RGD Reference Report - Chaihu-shugan-san administration ameliorates perimenopausal anxiety and depression in rats. - Rat Genome Database

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Chaihu-shugan-san administration ameliorates perimenopausal anxiety and depression in rats.

Authors: Chen, S  Asakawa, T  Ding, S  Liao, L  Zhang, L  Shen, J  Yu, J  Sugiyama, K  Namba, H  Li, C 
Citation: Chen S, etal., PLoS One. 2013 Aug 27;8(8):e72428. doi: 10.1371/journal.pone.0072428.
RGD ID: 7364908
Pubmed: PMID:24015243   (View Abstract at PubMed)
PMCID: PMC3754981   (View Article at PubMed Central)
DOI: DOI:10.1371/journal.pone.0072428   (Journal Full-text)

Chaihu-Shugan-San (CSS) is a traditional Chinese herbal formula that is widely used for treating perimenopausal symptoms in China; however, its mechanisms remain unknown. The present study was designed to investigate potential CSS mechanisms in rats with unpredicted chronic mild stress (UCMS) and normally aging rats (52 weeks of age). We performed the sucrose consumption test along with the forced swimming test to confirm depression-like behavior and the open field test (OFT) to confirm anxiety-like behavior in the animals. In addition, we used an enzyme-linked immunosorbent assay to measure serum and hippocampal estradiol (E2) levels and a quantitative real-time polymerase chain reaction to assess hippocampal mRNA levels of estrogen receptors (ERs) alpha and beta as well as G protein-coupled receptor 30 (GPR30). We found that CSS administration resulted in a significant increase in the ratio of hippocampal ERalpha and ERbeta mRNA (ERalpha/ERbeta ratio) in UCMS rats (p<0.001). However, no significant changes were observed in E2 levels, ERalpha mRNA expression, and GPR30 mRNA expression. In contrast, changes in ERalpha/ERbeta mRNA ratio were sensitively associated with changes in mood states in the animal models. These findings suggest that enhancement of ERalpha/ERbeta ratio may play a role in the pharmacological mechanisms of CSS. Furthermore, this ratio can be employed as a potential index for evaluating mood states in animal models and can be considered as a therapeutic target for perimenopausal anxiety and depression in the future.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
anxiety disorder treatmentISOEsr2 (Rattus norvegicus)7364908; 7364908 RGD 
anxiety disorder treatmentIDA 7364908 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Esr2  (estrogen receptor 2)

Genes (Mus musculus)
Esr2  (estrogen receptor 2 (beta))

Genes (Homo sapiens)
ESR2  (estrogen receptor 2)


Additional Information