GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esr2 | affects response to substance | ISO | Esr2 (Mus musculus) | 6480464 | CTD | ESR2 protein affects the susceptibility to 27-hydroxycholesterol | PMID:17873880 | Esr2 | multiple interactions | ISO | Esr2 (Mus musculus) | 6480464 | CTD | ESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS2 mRNA]; ESR2 protein affects the reaction [27-hydroxycholesterol results in decreased expression of NOS3 mRNA] | PMID:17873880 | Esr2 | multiple interactions | ISO | ESR2 (Homo sapiens) | 6480464 | CTD | 27-hydroxycholesterol binds to and affects the folding of and results in increased activity of ESR2 protein; 27-hydroxycholesterol binds to and results in decreased activity of ESR2 protein; 27-hydroxycholesterol inhibits the reaction [Estradiol results in increased activity of ESR2 protein] | PMID:17872378 PMID:17873880 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |