RGD Reference Report - Depletion of oestrogen receptor-beta expression in magnocellular arginine vasopressin neurones by hypovolaemia and dehydration. - Rat Genome Database

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Depletion of oestrogen receptor-beta expression in magnocellular arginine vasopressin neurones by hypovolaemia and dehydration.

Authors: Somponpun, SJ  Sladek, CD 
Citation: Somponpun SJ and Sladek CD, J Neuroendocrinol. 2004 Jun;16(6):544-9.
RGD ID: 8694206
Pubmed: PMID:15189329   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1365-2826.2004.01200.x   (Journal Full-text)

Oestrogen receptor (ER)-beta expression correlates inversely with osmotic control of arginine vasopressin (AVP) release such that cellular dehydration induced by 72 h of 2% saline consumption depletes ER-beta in the magnocellular AVP neurones in the supraoptic (SON) and paraventricular nuclei (PVN). The current studies were performed to determine whether other pathways that stimulate AVP release, such as hypovolaemia, also regulate ER-beta expression in these nuclei, and to evaluate the time course of the change in ER-beta expression during water deprivation and subsequent rehydration. ER-beta expression was evaluated immunocytochemically. In rats made hypovolaemic with a subcutaneous injection of 40% polyethylene glycol (PEG), a significant depletion of ER-beta in both SON and magnocellular PVN (P

Objects referenced in this article
Gene Esr2 estrogen receptor 2 Rattus norvegicus

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