RGD Reference Report - Sex-dependent association of blood pressure with oestrogen receptor genes ERalpha and ERbeta. - Rat Genome Database

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Sex-dependent association of blood pressure with oestrogen receptor genes ERalpha and ERbeta.

Authors: Ellis, JA  Infantino, T  Harrap, SB 
Citation: Ellis JA, etal., J Hypertens. 2004 Jun;22(6):1127-31.
RGD ID: 1581017
Pubmed: PMID:15167447   (View Abstract at PubMed)

BACKGROUND: There is mounting physiological evidence for an important role of the oestrogen receptors, ERalpha and ERbeta, in vasodilatation and the response to vascular injury. In addition, genetic studies have suggested that the genes encoding these receptors may be involved in the genetic regulation of blood pressure. The existence of such sex steroid-related genes may help to explain the observed sex differences in blood pressure. OBJECTIVE: To investigate the role of the oestrogen receptor genes (ERalpha and ERbeta) in blood pressure variation in women and in men. DESIGN: We performed a genetic association study of the oestrogen receptor genes in 718 unrelated healthy white individuals (386 men and 332 women) from the parental generation of the Victorian Family Heart Study, a general population survey of cardiovascular risk. METHODS: Participants were genotyped for single nucleotide polymorphisms (SNPs) in ERalpha and ERbeta, and blood pressure phenotypes were compared between genotype groups by analysis of variance. RESULTS: When genotype groups were compared, men inheriting the 'a' allele of the ERalpha SNP had significantly higher systolic blood pressure than men with other genotypes [127.7 +/-14.3 mmHg (mean +/- SD) compared with 132.4 +/- 16.1 mmHg; P = 0.014)]. In addition, men inheriting the 'b' allele of the ERbeta SNP had significantly higher diastolic blood pressure than men with other genotypes (81.4 +/-8.1 mmHg compared with 84.4 +/- 9.6 mmHg; P = 0.004). No significant associations between the oestrogen receptor genes and blood pressure were detected in women. DISCUSSION: These results suggest that ERalpha and ERbeta may be involved in the genetic regulation of blood pressure in men, that the two genes may have different roles, and that these genes may contribute to the differences in blood pressures between the sexes.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
hypertension  IAGP 1581017 RGD 
hypertension  ISOESR2 (Homo sapiens)1581017; 1581017 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Esr2  (estrogen receptor 2)

Genes (Mus musculus)
Esr2  (estrogen receptor 2 (beta))

Genes (Homo sapiens)
ESR2  (estrogen receptor 2)


Additional Information