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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2582
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2
Acc ID: CHEBI:34575
Term: bisphenol F
Definition: A bisphenol that is methane in which two of the hydrogens have been replaced by 4-hydroxyphenyl groups.
Chemical ID: MESH:C008745
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr2increases expressionEXP 6480464CTDbisphenol F results in increased expression of ESR2 proteinPMID:37601897
Esr2affects bindingISOESR2 (Homo sapiens)6480464CTDbisphenol F binds to ESR2 proteinPMID:31836225
Esr2decreases expressionISOESR2 (Homo sapiens)6480464CTDbisphenol F results in decreased expression of ESR2 proteinPMID:34831106
Esr2increases activityISOESR2 (Homo sapiens)6480464CTD4,4'-bisphenol F results in increased activity of ESR2 proteinPMID:30582956 PMID:31388671
Esr2increases expressionISOEsr2 (Mus musculus)6480464CTD4,4'-bisphenol F results in increased expression of ESR2 mRNAPMID:30196065
Esr2increases expressionISOESR2 (Homo sapiens)6480464CTD4,4'-bisphenol F results in increased expression of ESR2 mRNAPMID:18973785
Esr2multiple interactionsISOESR2 (Homo sapiens)6480464CTD4,4'-bisphenol F inhibits the reaction [Estradiol binds to ESR2 protein]PMID:31195007
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