RGD Reference Report - Anatomical evidence for transsynaptic influences of estrogen on brain-derived neurotrophic factor expression. - Rat Genome Database

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Anatomical evidence for transsynaptic influences of estrogen on brain-derived neurotrophic factor expression.

Authors: Blurton-Jones, M  Kuan, PN  Tuszynski, MH 
Citation: Blurton-Jones M, etal., J Comp Neurol. 2004 Jan 12;468(3):347-60.
RGD ID: 1582273
Pubmed: PMID:14681930   (View Abstract at PubMed)
DOI: DOI:10.1002/cne.10989   (Journal Full-text)

Several studies have demonstrated that estrogen modulates brain-derived neurotrophic factor (BDNF) mRNA and protein within the adult hippocampus and cortex. However, mechanisms underlying this regulation are unknown. Although an estrogen response element (ERE)-like sequence has been identified within the BDNF gene, such a classical mechanism of estrogen-induced transcriptional activation requires the colocalized expression of estrogen receptors within cells that produce BDNF. Developmental studies have demonstrated such a relationship, but to date no studies have examined colocalization of estrogen receptors and BDNF within the adult brain. By utilizing double-label immunohistochemistry for BDNF, estrogen receptor-alpha (ER-alpha), and estrogen receptor-beta (ER-beta), we found only sparse colocalization between ER-alpha and BDNF in the hypothalamus, amygdala, prelimbic cortex, and ventral hippocampus. Furthermore, ER-beta and BDNF do not colocalize in any brain region. Given the recent finding that cortical ER-beta is almost exclusively localized to parvalbumin-immunoreactive GABAergic neurons, we performed BDNF/parvalbumin double labeling and discovered that axons from cortical ER-beta-expressing inhibitory neurons terminate on BDNF-immunoreactive pyramidal cells. Collectively, these findings support a potential transsynaptic relationship between estrogen state and cortical BDNF: By directly modulating GABAergic interneurons, estrogen may indirectly influence the activity and expression of BDNF-producing cortical neurons.

Objects referenced in this article
Gene Esr2 estrogen receptor 2 Rattus norvegicus

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