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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:transient cerebral ischemia
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Accession:DOID:224 term browser browse the term
Definition:A brain ischemia that is characterized by ischemia of brief duration and without resultant tissue death. (DO)
Synonyms:exact_synonym: Brain Stem Ischemia, Transient;   Brain Stem Transient Ischemic Attack;   Brain TIA;   Brainstem Transient Ischemic Attack;   Carotid Circulation Transient Ischemic Attack;   Posterior Circulation Transient Ischemic Attack;   TIA;   TIA (Transient Ischemic Attack);   TIA - transient ischaemic attack;   Transient Brainstem Ischemia;   Transient Cerebral Ischemias;   Transient cerebral ischaemia;   anterior circulation transient ischemic attack;   crescendo transient ischemic attacks;   transient brainstem ischemias;   transient ischemic attack;   transient ischemic attacks;   vertebrobasilar circulation transient ischemic attack
 related_synonym: Brain Ischemia-Reperfusion Injury;   Brain Reperfusion Injury
 primary_id: MESH:D002546
 xref: EFO:0003764;   ICD10CM:G45.9;   NCI:C50781
For additional species annotation, visit the Alliance of Genome Resources.


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transient cerebral ischemia term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acvrl1 activin A receptor, type II-like 1 ISO RGD PMID:15781474 RGD:1579751 NCBI chr15:101,026,403...101,043,217
Ensembl chr15:101,026,403...101,043,217 		JBrowse link
G Adamts1 ADAM metallopeptidase with thrombospondin type 1 motif 1 ISO mRNA, protein:increased expression:brain RGD PMID:16630594 RGD:9681747 NCBI chr16:85,590,715...85,600,001
Ensembl chr16:85,590,715...85,600,001 		JBrowse link
G Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif 4 ISO RGD PMID:16630594 RGD:9681747 NCBI chr 1:171,077,698...171,089,836
Ensembl chr 1:171,077,990...171,088,206 		JBrowse link
G Adarb1 adenosine deaminase, RNA-specific, B1 ISO RGD PMID:16504947 RGD:10755337 NCBI chr10:77,126,561...77,254,125
Ensembl chr10:77,126,560...77,254,104 		JBrowse link
G Adora1 adenosine A1 receptor ISO CTD Direct Evidence: therapeutic CTD PMID:23437309 NCBI chr 1:134,126,953...134,163,195
Ensembl chr 1:134,126,963...134,163,169 		JBrowse link
G Ager advanced glycosylation end product-specific receptor ISO
IEP		 protein:altered expression:cerebral cortex, striatum (rat)
protein:increased expression:brain, plasma		 RGD PMID:22528836 PMID:23288172 RGD:7245542, RGD:8696004 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910 		JBrowse link
G Agt angiotensinogen ISO RGD PMID:21934531 RGD:8549480 NCBI chr 8:125,283,326...125,296,445
Ensembl chr 8:125,283,273...125,296,445 		JBrowse link
G Ahr aryl-hydrocarbon receptor treatment ISO RGD PMID:32913241 RGD:401793747 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 ISO
IEP		 mRNA:decreased expression, altered localization:CA1 pyramidal layer, nucleus:
protein:increased expression:nucleus:		 RGD PMID:14526224 PMID:15087715 RGD:10047409, RGD:10053562 NCBI chr  X:47,563,821...47,602,440
Ensembl chr  X:47,563,821...47,602,440 		JBrowse link
G Ang angiogenin, ribonuclease, RNase A family, 5 treatment ISO RGD PMID:30258350 RGD:155663419 NCBI chr14:51,328,607...51,339,462
Ensembl chr14:51,328,607...51,339,466 		JBrowse link
G Ank1 ankyrin 1, erythroid ISO RGD PMID:9202331 RGD:1599109 NCBI chr 8:23,464,852...23,640,517
Ensembl chr 8:23,464,860...23,640,513 		JBrowse link
G Ank2 ankyrin 2, brain ISO RGD PMID:9202331 RGD:1599109 NCBI chr 3:126,715,256...127,293,996
Ensembl chr 3:126,715,261...127,292,999 		JBrowse link
G Apoe apolipoprotein E ISO RGD PMID:19623195 RGD:6903926 NCBI chr 7:19,430,169...19,434,326
Ensembl chr 7:19,430,034...19,433,113 		JBrowse link
G Aqp4 aquaporin 4 treatment ISO RGD PMID:24773551 RGD:13207320 NCBI chr18:15,522,451...15,544,039
Ensembl chr18:15,522,553...15,544,039 		JBrowse link
G Atf2 activating transcription factor 2 ISO RGD PMID:10077326 PMID:9813301 RGD:10047405, RGD:10047413 NCBI chr 2:73,646,853...73,723,094
Ensembl chr 2:73,646,853...73,722,983 		JBrowse link
G Atp5f1b ATP synthase F1 subunit beta ISO protein:increased expression:cerebrum (rat) RGD PMID:21950801 RGD:13792582 NCBI chr10:127,919,176...127,926,257
Ensembl chr10:127,919,142...127,926,260 		JBrowse link
G Axin2 axin 2 treatment ISO RGD PMID:31650542 RGD:151356749 NCBI chr11:108,808,687...108,841,609
Ensembl chr11:108,811,175...108,841,609 		JBrowse link
G Bace1 beta-site APP cleaving enzyme 1 ISO protein:increased activity,increased expression:brain cortex RGD PMID:15120577 RGD:13782170 NCBI chr 9:45,749,878...45,775,694
Ensembl chr 9:45,749,878...45,775,697 		JBrowse link
G Bad BCL2-associated agonist of cell death ISO CTD Direct Evidence: marker/mechanism CTD PMID:12629175 NCBI chr19:6,919,229...6,929,273
Ensembl chr19:6,919,229...6,929,267 		JBrowse link
G Bax BCL2-associated X protein treatment ISO RGD PMID:21167243 RGD:10054102 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bbc3 BCL2 binding component 3 ISO protein:increased expression:hippocampus CA1, pyramidal cell RGD PMID:12913114 RGD:634629 NCBI chr 7:16,042,307...16,052,130
Ensembl chr 7:16,042,318...16,052,130 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 treatment ISO protein:decreased expression:brain RGD PMID:18083315 PMID:16732092 PMID:22509406 RGD:2290557, RGD:11522725, RGD:11561910 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l2 BCL2-like 2 treatment ISO protein:increased expression:cortex and caudate putamen RGD PMID:10724126 PMID:12571640 RGD:14394498, RGD:14394500 NCBI chr14:55,120,900...55,125,691
Ensembl chr14:55,120,834...55,125,691 		JBrowse link
G Becn1 beclin 1, autophagy related treatment ISO RGD PMID:22509406 RGD:11561910 NCBI chr11:101,179,084...101,193,112
Ensembl chr11:101,176,778...101,193,112 		JBrowse link
G Bex3 brain expressed X-linked 3 ISO RGD PMID:11124986 RGD:9743974 NCBI chr  X:135,171,002...135,172,727
Ensembl chr  X:135,171,002...135,172,727 		JBrowse link
G Bnip3 BCL2/adenovirus E1B interacting protein 3 ISO RGD PMID:14972662 RGD:2314028 NCBI chr 7:138,492,565...138,511,235
Ensembl chr 7:138,492,565...138,511,248 		JBrowse link
G C3 complement component 3 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:23199288 PMID:22004711 RGD:7411628 NCBI chr17:57,510,967...57,535,136
Ensembl chr17:57,510,970...57,535,136 		JBrowse link
G Cab39 calcium binding protein 39 ISO protein:increased expression:brain RGD PMID:27798271 RGD:14398833 NCBI chr 1:85,707,796...85,779,298
Ensembl chr 1:85,721,162...85,779,297 		JBrowse link
G Camk2a calcium/calmodulin-dependent protein kinase II alpha ISO
IEP		 protein:increased expression:hippocampus RGD PMID:12951199 PMID:12199152 RGD:7241547, RGD:13681927 NCBI chr18:61,058,704...61,121,224
Ensembl chr18:61,058,690...61,121,224 		JBrowse link
G Casp3 caspase 3 ISO RGD PMID:21712070 RGD:10053706 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp7 caspase 7 treatment ISO RGD PMID:25872160 RGD:13782285 NCBI chr19:56,382,640...56,430,780
Ensembl chr19:56,385,561...56,430,776 		JBrowse link
G Casp8 caspase 8 treatment ISO protein:increased expression:cerebral cortex: RGD PMID:30148677 PMID:18096138 RGD:13782286, RGD:4142863 NCBI chr 1:58,834,553...58,886,663
Ensembl chr 1:58,834,533...58,886,662 		JBrowse link
G Casp9 caspase 9 ISO associated with Diabetes Mellitus, Experimental;protein:increased expression:neocortex
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:11333366 PMID:15246841 PMID:21712070 RGD:2311321, RGD:10053706 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Cav1 caveolin 1, caveolae protein treatment ISO
IMP		 RGD PMID:22007835 PMID:22007835 RGD:8661794, RGD:8661794 NCBI chr 6:17,306,387...17,341,323
Ensembl chr 6:17,306,334...17,341,451 		JBrowse link
G Cbl Casitas B-lineage lymphoma treatment ISO RGD PMID:18773943 RGD:4108486 NCBI chr 9:44,054,273...44,145,556
Ensembl chr 9:44,054,273...44,145,346 		JBrowse link
G Cbs cystathionine beta-synthase treatment IMP XCO:0000348
XCO:0000807		 RGD PMID:22212488 PMID:22212488 RGD:41410880, RGD:41410880 NCBI chr17:31,831,602...31,856,170
Ensembl chr17:31,827,868...31,856,212 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 treatment ISO mRNA:increased expression:brain (rat) RGD PMID:21487414 PMID:7860708 RGD:8549519, RGD:8549729 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccl20 C-C motif chemokine ligand 20 treatment ISO RGD PMID:19428685 RGD:7488896 NCBI chr 1:83,094,487...83,096,888
Ensembl chr 1:83,094,487...83,096,888 		JBrowse link
G Ccnh cyclin H ISO mRNA, protein:increased expression:hippocampus RGD PMID:10501206 RGD:69371 NCBI chr13:85,337,504...85,361,850
Ensembl chr13:85,337,527...85,371,588 		JBrowse link
G Ccr6 C-C motif chemokine receptor 6 ISO mRNA:increased expression:brain RGD PMID:19428685 RGD:7488896 NCBI chr17:8,454,875...8,477,353
Ensembl chr17:8,454,875...8,475,973 		JBrowse link
G Cd40 CD40 antigen severity IMP RGD PMID:15795333 RGD:11352234 NCBI chr 2:164,897,535...164,913,574
Ensembl chr 2:164,897,547...164,914,868 		JBrowse link
G Cd40lg CD40 ligand severity IMP RGD PMID:15795333 RGD:11352234 NCBI chr  X:56,257,448...56,269,402
Ensembl chr  X:56,257,503...56,269,402 		JBrowse link
G Cdk5 cyclin dependent kinase 5 treatment ISO RGD PMID:28254431 RGD:13506925 NCBI chr 5:24,612,595...24,628,737
Ensembl chr 5:24,623,239...24,628,528 		JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A IEP protein:decreased expression:striatum, neuron RGD PMID:11438580 RGD:8552691 NCBI chr 4:89,192,710...89,212,856
Ensembl chr 4:89,192,708...89,212,890 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha ISO mRNA, protein:increased expression:hippocampal pyramidal cell layer (rat) RGD PMID:9795105 RGD:10401192 NCBI chr 7:34,818,718...34,821,353
Ensembl chr 7:34,818,718...34,821,353 		JBrowse link
G Chka choline kinase alpha ISO mRNA:increased expression:cerebral cortex (rat) RGD PMID:16300643 RGD:10401831 NCBI chr19:3,901,585...3,944,368
Ensembl chr19:3,901,773...3,944,369 		JBrowse link
G Coq7 demethyl-Q 7 severity IMP RGD PMID:20170652 RGD:10402096 NCBI chr 7:118,108,881...118,132,529
Ensembl chr 7:118,108,882...118,132,579 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 ISO RGD PMID:10077326 RGD:10047405 NCBI chr 1:64,571,963...64,643,707
Ensembl chr 1:64,571,804...64,643,707 		JBrowse link
G Crem cAMP responsive element modulator ISO mRNA:increased expression:cerebral cortex (rat) RGD PMID:12437578 RGD:632385 NCBI chr18:3,263,181...3,337,688
Ensembl chr18:3,266,048...3,337,748 		JBrowse link
G Csf3 colony stimulating factor 3 (granulocyte) treatment ISO RGD PMID:12624302 RGD:10450512 NCBI chr11:98,591,287...98,594,457
Ensembl chr11:98,592,089...98,594,455 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 ISO protein:decreased expression:hippocampus RGD PMID:24447880 RGD:9491776 NCBI chr 8:95,498,808...95,509,055
Ensembl chr 8:95,498,637...95,509,055 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 ISO mRNA,protein:decreased expression:hippocampus RGD PMID:24447880 RGD:9491776 NCBI chr 9:119,877,749...119,897,362
Ensembl chr 9:119,877,749...119,898,945 		JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 ISO protein:increased expression:hippocampus: RGD PMID:24924806 RGD:11352662 NCBI chr 6:117,145,496...117,158,329
Ensembl chr 6:117,145,496...117,158,328 		JBrowse link
G Cycs cytochrome c, somatic ISO CTD Direct Evidence: marker/mechanism CTD PMID:11333366 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Daxx Fas death domain-associated protein treatment ISO mRNA,protein:increased expression:cerebral cortex: RGD PMID:17967739 PMID:18096138 RGD:9587802, RGD:4142863 NCBI chr17:34,128,379...34,134,564
Ensembl chr17:34,128,388...34,134,564 		JBrowse link
G Dbn1 drebrin 1 ISO RGD PMID:8583659 RGD:10398814 NCBI chr13:55,621,241...55,635,874
Ensembl chr13:55,621,242...55,635,924 		JBrowse link
G Dffb DNA fragmentation factor, beta subunit ISO mRNA, protein:increased expression:hippocampus CA1 RGD PMID:11425895 RGD:628524 NCBI chr 4:154,048,904...154,059,578
Ensembl chr 4:154,048,906...154,059,583 		JBrowse link
G Dll4 delta like canonical Notch ligand 4 ameliorates
disease_progression
treatment		 IMP
ISO		 RGD PMID:31927543 PMID:30653356 PMID:30258350 RGD:155663354, RGD:155663383, RGD:155663419 NCBI chr 2:119,156,286...119,166,145
Ensembl chr 2:119,156,265...119,166,443 		JBrowse link
G Dusp1 dual specificity phosphatase 1 ISO protein:increased expression:brain RGD PMID:22197701 RGD:7771582 NCBI chr17:26,724,565...26,727,446
Ensembl chr17:26,724,564...26,781,102 		JBrowse link
G Dusp16 dual specificity phosphatase 16 ISO protein:increased expression, altered localization:hippocampus, cytosol, nucleus RGD PMID:23280045 RGD:7775014 NCBI chr 6:134,692,431...134,769,687
Ensembl chr 6:134,692,431...134,769,588 		JBrowse link
G Eed embryonic ectoderm development ISO RGD PMID:24007266 RGD:9588303 NCBI chr 7:89,603,862...89,630,184
Ensembl chr 7:89,603,862...89,630,191 		JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2, subunit 1 alpha IDA
ISO		 associated with Heart Arrest RGD PMID:11520898 PMID:10541873 RGD:10395353, RGD:11041881 NCBI chr12:78,908,846...78,933,784
Ensembl chr12:78,908,593...78,933,784 		JBrowse link
G Elane elastase, neutrophil expressed treatment ISO RGD PMID:19168036 RGD:10450558 NCBI chr10:79,722,146...79,724,050
Ensembl chr10:79,722,081...79,724,049 		JBrowse link
G Elk1 ELK1, member of ETS oncogene family treatment ISO RGD PMID:17091294 RGD:7488902 NCBI chr  X:20,799,634...20,816,847
Ensembl chr  X:20,799,634...20,816,847 		JBrowse link
G Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 ISO mRNA:increased expression:brain: RGD PMID:9634555 RGD:9685492 NCBI chr19:40,600,810...40,730,046
Ensembl chr19:40,600,810...40,730,046 		JBrowse link
G Ep300 E1A binding protein p300 ISO mRNA:increased expression:cerebrum, ipsilateral side (rat) RGD PMID:22196858 RGD:7349341 NCBI chr15:81,470,329...81,536,273
Ensembl chr15:81,469,552...81,536,278 		JBrowse link
G Epo erythropoietin treatment ISO RGD PMID:22282883 PMID:24702327 RGD:10401060, RGD:11041699 NCBI chr 5:137,481,282...137,484,078
Ensembl chr 5:137,481,282...137,531,504 		JBrowse link
G Ercc1 excision repair cross-complementing rodent repair deficiency, complementation group 1 treatment ISO human gene in a rat model RGD PMID:19440222 RGD:2313668 NCBI chr 7:19,079,016...19,090,449
Ensembl chr 7:19,078,703...19,090,449 		JBrowse link
G Ercc6 excision repair cross-complementing rodent repair deficiency, complementation group 6 ISO mRNA, protein:increased expression:cerebral cortex RGD PMID:10437118 RGD:10401104 NCBI chr14:32,235,248...32,302,947
Ensembl chr14:32,235,478...32,302,947 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) treatment ISO RGD PMID:24548484 PMID:25098259 RGD:10045843, RGD:10045845 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Esr2 estrogen receptor 2 (beta) ISO RGD PMID:23593292 RGD:7364962 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G F11r F11 receptor treatment ISO RGD PMID:22868201 RGD:7488943 NCBI chr 1:171,265,129...171,292,161
Ensembl chr 1:171,265,103...171,292,171 		JBrowse link
G F12 coagulation factor XII (Hageman factor) treatment IMP
ISO		 RGD PMID:16533887 PMID:16533887 RGD:11041786, RGD:11041786 NCBI chr13:55,565,771...55,574,617
Ensembl chr13:55,565,771...55,574,606 		JBrowse link
G Fadd Fas associated via death domain ISO mRNA,protein:increased expression:cerebral cortex: RGD PMID:18096138 RGD:4142863 NCBI chr 7:144,132,060...144,136,178
Ensembl chr 7:144,131,055...144,136,200 		JBrowse link
G Fas Fas cell surface death receptor treatment ISO
IMP		 protein:increased expression:brain (rat) RGD PMID:18410517 PMID:10972965 PMID:18981705 PMID:30301943 RGD:2311437, RGD:8662928, RGD:8686422, RGD:153297779 NCBI chr19:34,267,926...34,305,175
Ensembl chr19:34,268,066...34,305,172 		JBrowse link
G Fgfr1 fibroblast growth factor receptor 1 ISO mRNA:increased expression:cerebral cortex: RGD PMID:8858623 RGD:10402044 NCBI chr 8:26,008,808...26,067,819
Ensembl chr 8:26,003,670...26,065,734 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 treatment ISO associated with Experimental Diabetes Mellitus RGD PMID:22432030 RGD:155882598 NCBI chr 7:129,764,181...129,868,538
Ensembl chr 7:129,764,181...132,725,079 		JBrowse link
G Flt1 FMS-like tyrosine kinase 1 treatment IDA RGD PMID:17077813 RGD:10402150 NCBI chr 5:147,498,414...147,663,419
Ensembl chr 5:147,498,414...147,662,821 		JBrowse link
G Fmr1 fragile X messenger ribonucleoprotein 1 ISO mRNA, protein:increased expression:striatum (rat) RGD PMID:22817682 RGD:11566024 NCBI chr  X:67,722,144...67,761,569
Ensembl chr  X:67,722,147...67,761,569 		JBrowse link
G Fto FTO alpha-ketoglutarate dependent dioxygenase ISO
IEP		 protein:decreased expression:cerebral cortex
mRNA:decreased expression:heart
mRNA:decreased expression:cerebral cortex		 RGD PMID:32426101 PMID:34413770 PMID:36479246 RGD:329901764, RGD:329901768, RGD:329951019 NCBI chr 8:92,039,995...92,395,061
Ensembl chr 8:92,040,153...92,395,067 		JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked ISO RGD PMID:22580330 RGD:10449127 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800 		JBrowse link
G Gad1 glutamate decarboxylase 1 disease_progression ISO RGD PMID:20659561 RGD:401900597 NCBI chr 2:70,392,109...70,432,358
Ensembl chr 2:70,383,416...70,432,358 		JBrowse link
G Gad2 glutamic acid decarboxylase 2 disease_progression ISO RGD PMID:20659561 RGD:401900597 NCBI chr 2:22,512,262...22,583,889
Ensembl chr 2:22,512,217...22,583,886 		JBrowse link
G Gamt guanidinoacetate methyltransferase ameliorates IMP DNA:deletion RGD PMID:24004504 RGD:329955375 NCBI chr10:80,093,985...80,096,846
Ensembl chr10:80,093,985...80,096,846 		JBrowse link
G Gatm glycine amidinotransferase (L-arginine:glycine amidinotransferase) exacerbates IMP DNA:deletion RGD PMID:24004504 RGD:329955375 NCBI chr 2:122,424,954...122,441,758
Ensembl chr 2:122,424,948...122,441,784 		JBrowse link
G Gch1 GTP cyclohydrolase 1 treatment ISO RGD PMID:9920651 RGD:329961573 NCBI chr14:47,391,352...47,426,870
Ensembl chr14:47,391,352...47,426,870 		JBrowse link
G Ghsr growth hormone secretagogue receptor ISO mRNA,protein:decreased expression:brain: RGD PMID:17560544 RGD:12907500 NCBI chr 3:27,425,500...27,433,384
Ensembl chr 3:27,425,500...27,432,159 		JBrowse link
G Gja1 gap junction protein, alpha 1 treatment IDA
ISO		 protein:increased expression:brain RGD PMID:22812228 PMID:23328809 RGD:7207263, RGD:8662426 NCBI chr10:56,253,297...56,266,519
Ensembl chr10:56,253,426...56,278,609 		JBrowse link
G Gjb6 gap junction protein, beta 6 ISO protein:increased expression:hippocampus: RGD PMID:21718970 RGD:6480433 NCBI chr14:57,360,760...57,370,764
Ensembl chr14:57,360,760...57,371,068 		JBrowse link
G Glrx glutaredoxin ISO mRNA,protein:decreased expression:brain: RGD PMID:10329397 RGD:9686043 NCBI chr13:75,988,004...75,998,270
Ensembl chr13:75,987,987...75,998,273 		JBrowse link
G Glul glutamate-ammonia ligase treatment ISO protein:increased expression:hippocampus
associated with carotid artery occlusion		 RGD PMID:27664163 PMID:21371894 PMID:21272618 PMID:25365917 RGD:401794415, RGD:401794419, RGD:401794590, RGD:401794591 NCBI chr 1:153,775,692...153,785,469
Ensembl chr 1:153,775,690...153,785,469 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1, soluble treatment ISO
IDA		 human protein in a rat model RGD PMID:24407245 PMID:20145654 PMID:21361730 RGD:13504852, RGD:13504854, RGD:13504855 NCBI chr19:43,488,191...43,514,743
Ensembl chr19:43,488,191...43,513,044 		JBrowse link
G Gp6 glycoprotein 6 platelet ameliorates IMP RGD PMID:34237320 RGD:401794450 NCBI chr 7:4,365,852...4,400,849
Ensembl chr 7:4,366,964...4,400,743 		JBrowse link
G Gpx3 glutathione peroxidase 3 treatment ISO RGD PMID:30098076 RGD:401827833 NCBI chr11:54,793,680...54,801,213
Ensembl chr11:54,793,279...54,801,203 		JBrowse link
G Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) ameliorates
treatment		 ISO
IMP		 associated with hyperhomocysteinemia RGD PMID:30885791 PMID:30885791 PMID:12932824 RGD:401940141, RGD:401940141, RGD:401950480 NCBI chr16:9,385,765...9,813,744
Ensembl chr16:9,385,762...9,813,424 		JBrowse link
G Grin2b glutamate receptor, ionotropic, NMDA2B (epsilon 2) ameliorates ISO RGD PMID:30885791 RGD:401940141 NCBI chr 6:135,690,219...136,150,658
Ensembl chr 6:135,690,231...136,150,509 		JBrowse link
G Gsr glutathione reductase treatment ISO RGD PMID:15525350 RGD:10401855 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G H2ax H2A.X variant histone treatment ISO RGD PMID:20830300 RGD:8693742 NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374 		JBrowse link
G Havcr2 hepatitis A virus cellular receptor 2 treatment ISO RGD PMID:24771108 RGD:9686115 NCBI chr11:46,345,758...46,372,082
Ensembl chr11:46,345,762...46,372,082 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit treatment ISO protein:increased expression:cerebral cortex, caudoputamen (rat) RGD PMID:20417628 PMID:30258350 RGD:9068877, RGD:155663419 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Hmgb1 high mobility group box 1 IEP protein:increased expression:brain, plasma RGD PMID:23288172 RGD:8696004 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299 		JBrowse link
G Hnrnpa2b1 heterogeneous nuclear ribonucleoprotein A2/B1 ISO protein:altered expression:cerebral cortex, hippocampus (rat) RGD PMID:20421594 RGD:10041006 NCBI chr 6:51,437,414...51,448,054
Ensembl chr 6:51,437,912...51,446,874 		JBrowse link
G Hnrnpab heterogeneous nuclear ribonucleoprotein A/B treatment ISO RGD PMID:22366221 RGD:9999181 NCBI chr11:51,490,927...51,497,708
Ensembl chr11:51,490,927...51,497,674 		JBrowse link
G Hrh2 histamine receptor H2 ISO protein:decreased expression:caudate putamen (rat) RGD PMID:16181737 RGD:9685533 NCBI chr13:54,345,990...54,390,201
Ensembl chr13:54,346,148...54,390,199 		JBrowse link
G Hsf1 heat shock factor 1 treatment ISO protein:increased expression:brain, nucleus (rat)
associated with Heart Arrest		 RGD PMID:26070787 PMID:23528677 RGD:10402389, RGD:10402772 NCBI chr15:76,361,562...76,385,355
Ensembl chr15:76,361,622...76,386,113 		JBrowse link
G Hspa5 heat shock protein 5 treatment ISO RGD PMID:25632565 RGD:11354959 NCBI chr 2:34,662,102...34,666,541
Ensembl chr 2:34,661,982...34,667,559 		JBrowse link
G Hspa8 heat shock protein 8 ISO protein:increased expression:brain, postsynaptic density (rat) RGD PMID:9425004 RGD:10059344 NCBI chr 9:40,712,572...40,716,498
Ensembl chr 9:40,712,280...40,721,383 		JBrowse link
G Hspb1 heat shock protein 1 ISO protein:increased expression:brain,astrocyte: RGD PMID:10559386 RGD:10402577 NCBI chr 5:135,916,773...135,918,417
Ensembl chr 5:135,916,773...135,918,417 		JBrowse link
G Htra2 HtrA serine peptidase 2 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:15306124 PMID:19462455 RGD:10402932 NCBI chr 6:83,028,247...83,031,552
Ensembl chr 6:83,028,247...83,032,254 		JBrowse link
G Htt huntingtin ISO protein:increased degradation:brain RGD PMID:12957494 RGD:1304431 NCBI chr 5:34,919,084...35,069,878
Ensembl chr 5:34,919,084...35,069,878 		JBrowse link
G Icam1 intercellular adhesion molecule 1 treatment ISO RGD PMID:22379785 RGD:8547729 NCBI chr 9:20,927,236...20,940,110
Ensembl chr 9:20,927,281...20,940,113 		JBrowse link
G Ifnb1 interferon beta 1, fibroblast ameliorates ISO RGD PMID:12973019 RGD:401851924 NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011 		JBrowse link
G Igf1 insulin-like growth factor 1 severity ISO protein:decreased expression:serum (rat) RGD PMID:25098324 RGD:12904924 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Ikbkb inhibitor of kappaB kinase beta treatment ISO RGD PMID:24261295 RGD:7495766 NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605 		JBrowse link
G Il10 interleukin 10 treatment ISO RGD PMID:24053818 RGD:7364868 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il1b interleukin 1 beta ISO
IDA		 RGD PMID:23147509 PMID:22284622 RGD:7175551, RGD:7175554 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il1rn interleukin 1 receptor antagonist ISO human protein in a rat model RGD PMID:15837124 PMID:20412072 RGD:1626674, RGD:8551852 NCBI chr 2:24,226,872...24,241,503
Ensembl chr 2:24,226,865...24,241,506 		JBrowse link
G Ilk integrin linked kinase ISO CTD Direct Evidence: marker/mechanism CTD PMID:15472100 NCBI chr 7:105,385,797...105,392,132
Ensembl chr 7:105,385,799...105,392,132 		JBrowse link
G Itgam integrin alpha M treatment IEP
ISO		 mRNA:increased expression:cerebral cortex (mouse)
mRNA:increased expression:brain (rat)		 RGD PMID:30123113 PMID:8160235 PMID:8581506 PMID:8964796 PMID:19563786 More... RGD:329853754, RGD:329901916, RGD:329901917, RGD:329901921, RGD:329901933, RGD:329901940, RGD:329902058, RGD:329902067 NCBI chr 7:127,661,812...127,717,663
Ensembl chr 7:127,661,812...127,717,663 		JBrowse link
G Itgb3 integrin beta 3 ISO RGD PMID:18638458 RGD:6907424 NCBI chr11:104,498,826...104,561,302
Ensembl chr11:104,498,826...104,561,302 		JBrowse link
G Itpr1 inositol 1,4,5-trisphosphate receptor 1 ISO mRNA:decreased expression:cerebral cortex (rat) RGD PMID:7500836 RGD:6482813 NCBI chr 6:108,190,044...108,528,077
Ensembl chr 6:108,190,057...108,528,070 		JBrowse link
G Jak1 Janus kinase 1 ISO RGD PMID:10756075 RGD:19165138 NCBI chr 4:101,009,171...101,122,493
Ensembl chr 4:101,009,564...101,122,479 		JBrowse link
G Jak2 Janus kinase 2 ISO RGD PMID:23764464 RGD:8694326 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480 		JBrowse link
G Kcnj10 potassium inwardly-rectifying channel, subfamily J, member 10 ISO protein:decreased expression:CA1 field of hippocampus, astrocyte, astrocyte projection RGD PMID:20833221 RGD:8662899 NCBI chr 1:172,168,777...172,201,652
Ensembl chr 1:172,168,777...172,201,652 		JBrowse link
G Kcnk2 potassium channel, subfamily K, member 2 severity
treatment		 IMP
ISO		 protein:increased expression:cerebral cortex (rat) RGD PMID:15175651 PMID:25062759 PMID:24154701 RGD:9831121, RGD:9831122, RGD:9831178 NCBI chr 1:188,940,127...189,134,951
Ensembl chr 1:188,940,127...189,134,470 		JBrowse link
G Kdm1a lysine (K)-specific demethylase 1A ISO protein:increased expression:cerebral cortex, hippocampus, dentate gyrus (rat) RGD PMID:20542065 RGD:9588301 NCBI chr 4:136,277,844...136,330,127
Ensembl chr 4:136,277,851...136,330,034 		JBrowse link
G Keap1 kelch-like ECH-associated protein 1 IEP protein:decreased expression:brain (mouse) RGD PMID:21075092 RGD:6893270 NCBI chr 9:21,141,026...21,150,628
Ensembl chr 9:21,141,026...21,150,657 		JBrowse link
G Klf5 Kruppel-like transcription factor 5 ameliorates ISO RGD PMID:32272873 RGD:45073134 NCBI chr14:99,536,127...99,550,848
Ensembl chr14:99,536,127...99,552,472 		JBrowse link
G Kmt2a lysine (K)-specific methyltransferase 2A treatment ISO RGD PMID:34694864 RGD:155888565 NCBI chr 9:44,714,652...44,793,492
Ensembl chr 9:44,714,652...44,792,594 		JBrowse link
G Lcn2 lipocalin 2 ISO protein:increased expression:brain RGD PMID:29122651 PMID:24916903 RGD:126781757, RGD:126790489 NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264 		JBrowse link
G Lmna lamin A ISO RGD PMID:17683050 RGD:2293745 NCBI chr 3:88,388,455...88,413,842
Ensembl chr 3:88,387,454...88,417,263 		JBrowse link
G Lpar1 lysophosphatidic acid receptor 1 treatment ISO RGD PMID:17173873 RGD:9850154 NCBI chr 4:58,435,252...58,554,601
Ensembl chr 4:58,435,255...58,553,898 		JBrowse link
G Ltbp1 latent transforming growth factor beta binding protein 1 treatment ISO RGD PMID:11720783 RGD:10412057 NCBI chr17:75,312,475...75,699,507
Ensembl chr17:75,312,563...75,699,507 		JBrowse link
G Madd MAP-kinase activating death domain ISO RGD PMID:12625816 RGD:9588641 NCBI chr 2:90,967,705...91,013,404
Ensembl chr 2:90,967,705...91,014,182 		JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha treatment ISO RGD PMID:22509406 RGD:11561910 NCBI chr 2:155,118,284...155,119,993
Ensembl chr 2:155,118,217...155,119,993 		JBrowse link
G Map2k4 mitogen-activated protein kinase kinase 4 ISO protein:increased threonine phosphorylation:heart, nucleus RGD PMID:9195981 RGD:7495830 NCBI chr11:65,579,070...65,679,185
Ensembl chr11:65,579,069...65,679,123 		JBrowse link
G Map3k5 mitogen-activated protein kinase kinase kinase 5 ISO protein:increased nitrosylation, activity:hippocampus: RGD PMID:23137546 RGD:10412334 NCBI chr10:19,809,847...20,018,496
Ensembl chr10:19,810,218...20,018,499 		JBrowse link
G Map3k7 mitogen-activated protein kinase kinase kinase 7 ameliorates IMP RGD PMID:32078472 PMID:32382778 PMID:34628598 PMID:32349637 RGD:155791642, RGD:155804272, RGD:155804283, RGD:155804284 NCBI chr 4:31,963,659...32,023,470
Ensembl chr 4:31,964,097...32,023,467 		JBrowse link
G Map4k1 mitogen-activated protein kinase kinase kinase kinase 1 treatment ISO RGD PMID:18498770 PMID:18382279 RGD:7495845, RGD:7495847 NCBI chr 7:28,681,506...28,702,704
Ensembl chr 7:28,681,475...28,702,704 		JBrowse link
G Mbd1 methyl-CpG binding domain protein 1 ISO mRNA:increased expression:hippocampus RGD PMID:12421618 RGD:9587846 NCBI chr18:74,400,676...74,415,808
Ensembl chr18:74,400,676...74,415,803 		JBrowse link
G Mbd2 methyl-CpG binding domain protein 2 ISO mRNA:increased expression:hippocampus RGD PMID:12421618 RGD:9587846 NCBI chr18:70,701,298...70,761,769
Ensembl chr18:70,701,260...70,759,202 		JBrowse link
G Mbd3 methyl-CpG binding domain protein 3 ISO mRNA:decreased expression:hippocampus RGD PMID:12421618 RGD:9587846 NCBI chr10:80,228,373...80,235,365
Ensembl chr10:80,228,373...80,235,384 		JBrowse link
G Mbp myelin basic protein ISO mRNA:increased expression:oligodendrocyte: RGD PMID:11460777 RGD:7349336 NCBI chr18:82,492,883...82,603,762
Ensembl chr18:82,493,271...82,603,762 		JBrowse link
G Mcfd2 multiple coagulation factor deficiency 2 ISO mRNA:increased expression:hippocampus RGD PMID:17610559 RGD:11062141 NCBI chr17:87,561,871...87,573,382
Ensembl chr17:87,561,871...87,573,363 		JBrowse link
G Mdm2 transformed mouse 3T3 cell double minute 2 treatment ISO RGD PMID:24334056 RGD:10412310 NCBI chr10:117,524,780...117,546,663
Ensembl chr10:117,524,780...117,546,663 		JBrowse link
G Mecp2 methyl CpG binding protein 2 ISO mRNA:increased expression:hippocampus RGD PMID:12421618 RGD:9587846 NCBI chr  X:73,070,198...73,129,296
Ensembl chr  X:73,070,198...73,129,296 		JBrowse link
G Mff mitochondrial fission factor treatment ISO RGD PMID:26116440 RGD:12879457 NCBI chr 1:82,702,599...82,730,111
Ensembl chr 1:82,702,611...82,730,115 		JBrowse link
G Mfn2 mitofusin 2 ISO protein:decreased expression:brain (rat) RGD PMID:25147362 RGD:13204807 NCBI chr 4:147,958,043...147,989,527
Ensembl chr 4:147,958,056...147,989,161 		JBrowse link
G Mir126a microRNA 126a exacerbates IMP RGD PMID:28101763 RGD:401850574 NCBI chr 2:26,481,369...26,481,441
Ensembl chr 2:26,481,369...26,481,441 		JBrowse link
G Mir155 microRNA 155 treatment ISO RGD PMID:33081480 RGD:151347423 NCBI chr16:84,511,028...84,511,092
Ensembl chr16:84,511,028...84,511,092 		JBrowse link
G Mir195a microRNA 195a severity ISO RGD PMID:32272873 RGD:45073134 NCBI chr11:70,125,868...70,125,961
Ensembl chr11:70,125,868...70,125,961 		JBrowse link
G Mir223 microRNA 223 ISO RGD PMID:31237865 RGD:25824937 NCBI chr  X:95,286,423...95,286,532
Ensembl chr  X:95,286,423...95,286,532 		JBrowse link
G Mmp2 matrix metallopeptidase 2 treatment ISO protein:increased activity, increased expression:brain RGD PMID:11592852 PMID:24828425 RGD:8547930, RGD:8657086 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp9 matrix metallopeptidase 9 treatment IMP
ISO		 protein:increased activity, increased expression:brain RGD PMID:16197500 PMID:11592852 PMID:23046750 PMID:24773551 RGD:8547921, RGD:8547930, RGD:13207323, RGD:13207320 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mt1 metallothionein 1 ISO mRNA:increased expression:cerebral cortex RGD PMID:10884303 RGD:10412650 NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955 		JBrowse link
G Mt2 metallothionein 2 ISO mRNA:increased expression:cerebral cortex RGD PMID:10884303 RGD:10412650 NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196 		JBrowse link
G Mt3 metallothionein 3 ISO mRNA, protein:increased expression:brain RGD PMID:10069533 RGD:9685804 NCBI chr 8:94,879,235...94,880,776
Ensembl chr 8:94,879,235...94,880,774 		JBrowse link
G Mtor mechanistic target of rapamycin kinase treatment ISO RGD PMID:30712471 RGD:155791663 NCBI chr 4:148,533,039...148,642,142
Ensembl chr 4:148,533,068...148,642,140 		JBrowse link
G Myb myeloblastosis oncogene ISO mRNA:increased expression:brain: RGD PMID:24828495 RGD:11532683 NCBI chr10:21,000,829...21,036,883
Ensembl chr10:21,000,834...21,036,883 		JBrowse link
G Nampt nicotinamide phosphoribosyltransferase treatment ISO RGD PMID:28528966 PMID:25603815 RGD:13781879, RGD:13781895 NCBI chr12:32,870,334...32,903,368
Ensembl chr12:32,869,544...32,903,348 		JBrowse link
G Ndrg2 N-myc downstream regulated gene 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:23451161 NCBI chr14:52,142,738...52,151,463
Ensembl chr14:52,142,728...52,151,615 		JBrowse link
G Ndrg4 N-myc downstream regulated gene 4 IMP RGD PMID:21636852 RGD:7247728 NCBI chr 8:96,403,602...96,441,584
Ensembl chr 8:96,403,608...96,441,747 		JBrowse link
G Nefh neurofilament, heavy polypeptide ISO protein:decreased expression:hippocampus RGD PMID:8726968 RGD:9743938 NCBI chr11:4,888,754...4,898,064
Ensembl chr11:4,888,754...4,898,064 		JBrowse link
G Nefl neurofilament, light polypeptide ISO protein:decreased expression:hippocampus RGD PMID:8726968 RGD:9743938 NCBI chr14:68,321,312...68,326,544
Ensembl chr14:68,321,312...68,326,544 		JBrowse link
G Nefm neurofilament, medium polypeptide ISO protein:decreased expression:hippocampus RGD PMID:8726968 RGD:9743938 NCBI chr14:68,356,994...68,362,453
Ensembl chr14:68,320,039...68,362,295 		JBrowse link
G Nf1 neurofibromin 1 ISO mRNA,protein:increased expression:astrocyte: RGD PMID:8820972 RGD:12789703 NCBI chr11:79,223,541...79,472,435
Ensembl chr11:79,230,519...79,472,438 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 ISO protein:increased expression:hippocampal pyramidal neuron, nucleus (rat) RGD PMID:9158652 RGD:10045943 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Ngb neuroglobin treatment ISO
IDA		 associated with Hypertension;mRNA, protein:decreased expression:brain RGD PMID:16647691 PMID:12621155 PMID:12621155 PMID:23342777 RGD:9743952, RGD:9743964, RGD:9743964, RGD:9743965 NCBI chr12:87,144,305...87,149,313
Ensembl chr12:87,144,305...87,149,313 		JBrowse link
G Ngfr nerve growth factor receptor (TNFR superfamily, member 16) ISO RGD PMID:11124986 RGD:9743974 NCBI chr11:95,459,644...95,478,524
Ensembl chr11:95,459,644...95,478,561 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 IEP mRNA, protein:increased expression:brain RGD PMID:20863826 RGD:5508733 NCBI chr 8:89,373,943...89,415,103
Ensembl chr 8:89,373,943...89,415,102 		JBrowse link
G Nono non-POU-domain-containing, octamer binding protein IEP protein:altered localization:cerebral cortex (mouse) RGD PMID:29426953 RGD:155883175 NCBI chr  X:100,473,295...100,492,193
Ensembl chr  X:100,472,924...100,492,197 		JBrowse link
G Nos1 nitric oxide synthase 1, neuronal ISO protein:increased serine phosphorylation:dentate gyrus RGD PMID:23806217 RGD:7257600 NCBI chr 5:118,004,904...118,096,905
Ensembl chr 5:117,919,097...118,096,905 		JBrowse link
G Nos3 nitric oxide synthase 3, endothelial cell treatment ISO protein:increased expression:serum (rat) RGD PMID:28944915 PMID:29312485 PMID:29298658 RGD:13450951, RGD:13503330, RGD:13503353 NCBI chr 5:24,569,772...24,589,472
Ensembl chr 5:24,569,808...24,589,472 		JBrowse link
G Notch1 notch 1 treatment ISO RGD PMID:30258350 RGD:155663419 NCBI chr 2:26,347,914...26,393,834
Ensembl chr 2:26,347,915...26,406,675 		JBrowse link
G Nox1 NADPH oxidase 1 ameliorates ISO RGD PMID:25617620 RGD:329955357 NCBI chr  X:132,987,170...133,038,455
Ensembl chr  X:132,987,170...133,122,705 		JBrowse link
G Nqo1 NAD(P)H dehydrogenase, quinone 1 treatment ISO protein:increased expression:brain (rat)
protein:increased expression:cerebral cortex (rat)		 RGD PMID:29017857 PMID:28552673 PMID:28169530 RGD:13439718, RGD:13439727, RGD:13442499 NCBI chr 8:108,114,856...108,139,012
Ensembl chr 8:108,114,857...108,129,838 		JBrowse link
G Nrg1 neuregulin 1 treatment
ameliorates		 ISO RGD PMID:31560696 PMID:30206770 RGD:405649728, RGD:405650589 NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825
Ensembl chr 8:32,304,579...33,374,825 		JBrowse link
G Nrp1 neuropilin 1 ISO mRNA:increased expression:brain RGD PMID:33675584 RGD:401901171 NCBI chr 8:129,085,553...129,231,957
Ensembl chr 8:129,085,085...129,229,844 		JBrowse link
G Nrxn1 neurexin I ISO associated with Hypertension;mRNA:decreased expression:cerebral cortex RGD PMID:12437578 RGD:632385 NCBI chr17:90,341,072...91,400,587
Ensembl chr17:90,341,059...91,400,499 		JBrowse link
G Ogg1 8-oxoguanine DNA-glycosylase 1 ISO protein:increased expression:cerebral cortex RGD PMID:14600440 RGD:8657406 NCBI chr 6:113,303,959...113,311,149
Ensembl chr 6:113,303,933...113,312,029 		JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase treatment IEP
ISO		 protein:altered expression:brain RGD PMID:22345048 PMID:24633199 RGD:7800722, RGD:13208946 NCBI chr16:29,398,099...29,481,924
Ensembl chr16:29,398,152...29,473,702 		JBrowse link
G Optn optineurin ISO protein:decreased expression:cerebral cortex (rat) RGD PMID:24235151 RGD:13434905 NCBI chr 2:5,023,902...5,069,210
Ensembl chr 2:5,025,453...5,068,862 		JBrowse link
G Parl presenilin associated, rhomboid-like severity IMP RGD PMID:23921894 RGD:12902620 NCBI chr16:20,098,570...20,121,090
Ensembl chr16:20,098,568...20,121,137 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase family, member 1 treatment ISO RGD PMID:19840223 PMID:19840223 RGD:2325713, RGD:2325713 NCBI chr 1:180,396,456...180,428,564
Ensembl chr 1:180,396,489...180,428,819 		JBrowse link
G Pawr PRKC, apoptosis, WT1, regulator ISO
IEP		 mRNA:increased expression:brain:
protein:increased expression:cortex,striatum:		 RGD PMID:14705148 PMID:11323519 RGD:1302269, RGD:9835381 NCBI chr10:108,168,050...108,250,708
Ensembl chr10:108,167,982...108,250,101 		JBrowse link
G Pax6 paired box 6 ISO protein:increased expression:cerebral cortex, striatum, astroglial cell (rat) RGD PMID:24114637 RGD:8552354 NCBI chr 2:105,499,241...105,528,755
Ensembl chr 2:105,499,245...105,527,709 		JBrowse link
G Pcna proliferating cell nuclear antigen ISO RGD PMID:9757027 RGD:10448974 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234 		JBrowse link
G Pde4d phosphodiesterase 4D, cAMP specific ISO protein:increased expression:hippocampus CA1 RGD PMID:22860212 RGD:7327148 NCBI chr13:108,790,711...110,092,503
Ensembl chr13:108,586,482...110,089,995 		JBrowse link
G Pdyn prodynorphin ISO mRNA:decreased expression:dentate gyrus, granule cell RGD PMID:8914861 RGD:401851049 NCBI chr 2:129,528,469...129,541,858
Ensembl chr 2:129,528,485...129,541,764 		JBrowse link
G Pecam1 platelet/endothelial cell adhesion molecule 1 IEP protein:increased expression:brain (mouse) RGD PMID:22382321 RGD:6766379 NCBI chr11:106,545,039...106,606,107
Ensembl chr11:106,545,043...106,641,454 		JBrowse link
G Plat plasminogen activator, tissue ISO Protein:increased expression, increased activity:hippocampus (rat) RGD PMID:15882815 RGD:1580875 NCBI chr 8:23,247,655...23,272,864
Ensembl chr 8:23,247,743...23,272,860 		JBrowse link
G Plau plasminogen activator, urokinase ISO protein:increased expression:cerebral cortex (rat) RGD PMID:21375013 PMID:19952306 RGD:7241584, RGD:7241795 NCBI chr14:20,886,730...20,893,456
Ensembl chr14:20,886,728...20,893,453 		JBrowse link
G Plxnd1 plexin D1 ameliorates ISO RGD PMID:30653356 RGD:155663383 NCBI chr 6:115,931,772...115,972,300
Ensembl chr 6:115,931,772...115,971,966 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma ISO
IMP		 RGD PMID:18378216 PMID:18973594 PMID:19221220 RGD:2301892, RGD:2301866, RGD:8553032 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A ISO protein:increased expression:cerebral cortex (rat) RGD PMID:15255948 RGD:9999154 NCBI chr 7:45,172,341...45,175,692
Ensembl chr 7:45,172,340...45,175,692 		JBrowse link
G Ppp1r9a protein phosphatase 1, regulatory subunit 9A treatment ISO RGD PMID:21278085 RGD:10043805 NCBI chr 6:4,902,702...5,165,661
Ensembl chr 6:4,902,917...5,165,661 		JBrowse link
G Ppp2r5e protein phosphatase 2, regulatory subunit B', epsilon treatment ISO RGD PMID:30712471 RGD:155791663 NCBI chr12:75,496,237...75,643,064
Ensembl chr12:75,497,655...75,643,019 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase IEP protein:decreased expression:cerebral cortex, striatum: RGD PMID:12415119 RGD:10413862 NCBI chr17:11,059,227...12,282,257
Ensembl chr17:11,059,271...12,282,248 		JBrowse link
G Ptafr platelet-activating factor receptor treatment ISO mRNA:decreased expression:cerebral cortex (rat) RGD PMID:17268849 PMID:8158141 RGD:9999221, RGD:10043297 NCBI chr 4:132,291,378...132,309,994
Ensembl chr 4:132,291,378...132,309,994 		JBrowse link
G Pten phosphatase and tensin homolog ISO RGD PMID:12414116 RGD:1358425 NCBI chr19:32,734,977...32,803,560
Ensembl chr19:32,734,897...32,803,560 		JBrowse link
G Ptger4 prostaglandin E receptor 4 (subtype EP4) ISO protein:increased expression:hippocampus (rat) RGD PMID:16437207 RGD:10043375 NCBI chr15:5,262,880...5,273,668
Ensembl chr15:5,236,142...5,273,668 		JBrowse link
G Ptgis prostaglandin I2 (prostacyclin) synthase treatment ISO RGD PMID:27834752 RGD:401960086 NCBI chr 2:167,045,114...167,095,069
Ensembl chr 2:167,033,725...167,082,524 		JBrowse link
G Ptn pleiotrophin ISO mRNA:increased expression:cerebral cortex, vasculature, macrophage (rat) RGD PMID:9570800 RGD:9831440 NCBI chr 6:36,691,863...36,787,114
Ensembl chr 6:36,691,864...36,787,155 		JBrowse link
G Ptpn13 protein tyrosine phosphatase, non-receptor type 13 ISO mRNA,protein:increased expression:cerebral cortex: RGD PMID:18096138 RGD:4142863 NCBI chr 5:103,573,058...103,746,227
Ensembl chr 5:103,573,058...103,746,169 		JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 treatment
severity		 ISO
IMP		 protein:decreased phosphorylation, decreased expression:striatum (rat) RGD PMID:24198371 PMID:24198371 PMID:24198371 RGD:9835010, RGD:9835010, RGD:9835010 NCBI chr 7:46,727,543...46,783,774
Ensembl chr 7:46,727,543...46,783,432 		JBrowse link
G Rack1 receptor for activated C kinase 1 ISO RGD PMID:24007266 RGD:9588303 NCBI chr11:48,691,187...48,697,068
Ensembl chr11:48,691,159...48,697,261 		JBrowse link
G Robo1 roundabout guidance receptor 1 disease_progression ISO
IEP		 protein:increased expression:hippocampus
protein:increased expression:brain, astrocyte		 RGD PMID:26764532 PMID:27686659 PMID:23473743 RGD:11573340, RGD:243048429, RGD:243048431 NCBI chr16:71,824,406...72,844,379
Ensembl chr16:72,105,194...72,842,983 		JBrowse link
G Robo2 roundabout guidance receptor 2 ISO protein:increased expression:brain, astrocyte RGD PMID:27686659 RGD:243048429 NCBI chr16:73,688,725...75,244,331
Ensembl chr16:73,688,727...74,889,765 		JBrowse link
G Robo4 roundabout guidance receptor 4 ISO protein:increased expression:hippocampus RGD PMID:26764532 RGD:11573340 NCBI chr 9:37,313,198...37,325,319
Ensembl chr 9:37,313,193...37,326,411 		JBrowse link
G Rps6 ribosomal protein S6 ISO RGD PMID:26556340 RGD:11041643 NCBI chr 4:86,772,336...86,775,604
Ensembl chr 4:86,772,897...86,775,649 		JBrowse link
G Sema3e sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E disease_progression ISO RGD PMID:30653356 RGD:155663383 NCBI chr 5:14,075,290...14,306,703
Ensembl chr 5:14,075,290...14,306,703 		JBrowse link
G Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 treatment ISO RGD PMID:26851971 RGD:11073692 NCBI chr 5:137,090,358...137,101,126
Ensembl chr 5:137,090,358...137,101,122 		JBrowse link
G Serpinf1 serine (or cysteine) peptidase inhibitor, clade F, member 1 treatment ISO human gene in a rat model RGD PMID:18624913 RGD:8613878 NCBI chr11:75,300,855...75,313,449
Ensembl chr11:75,300,595...75,313,527 		JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 ISO mRNA:increased expression:hippocampus, pyramidal cell RGD PMID:15046873 RGD:1580967 NCBI chr10:21,758,083...21,875,802
Ensembl chr10:21,758,083...21,875,802 		JBrowse link
G Sin3a transcriptional regulator, SIN3A (yeast) ISO RGD PMID:24063527 RGD:9495912 NCBI chr 9:56,979,271...57,035,652
Ensembl chr 9:56,979,324...57,035,650 		JBrowse link
G Sirt6 sirtuin 6 ISO mRNA, protein:decreased expression:brain RGD PMID:23899523 RGD:9586062 NCBI chr10:81,457,621...81,463,631
Ensembl chr10:81,457,619...81,463,631 		JBrowse link
G Slc12a2 solute carrier family 12, member 2 ISO RGD PMID:27798271 RGD:14398833 NCBI chr18:58,011,505...58,079,893
Ensembl chr18:58,011,750...58,079,893 		JBrowse link
G Slc17a6 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 6 ISO RGD PMID:23458738 RGD:9999193 NCBI chr 7:51,271,578...51,320,874
Ensembl chr 7:51,271,754...51,320,867 		JBrowse link
G Slc17a7 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 7 ISO RGD PMID:23458738 RGD:9999193 NCBI chr 7:44,813,345...44,825,563
Ensembl chr 7:44,813,373...44,825,566 		JBrowse link
G Slc17a8 solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8 ISO RGD PMID:23458738 RGD:9999193 NCBI chr10:89,409,882...89,457,111
Ensembl chr10:89,409,882...89,457,115 		JBrowse link
G Slit2 slit guidance ligand 2 ISO protein:increased expression:hippocampus
protein:increased expression:brain, astrocyte		 RGD PMID:26764532 PMID:27686659 RGD:11573340, RGD:243048429 NCBI chr 5:48,138,633...48,465,077
Ensembl chr 5:48,140,480...48,465,075 		JBrowse link
G Smpd3 sphingomyelin phosphodiesterase 3, neutral ISO RGD PMID:24007266 RGD:9588303 NCBI chr 8:106,979,180...107,064,597
Ensembl chr 8:106,979,180...107,064,620 		JBrowse link
G Socs1 suppressor of cytokine signaling 1 treatment ISO RGD PMID:33081480 RGD:151347423 NCBI chr16:10,601,672...10,603,400
Ensembl chr16:10,600,104...10,603,400 		JBrowse link
G Sod1 superoxide dismutase 1, soluble treatment ISO human protein in a rat model
human gene in a rat model
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:12629175 PMID:15829915 PMID:16538228 PMID:16868554 PMID:21531066 More... RGD:8655885, RGD:8655986 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:11333366 PMID:30716316 RGD:27095883 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 exacerbates ISO RGD PMID:23764464 PMID:23884942 RGD:8694326, RGD:8694331 NCBI chr11:100,777,632...100,830,447
Ensembl chr11:100,775,924...100,830,366 		JBrowse link
G Tert telomerase reverse transcriptase treatment ISO RGD PMID:21914402 RGD:11038669 NCBI chr13:73,775,030...73,797,962
Ensembl chr13:73,775,030...73,797,962 		JBrowse link
G Tfpi tissue factor pathway inhibitor treatment ISO RGD PMID:18067952 RGD:11062087 NCBI chr 2:84,263,199...84,307,119
Ensembl chr 2:84,263,199...84,307,119 		JBrowse link
G Tia1 cytotoxic granule-associated RNA binding protein 1 ISO RGD PMID:16055272 RGD:10059581 NCBI chr 6:86,381,001...86,410,387
Ensembl chr 6:86,381,201...86,410,387 		JBrowse link
G Tial1 Tia1 cytotoxic granule-associated RNA binding protein-like 1 ISO RGD PMID:10700014 RGD:1357161 NCBI chr 7:128,041,496...128,063,450
Ensembl chr 7:128,041,501...128,063,441 		JBrowse link
G Tnf tumor necrosis factor treatment ISO mRNA:increased expression:striatum,hippocampus: RGD PMID:24053818 PMID:11412877 RGD:7364868, RGD:13825263 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a treatment ISO mRNA:increased expression:striatum,hippocampus: RGD PMID:21868309 PMID:11412877 RGD:8661762, RGD:13825263 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447 		JBrowse link
G Trpc6 transient receptor potential cation channel, subfamily C, member 6 treatment ISO
IMP		 RGD PMID:23435869 PMID:23043486 PMID:20811149 RGD:7247582, RGD:7247583, RGD:7247585 NCBI chr 9:8,543,868...8,680,753
Ensembl chr 9:8,544,143...8,680,742 		JBrowse link
G Trpm2 transient receptor potential cation channel, subfamily M, member 2 ISO mRNA:increased expression:cerebral cortex RGD PMID:16777714 RGD:10003026 NCBI chr10:77,743,556...77,805,746
Ensembl chr10:77,743,556...77,806,397 		JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 IMP RGD PMID:22284622 RGD:7175554 NCBI chr11:73,158,315...73,191,194
Ensembl chr11:73,158,214...73,191,189 		JBrowse link
G Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) treatment ISO RGD PMID:19772611 RGD:7204428 NCBI chr 7:100,142,565...100,148,832
Ensembl chr 7:100,142,544...100,151,227 		JBrowse link
G Vwf Von Willebrand factor treatment ISO RGD PMID:22771326 RGD:7207039 NCBI chr 6:125,529,911...125,663,642
Ensembl chr 6:125,523,737...125,663,642 		JBrowse link
G Wnk1 WNK lysine deficient protein kinase 1 ISO RGD PMID:27798271 RGD:14398833 NCBI chr 6:119,900,930...120,015,659
Ensembl chr 6:119,900,930...120,015,633 		JBrowse link
G Wnk2 WNK lysine deficient protein kinase 2 ISO RGD PMID:27798271 RGD:14398833 NCBI chr13:49,189,778...49,302,110
Ensembl chr13:49,189,779...49,301,490 		JBrowse link
G Wnk4 WNK lysine deficient protein kinase 4 ISO RGD PMID:27798271 RGD:14398833 NCBI chr11:101,151,363...101,168,235
Ensembl chr11:101,151,393...101,168,235 		JBrowse link
G Xrcc1 X-ray repair complementing defective repair in Chinese hamster cells 1 treatment ISO RGD PMID:19840223 RGD:2325713 NCBI chr 7:24,246,124...24,272,863
Ensembl chr 7:24,245,714...24,272,865 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 16121
    Nutritional and Metabolic Diseases 7404
      disease of metabolism 7404
        acquired metabolic disease 2327
          Reperfusion Injury 829
            transient cerebral ischemia 241
              basilar artery insufficiency + 0
              vertebral artery insufficiency + 0
Path 2
Term Annotations click to browse term
  disease 16121
    disease of anatomical entity 15680
      nervous system disease 13560
        central nervous system disease 12117
          brain disease 11377
            cerebrovascular disease 998
              brain ischemia 635
                transient cerebral ischemia 241
                  basilar artery insufficiency + 0
                  vertebral artery insufficiency + 0
paths to the root