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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2582
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr2decreases expressionEXP 6480464CTDCadmium Chloride results in decreased expression of ESR2 mRNA; Cadmium Chloride results in decreased expression of ESR2 proteinPMID:20186393
Esr2increases expressionISOESR2 (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of ESR2 proteinPMID:30682495
Esr2multiple interactionsISOESR2 (Homo sapiens)6480464CTDFulvestrant inhibits the reaction [Cadmium Chloride results in increased expression of ESR2 protein]PMID:30682495
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