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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2582
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2
Acc ID: CHEBI:4903
Term: 17alpha-ethynylestradiol
Definition: A 3-hydroxy steroid that is estradiol substituted by a ethynyl group at position 17. It is a xenoestrogen synthesized from estradiol and has been shown to exhibit high estrogenic potency on oral administration.
Chemical ID: MESH:D004997
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr2affects bindingEXP 6480464CTDEthinyl Estradiol binds to ESR2 proteinPMID:19913605
Esr2affects expressionEXP 6480464CTDEthinyl Estradiol affects the expression of ESR2 mRNAPMID:16551644
Esr2decreases expressionEXP 6480464CTDEthinyl Estradiol results in decreased expression of ESR2 mRNA; Ethinyl Estradiol results in decreased expression of ESR2 proteinPMID:12834913 PMID:14709816 PMID:20186393 PMID:24752507 PMID:27571134
Esr2increases expressionEXP 6480464CTDEthinyl Estradiol results in increased expression of ESR2 mRNAPMID:16183386
Esr2multiple interactionsEXP 6480464CTD[Ethinyl Estradiol co-treated with Triclosan] results in decreased expression of ESR2 mRNA; fulvestrant inhibits the reaction [[Ethinyl Estradiol co-treated with Triclosan] results in decreased expression of ESR2 mRNA]PMID:23261820
Esr2affects bindingISOEsr2 (Mus musculus)6480464CTDEthinyl Estradiol binds to ESR2 proteinPMID:19913605
Esr2affects bindingISOESR2 (Homo sapiens)6480464CTDEthinyl Estradiol binds to ESR2 proteinPMID:11518614 PMID:12224631 PMID:19913605
Esr2increases activityISOESR2 (Homo sapiens)6480464CTDEthinyl Estradiol results in increased activity of ESR2 proteinPMID:12387416
Esr2increases expressionISOEsr2 (Mus musculus)6480464CTDEthinyl Estradiol results in increased expression of ESR2 mRNAPMID:16606610 PMID:24781736
Esr2increases expressionISOESR2 (Homo sapiens)6480464CTDEthinyl Estradiol results in increased expression of ESR2 proteinPMID:10633228
Esr2increases methylationISOEsr2 (Mus musculus)6480464CTDEthinyl Estradiol results in increased methylation of ESR2 promoterPMID:31463084
Esr2multiple interactionsISOEsr2 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ESR2 mRNA; Ethinyl Estradiol inhibits the reaction [Streptozocin results in decreased expression of ESR2 mRNA]PMID:17942748 PMID:24781736
Esr2multiple interactionsISOESR2 (Homo sapiens)6480464CTDEthinyl Estradiol binds to and results in increased activity of ESR2 protein; Ethinyl Estradiol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of ESR2 protein]; Ethinyl Estradiol promotes the reaction [ESR2 protein alternative form binds to ESR2 protein alternative form]PMID:10633228 PMID:16938840 PMID:25752796 PMID:33049310
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