GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esr2 | affects binding | EXP | | 8694130 | RGD | Coumestrol binds to Esr2 protein | | Esr2 | | IPI | coumestrol | 8694130 | RGD | | | Esr2 | affects binding | EXP | | 6480464 | CTD | Coumestrol binds to ESR2 protein | PMID:19913605 | Esr2 | increases expression | EXP | | 6480464 | CTD | Coumestrol results in increased expression of ESR2 mRNA | PMID:34848279 | Esr2 | multiple interactions | EXP | | 6480464 | CTD | [Fulvestrant co-treated with Coumestrol] results in increased expression of ESR2 mRNA; Coumestrol inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]; Coumestrol inhibits the reaction [Estradiol binds to ESR2 protein alternative form] | PMID:34848279 PMID:9048584 PMID:9492041 | Esr2 | affects binding | ISO | Esr2 (Mus musculus) | 6480464 | CTD | Coumestrol binds to ESR2 protein | PMID:19913605 | Esr2 | affects binding | ISO | ESR2 (Homo sapiens) | 6480464 | CTD | Coumestrol binds to ESR2 protein | PMID:11518614 PMID:12224631 PMID:16566672 PMID:19913605 | Esr2 | affects response to substance | ISO | Esr2 (Mus musculus) | 6480464 | CTD | ESR2 protein affects the susceptibility to Coumestrol | PMID:23526725 | Esr2 | affects response to substance | ISO | ESR2 (Homo sapiens) | 6480464 | CTD | ESR2 protein affects the susceptibility to Coumestrol | PMID:17275032 | Esr2 | increases activity | ISO | ESR2 (Homo sapiens) | 6480464 | CTD | Coumestrol results in increased activity of ESR2 protein | PMID:16118406 | Esr2 | increases expression | ISO | Esr2 (Mus musculus) | 6480464 | CTD | Coumestrol results in increased expression of ESR2 protein; Coumestrol results in increased expression of ESR2 protein alternative form | PMID:21708076 PMID:27634370 | Esr2 | multiple interactions | ISO | Esr2 (Mus musculus) | 6480464 | CTD | ESR2 protein affects the reaction [Coumestrol results in increased expression of SOD2 protein] | PMID:23526725 | Esr2 | multiple interactions | ISO | ESR2 (Homo sapiens) | 6480464 | CTD | Coumestrol binds to and results in increased activity of ESR2 protein; Coumestrol inhibits the reaction [Estradiol binds to ESR2 protein]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of ADRA2A mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of ANLN mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of ANP32E mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of ASPM mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of AURKA mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of BIN3 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of CCNA2 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of CDCA3 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of CENPF mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of CLCC1 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of CTNNAL1 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of CXCL12 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of DEPDC1 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of DEPDC1B mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of DHRS2 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of EXOSC9 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of FABP5 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of FCMR mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of FHL1 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of GAL mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of GPSM2 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of GREB1 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of GTSE1 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of HMGB2 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of HMMR mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of IGFBP4 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of IL17RB mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of IL20 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of IRS1 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of KCNK5 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of KIF18A mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of MKI67 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of MYB mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of MYC mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of NCAPG mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of NEK2 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of NPY1R mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of NUSAP1 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of PDLIM3 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of PDZK1 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of PIF1 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of PKIB mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of PLK1 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of RACGAP1 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of RASGRP1 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of RERG mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of SLC26A2 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of SPC25 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of ST8SIA6 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of STC2 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of TFF1 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of TMPRSS3 mRNA]; ESR2 protein affects the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of TRAF4 mRNA]; ESR2 protein promotes the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of CDKN2C mRNA]; ESR2 protein promotes the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of CDKN3 mRNA]; ESR2 protein promotes the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of KIF14 mRNA]; ESR2 protein promotes the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of KIF15 mRNA]; ESR2 protein promotes the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of KIF20A mRNA]; ESR2 protein promotes the reaction [[Coumestrol co-treated with ESR1 protein] results in increased expression of TOP2A mRNA] | PMID:12765243 PMID:15084758 PMID:16566672 PMID:18310284 PMID:9751507 | | ||||||||||||||||||||||
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