RGD Reference Report - Estrogen receptor beta is involved in the anorectic action of estrogen. - Rat Genome Database

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Estrogen receptor beta is involved in the anorectic action of estrogen.

Authors: Liang, YQ  Akishita, M  Kim, S  Ako, J  Hashimoto, M  Iijima, K  Ohike, Y  Watanabe, T  Sudoh, N  Toba, K  Yoshizumi, M  Ouchi, Y 
Citation: Liang YQ, etal., Int J Obes Relat Metab Disord. 2002 Aug;26(8):1103-9.
RGD ID: 8694342
Pubmed: PMID:12119576   (View Abstract at PubMed)
DOI: DOI:10.1038/sj.ijo.0802054   (Journal Full-text)

OBJECTIVE: Estrogen has been implicated in feeding behavior and adiposity. This study was undertaken to elucidate the mechanism underlying the anti-obesity and anorectic action of estrogen and the role of estrogen receptor (ER) in the central nervous system. METHODS AND RESULTS: Ovariectomy in 8-week-old female Wistar rats induced hyperphagia along with an increase in body weight and abdominal fat accumulation compared to control sham-operated rats. These changes were fully reversed by subcutaneous replacement of estradiol and were abrogated by pair-feeding. Then, the effects of intracerebroventricular infusion of estradiol, alone or in combination with antisense oligodeoxynucleotides (ODN), for ER in ovariectomized rats were examined. The estradiol group showed 10-20% lower daily food intake, and after the 2-week infusion period a 14% reduction in body weight with a similar reduction in abdominal fat compared to the vehicle group. The inhibitory effect of estradiol on food intake and body weight was blocked by co-administration of ER-beta antisense ODN, whereas ER-alpha antisense ODN did not show any influence. CONCLUSION: These results indicate that ER-beta in the central nervous system is involved in the anorectic action of estrogen.

Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
negative regulation of feeding behavior  IMP 8694342 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Esr2  (estrogen receptor 2)


Additional Information