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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2582
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2
Acc ID: CHEBI:17026
Term: progesterone
Definition: A C21-steroid hormone in which a pregnane skeleton carries oxo substituents at positions 3 and 20 and is unsaturated at C(4)-C(5). As a hormone, it is involved in the female menstrual cycle, pregnancy and embryogenesis of humans and other species.
Chemical ID: MESH:D011374
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr2decreases expressionEXP 6480464CTDProgesterone results in decreased expression of ESR2 mRNAPMID:19094096
Esr2multiple interactionsEXP 6480464CTD[Estradiol co-treated with Progesterone] results in decreased expression of ESR2 mRNA; Progesterone inhibits the reaction [Estradiol results in increased expression of ESR2 mRNA]PMID:19094096 PMID:21277368
Esr2affects bindingISOESR2 (Homo sapiens)6480464CTDProgesterone binds to ESR2 proteinPMID:19913605
Esr2increases expressionISOESR2 (Homo sapiens)6480464CTDProgesterone metabolite results in increased expression of ESR2 mRNAPMID:17683929
Esr2multiple interactionsISOEsr2 (Mus musculus)6480464CTDESR2 affects the reaction [[Estradiol co-treated with Progesterone] results in increased expression of OXT mRNA]; Progesterone inhibits the reaction [ESR2 protein promotes the reaction [Estradiol results in increased expression of LPL mRNA]]PMID:12834440 PMID:17974624
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