Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2582
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2
Acc ID: CHEBI:44616
Term: afimoxifene
Definition: A tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen.
Chemical ID: MESH:C016601
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr2affects bindingEXP 8694325RGD4-hydroxytamoxifen binds to Esr2 protein 
Esr2affects bindingEXP 6480464CTDafimoxifene binds to ESR2 proteinPMID:19913605
Esr2multiple interactionsEXP 6480464CTDafimoxifene inhibits the reaction [16 alpha-iodoestradiol binds to ESR2 protein]; afimoxifene inhibits the reaction [Estradiol binds to ESR2 protein alternative form]PMID:9048584 PMID:9492041
Esr2affects bindingISOESR2 (Homo sapiens)6480464CTDafimoxifene binds to ESR2 proteinPMID:17203231 PMID:19913605 PMID:34499926 PMID:9751507
Esr2affects expressionISOESR2 (Homo sapiens)6480464CTDafimoxifene affects the expression of ESR2 proteinPMID:15721411
Esr2increases activityISOESR2 (Homo sapiens)6480464CTDafimoxifene results in increased activity of ESR2 proteinPMID:28704378
Esr2increases response to substanceISOESR2 (Homo sapiens)6480464CTDESR2 protein results in increased susceptibility to afimoxifenePMID:15821116
Esr2multiple interactionsISOESR2 (Homo sapiens)6480464CTD1,1-bis(4-hydroxyphenyl)-2,2-dichloroethylene affects the reaction [afimoxifene binds to ESR2 protein]; 4,4'-hexafluorisopropylidene diphenol affects the reaction [afimoxifene binds to ESR2 protein]; afimoxifene binds to and results in decreased activity of ESR2 protein; afimoxifene inhibits the reaction [Estradiol binds to ESR2 protein]; afimoxifene inhibits the reaction [Estradiol results in increased activity of ESR2 protein]; afimoxifene inhibits the reaction [methoxyacetic acid promotes the reaction [Estradiol results in increased activity of ESR2 protein]]; bisphenol A inhibits the reaction [afimoxifene binds to ESR2 protein]; ESR2 protein inhibits the reaction [afimoxifene results in increased expression of FARP1 mRNA]; ESR2 protein inhibits the reaction [afimoxifene results in increased expression of IER3 mRNA]; ESR2 protein inhibits the reaction [afimoxifene results in increased expression of RAB30 mRNA]; ESR2 protein inhibits the reaction [afimoxifene results in increased expression of SOCS1 mRNA]PMID:15103026 PMID:15537743 PMID:16849584 PMID:28248286 PMID:34499926 PMID:9751507
Go Back to source page   Continue to Ontology report