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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2582
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2
Acc ID: CHEBI:64022
Term: nebivolol
Definition: A racemate consisting of equal amounts of (R,S,S,S)-nebivolol and (S,R,R,R)-nebivolol. A cardioselective beta blocker, it has vasodilatory activity but lacks intrinsic sympathomimetic and membrane-stabilising activity. It is used as the hydrochloride salt for the management of hypertension, and as an adjunct to standard therapy in elderly patients with stable chronic heart failure.
Chemical ID: MESH:D000068577
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr2affects activityISOESR2 (Homo sapiens)6480464CTDNebivolol affects the activity of ESR2 proteinPMID:19330906
Esr2multiple interactionsISOESR2 (Homo sapiens)6480464CTDNebivolol binds to and results in decreased activity of ESR2 proteinPMID:25752796
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