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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2582
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2
Acc ID: CHEBI:50207
Term: sophoraflavanone B
Definition: A trihydroxyflavanone that is (S)-naringenin having a prenyl group at position 8.
Chemical ID: MESH:C119737
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr2decreases expressionEXP 6480464CTD8-prenylnaringenin results in decreased expression of ESR2 mRNAPMID:16522720
Esr2increases expressionEXP 6480464CTD8-prenylnaringenin results in increased expression of ESR2 mRNAPMID:34848279
Esr2multiple interactionsEXP 6480464CTD[Fulvestrant co-treated with 8-prenylnaringenin] results in increased expression of ESR2 mRNAPMID:34848279
Esr2increases activityISOESR2 (Homo sapiens)6480464CTD8-prenylnaringenin results in increased activity of ESR2 proteinPMID:17716812
Esr2multiple interactionsISOESR2 (Homo sapiens)6480464CTD8-prenylnaringenin analog binds to and results in decreased activity of ESR2 protein; 8-prenylnaringenin binds to and results in increased activity of ESR2 proteinPMID:16076101 PMID:17149865
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