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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2582
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2
Acc ID: CHEBI:17263
Term: estrone
Definition: A 17-oxo steroid that is estra-1,3,5(10)-triene substituted by an hydroxy group at position 3 and an oxo group at position 17.
Chemical ID: MESH:D004970
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr2affects bindingEXP 8694130RGDEstrone binds to Esr2 protein 
Esr2affects bindingEXP 6480464CTDEstrone binds to ESR2 proteinPMID:19913605
Esr2increases activityEXP 6480464CTDEstrone results in increased activity of ESR2 proteinPMID:8650195
Esr2multiple interactionsEXP 6480464CTDEstrone inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]; Estrone inhibits the reaction [Estradiol binds to ESR2 protein alternative form]; Estrone inhibits the reaction [Estradiol binds to ESR2 protein]PMID:8650195 PMID:9048584 PMID:9492041
Esr2affects bindingISOESR2 (Homo sapiens)6480464CTDEstrone binds to ESR2 proteinPMID:11518614 PMID:19913605
Esr2affects localizationISOEsr2 (Mus musculus)6480464CTDEstrone affects the localization of ESR2 proteinPMID:20950447
Esr2multiple interactionsISOESR2 (Homo sapiens)6480464CTDEstrone binds to and results in increased activity of ESR2 proteinPMID:33049310
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