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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2582
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2
Acc ID: CHEBI:78802
Term: diarylheptanoid
Definition: A family of plant metabolites with a common 1,7-diphenylheptane structural skeleton, carrying various substituents. They are mainly distributed in the roots, rhizomes and bark of Alpinia, Zingiber, Curcuma and Alnus species.
Chemical ID: MESH:D036381
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr2increases activityISOESR2 (Homo sapiens)6480464CTDDiarylheptanoids results in increased activity of ESR2 proteinPMID:19654927
Esr2multiple interactionsISOESR2 (Homo sapiens)6480464CTDfulvestrant inhibits the reaction [Diarylheptanoids results in increased activity of ESR2 protein]PMID:19654927
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