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Gene-Chemical Interaction Annotations
Gene-Chemical Interaction AnnotationsTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | (-)-epigallocatechin 3-gallate | multiple interactions | ISO | RGD:1318943 | 6480464 | [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HTRA2 mRNA | CTD | PMID:22079256 | 17beta-estradiol | affects expression | ISO | RGD:1318943 | 6480464 | Estradiol affects the expression of HTRA2 mRNA | CTD | PMID:22574217 | 17beta-hydroxy-17-methylestra-4,9,11-trien-3-one | decreases expression | ISO | RGD:1318943 | 6480464 | Metribolone results in decreased expression of HTRA2 protein | CTD | PMID:17152098 | apocynin | multiple interactions | ISO | RGD:1318943 | 6480464 | [tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione affects the localization of HTRA2 protein] | CTD | PMID:20153346 | bis(2-ethylhexyl) phthalate | affects expression | EXP | | 6480464 | Diethylhexyl Phthalate affects the expression of HTRA2 mRNA | CTD | PMID:21636974 | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of HTRA2 mRNA | CTD | PMID:21636974 | cadmium dichloride | decreases expression | EXP | | 6480464 | Cadmium Chloride results in decreased expression of HTRA2 mRNA | CTD | PMID:20883709 | calcitriol | decreases expression | ISO | RGD:1318943 | 6480464 | Calcitriol results in decreased expression of HTRA2 mRNA | CTD | PMID:21592394 | calcitriol | multiple interactions | ISO | RGD:1318943 | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of HTRA2 mRNA | CTD | PMID:21592394 | chlorpyrifos | decreases expression | EXP | | 6480464 | Chlorpyrifos results in decreased expression of HTRA2 mRNA | CTD | PMID:20350560 | cisplatin | increases expression | ISO | RGD:1318943 | 6480464 | Cisplatin results in increased expression of HTRA2 protein | CTD | PMID:15863139 | clofibric acid | multiple interactions | ISO | RGD:1308906 | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of HTRA2 mRNA | CTD | PMID:17602206 | cobalt dichloride | decreases expression | ISO | RGD:1318943 | 6480464 | cobaltous chloride results in decreased expression of HTRA2 mRNA | CTD | PMID:19376846 | diarsenic trioxide | increases expression | ISO | RGD:1318943 | 6480464 | arsenic trioxide results in increased expression of HTRA2 mRNA | CTD | PMID:22521957 | diarsenic trioxide | multiple interactions | ISO | RGD:1318943 | 6480464 | [arsenic trioxide co-treated with TNF protein] affects the localization of HTRA2 protein | CTD | PMID:17673311 | diarsenic trioxide | multiple interactions | ISO | RGD:1318943 | 6480464 | [lonidamine co-treated with arsenic trioxide] affects the localization of HTRA2 protein | CTD | PMID:21889928 | diarsenic trioxide | multiple interactions | ISO | RGD:1318943 | 6480464 | [arsenic trioxide co-treated with Quercetin] affects the localization of HTRA2 protein | CTD | PMID:18359480 | diazoxide | decreases expression | EXP | | 6480464 | Isoproterenol results in decreased expression of HTRA2 mRNA | CTD | PMID:21335049 | dibutyl phthalate | increases expression | EXP | | 6480464 | Dibutyl Phthalate results in increased expression of HTRA2 mRNA | CTD | PMID:21266533 | ethanol | increases expression | EXP | | 6480464 | Ethanol results in increased expression of HTRA2 protein | CTD | PMID:19429258 | ethanol | multiple interactions | ISO | RGD:1318943 | 6480464 | ALDH2 protein inhibits the reaction [Ethanol results in increased expression of HTRA2 protein] | CTD | PMID:19429258 | hydrogen peroxide | multiple interactions | ISO | RGD:1318943 | 6480464 | [Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of HTRA2 protein | CTD | PMID:18951874 | isoprenaline | decreases expression | EXP | | 6480464 | Isoproterenol results in decreased expression of HTRA2 mRNA | CTD | PMID:21335049 | lonidamine | multiple interactions | ISO | RGD:1318943 | 6480464 | [lonidamine co-treated with arsenic trioxide] affects the localization of HTRA2 protein | CTD | PMID:21889928 | N-nitrosodiethylamine | multiple interactions | ISO | RGD:1308906 | 6480464 | [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of HTRA2 mRNA | CTD | PMID:17602206 | paraquat | affects localization | ISO | RGD:1308906 | 6480464 | Paraquat affects the localization of HTRA2 protein | CTD | PMID:22245251 | phlorizin | decreases expression | EXP | | 6480464 | Phlorhizin results in decreased expression of HTRA2 mRNA | CTD | PMID:22538082 | quercetin | multiple interactions | ISO | RGD:1318943 | 6480464 | [arsenic trioxide co-treated with Quercetin] affects the localization of HTRA2 protein | CTD | PMID:18359480 | resveratrol | increases expression | EXP | | 6480464 | resveratrol results in increased expression of HTRA2 mRNA | CTD | PMID:22610192 | rotenone | increases expression | ISO | RGD:1318943 | 6480464 | Rotenone results in increased expression of HTRA2 protein | CTD | PMID:19763263 | rotenone | decreases expression | ISO | RGD:1318943 | 6480464 | Rotenone results in decreased expression of HTRA2 protein | CTD | PMID:19763263 | S-nitrosoglutathione | multiple interactions | ISO | RGD:1318943 | 6480464 | [tempol co-treated with UCF 101 co-treated with acetovanillone] inhibits the reaction [S-Nitrosoglutathione affects the localization of HTRA2 protein] | CTD | PMID:20153346 | S-nitrosoglutathione | affects localization | ISO | RGD:1318943 | 6480464 | S-Nitrosoglutathione affects the localization of HTRA2 protein | CTD | PMID:20153346 | simvastatin | affects localization | ISO | RGD:1318943 | 6480464 | Simvastatin affects the localization of HTRA2 protein | CTD | PMID:20045437 | testosterone | multiple interactions | ISO | RGD:1318943 | 6480464 | [Testosterone co-treated with Calcitriol] results in decreased expression of HTRA2 mRNA | CTD | PMID:21592394 | testosterone | decreases expression | ISO | RGD:1318943 | 6480464 | Testosterone results in decreased expression of HTRA2 mRNA | CTD | PMID:21592394 | theophylline | multiple interactions | ISO | RGD:1318943 | 6480464 | [Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of HTRA2 protein | CTD | PMID:18951874 | toluene | affects expression | ISO | RGD:1308906 | 6480464 | Toluene affects the expression of HTRA2 mRNA | CTD | PMID:21827849 | trans-resveratrol | increases expression | EXP | | 6480464 | resveratrol results in increased expression of HTRA2 mRNA | CTD | PMID:22610192 | trichostatin A | multiple interactions | ISO | RGD:1318943 | 6480464 | [vorinostat co-treated with trichostatin A] affects the localization of HTRA2 protein | CTD | PMID:16026644 | | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Gene Ontology Annotations
Molecular Pathway Annotations| External Database Links | |
| KEGG Pathway | Parkinson's disease |
Phenotype Annotations
Disease Annotations
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Gene-Chemical Interaction Annotations
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Gene Ontology Annotations
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Molecular Pathway Annotations
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| External Database Links | |
| KEGG Pathway | Parkinson's disease |
Phenotype Annotations
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References - curated| 1. |
Althaus J, etal., Neurochem Int. 2007 Jan;50(1):172-80. Epub 2006 Sep 15. |
| 2. |
Bogaerts V, etal., Hum Mutat. 2008 Jun;29(6):832-40. |
| 3. |
Hu XY, etal., APMIS. 2006 Dec;114(12):893-8. |
| 4. |
Inagaki R, etal., Eur J Neurosci. 2008 Jul;28(1):30-40. |
| 5. |
Jones JM, etal., Nature. 2003 Oct 16;425(6959):721-7. Epub 2003 Oct 8. |
| 6. |
Lee SH, etal., APMIS. 2003 May;111(5):586-90. |
| 7. |
Lin CH, etal., Hum Genet. 2011 Dec;130(6):817-27. Epub 2011 Jun 24. |
| 8. |
Liu HR, etal., Circulation. 2005 Jan 4;111(1):90-6. Epub 2004 Dec 20. |
| 9. |
Martins LM, etal., Mol Cell Biol. 2004 Nov;24(22):9848-62. |
| 10. |
MGD data from the GO Consortium |
| 11. |
MGD IEA |
| 12. |
Narkiewicz J, etal., Clin Biochem. 2008 May;41(7-8):561-9. Epub 2008 Jan 16. |
| 13. |
Narkiewicz J, etal., Oncol Rep. 2009 Jun;21(6):1529-37. |
| 14. |
Pipeline to import KEGG annotations from KEGG into RGD Pathway Ontology |
| 15. |
Rami A, etal., Neurochem Res. 2010 Dec;35(12):2199-207. Epub 2010 Dec 4. |
| 16. |
RGD automated import pipeline |
| 17. |
RGD automated import pipeline for gene-chemical interactions |
| 18. |
RGD Automated Pipelines |
| 19. |
Saito A, etal., Brain Res Mol Brain Res. 2004 Aug 23;127(1-2):89-95. |
| 20. |
Simon-Sanchez J and Singleton AB, Hum Mol Genet. 2008 Jul 1;17(13):1988-93. Epub 2008 Mar 25. |
| 21. |
Strauss KM, etal., Hum Mol Genet. 2005 Aug 1;14(15):2099-111. Epub 2005 Jun 16. |
| 22. |
Wang CY, etal., Brain Res. 2011 Apr 18;1385:293-7. Epub 2011 Feb 19. |
| 23. |
Westerlund M, etal., FASEB J. 2011 Apr;25(4):1345-52. Epub 2010 Dec 16. |
References - uncurated| PubMed | 10051670 |
| 10349636 | |
| 10922068 | |
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| 11007969 | |
| 11042159 | |
| 11076861 | |
| 11217851 | |
| 11287196 | |
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| 18479146 | |
| 18614015 | |
| 18772386 | |
| 18799693 | |
| 19023330 | |
| 19435805 | |
| 19443712 | |
| 19631192 | |
| 20064504 | |
| 20123086 | |
| 20219823 | |
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| 20614026 | |
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| 7987303 | |
| 8188273 | |
| 8325640 | |
| 8889548 | |
| 9070275 | |
| 9073523 | |
| 9806835 | |
| 9927484 |
RGD Disease Portals| Htra2 has been annotated in the following RGD Disease Portals. |
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Comparative Map Data| Htra2 (Mus musculus) |
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| HTRA2 (Homo sapiens) |
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| Htra2 (Rattus norvegicus) |
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Nucleotide Sequences| Nucleotide RefSeqs | NM_019752 | (Get FASTA) | Search GEO for Microarray Profiles |
| GenBank Nucleotide | AAHY01054875 | (Get FASTA) | Search GEO for Microarray Profiles |
| AC104324 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AC134899 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF164513 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AF175324 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK011536 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK146338 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK159188 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK176936 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK178298 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK179655 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK182973 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK186135 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK188221 | (Get FASTA) | Search GEO for Microarray Profiles | |
| AK215600 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC033276 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BC049880 | (Get FASTA) | Search GEO for Microarray Profiles | |
| BM899329 | (Get FASTA) | Search GEO for Microarray Profiles | |
| CH466523 | (Get FASTA) | Search GEO for Microarray Profiles |
| RefSeq Acc Id: | NM_019752 | |||||||||||||||||||||||||
| RefSeq Status: | VALIDATED | |||||||||||||||||||||||||
| Type: | CODING | |||||||||||||||||||||||||
| Protein Acc Id: | NP_062726 | |||||||||||||||||||||||||
| Position: |
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Protein Sequences| Protein RefSeqs | NP_062726 | (Get FASTA) |
| GenBank Protein | AAD50499 | (Get FASTA) |
| AAF89534 | (Get FASTA) | |
| AAH49880 | (Get FASTA) | |
| BAE27092 | (Get FASTA) | |
| BAE34885 | (Get FASTA) | |
| EDK99048 | (Get FASTA) | |
| EDK99049 | (Get FASTA) | |
| EDK99050 | (Get FASTA) | |
| Q9JIY5 | (Get FASTA) |
Promoters| RGD ID: | 6848001 | ||||||||||
| Promoter ID: | MM_ACW:41726 | ||||||||||
| Type: | Non-CpG | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | MEF_B4 | ||||||||||
| Transcripts: | HTRA2.LSEP07-UNSPLICED | ||||||||||
| Position: |
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| RGD ID: | 6839470 | ||||||||||
| Promoter ID: | MM_KWN:46562 | ||||||||||
| Type: | CpG-Island | ||||||||||
| SO ACC ID: | SO:0000170 | ||||||||||
| Source: | MPROMDB | ||||||||||
| Tissues & Cell Lines: | 3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day2, BoneMarrow_0Hour, BoneMarrow_2Hour, BoneMarrow_4Hour, ES_Cell, Liver, Lung, MEF_B6, Spleen | ||||||||||
| Transcripts: | ENSMUST00000113962, ENSMUST00000113963, OTTMUST00000053814, OTTMUST00000053816, OTTMUST00000053818, OTTMUST00000053821, OTTMUST00000053822, UC009CLV.1, UC009CLW.1, UC009CLX.1 | ||||||||||
| Position: |
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External Database Links| Database | Acc Id | Source(s) |
| Ensembl Genes | ENSMUSG00000068329 | ENTREZGENE |
| Ensembl Protein | ENSMUSP00000087073 | ENTREZGENE |
| Ensembl Transcript | ENSMUST00000089645 | ENTREZGENE |
| Entrez Gene | 64704 | ENTREZGENE |
| Germonline | ENSMUSG00000068329 | |
| HomoloGene Group ID | 113300 | ENTREZGENE |
| InterPro | PDZ/DHR/GLGF | UniProtKB/Swiss-Prot |
| Pept_cys/ser_Trypsin-like | UniProtKB/Swiss-Prot | |
| Peptidase_S1C | UniProtKB/Swiss-Prot | |
| IPI | IPI00275992 | UniProtKB/Swiss-Prot |
| IPI00830249 | UniProtKB/TrEMBL | |
| IPI00830364 | UniProtKB/TrEMBL | |
| IPI00830476 | UniProtKB/TrEMBL | |
| IPI00831347 | UniProtKB/TrEMBL | |
| KEGG Report | mmu:64704 | ENTREZGENE, UniProtKB/Swiss-Prot |
| MGD | MGI:1928676 | ENTREZGENE |
| Pfam | PDZ_2 | UniProtKB/Swiss-Prot |
| PRINTS | PROTEASES2C | UniProtKB/Swiss-Prot |
| PROSITE | PDZ | UniProtKB/Swiss-Prot |
| SMART | PDZ | UniProtKB/Swiss-Prot |
| Superfamily-SCOP | PDZ | UniProtKB/Swiss-Prot |
| Pept_Ser_Cys | UniProtKB/Swiss-Prot | |
| UniGene | Mm.21880 | ENTREZGENE |
| UniProt | D3YX27_MOUSE | UniProtKB/TrEMBL |
| D3YX28_MOUSE | UniProtKB/TrEMBL | |
| F6TCV0_MOUSE | UniProtKB/TrEMBL | |
| F6XUR8_MOUSE | UniProtKB/TrEMBL | |
| HTRA2_MOUSE | UniProtKB/Swiss-Prot | |
| Q3TXN0_MOUSE | UniProtKB/TrEMBL | |
| Q3UJR3_MOUSE | UniProtKB/TrEMBL | |
| Q80V84_MOUSE | UniProtKB/TrEMBL |
| More on Htra2 | |
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Entrez Gene |
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Ensembl Gene |
![]() | Genome Browser |
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MGI Report |
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NCBI Map Viewer |
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Vista |
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Vista + UCSC |
| RGD Object Information | |
| RGD ID: | 1318944 |
| Created: | 2005-01-12 |
| Species: | Mus musculus |
| Last Modified: | 2013-02-27 |
| Status: | ACTIVE |
© Bioinformatics Program, HMGC at the Medical College of Wisconsin
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.




