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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2582
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr2affects bindingEXP 6480464CTDresveratrol binds to ESR2 proteinPMID:11014220
Esr2decreases expressionEXP 6480464CTDresveratrol results in decreased expression of ESR2 proteinPMID:22104698
Esr2multiple interactionsEXP 6480464CTD[2,3-bis(4-hydroxyphenyl)-propionitrile binds to and results in increased activity of ESR2 protein] inhibits the reaction [resveratrol results in decreased expression of PRL protein]; resveratrol affects the reaction [Oxygen deficiency affects the expression of ESR2 mRNA]; resveratrol affects the reaction [Oxygen deficiency affects the expression of ESR2 protein]; resveratrol binds to and results in increased activity of ESR2 protein; resveratrol inhibits the reaction [Oxygen deficiency results in decreased expression of ESR2 mRNA]; resveratrol inhibits the reaction [Oxygen deficiency results in decreased expression of ESR2 protein]PMID:11014220 PMID:22104698 PMID:24333797
Esr2affects bindingISOESR2 (Homo sapiens)6480464CTDresveratrol analog binds to ESR2 protein; resveratrol binds to ESR2 proteinPMID:11507064 PMID:21248286 PMID:26970359
Esr2affects response to substanceISOEsr2 (Mus musculus)6480464CTDESR2 protein affects the susceptibility to resveratrolPMID:23526725
Esr2increases activityISOESR2 (Homo sapiens)6480464CTDresveratrol results in increased activity of ESR2 proteinPMID:16118406 PMID:17935960
Esr2increases expressionISOEsr2 (Mus musculus)6480464CTDresveratrol results in increased expression of ESR2 proteinPMID:17675339
Esr2increases expressionISOESR2 (Homo sapiens)6480464CTDResveratrol analog results in increased expression of ESR2 mRNA; Resveratrol analog results in increased expression of ESR2 protein; Resveratrol results in increased expression of ESR2 mRNA; Resveratrol results in increased expression of ESR2 proteinPMID:15149879 PMID:24299158 PMID:25242450 PMID:26970359
Esr2multiple interactionsISOEsr2 (Mus musculus)6480464CTDESR2 gene mutant form inhibits the reaction [resveratrol results in increased expression of SOD2 protein]; ESR2 protein affects the reaction [resveratrol results in increased expression of SOD2 protein]PMID:23526725 PMID:24361291
Esr2multiple interactionsISOESR2 (Homo sapiens)6480464CTDESR2 protein promotes the reaction [resveratrol analog results in decreased expression of MYC protein]; fulvestrant inhibits the reaction [resveratrol results in increased activity of ESR2 protein]; resveratrol binds to and results in decreased activity of ESR2 protein; resveratrol binds to and results in increased activity of ESR2 protein; resveratrol inhibits the reaction [Estradiol binds to ESR2 protein]; resveratrol promotes the reaction [Estradiol results in increased activity of ESR2 protein]PMID:11507064 PMID:12765243 PMID:15084758 PMID:16118406 PMID:17935960 PMID:26970359
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