937,387 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl838,868,526 - 38,925,228 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1838,489,186 - 38,557,866 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0838,561,325 - 38,629,870 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0838,921,461 - 38,990,144 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Esr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864066,173,041 - 66,235,531 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364957,956,766 - 8,004,357 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364957,956,168 - 8,018,356 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ESR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1193,829,560 - 193,906,565 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11193,823,666 - 193,907,330 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21215,715,909 - 215,788,512 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ESR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12441,426,333 - 41,513,802 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2441,447,224 - 41,512,486 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605329,619,854 - 29,688,619 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Esr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473436,759,104 - 36,825,295 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473436,742,913 - 36,862,993 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Esr2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1790,294,602 - 90,345,780 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Esr2
362 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:912
Count of miRNA genes:211
Interacting mature miRNAs:256
Transcripts:ENSRNOT00000007109, ENSRNOT00000041872, ENSRNOT00000042682, ENSRNOT00000043602
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)686494122112380234Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)699437079125323237Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)699708426112483760Rat

Markers in Region
D6Rat87  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr86100,612,488 - 100,612,677 (+)Marker Load Pipeline
mRatBN7.2694,876,831 - 94,877,020 (+)MAPPERmRatBN7.2
Rnor_6.0699,182,033 - 99,182,221NCBIRnor6.0
Rnor_5.06108,593,793 - 108,593,981UniSTSRnor5.0
RGSC_v3.4698,742,972 - 98,743,161RGDRGSC3.4
RGSC_v3.4698,742,973 - 98,743,161UniSTSRGSC3.4
Celera693,302,793 - 93,302,965UniSTS
RGSC_v3.1698,746,429 - 98,746,617RGD
RH 3.4 Map6677.0RGD
RH 3.4 Map6677.0UniSTS
SHRSP x BN Map656.7498RGD
SHRSP x BN Map656.7498UniSTS
FHH x ACI Map668.02RGD
Cytogenetic Map6q24UniSTS
RH94710  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2694,859,175 - 94,859,351 (+)MAPPERmRatBN7.2
Rnor_6.0699,164,641 - 99,164,816NCBIRnor6.0
Rnor_5.06108,576,715 - 108,576,890UniSTSRnor5.0
RGSC_v3.4698,691,449 - 98,691,624UniSTSRGSC3.4
Celera693,284,878 - 93,285,053UniSTS
RH 3.4 Map6686.1UniSTS
Cytogenetic Map6q24UniSTS
Esr2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2694,898,051 - 94,899,380 (+)MAPPERmRatBN7.2
Rnor_6.0699,203,253 - 99,204,581NCBIRnor6.0
Rnor_5.06108,615,013 - 108,616,341UniSTSRnor5.0
RGSC_v3.4698,764,193 - 98,765,521UniSTSRGSC3.4
Celera693,323,998 - 93,325,324UniSTS
Cytogenetic Map6q24UniSTS


Genetic Models
This gene Esr2 is modified in the following models/strains:
SD-Esr2em1Soar    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
15 5 27 106 27 37 6 42 6 4 141 77 4 102 38 73 31 13 13

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240221 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594039 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594040 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB012721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB190769 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB190770 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB530987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC128637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF042058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF042059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF042060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF042061 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF161187 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ002602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ002603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473947 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U57439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000007109   ⟹   ENSRNOP00000007109
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6100,582,231 - 100,644,709 (-)Ensembl
mRatBN7.2 Ensembl694,809,547 - 94,908,919 (-)Ensembl
Rnor_6.0 Ensembl699,164,875 - 99,204,590 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000041872   ⟹   ENSRNOP00000041339
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6100,589,717 - 100,644,709 (-)Ensembl
mRatBN7.2 Ensembl694,809,547 - 94,908,919 (-)Ensembl
Rnor_6.0 Ensembl699,164,875 - 99,204,590 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000042682   ⟹   ENSRNOP00000040505
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6100,545,206 - 100,644,574 (-)Ensembl
mRatBN7.2 Ensembl694,809,547 - 94,908,919 (-)Ensembl
Rnor_6.0 Ensembl699,164,357 - 99,214,251 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000043602   ⟹   ENSRNOP00000043144
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6100,595,042 - 100,635,281 (-)Ensembl
mRatBN7.2 Ensembl694,859,125 - 94,899,624 (-)Ensembl
Rnor_6.0 Ensembl699,164,590 - 99,204,825 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000136371   ⟹   ENSRNOP00000103670
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6100,595,042 - 100,644,709 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000146712   ⟹   ENSRNOP00000101904
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6100,589,648 - 100,644,709 (-)Ensembl
RefSeq Acc Id: NM_012754   ⟹   NP_036886
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,594,551 - 100,644,709 (-)NCBI
mRatBN7.2694,858,894 - 94,909,054 (-)NCBI
Rnor_6.0699,164,359 - 99,214,116 (-)NCBI
Rnor_5.06108,576,398 - 108,626,196 (-)NCBI
RGSC_v3.4698,691,167 - 98,775,299 (-)RGD
Celera693,284,596 - 93,334,744 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240221   ⟹   XP_006240283
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86100,589,553 - 100,645,240 (-)NCBI
mRatBN7.2694,858,438 - 94,909,630 (-)NCBI
Rnor_6.0699,163,953 - 99,214,710 (-)NCBI
Rnor_5.06108,576,398 - 108,626,196 (-)NCBI
Sequence:
RefSeq Acc Id: NP_036886   ⟸   NM_012754
- UniProtKB: Q9R185 (UniProtKB/Swiss-Prot),   Q62986 (UniProtKB/Swiss-Prot),   O70195 (UniProtKB/Swiss-Prot),   O55016 (UniProtKB/Swiss-Prot),   O55015 (UniProtKB/Swiss-Prot),   O35785 (UniProtKB/Swiss-Prot),   O35784 (UniProtKB/Swiss-Prot),   F7F997 (UniProtKB/TrEMBL),   Q59IV9 (UniProtKB/TrEMBL),   A0A9K3Y725 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240283   ⟸   XM_006240221
- Peptide Label: isoform X1
- UniProtKB: Q9R185 (UniProtKB/Swiss-Prot),   Q62986 (UniProtKB/Swiss-Prot),   O70195 (UniProtKB/Swiss-Prot),   O55016 (UniProtKB/Swiss-Prot),   O55015 (UniProtKB/Swiss-Prot),   O35785 (UniProtKB/Swiss-Prot),   O35784 (UniProtKB/Swiss-Prot),   Q59IV8 (UniProtKB/TrEMBL),   F7EVJ6 (UniProtKB/TrEMBL),   A0A9K3Y862 (UniProtKB/TrEMBL),   A6HC96 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000043144   ⟸   ENSRNOT00000043602
Ensembl Acc Id: ENSRNOP00000041339   ⟸   ENSRNOT00000041872
Ensembl Acc Id: ENSRNOP00000007109   ⟸   ENSRNOT00000007109
Ensembl Acc Id: ENSRNOP00000040505   ⟸   ENSRNOT00000042682
Ensembl Acc Id: ENSRNOP00000101904   ⟸   ENSRNOT00000146712
Ensembl Acc Id: ENSRNOP00000103670   ⟸   ENSRNOT00000136371
Protein Domains
NR LBD   Nuclear receptor

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q62986-F1-model_v2 AlphaFold Q62986 1-530 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2582 AgrOrtholog
BioCyc Gene G2FUF-37069 BioCyc
Ensembl Genes ENSRNOG00000005343 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000042682 ENTREZGENE
Gene3D-CATH 1.10.565.10 UniProtKB/Swiss-Prot
  3.30.50.10 UniProtKB/Swiss-Prot
InterPro ER-beta/gamma UniProtKB/Swiss-Prot
  Estrogen_rcpt_beta_N UniProtKB/Swiss-Prot
  NHR-like_dom_sf UniProtKB/Swiss-Prot
  Nucl_hrmn_rcpt_lig-bd UniProtKB/Swiss-Prot
  Nuclear_hormone_rcpt_NR3 UniProtKB/Swiss-Prot
  Nuclear_hrmn_rcpt UniProtKB/Swiss-Prot
  Oest_rcpt/oest-rel_rcp UniProtKB/Swiss-Prot
  Znf_hrmn_rcpt UniProtKB/Swiss-Prot
  Znf_NHR/GATA UniProtKB/Swiss-Prot
KEGG Report rno:25149 UniProtKB/Swiss-Prot
NCBI Gene 25149 ENTREZGENE
PANTHER KNIRPS-RELATED PROTEIN-RELATED UniProtKB/Swiss-Prot
Pfam ERbeta_N UniProtKB/Swiss-Prot
  Hormone_recep UniProtKB/Swiss-Prot
  zf-C4 UniProtKB/Swiss-Prot
PharmGKB ESR2 RGD
PhenoGen Esr2 PhenoGen
PIRSF ER-b UniProtKB/Swiss-Prot
  ER-like_NR UniProtKB/Swiss-Prot
PRINTS STRDHORMONER UniProtKB/Swiss-Prot
  STROIDFINGER UniProtKB/Swiss-Prot
PROSITE NR_LBD UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_1 UniProtKB/Swiss-Prot
  NUCLEAR_REC_DBD_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005343 RatGTEx
SMART HOLI UniProtKB/Swiss-Prot
  ZnF_C4 UniProtKB/Swiss-Prot
Superfamily-SCOP Glucocorticoid receptor-like (DNA-binding domain) UniProtKB/Swiss-Prot
  SSF48508 UniProtKB/Swiss-Prot
UniProt A0A9K3Y725 ENTREZGENE, UniProtKB/TrEMBL
  A0A9K3Y862 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LEB5_RAT UniProtKB/TrEMBL
  A0ABK0LEW5_RAT UniProtKB/TrEMBL
  A6HC95_RAT UniProtKB/TrEMBL
  A6HC96 ENTREZGENE, UniProtKB/TrEMBL
  D0G882_RAT UniProtKB/TrEMBL
  D3ZQD5_RAT UniProtKB/TrEMBL
  D4AEI3_RAT UniProtKB/TrEMBL
  ESR2_RAT UniProtKB/Swiss-Prot
  F7EVJ6 ENTREZGENE
  F7F997 ENTREZGENE
  O35784 ENTREZGENE
  O35785 ENTREZGENE
  O55015 ENTREZGENE
  O55016 ENTREZGENE
  O70195 ENTREZGENE
  Q59IV8 ENTREZGENE, UniProtKB/TrEMBL
  Q59IV9 ENTREZGENE, UniProtKB/TrEMBL
  Q62986 ENTREZGENE
  Q9R185 ENTREZGENE
UniProt Secondary O35784 UniProtKB/Swiss-Prot
  O35785 UniProtKB/Swiss-Prot
  O55015 UniProtKB/Swiss-Prot
  O55016 UniProtKB/Swiss-Prot
  O70195 UniProtKB/Swiss-Prot
  Q9R185 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-29 Esr2  estrogen receptor 2  Esr2  estrogen receptor 2 (ER beta)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Esr2  estrogen receptor 2 (ER beta)  Esr2  estrogen receptor 2 beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Esr2  estrogen receptor 2 beta    estrogen receptor 2   Name updated 1299863 APPROVED
2002-06-10 Esr2  estrogen receptor 2       Name updated 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression abundantly expressed in atria but not in the ventricles of adults 69504
gene_expression abundant in myocytes secreting atrial natriuretic peptide (ANP) 69504
gene_expression developmentally regulated in heart 69504
gene_function binds to estrogen and serves as transcriptional coactivator for estrogen-sensitive genes 68681
gene_function forms a complex with testosterone metabolite 5a-androstane-3b,17 b-diol 68681
gene_pathway Esr2, 3b-Adiol, and CYP7B1 are components of a pathway that regulates growth of the rodent ventral prostate 625746
gene_process involved in regulating the androgen receptor (AR) content of the prostate and in restraining epithelial growth 68730
gene_process activity of Esr2 during early development could be a decisive factor in determining prostate size 625746
gene_process may be a negative regulator of estrogen action 728646