RGD Reference Report - Histological observation of the development of follicles and follicular atresia in immature rat ovaries. - Rat Genome Database

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Histological observation of the development of follicles and follicular atresia in immature rat ovaries.

Authors: Takagi, K  Yamada, T  Miki, Y  Umegaki, T  Nishimura, M  Sasaki, J 
Citation: Takagi K, etal., Acta Med Okayama. 2007 Oct;61(5):283-98.
RGD ID: 2289161
Pubmed: PMID:17971845   (View Abstract at PubMed)

To clarify the development of follicular growth and atresia in the immature ovary, rats. ovaries and blood were removed at fixed points during the period from 0 to 35 days after birth (Day 0 to Day 35). The ovaries were immunohistochemically examined, and blood concentrations of serum follicle-stimulating hormone (FSH) and estrogen (E) were measured. We investigated how time-course changes in follicular cell proliferation, estrogen receptor beta (ERbeta), apoptosis, and FSH and E concentrations are connected with follicular growth and atresia. Apoptosis was found in the ova from Day 0 to Day 3. On Day 15, apoptosis occurred in some granulosa cell nuclei in some follicles, but BrdU uptake and the presence of cyclin D2 and ER beta could be observed in other granulosa cells. From Day 17, apoptosis increased in the follicular granulosa cells, and BrdU uptake and the presence of cyclin D2 and ERbeta were decreased. Follicular atresia continued, reaching a peak on Day 30. Serum FSH and E concentrations increased until Day 15, then markedly decreased after Day 17. The mechanism of apoptosis in the ova from Day 0 to 3 has not been clarified. However, the onset of follicular atresia was caused by apoptotic degeneration from Days 15 to 17. These results showed that the oocytes were selected by apoptosis at 2 points in the time-course of the maturation of the ovary.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
ovarian follicle development  IEP 2289161; 2289161 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Ccnd2  (cyclin D2)
Esr2  (estrogen receptor 2)


Additional Information