RGD Reference Report - Estrogen receptor expression by peripheral blood mononuclear cells of patients with systemic lupus erythematosus. - Rat Genome Database

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Estrogen receptor expression by peripheral blood mononuclear cells of patients with systemic lupus erythematosus.

Authors: Inui, A  Ogasawara, H  Naito, T  Sekigawa, I  Takasaki, Y  Hayashida, Y  Takamori, K  Ogawa, H 
Citation: Inui A, etal., Clin Rheumatol. 2007 Oct;26(10):1675-8. Epub 2007 Feb 16.
RGD ID: 5508843
Pubmed: PMID:17874259   (View Abstract at PubMed)
DOI: DOI:10.1007/s10067-007-0568-3   (Journal Full-text)

To investigate the influence of sex hormones on the development of systemic lupus erythematosus (SLE), we examined the estrogen receptor (ER) expression by peripheral blood mononuclear cells (PBMC) in patients with SLE using the real-time quantitative polymerase chain reaction (TaqMan) method. The expression of messenger RNA (mRNA) for ER alpha (ERa) was increased and expression of ER beta (ERb) mRNA was decreased in PBMC from SLE patients compared with PBMC from normal controls. These findings may be useful for elucidation of the pathophysiology of SLE.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
systemic lupus erythematosus  IEP 5508843mRNA:decreased expression:leukocyte and mononuclearRGD 
systemic lupus erythematosus  ISOESR2 (Homo sapiens)5508843; 5508843mRNA:decreased expression:leukocyte and mononuclearRGD 

Objects Annotated

Genes (Rattus norvegicus)
Esr2  (estrogen receptor 2)

Genes (Mus musculus)
Esr2  (estrogen receptor 2 (beta))

Genes (Homo sapiens)
ESR2  (estrogen receptor 2)


Additional Information